EKS-LAC-00354
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LAC-00354
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PEK305.44.4E-91346760415
StatusUnreviewed
Ensembl ProteinENSLACP00000000763
UniProt AccessionH2ZTP2;
Protein Name
Protein Synonyms/Alias
Gene NameEIF2AK4
Gene Synonyms/Alias EIF2AK4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLACG00000000685ENSLACP00000000763ENSLACT00000000770
OrganismLatimeria chalumnae
Functional Description
Protein Length1410
Protein Sequence
(FASTA)
RRERQYSVCS NEDQTRVYET LHFSTGSMGE LIVHRGKCIG ESKLLGRSVY NALEVAMGNF 60
VIVYEWVLQW KKKIGTFFTS QEKEKIEKCK KQIQGAETEF SSLLKLSHPN LVEYIAMQHK 120
EQEDSIVVYI VVEHFSGSSL SSNLTKGTPV PVERLRHYTS QILSALEFLH SNSVVHKALG 180
ASSVLVDSEG RVKLKDYSIS KRLADVCKED VFEQTRVRFS EDALPNKMGK KGDVWKLGLL 240
LLALSQGRVV TEYPVSVPGH LPCDFQDFLK KCVCLEDKER WSAQQLLEHS FLNTPRVKSP 300
TPLAEDSLED YSRVECVETV TGIRQFAGSV FYTETQREHS RYYNEFEELQ LLGRGAFGAV 360
IKVQNKLDGC CYAVKRIQVN PTSKQFRRIK GEVTLLSRLN HENIVRYYNA WIERHEIPSP 420
CSEPPGNSEQ RKTSAELSGN GRNALGLVDN IEDNAPAPVL TSSVEWSTSC ERSVSAKCNG 480
AASASSDEEE DEDGVFSPSF LPDASDSDSD IVFENGDENT DNPERRDSNS EKKDGYTESD 540
ASEIKVVPQT IHHLYIQMEY CEKSTLRDTI DQELYQDTKR LWRLFREILD GLAYIHEQGM 600
IHRDLKPVNI FLDSNDHVKI GDFGLATDHP ANVASEKQEV EGSGSLQFLK PDPAGKLTGM 660
VGTVLYVSPE VQGNTKATYN QRLEYFSIGC LFLLPLLGPY IRTKHEIFVV SGLLCRPNIE 720
FPEDFDDIQH EKQQIVISWL LNHDPAKRPS AVELLKSELL PPPEMEASEL HEVLQHTLAN 780
VNRKAYRTMV SQIFAQHITP GIDYTYDSDM QKGNFSSAGI VVQQFVYETV SRIFKRHGAI 840
KLQTPLLMPK NKKLYENNEV AYFMDHSGML VMLPYDLRVP FARFVAKNKV TDLKRFCVER 900
VFRPRRLDRS HPKELWECAF DIVTSSTASL LPDAETIYTI TEIIQEFQVL QERNYSIYLN 960
HTSLLKAVML HCGIPEDKLG HVYSILYDTM VESVTSQFVK SKFFLWELSM SEIYGIHLFK 1020
SESASVEALI GKYPTLTEDS LGTIKGIKGH FQVDPEAKPS IFKPRSSPYM LCEKVNAELE 1080
RLQKEGIIEP VEFADWAVPV VPVLKADRQT VHICGDFKTT VNRVGYHINA EGLQLVAEKV 1140
CAIARALEPT KVCEFCELCI LVLGRISILK SLTLTTLLYP DTYIVLMVVS FLSSSQKEVL 1200
DHCRRAWISF VALISDKEGS YVKLISFEKD RQIERRILER DLVEYITQKL RTKVSEDRNN 1260
