EKS-LAC-00387

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00387

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	410.5	2.8E-123	511	762	252

Status

Unreviewed

Ensembl Protein

ENSLACP00000000244

UniProt Accession

H2ZS73;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000000219	ENSLACP00000000244	ENSLACT00000000246

Organism

Latimeria chalumnae

Functional Description

Protein Length

782

Protein Sequence
(FASTA)

GNPGPPGQAG PRGPPGPPGS PGKSGYGVQG PPGPSGPPGP QGYSASGKPG HPGSPGKSGE 60

RGVPGIKGEP GHPGSQGPRG PLGPPGIPGP AGLVGIGKPG PEGRPGAAGA RGEPGEKGPP 120

GSPGPQGPKG DAVFGAPGSP GQKGHPGLQG PPGPSGPARI GKTGRNGFPG APGEKGDPGL 180

PGRPGQQGIK GHPGLPGSPG EMGIGKPGAD GVSGLPGPPG LKGLQGPPGM PGSPGMPGVG 240

KSGVPGMKGN KGVDGHPGFP GPKGEPGLAG TPGLPGEPGK SGTPGPPGFN GLPGEIGLPG 300

PKGDPGQPGH KGIPGIKGEP GAPGSNGKSG YPGPSGPVGP KGPPGQPGPK GSDWWLARTL 360

RQVGPREKEE GYIPSNYVAP VASKESQKWF FGGIKRADAE RQLLSPENQH GAFLIRESES 420

QKGDFSLSVK DNMIKAVKHY RIRQLDQGGY FINRNIPFQT LFELVSYYSK KSNGLCVKLG 480

DPCKKLHGNT PVTNGLSYNT ADQWEIERNS LKFLKKLGAG QFGEVWEGLW NSTTPVAIKT 540

LKTGTMDPKD FLREAQVMKK LRHPNLIQLY AVCSLEQPIY IITELMRNGS LLEYLQKDNG 600

NILDISDLVD MATQVAAGMA YLEIQNYIHR DLAARNVLVG ENNICKVADF GLARVFMVDS 660

EGIYEPKGGK FPIKWTAPEA IHFNKFTIKS DVWSFGILLT EIVTFGKMPY PGMTNYQVIQ 720

ELSAGYRMPC PENCPPQLYE IMVDCWKERD VERPTFETLK WRLEDFFEMD PSSYSDSEAF 780

VR 782

Nucleotide Sequence
(FASTA)

