EKS-LAC-00401

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00401

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	363.9	6.5E-109	479	736	258

Status

Unreviewed

Ensembl Protein

ENSLACP00000000191

UniProt Accession

H2ZS20;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K5

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000000172	ENSLACP00000000191	ENSLACT00000000193

Organism

Latimeria chalumnae

Functional Description

Protein Length

1171

Protein Sequence
(FASTA)

LQTCTGNYIF IPYMVTPHNK VYCCESSFMK GFTELMQPSF EAFLGPICLP LVERFTQLLK 60

VAQTSSCQYF REIILSDIRK ARELYSGKEL AVELARIRQR VDNIELLSAD IVINLLLSYR 120

DIQDYDSIVN LVETLEKLPT FDLLSHHHVK FHYAFALNRR NKPGDRQRAL EIMLPTVESE 180

NQVASDMYCL VGRIFKDTFL DSGFADTDSR DNGIHWFRRA FESEPTLHSG INYAVLLLAA 240

GHQFDTSFEL RKAGVKLSSL LGKKGSLEKL QSYWDVGFFL GASILASDHL RVIQASEKLF 300

KLKAPAWYIR SLVETIRIYQ HFRKQSPEQP VAKQELVDFW MDFLVETTNK DVSLVRFPVL 360

ILEPTKVYQP SYLSINNEAE EKTVSIWHVS PDDKKGIHEW NFAATSIRGV SVSKFDERCC 420

FLYILYNSDD FQLYFCTERH CKRFCEMVNN ITEEAGRGTE EGECDSDALE YDYEYDENRE 480

RVILGKGTYG VVYAGRDLSN QVRIAIKEIP ERDSRYSQPL HEEIALHKHL KHKNIVQYLG 540

SISENGFIKI FMEQVPGGSL SALLRSKWGP LKDNEQTIGF YTKQILEGLK YLHDNQIVHR 600

DIKGDNVLIN TYSGILKISD FGTSKRLAGI NPCTETFTGT LQYMAPEIID KGPRGYGKPA 660

DIWSLGCTII EMATGKPPFY ELGEPQAAMF KVGMFKIHPE IPDSMSPEAK AFLLRCFEPD 720

PDMRATATEL LTDEFLKVTS KKKRSQTKLT GIFIKKMYMT KIFVKIEVLL VKESVSLEHS 780

TITNDTCLKE DQSPVGIRPS DCKPQKKKKN LLMFLHIPDD HFEDHSAPPS PEEKDSGFFM 840

LKKDSERRAT LHKILSEDQE RVVRNLLESL AQGAEEPRLK WEHITALVVS LREFVRTPDR 900

KIIATTLSKL KLELDFDSHA ISQVQVVLFG FQEAVNKVLR NQNIKPHWMF ALDNIIRKAV 960

QTAITILVPE LRAHFSLPSE SDAADQDEEE EEEGSHDQVQ EHTIQRPSGV HEDAVPTSGV 1020

STLSSTMSHD DPQNTHRSLS VQLGRLKIET NRLLEDLMQK EKEYQMLLLQ AIEEKNQEIK 1080

RLKTKSQPID IPAPFVCHYS YSGTPDEDPS LVNWLREHGV DQDTIEKLLA EDYRLNDLLY 1140

FVTREDLKYL RLRGGMLCKL WKAIAHHREE H 1171

Nucleotide Sequence
(FASTA)

