EKS-LAC-00311

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00311

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	444.3	1.4E-133	417	673	257

Status

Unreviewed

Ensembl Protein

ENSLACP00000001477

UniProt Accession

H2ZVQ6;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB3

Gene Synonyms/Alias

ERBB3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000001321	ENSLACP00000001477	ENSLACT00000001490

Organism

Latimeria chalumnae

Functional Description

Protein Length

1047

Protein Sequence
(FASTA)

NYVVDQSSCV RACPSDKMEV EKNGIKICEL CTGVCPKACR GTKVGSQYET VDSRNIDSFI 60

NCTKILGNLD FLVTGINGDE WRQTTPLNPE KLRVFETVRE ITGYLNIQAW PENMTDFNVF 120

SNLTTIGGRT QYQRGFSLLI MKNSNVTSLG FHSLKEISAG NVYISDNPQL CFYPTTINWK 180

LLFSFRRQRT DIKNNRSLKK CVAEGKVCDP LCSSTGCWGP GPDQCISCKN YSRKGTCVQS 240

CHFFEGDYRE YSEESRCLSC HPECQAIKDG KTCNGSGPDH CVKCAHYKDG PHCVETCPEG 300

IMGKRGLIFK YPDPNGVCQP CHENCTQGCS GPNLDDCMGP SSPQNSKTST IIAAAVVGGL 360

FVTTSSFLLA LLYWRGLMIR KKRAMRRYLE NIENHEPMEP GEKANKVHAR KLKETELRKL 420

KILGSGVFGT VYKGIWIPEG DSVKIPVAIK AIQDRTGRQT FHNITENIIA MGCLEHPHVL 480

RLLGICPGAG LQLVTQLMPM GSLLEYIRKH QDKVNPQLLL NWCIQIAKGM YYLEEHRMVH 540

RNLAARNVMM KSPNLVQVAD FGIADLLYPD DKKYLYNEIK TPIKWMALES IHFRRYTHQS 600

DVWSYGVTIW EMMTFGSEPY AGIRLQEVPD LLEKGERLSQ PPICTIDVYM VMVKCWMIDE 660

NIRPTFKELA SEFTRMARDP PRYLVVKKES GTISSSLADQ PHLGENDPDD VDGLDPESDL 720

EETDMNSQLN ISMSLLVSRQ RIDSARGNQN LLLPPTGYMP MGANGSEESR QNTLRSVDLG 780

SRRTLRMRNE SMTRTVSESS EGHGTLSEMD PNDDLSLSGT LHCGQRKRED SAYLSNRASM 840

TTPSVFGDTE EDVNGYVIPN QNSKEGSKSM SGMDSRSEML NQLSNQASPS TSKFMEGQEY 900

EYMNKRSSKS SSPDQDTPKQ EEEEDYEYMN KQPILCKSLN GDKIHKYQSV PQQPTEDNYF 960

YTNRDPDEKE SGKEYEIMDT VASQLDSAEQ GLEYQNLPSP RKGQAHQNGY VKVGRAVPSL 1020

EDSTDCAFDN PDYWHSRLFT RSDAQRV 1047

Nucleotide Sequence
(FASTA)

