EKS-LAC-00156

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00156

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	561.6	2.7E-169	383	659	277

Status

Unreviewed

Ensembl Protein

ENSLACP00000022021

UniProt Accession

H2ZTB7;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR3

Gene Synonyms/Alias

FGFR3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000000568	ENSLACP00000022021	ENSLACT00000026674
ENSLACG00000000568	ENSLACP00000000638	ENSLACT00000000641

Organism

Latimeria chalumnae

Functional Description

Protein Length

723

Protein Sequence
(FASTA)

MPINRTHVGQ RLLKIINVSY DDSGIYTCRL EHSEKVLSNY TVKVTDSLSS GDDEDDDEES 60

EDTAPYWTRP ERMEKRLLAV PAANTVRFRC PAAGNPTPTI HWLKNGREFK GEHRMGGIKL 120

RHQQWSLVME SVVPSDRGNY TCIVENKYGS ISHTYQLDVL ERSPHRPILQ AGLPANQTVV 180

VGSDVEFHCK VYSDAQPHIQ WLKHVEVNGS KYGPDGAPYV TVLKTAGINT TDKELEILYL 240

RNVTFEDAGE YTCLAGNSIG YSHHSAWLTV LPELVKEDDS GSVYADILIY VISGVLLILT 300

IIIVILCRMR MSTKKTLNAP PVQKLSKFPL KRQVSLESNS SMNSNTPLVR ITRLSSSDGP 360

MLANVSELEL PADPKWEYQR SRLTLGKPLG EGCFGQVVMA EAIGIDKDKP NKPVTVAVKM 420

LKDDATDKDL SDLVSEMEMM KMIGKHKNII NLLGACTQDG PLYVLVEYAS KGNLREYLRA 480

RRPPGMDYSF DTCKIPDEQL TFKDLVSCAY QVARGMEYLA SQKCIHRDLA ARNVLVTDDN 540

VMKIADFGLA RDVHNIDYYK KTTNGRLPVK WMAPEALFDR VYTHQSDVWS YGVLLWEIFT 600

LGGSPYPGIP VEELFKLLKE GHRMDKPANC THELYMIMRE CWHAIPSQRP TFKQLVEDLD 660

RVLTMTSTDE YLDLSVTFEQ YSPTCQDSHS TCSSGDDSVF AHDPLPDEPC LPKHQQCNGV 720

IRT 723

Nucleotide Sequence
(FASTA)