TTGCAGACAT GCACAGGTAA CTACATTTTT ATCCCCTACA TGGTGACTCC GCACAATAAG 60

GTGTACTGCT GTGAAAGCAG CTTCATGAAG GGGTTTACTG AGTTAATGCA GCCTAGTTTC 120

GAGGCATTTC TTGGGCCTAT CTGTTTGCCA TTGGTAGAAC GTTTCACACA ACTGCTGAAG 180

GTAGCGCAAA CAAGTTCTTG CCAATACTTC CGGGAAATCA TTCTCAGTGA CATCAGGAAG 240

GCCCGTGAGC TGTATAGTGG TAAGGAGCTA GCAGTCGAAT TGGCAAGGAT ACGACAGCGC 300

GTGGATAACA TTGAACTCCT TTCAGCAGAT ATTGTCATCA ACTTACTGCT GTCCTATAGA 360

GACATTCAGG ATTATGACTC CATTGTGAAT CTAGTGGAGA CATTGGAAAA GCTTCCAACT 420

TTTGATCTGC TGTCACATCA CCATGTGAAA TTTCATTACG CCTTTGCTTT GAATCGGAGA 480

AATAAACCCG GTGACAGGCA GAGGGCCCTG GAGATAATGC TACCCACGGT GGAGTCAGAG 540

AACCAGGTTG CATCAGATAT GTACTGTCTG GTTGGACGGA TTTTCAAGGA CACCTTTTTG 600

GACTCCGGGT TTGCTGACAC AGATAGCCGA GACAATGGGA TACACTGGTT CAGGAGGGCA 660

TTTGAATCTG AGCCAACACT GCATTCAGGA ATCAATTATG CCGTCCTCCT CTTGGCAGCT 720

GGACACCAGT TTGATACTTC ATTTGAGCTG CGCAAAGCTG GAGTGAAGCT GAGCAGCCTG 780

CTGGGTAAAA AAGGAAGCCT AGAGAAGCTC CAAAGTTACT GGGATGTGGG ATTCTTCCTG 840

GGAGCCAGCA TCCTGGCCAG TGACCACCTC AGAGTGATTC AAGCCTCGGA AAAGCTCTTT 900

AAGCTAAAGG CCCCTGCATG GTATATAAGG TCTCTTGTAG AAACAATCCG GATATATCAG 960

CATTTTAGGA AGCAGAGTCC AGAACAGCCT GTAGCCAAAC AGGAACTGGT GGATTTTTGG 1020

ATGGACTTTC TTGTTGAAAC CACAAATAAG GATGTGTCTT TAGTAAGATT TCCTGTCTTA 1080

ATATTGGAGC CAACCAAAGT CTACCAGCCT TCTTATCTCT CCATCAATAA TGAAGCTGAA 1140

GAGAAGACTG TGTCCATCTG GCATGTGTCT CCAGATGATA AGAAAGGTAT TCATGAATGG 1200

AACTTTGCCG CTACTTCCAT CAGGGGTGTG AGTGTTTCCA AGTTTGATGA ACGCTGTTGT 1260

TTTCTATACA TTCTGTACAA CTCTGATGAC TTTCAGCTTT ACTTTTGCAC AGAGCGTCAC 1320

TGCAAGAGGT TTTGTGAAAT GGTGAATAAT ATAACAGAAG AGGCTGGCAG AGGTACTGAA 1380

GAAGGTGAAT GTGACAGCGA TGCACTGGAG TACGACTATG AGTATGATGA GAACCGGGAA 1440

AGAGTGATCT TGGGCAAGGG GACGTACGGT GTTGTTTATG CAGGAAGGGA TCTGAGCAAT 1500

CAAGTTAGGA TTGCCATCAA AGAAATCCCT GAAAGGGACA GCAGATACTC CCAGCCCTTA 1560

CATGAAGAGA TAGCTCTGCA CAAACACCTG AAGCATAAGA ACATTGTCCA GTACCTGGGG 1620

TCTATTAGCG AGAATGGATT TATCAAAATT TTTATGGAGC AGGTTCCTGG AGGTAGCCTT 1680

TCTGCCCTGT TGCGATCCAA ATGGGGACCC TTAAAGGACA ATGAGCAGAC GATTGGTTTT 1740

TATACCAAGC AGATCCTGGA GGGGTTGAAA TATCTACATG ACAACCAGAT AGTACATCGA 1800

GACATCAAGG GGGACAATGT CCTGATAAAC ACATACAGTG GAATACTGAA AATTTCTGAC 1860

TTTGGCACTT CCAAGAGGCT CGCAGGGATT AACCCATGTA CTGAAACCTT CACTGGTACA 1920

CTTCAGTATA TGGCGCCTGA AATTATTGAC AAGGGACCAA GAGGCTATGG CAAACCTGCA 1980

GATATCTGGT CGTTGGGATG TACCATCATT GAAATGGCTA CAGGGAAACC CCCATTTTAT 2040

GAACTGGGAG AACCTCAGGC AGCCATGTTT AAGGTGGGGA TGTTTAAAAT CCACCCAGAG 2100

ATCCCAGACT CCATGTCACC AGAAGCTAAA GCCTTCCTCC TGCGTTGTTT TGAGCCAGAC 2160

CCGGATATGC GAGCGACTGC CACCGAATTA CTTACCGATG AGTTTTTGAA GGTCACAAGC 2220

AAGAAAAAGA GGTCACAAAC CAAATTAACA GGTATCTTCA TAAAGAAGAT GTATATGACA 2280

AAGATTTTTG TCAAAATAGA AGTGCTTCTA GTCAAAGAGA GCGTATCATT GGAGCACTCT 2340

ACTATTACCA ATGACACTTG TCTGAAAGAA GACCAATCGC CTGTTGGGAT CAGGCCTTCT 2400

GATTGCAAGC CACAAAAAAA AAAAAAAAAT CTTCTAATGT TTTTGCATAT ACCAGATGAC 2460

CATTTTGAGG ATCATAGTGC ACCCCCATCC CCTGAAGAGA AGGATTCTGG GTTCTTTATG 2520