SRDTLELHSS QIQKGSLPNT SGSSEPHGSS LVPNVQIISS DKLSASNKRR YESQVASRLQ 1320
TLVNQLQQKS TEVQVLAVDL PKETIINLLS LECYADEQTF YASVKQLMSR LPKQRYLKSV 1380
CDEIYHFKIE KRISVLILYS YKDDYYKILF 1410
Nucleotide Sequence
(FASTA)
AGACGAGAGC GTCAGTATTC GGTTTGCAGT AACGAAGATC AGACACGAGT ATATGAAACT 60
CTTCACTTTT CCACGGGGTC GATGGGAGAG CTGATTGTTC ACAGAGGGAA GTGTATTGGT 120
GAGAGCAAGC TGCTGGGCAG GTCTGTATAC AATGCTTTAG AAGTTGCTAT GGGAAACTTT 180
GTGATTGTTT ATGAATGGGT TCTACAGTGG AAGAAAAAGA TTGGAACATT TTTTACAAGC 240
CAGGAAAAGG AAAAGATTGA AAAATGTAAA AAACAGATTC AGGGTGCAGA GACAGAGTTC 300
AGCTCTCTGT TGAAGCTGTC ACATCCAAAC TTGGTGGAGT ATATAGCCAT GCAGCACAAG 360
GAACAGGAGG ATTCCATTGT TGTGTACATT GTAGTGGAAC ATTTCAGTGG CAGCAGTCTG 420
TCCTCCAACC TGACCAAAGG GACCCCAGTC CCAGTAGAGC GGCTACGACA TTACACTTCC 480
CAGATCCTGT CTGCCTTGGA GTTCCTGCAT AGTAACTCCG TGGTACACAA GGCACTGGGA 540
GCCTCCAGTG TTCTGGTGGA CAGCGAAGGC CGGGTGAAGT TAAAGGACTA CAGTATCTCC 600
AAGCGGCTGG CAGATGTGTG TAAGGAGGAT GTGTTTGAGC AGACCCGGGT GCGATTCAGT 660
GAAGATGCGC TTCCAAACAA GATGGGGAAG AAGGGAGACG TGTGGAAGCT GGGCCTTCTC 720
CTGTTGGCAC TCAGTCAGGG GCGAGTCGTG ACGGAATATC CGGTCAGCGT TCCCGGTCAT 780
CTGCCCTGTG ACTTCCAGGA CTTCTTAAAA AAGTGTGTTT GCTTGGAAGA CAAGGAGCGT 840
TGGAGTGCTC AACAGCTGCT TGAACATTCC TTTTTAAACA CTCCGCGAGT GAAGTCCCCC 900
ACACCGCTGG CCGAGGACAG TCTTGAGGAT TATTCAAGAG TGGAGTGTGT GGAAACAGTT 960
ACAGGCATCA GGCAGTTTGC TGGTTCTGTA TTTTACACGG AAACACAGCG AGAACATTCC 1020
CGATATTACA ATGAATTTGA GGAGCTTCAG CTACTGGGTA GAGGAGCCTT CGGAGCTGTC 1080
ATCAAGGTTC AAAACAAACT GGACGGCTGC TGTTATGCTG TGAAACGCAT CCAGGTAAAT 1140
CCAACCAGCA AGCAGTTCCG AAGAATAAAG GGAGAAGTGA CATTACTTTC CCGATTGAAC 1200
CATGAAAACA TTGTCCGATA TTACAATGCC TGGATCGAGA GGCATGAAAT CCCTTCTCCA 1260
TGCTCTGAGC CCCCAGGAAA CTCAGAGCAG AGGAAGACTT CTGCAGAGCT TAGTGGGAAT 1320
GGGAGAAACG CACTGGGGTT AGTGGATAAC ATTGAGGATA ATGCCCCTGC CCCTGTGCTG 1380
ACCAGCTCGG TAGAGTGGAG CACCTCCTGT GAGAGATCTG TGAGTGCCAA GTGCAATGGA 1440
GCAGCTTCAG CATCCAGTGA TGAGGAAGAG GATGAAGATG GTGTCTTTTC TCCATCATTT 1500
TTACCTGATG CCTCAGACTC CGACAGTGAC ATTGTTTTTG AAAATGGAGA TGAAAACACT 1560