ATGCCCATCA ACAGGACTCA CGTAGGACAA AGACTGCTGA AAATAATTAA CGTGTCCTAC 60

GATGACTCTG GGATTTACAC CTGTAGGCTT GAGCACTCAG AGAAGGTGCT GAGTAATTAC 120

ACTGTCAAAG TCACAGACTC CTTATCATCT GGGGATGATG AAGATGATGA TGAAGAATCT 180

GAAGACACAG CACCGTATTG GACACGTCCA GAGCGAATGG AAAAAAGGCT CCTTGCAGTG 240

CCAGCAGCGA ATACAGTCCG CTTCCGCTGC CCAGCTGCAG GCAACCCCAC CCCCACAATA 300

CACTGGCTAA AGAATGGCAG AGAATTTAAG GGAGAACATA GAATGGGTGG CATTAAGCTA 360

AGACACCAAC AGTGGAGTTT GGTGATGGAA AGTGTAGTCC CATCAGACCG TGGAAACTAC 420

ACGTGCATAG TCGAGAACAA ATATGGCAGC ATTAGCCATA CTTATCAGCT GGATGTACTG 480

GAGAGATCGC CTCACCGGCC CATCTTACAA GCTGGACTGC CTGCTAATCA AACTGTGGTG 540

GTGGGCAGTG ATGTCGAATT CCACTGCAAG GTGTACAGCG ATGCTCAGCC TCACATTCAG 600

TGGCTGAAGC ACGTGGAGGT TAATGGCAGT AAATATGGGC CTGATGGGGC TCCATATGTC 660

ACTGTGCTGA AAACGGCAGG CATTAATACA ACGGATAAAG AGCTAGAAAT TCTGTACTTG 720

CGAAATGTTA CTTTTGAGGA TGCAGGGGAG TATACCTGTT TAGCTGGGAA TTCTATTGGG 780

TATTCACACC ACTCTGCATG GCTGACCGTG CTACCAGAAC TGGTAAAAGA GGATGACTCT 840

GGGTCTGTCT ACGCAGATAT CCTTATTTAT GTAATCAGCG GTGTCCTTCT CATACTAACT 900

ATCATCATCG TGATTCTCTG TCGAATGAGA ATGTCTACTA AGAAAACACT AAACGCACCT 960

CCAGTCCAAA AGCTCTCCAA GTTTCCACTC AAAAGACAGG TGTCCTTGGA GTCCAACTCC 1020

TCCATGAATT CCAACACTCC ATTGGTTAGG ATCACCCGCC TTTCATCCAG TGATGGACCA 1080

ATGCTGGCTA ATGTATCAGA GCTTGAACTT CCTGCTGATC CCAAATGGGA ATATCAACGA 1140

TCAAGGCTGA CACTGGGGAA ACCCCTTGGT GAGGGTTGCT TTGGCCAAGT GGTCATGGCA 1200

GAAGCTATTG GAATTGATAA AGACAAACCA AATAAGCCTG TTACTGTAGC TGTCAAGATG 1260

TTAAAAGATG ATGCAACAGA TAAGGACCTT TCAGATTTAG TTTCAGAAAT GGAAATGATG 1320

AAGATGATTG GAAAGCATAA AAACATAATT AACCTTCTAG GAGCCTGCAC ACAGGATGGC 1380

CCTCTGTATG TTTTGGTTGA ATATGCATCA AAAGGAAACT TGCGGGAGTA CCTTAGGGCA 1440

CGCCGCCCCC CTGGAATGGA TTACTCATTT GACACCTGCA AGATCCCAGA TGAGCAACTA 1500

ACCTTTAAAG ACTTGGTGTC ATGTGCGTAC CAAGTGGCAC GTGGTATGGA GTACCTGGCA 1560

TCACAAAAGT GTATTCACCG AGACCTTGCT GCCAGAAATG TTTTAGTAAC AGATGACAAT 1620

GTCATGAAGA TTGCAGATTT TGGCCTTGCC AGAGATGTAC ACAACATTGA CTACTACAAG 1680

AAAACAACAA ATGGTCGGCT GCCCGTGAAA TGGATGGCTC CGGAGGCTTT GTTTGACCGG 1740

GTCTACACTC ATCAGAGTGA CGTCTGGTCC TACGGAGTTC TGTTGTGGGA GATCTTTACT 1800

TTGGGAGGAT CACCATACCC AGGGATCCCT GTTGAAGAGT TATTTAAACT TTTGAAAGAA 1860

GGTCACCGTA TGGACAAACC AGCAAATTGT ACACATGAGC TGTACATGAT AATGAGGGAA 1920

TGTTGGCATG CAATTCCATC ACAAAGGCCC ACATTTAAGC AGTTAGTTGA GGACCTTGAC 1980

AGGGTCTTGA CAATGACATC AACTGATGAA TATTTAGATT TATCAGTTAC ATTTGAGCAG 2040

TATTCACCAA CATGTCAAGA CTCTCATAGT ACATGCTCCT CAGGAGATGA CTCTGTCTTT 2100

GCCCATGATC CTCTCCCCGA TGAACCTTGT CTTCCTAAGC ATCAGCAGTG TAATGGTGTC 2160

ATCAGGACGT GA 2172

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aeaig+dkdk++k vtvavkmlk+datdkdl+dlvseme++k+

Q: 383   LTLGKPLGEGCFGQVVMAEAIGIDKDKPNKPVTVAVKMLKDDATDKDLSDLVSEMEMMKM  442

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyv+veya+kGnlre+lrarrp+g+++s d++k+++eqlt+

Q: 443   IGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKIPDEQLTF  502

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylas+kcihrdlaarnvlvt+dnv+kiadfGlardvh+idyykkt

Q: 503   KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTDDNVMKIADFGLARDVHNIDYYKKT  562

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvws+Gvllwei+tlGgspypgi+veelfkllkeGh

Q: 563   TNGRLPVKWMAPEALFDRVYTHQSDVWSYGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH  622

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kpa+ct+ely++mrecwha +s+rptfkqlvedl

Q: 623   RMDKPANCTHELYMIMRECWHAIPSQRPTFKQLVEDL  659

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA IGIDKDKPNK PVTVAVKMLK DDATDKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVLVEYASKG NLREYLRARR PPGMDYSFDT CKIPDEQLTF 120

KDLVSCAYQV ARGMEYLASQ KCIHRDLAAR NVLVTDDNVM KIADFGLARD VHNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSYG VLLWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPANCTH ELYMIMRECW HAIPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013