GGAAATCCAG GACCCCCAGG GCAAGCTGGG CCAAGAGGTC CCCCAGGTCC TCCAGGTTCT 60

CCAGGAAAGT CAGGATATGG AGTGCAAGGA CCACCAGGAC CTTCAGGACC ACCAGGACCA 120

CAAGGATATT CTGCTTCTGG AAAGCCAGGT CACCCAGGTT CACCAGGAAA ATCAGGAGAA 180

AGGGGAGTGC CTGGGATTAA AGGAGAGCCA GGGCATCCTG GGTCTCAAGG GCCAAGAGGG 240

CCACTTGGGC CTCCCGGGAT TCCTGGCCCA GCTGGACTTG TTGGTATTGG TAAACCAGGC 300

CCAGAAGGAA GGCCTGGTGC AGCAGGAGCA AGAGGCGAGC CTGGAGAAAA GGGACCACCA 360

GGGTCTCCTG GCCCTCAAGG TCCAAAGGGA GATGCTGTAT TTGGAGCTCC AGGAAGTCCA 420

GGTCAGAAAG GTCACCCAGG GCTTCAGGGG CCACCAGGAC CATCTGGACC TGCTAGAATA 480

GGAAAAACTG GTAGGAATGG ATTTCCAGGA GCACCAGGTG AAAAAGGGGA TCCAGGTCTC 540

CCTGGTAGGC CAGGGCAGCA AGGAATTAAA GGTCATCCAG GATTACCTGG TTCACCTGGA 600

GAGATGGGAA TAGGAAAGCC AGGTGCAGAT GGTGTATCAG GATTACCAGG CCCTCCTGGT 660

TTGAAAGGTC TACAAGGGCC TCCAGGCATG CCTGGGTCAC CTGGGATGCC TGGTGTCGGA 720

AAATCGGGTG TGCCAGGAAT GAAGGGAAAT AAAGGTGTTG ATGGCCATCC AGGTTTTCCT 780

GGTCCAAAAG GGGAGCCAGG TCTAGCTGGT ACTCCAGGAC TACCTGGAGA GCCAGGAAAA 840

TCTGGAACAC CTGGACCTCC TGGCTTTAAT GGACTTCCAG GTGAAATTGG TTTACCAGGA 900

CCAAAAGGTG ATCCTGGACA ACCTGGGCAC AAAGGCATTC CAGGAATTAA AGGTGAGCCA 960

GGAGCGCCCG GTTCAAATGG AAAATCAGGA TATCCCGGGC CATCCGGTCC AGTAGGTCCC 1020

AAAGGCCCAC CTGGACAGCC AGGTCCAAAA GGTTCGGACT GGTGGCTGGC CAGGACCCTC 1080

AGGCAGGTGG GACCCAGAGA AAAAGAAGAA GGCTACATCC CCTCCAACTA CGTGGCGCCC 1140

GTGGCCAGCA AGGAATCTCA AAAGTGGTTT TTCGGAGGAA TCAAGAGGGC AGATGCAGAA 1200

AGACAGCTGT TATCTCCTGA GAATCAACAT GGCGCTTTCC TTATTAGAGA GAGTGAAAGC 1260

CAGAAGGGTG ACTTTTCACT GTCAGTAAAG GACAATATGA TAAAAGCTGT GAAACACTAC 1320

AGAATCAGAC AGCTAGATCA AGGTGGCTAC TTCATTAACA GGAATATCCC TTTCCAAACC 1380

TTGTTTGAGC TGGTCAGCTA CTACAGCAAG AAATCAAATG GCCTGTGTGT AAAGCTTGGT 1440

GATCCGTGCA AAAAGCTGCA TGGAAATACC CCTGTTACCA ATGGGCTGTC TTACAACACT 1500

GCAGATCAAT GGGAGATTGA ACGCAACTCT TTGAAGTTCT TGAAAAAATT AGGAGCTGGC 1560

CAGTTTGGAG AGGTCTGGGA AGGACTATGG AACAGCACTA CACCCGTCGC CATCAAAACT 1620

CTGAAGACTG GCACAATGGA TCCGAAAGAC TTCCTCAGGG AGGCACAAGT GATGAAGAAG 1680

CTGAGGCATC CGAATCTGAT CCAGCTCTAT GCCGTTTGCT CGTTGGAGCA ACCAATTTAT 1740

ATTATTACTG AGCTGATGAG GAATGGAAGC CTGCTCGAAT ACCTCCAGAA AGATAATGGA 1800

AACATCCTTG ACATCTCTGA CCTGGTAGAC ATGGCAACTC AAGTCGCTGC AGGAATGGCC 1860

TACCTGGAAA TTCAGAATTA TATCCACAGA GACTTGGCTG CTCGAAATGT ACTTGTTGGT 1920

GAAAACAATA TCTGTAAAGT TGCTGATTTT GGACTTGCCA GAGTTTTTAT GGTGGACAGT 1980

GAAGGTATAT ATGAACCAAA AGGAGGAAAG TTTCCTATTA AATGGACTGC ACCAGAGGCA 2040

ATCCATTTCA ATAAATTCAC CATCAAATCA GATGTGTGGT CATTTGGGAT CCTGCTAACT 2100

GAGATTGTGA CATTTGGAAA GATGCCTTAT CCAGGAATGA CAAATTATCA GGTAATCCAA 2160

GAACTATCAG CAGGATATAG AATGCCATGT CCTGAGAACT GTCCCCCTCA GCTTTATGAG 2220

ATAATGGTGG ACTGCTGGAA GGAAAGAGAT GTGGAACGGC CAACATTCGA AACACTGAAG 2280

TGGAGGTTGG AGGACTTTTT TGAAATGGAC CCTTCTTCCT ACTCGGATTC TGAAGCATTT 2340

GTGAGATAG 2349

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lk++kklG+GqfGevw+g+w+++++va+ktlk+gt++p++fl+eaq++kklrh++l++ly

Q: 511   LKFLKKLGAGQFGEVWEGLWNSTTPVAIKTLKTGTMDPKDFLREAQVMKKLRHPNLIQLY  570

         5789********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av+s e+Piyi+telm++Gsll++l++++g+ l +++lvd+a+qva+Gmayle +n+ihr

Q: 571   AVCSLEQPIYIITELMRNGSLLEYLQKDNGNILDISDLVDMATQVAAGMAYLEIQNYIHR  630

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++++kvadfGlar++    + +y++k g k+PikWtaPeai+++kftik

Q: 631   DLAARNVLVGENNICKVADFGLARVFMvdsEGIYEPK-GGKFPIKWTAPEAIHFNKFTIK  689

         ************************7654446677776.689*******************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGillteivt Gk+PypGmtn +v++++++gyr+p+pe+cp +lye+++ cwk++

Q: 690   SDVWSFGILLTEIVTFGKMPYPGMTNYQVIQELSAGYRMPCPENCPPQLYEIMVDCWKER  749

         ************************************************************

S: 238   peerPtfetlqev  250

           erPtfetl++

Q: 750   DVERPTFETLKWR  762

         **********986

Domain Sequence
(FASTA)

LKFLKKLGAG QFGEVWEGLW NSTTPVAIKT LKTGTMDPKD FLREAQVMKK LRHPNLIQLY 60

AVCSLEQPIY IITELMRNGS LLEYLQKDNG NILDISDLVD MATQVAAGMA YLEIQNYIHR 120

DLAARNVLVG ENNICKVADF GLARVFMVDS EGIYEPKGGK FPIKWTAPEA IHFNKFTIKS 180

DVWSFGILLT EIVTFGKMPY PGMTNYQVIQ ELSAGYRMPC PENCPPQLYE IMVDCWKERD 240

VERPTFETLK WR 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR008160	; Collagen.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF01391	; Collagen; 5.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.

SMARTs

SM00252	; SH2; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013