GACAATCCAG AACGGAGAGA CAGCAACAGT GAGAAGAAAG ATGGCTACAC GGAGAGTGAT 1620
GCTTCAGAGA TTAAAGTAGT GCCTCAGACC ATCCATCACC TCTATATTCA GATGGAATAC 1680
TGTGAGAAGA GCACATTACG AGATACAATC GATCAGGAGC TCTATCAGGA TACCAAGCGC 1740
CTCTGGAGGC TTTTCCGAGA AATCTTGGAT GGATTGGCAT ATATCCATGA ACAAGGTATG 1800
ATTCATCGAG ACCTGAAACC TGTGAATATT TTCTTGGATT CTAACGATCA TGTGAAAATA 1860
GGAGACTTTG GTTTAGCCAC TGACCACCCA GCTAATGTGG CTTCTGAAAA ACAGGAGGTG 1920
GAAGGAAGTG GATCTCTTCA GTTTTTAAAA CCAGATCCTG CAGGAAAGCT GACTGGGATG 1980
GTGGGAACAG TCTTGTATGT GAGTCCAGAG GTCCAAGGAA ACACGAAGGC TACATACAAT 2040
CAGAGACTAG AGTACTTTTC TATCGGCTGT CTATTTTTGC TTCCACTGCT GGGTCCTTAT 2100
ATTAGGACAA AGCACGAGAT ATTTGTTGTG TCAGGGCTGC TTTGTAGACC AAACATTGAG 2160
TTTCCAGAAG ATTTTGATGA CATCCAACAT GAGAAACAGC AAATAGTGAT TTCATGGTTG 2220
TTGAACCATG ACCCAGCAAA ACGTCCTAGT GCTGTGGAGC TGCTGAAAAG TGAATTGCTG 2280
CCCCCTCCTG AGATGGAGGC GTCTGAACTC CATGAAGTAC TTCAGCACAC TCTGGCTAAT 2340
GTTAATCGGA AAGCATATCG AACCATGGTC AGCCAAATTT TCGCTCAGCA TATTACTCCT 2400
GGTATCGACT ACACATACGA TAGTGATATG CAGAAGGGTA ATTTTTCCAG CGCCGGCATC 2460
GTTGTGCAGC AGTTTGTATA TGAGACTGTC AGCCGGATCT TTAAGAGACA TGGTGCTATC 2520
AAACTGCAGA CACCACTGCT GATGCCAAAG AACAAGAAAC TGTACGAGAA CAATGAGGTG 2580
GCCTATTTCA TGGATCACAG CGGTATGCTG GTCATGCTAC CATATGATCT CAGGGTTCCT 2640
TTTGCAAGAT TTGTAGCTAA AAATAAAGTA ACGGATTTGA AAAGATTCTG TGTTGAACGT 2700
GTTTTCCGAC CTCGGCGGTT AGATCGTTCC CATCCTAAAG AACTCTGGGA ATGTGCTTTT 2760
GATATTGTTA CATCGAGCAC AGCTAGTCTT CTTCCCGATG CCGAGACCAT CTACACCATC 2820
ACTGAGATCA TCCAGGAATT CCAAGTCCTG CAGGAGCGAA ACTACAGTAT TTACCTGAAC 2880
CACACCTCCC TCCTAAAAGC TGTGATGCTG CATTGTGGGA TTCCGGAGGA TAAGCTTGGA 2940
CATGTGTACA GTATTCTGTA TGACACCATG GTGGAGTCAG TAACGTCGCA ATTTGTAAAG 3000
AGCAAATTCT TTTTATGGGA ACTGTCGATG TCGGAGATTT ATGGTATACA TTTGTTTAAG 3060
TCTGAATCTG CAAGCGTGGA AGCCCTTATT GGGAAATATC CTACCTTGAC AGAAGATAGT 3120
CTGGGAACCA TAAAAGGGAT CAAGGGACAT TTTCAAGTTG ACCCAGAGGC AAAGCCAAGT 3180
ATTTTCAAGC CAAGATCTAG TCCATACATG CTTTGTGAAA AGGTGAATGC GGAACTGGAA 3240