AATTATGTGG TTGATCAGAG CTCGTGTGTG CGGGCATGTC CGAGTGATAA GATGGAGGTG 60

GAGAAGAACG GAATTAAGAT TTGCGAACTC TGTACTGGAG TGTGCCCAAA AGCCTGTCGG 120

GGTACAAAGG TGGGCAGTCA GTATGAGACA GTGGATTCTC GGAACATTGA CAGCTTCATA 180

AACTGCACCA AAATATTGGG GAATCTGGAC TTCCTTGTTA CTGGAATAAA TGGTGATGAG 240

TGGAGACAGA CAACCCCCCT GAACCCAGAG AAACTCCGAG TATTTGAAAC TGTCCGTGAG 300

ATCACAGGCT ATTTGAATAT TCAGGCTTGG CCAGAAAACA TGACTGACTT CAATGTCTTC 360

TCCAACCTCA CCACCATTGG AGGGAGGACC CAGTATCAAC GGGGCTTCTC TCTTCTGATC 420

ATGAAGAATA GCAATGTGAC ATCTCTTGGT TTTCATTCGC TAAAGGAAAT CAGTGCTGGA 480

AATGTTTACA TCAGTGACAA CCCTCAGCTG TGTTTTTACC CTACTACCAT CAACTGGAAG 540

CTGCTCTTCT CATTCAGACG GCAGCGTACC GACATCAAAA ACAATAGAAG TCTGAAGAAA 600

TGTGTTGCTG AGGGGAAGGT GTGTGACCCG CTGTGCTCTA GCACTGGGTG CTGGGGTCCT 660

GGCCCAGATC AGTGCATTTC CTGTAAAAAC TACAGTCGCA AGGGAACCTG CGTGCAGTCT 720

TGTCACTTCT TTGAGGGAGA TTACCGGGAG TATTCTGAAG AGTCCAGATG TCTTTCATGT 780

CACCCAGAGT GCCAGGCGAT CAAGGATGGA AAAACCTGCA ATGGATCGGG ACCAGATCAT 840

TGTGTGAAAT GTGCCCACTA CAAAGATGGC CCTCACTGTG TGGAGACCTG CCCTGAGGGG 900

ATCATGGGAA AGAGAGGCCT CATCTTTAAA TATCCTGACC CCAATGGCGT ATGTCAGCCC 960

TGTCACGAGA ACTGCACCCA GGGGTGCAGC GGTCCGAACT TGGACGACTG TATGGGACCT 1020

TCATCACCCC AGAATAGTAA AACCTCAACA ATAATAGCAG CAGCTGTAGT GGGAGGCCTC 1080

TTTGTGACAA CATCATCATT TCTGTTGGCA CTGTTATACT GGCGTGGATT GATGATCCGG 1140

AAGAAGAGAG CCATGCGGAG ATACCTGGAG AACATAGAGA ACCATGAGCC AATGGAACCT 1200

GGAGAAAAAG CCAATAAGGT TCACGCTCGG AAACTTAAAG AGACAGAGTT ACGAAAGTTG 1260

AAGATCTTGG GGTCCGGGGT CTTTGGAACC GTATACAAGG GAATATGGAT TCCTGAGGGA 1320

GATTCCGTGA AGATTCCAGT TGCTATTAAA GCCATTCAGG ACCGAACTGG TAGACAGACC 1380

TTCCACAATA TCACTGAGAA CATAATTGCA ATGGGGTGTC TGGAGCACCC TCACGTGTTA 1440

CGTCTGCTGG GGATCTGCCC TGGGGCAGGG CTGCAGTTGG TCACACAGCT CATGCCAATG 1500

GGGTCCCTCC TGGAGTACAT CCGCAAGCAC CAGGACAAAG TCAATCCCCA ACTGCTGCTC 1560

AACTGGTGTA TCCAAATAGC CAAGGGGATG TACTACCTGG AAGAACATCG CATGGTCCAC 1620

CGAAATCTGG CTGCTCGAAA TGTCATGATG AAAAGTCCCA ACCTTGTCCA GGTGGCAGAC 1680

TTTGGCATTG CTGACCTCCT ATATCCAGAT GATAAGAAGT ACCTCTACAA TGAAATAAAG 1740

ACTCCAATCA AATGGATGGC CTTAGAGAGT ATTCACTTCA GGAGATATAC TCATCAGAGT 1800

GATGTCTGGA GCTACGGTGT GACGATCTGG GAGATGATGA CCTTTGGCTC AGAGCCCTAT 1860

GCAGGGATTC GTTTGCAAGA AGTTCCCGAT CTCCTGGAGA AAGGAGAACG TCTGTCCCAG 1920

CCACCCATCT GTACCATTGA CGTCTATATG GTCATGGTCA AATGTTGGAT GATTGATGAA 1980

AACATTCGGC CAACATTTAA GGAACTGGCC AGTGAATTCA CCCGTATGGC CCGTGATCCA 2040

CCTAGATACC TGGTTGTCAA GAAAGAAAGT GGCACGATCA GTAGCTCTCT TGCAGACCAG 2100