TTGAAGAAGG ACAGTGAGCG TAGAGCTACT TTGCATAAAA TCCTTTCAGA GGACCAGGAG 2580

AGAGTGGTTA GAAACTTGCT GGAATCTTTA GCTCAGGGTG CTGAAGAACC CAGGCTGAAG 2640

TGGGAACACA TCACTGCTCT TGTAGTGAGC CTCCGGGAAT TTGTTAGGAC TCCCGACCGC 2700

AAAATCATTG CCACGACTCT GTCAAAACTG AAGCTGGAGT TAGACTTTGA CAGCCATGCT 2760

ATAAGCCAAG TCCAGGTGGT GCTCTTTGGT TTTCAAGAAG CTGTCAATAA AGTTCTACGA 2820

AACCAGAACA TAAAGCCCCA CTGGATGTTT GCACTAGACA ACATTATTCG GAAGGCTGTG 2880

CAGACTGCTA TCACTATTCT GGTTCCCGAA CTGAGGGCAC ATTTCAGTCT CCCCTCTGAA 2940

AGTGATGCAG CAGACCAGGA TGAGGAGGAA GAGGAGGAAG GTAGTCATGA CCAGGTTCAG 3000

GAGCACACAA TTCAGAGACC TAGTGGTGTC CATGAAGATG CAGTACCTAC CTCAGGTGTG 3060

AGCACACTCA GTTCAACCAT GTCCCATGAT GACCCGCAGA ACACTCACCG GTCCCTGAGC 3120

GTACAACTCG GGCGGCTCAA AATAGAAACC AACCGGTTAT TGGAGGACTT GATGCAAAAG 3180

GAAAAAGAGT ATCAAATGCT TCTGCTGCAA GCCATTGAAG AAAAGAACCA AGAGATTAAA 3240

CGGCTAAAGA CAAAATCACA ACCAATTGAT ATTCCTGCAC CCTTTGTGTG CCACTACAGT 3300

TACTCTGGCA CACCTGATGA AGACCCTAGC CTTGTGAATT GGTTAAGGGA ACATGGAGTA 3360

GACCAGGATA CTATTGAAAA ATTGCTGGCA GAAGATTACA GGCTGAATGA TCTCCTCTAC 3420

TTTGTGACAC GAGAAGACTT GAAGTATTTA AGGCTAAGAG GCGGGATGCT GTGTAAGCTG 3480

TGGAAGGCTA TCGCTCATCA CAGAGAGGAG CAT 3513

Domain Profile

S: 2     qkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHe  61

         ++r ++gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k+lkH+

Q: 479   RERVILGKGTYGVVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKHLKHK  533

         57899**************************...888775..9*****************

S: 62    nivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLH  118

         niv+y+G+ +e++ +kif+E+v+gGsls+ll+ k+g+l+  e++i +ytkqilegl+yLH

Q: 534   NIVQYLGSISENGFIKIFMEQVPGGSLSALLRsKWGPLKdnEQTIGFYTKQILEGLKYLH  593

         ********************************9*****9999******************

S: 119   ekkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvik  177

         +++ivHRDiKg+N+l+++ sg++k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+

Q: 594   DNQIVHRDIKGDNVLINTySGILKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIID  650

         ****************************************...8****************

S: 178   kkekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegk  237

         k+ +gyg+ aDiWslgc++iem+tgk+Pf el+e++a+mfkvg+ k++Peip+++s+e+k

Q: 651   KGPRGYGKPADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKIHPEIPDSMSPEAK  710

         ************************************************************

S: 238   dflekcleldpkkrpsaeeLLkhefl  263

         +fl +c+e dp+ r++a+eLL++efl

Q: 711   AFLLRCFEPDPDMRATATELLTDEFL  736

         ***********************996

Domain Sequence
(FASTA)

RERVILGKGT YGVVYAGRDL SNQVRIAIKE IPERDSRYSQ PLHEEIALHK HLKHKNIVQY 60

LGSISENGFI KIFMEQVPGG SLSALLRSKW GPLKDNEQTI GFYTKQILEG LKYLHDNQIV 120

HRDIKGDNVL INTYSGILKI SDFGTSKRLA GINPCTETFT GTLQYMAPEI IDKGPRGYGK 180

PADIWSLGCT IIEMATGKPP FYELGEPQAA MFKVGMFKIH PEIPDSMSPE AKAFLLRCFE 240

PDPDMRATAT ELLTDEFL 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013