AGACTACAGA AAGAGGGCAT TATTGAACCT GTTGAATTTG CAGACTGGGC AGTGCCAGTT 3300
GTTCCAGTAT TAAAGGCTGA TAGACAAACT GTGCATATTT GTGGGGATTT CAAGACAACG 3360
GTGAACAGAG TAGGTTACCA TATCAATGCA GAAGGGTTGC AACTAGTGGC TGAGAAGGTG 3420
TGTGCTATTG CTAGAGCCCT AGAACCTACA AAGGTATGTG AGTTTTGTGA ATTATGTATA 3480
CTGGTTCTTG GAAGGATTTC CATACTTAAA AGCCTCACAC TGACTACACT GCTGTATCCG 3540
GATACATATA TTGTATTAAT GGTTGTGTCT TTTCTCTCTT CTTCACAAAA AGAAGTTCTG 3600
GATCACTGTA GAAGGGCCTG GATTTCCTTC GTAGCGTTGA TCTCTGACAA GGAAGGAAGT 3660
TACGTGAAGT TAATCTCCTT TGAAAAGGAC AGACAGATTG AACGAAGAAT CTTGGAAAGA 3720
GACCTGGTAG AATATATCAC TCAAAAACTG AGGACCAAAG TCTCCGAGGA TAGAAACAAC 3780
AGTAGAGACA CTTTAGAGCT TCATTCTTCC CAAATTCAGA AGGGCTCACT GCCAAATACC 3840
TCAGGTTCAT CTGAACCACA TGGAAGCAGC CTTGTGCCAA ACGTGCAAAT AATCTCTTCA 3900
GATAAACTGT CAGCCAGTAA CAAGCGACGC TATGAATCTC AGGTAGCTTC AAGACTGCAG 3960
ACTCTAGTGA ATCAACTGCA GCAGAAGAGC ACAGAAGTAC AAGTATTAGC AGTTGATCTG 4020
CCAAAAGAAA CAATAATAAA CCTTTTATCA TTGGAGTGTT ATGCAGATGA ACAGACCTTT 4080
TATGCAAGTG TGAAGCAATT AATGTCTCGA CTTCCAAAGC AGCGCTATCT AAAATCTGTG 4140
TGTGATGAAA TTTACCATTT CAAAATTGAA AAAAGAATCT CAGTGCTCAT TCTATACAGT 4200
TACAAAGACG ATTACTACAA GATCCTTTTC TAG 4233
Domain Profile
S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60
         fee+++lG+G+fg+V+k++nkld+++ya+kri++n  +k++++++ ev++L++l+h+niv
Q: 346   FEELQLLGRGAFGAVIKVQNKLDGCCYAVKRIQVNPTSKQFRRIKGEVTLLSRLNHENIV  405
         89**********************************************************
S: 61    rYfaawleekeesl..............................................  74
         rY++aw+e++e +                                               
Q: 406   RYYNAWIERHEIPSpcseppgnseqrktsaelsgngrnalglvdniednapapvltssve  465
         **********988899************************99999999999999999999
S: 75    ...........................................tdsseveaeaeleeses  91
                                                    +                
Q: 466   wstscersvsakcngaasassdeeededgvfspsflpdasdsdS----------------  509
         99888888888888888777766666666666666666654440................
S: 92    seesdtk..........................................llyiqmelcek  109
               +                                          +lyiqme+cek
Q: 510   ------DivfengdentdnperrdsnsekkdgytesdaseikvvpqtihHLYIQMEYCEK  563
         ......1444444444444444444466666666777889999999999***********
S: 110   etLkdwiderkllesrselvmrlfkqllegleylHskgliHrdLkpsniFldsddqvKig  169
         +tL+d+id++ l++++++l+ rlf+++l+gl+y+H++g+iHrdLkp+niFlds+d+vKig
Q: 564   STLRDTIDQE-LYQDTKRLW-RLFREILDGLAYIHEQGMIHRDLKPVNIFLDSNDHVKIG  621
         **********.9********.***************************************
S: 170   DFgLatalaealkedvkqdaqske.........akhtgqvgtklymsPeql..eksqYnk  218
         DFgLat+   +   + ++ + s++         +k tg+vgt ly+sPe++  +k++Yn+
Q: 622   DFGLATDHPANVASEKQEVEGSGSlqflkpdpaGKLTGMVGTVLYVSPEVQgnTKATYNQ  681
         *******887776666666666667688887777*****************999******
S: 219   kvDifsLGli.lfeLly.pfstemervetltel.rd..gkipedfdd.kvpkekkllqkl  272
         +   fs+G + l+ Ll   + t+ e   ++  l     +++pedfdd +++k++ ++++l
Q: 682   RLEYFSIGCLfLLPLLGpYIRTKHEI-FVVSGLlCRpnIEFPEDFDDiQHEKQQIVISWL  740
         ********872567888556776665.55555423345**********************
S: 273   lsrdpkeRpsasellksell  292
         l++dp++Rpsa ellksell
Q: 741   LNHDPAKRPSAVELLKSELL  760
         *****************986
Domain Sequence
(FASTA)
FEELQLLGRG AFGAVIKVQN KLDGCCYAVK RIQVNPTSKQ FRRIKGEVTL LSRLNHENIV 60
RYYNAWIERH EIPSPCSEPP GNSEQRKTSA ELSGNGRNAL GLVDNIEDNA PAPVLTSSVE 120
WSTSCERSVS AKCNGAASAS SDEEEDEDGV FSPSFLPDAS DSDSDIVFEN GDENTDNPER 180
RDSNSEKKDG YTESDASEIK VVPQTIHHLY IQMEYCEKST LRDTIDQELY QDTKRLWRLF 240
REILDGLAYI HEQGMIHRDL KPVNIFLDSN DHVKIGDFGL ATDHPANVAS EKQEVEGSGS 300
LQFLKPDPAG KLTGMVGTVL YVSPEVQGNT KATYNQRLEY FSIGCLFLLP LLGPYIRTKH 360
EIFVVSGLLC RPNIEFPEDF DDIQHEKQQI VISWLLNHDP AKRPSAVELL KSELL 415
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-ANC-00331
EKS-BOT-00339
EKS-CAE-00274
EKS-CAJ-00348
EKS-CAF-00347
EKS-CAP-00373
EKS-CII-00190
EKS-DAR-00703
EKS-DRM-00167
EKS-EQC-00331
EKS-FEC-00330
EKS-GAG-00288
EKS-GAA-00422
EKS-GOG-00336
EKS-HOS-00346
EKS-ICT-00323
EKS-LOA-00353
EKS-MEG-00280
EKS-MOD-00335
EKS-MUM-00374
EKS-MUP-00335
EKS-MYL-00338
EKS-NOL-00310
EKS-ORN-00443
EKS-ORA-00296
EKS-ORC-00318
EKS-ORL-00410
EKS-OTG-00344
EKS-PAT-00322
EKS-PES-00299
EKS-PEM-00180
EKS-POA-00333
EKS-RAN-00354
EKS-SAH-00318
EKS-SUS-00304
EKS-TAG-00415
EKS-TAR-00446
EKS-TEN-00442
EKS-TUT-00087
EKS-XET-00433
EKS-XIM-00429
EKS-SAC-00083
EKS-SCP-00084
Gene Ontology
GO:0005524; F:ATP binding
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity
KEGG
InterPros
IPR026920; EIF2AK4.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 3.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013