CCCCATCTCG GTGAGAATGA CCCAGATGAT GTAGATGGCC TGGATCCTGA GTCAGATCTC 2160

GAAGAAACAG ACATGAACTC CCAACTTAAC ATCTCAATGA GTCTTCTCGT ATCTAGACAG 2220

CGAATAGATT CTGCCAGGGG AAATCAGAAT CTGCTTCTCC CTCCAACGGG TTACATGCCC 2280

ATGGGTGCAA ACGGCAGTGA GGAGTCTCGC CAGAACACCT TGAGAAGTGT GGACTTGGGA 2340

TCCAGACGCA CCCTAAGGAT GAGAAATGAG TCCATGACCC GCACGGTGTC CGAATCCTCA 2400

GAAGGCCATG GCACTCTCTC CGAAATGGAT CCAAATGACG ACTTGTCATT AAGCGGAACG 2460

CTGCACTGTG GGCAGCGCAA ACGGGAAGAC AGTGCCTACC TATCAAACCG GGCGAGTATG 2520

ACAACCCCCT CTGTCTTTGG AGATACTGAA GAAGATGTTA ACGGTTATGT GATACCAAAT 2580

CAAAATAGCA AAGAGGGAAG TAAATCCATG AGTGGCATGG ACTCTAGAAG TGAAATGCTC 2640

AATCAACTCT CCAATCAGGC AAGCCCAAGT ACTTCAAAAT TTATGGAAGG CCAGGAGTAT 2700

GAGTATATGA ACAAGCGATC ATCTAAATCC AGCAGTCCTG ACCAAGATAC CCCAAAACAG 2760

GAAGAGGAGG AGGACTATGA GTATATGAAC AAACAACCTA TTCTCTGCAA ATCTCTAAAT 2820

GGTGACAAAA TTCACAAATA TCAGTCAGTG CCTCAGCAAC CCACAGAAGA CAACTATTTT 2880

TACACCAACA GAGATCCAGA TGAGAAGGAA TCTGGGAAGG AATATGAAAT TATGGACACA 2940

GTGGCCTCAC AACTTGACTC TGCTGAACAA GGGCTGGAGT ACCAAAACCT TCCCTCACCA 3000

CGGAAGGGCC AGGCACATCA GAACGGGTAC GTGAAAGTGG GCAGAGCAGT ACCATCCCTG 3060

GAGGACAGTA CAGACTGTGC CTTCGATAAC CCAGACTATT GGCATAGCCG TCTCTTCACC 3120

CGGAGTGATG CCCAGCGGGT TTAA 3144

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         l+klk+lGsG+fGtvykGiwipeg++vkipvaik ++++tg+++++++++++++++ l+h

Q: 417   LRKLKILGSGVFGTVYKGIWIPEGDSVKIPVAIKAIQDRTGRQTFHNITENIIAMGCLEH  476

         69**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+c    lqlvtql+p+G+ll+y+r+h+dk+ +q llnwc+qiakGm+ylee+

Q: 477   PHVLRLLGICPGAGLQLVTQLMPMGSLLEYIRKHQDKVNPQLLLNWCIQIAKGMYYLEEH  536

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         r+vhr+laarnv++kspn v+++dfG+a+ll  d+k++ +++ k+pikw+alesi++r+y

Q: 537   RMVHRNLAARNVMMKSPNLVQVADFGIADLLYPDDKKYLYNEIKTPIKWMALESIHFRRY  596

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvt+we++tfG++py+gi+++e+pdllekGerl+qppictidvymv+vkcw

Q: 597   THQSDVWSYGVTIWEMMTFGSEPYAGIRLQEVPDLLEKGERLSQPPICTIDVYMVMVKCW  656

         ************************************************************

S: 241   midaesrpkfkelaeef  257

         mid+++rp+fkela+ef

Q: 657   MIDENIRPTFKELASEF  673

         ***************99

Domain Sequence
(FASTA)

LRKLKILGSG VFGTVYKGIW IPEGDSVKIP VAIKAIQDRT GRQTFHNITE NIIAMGCLEH 60

PHVLRLLGIC PGAGLQLVTQ LMPMGSLLEY IRKHQDKVNP QLLLNWCIQI AKGMYYLEEH 120

RMVHRNLAAR NVMMKSPNLV QVADFGIADL LYPDDKKYLY NEIKTPIKWM ALESIHFRRY 180

THQSDVWSYG VTIWEMMTFG SEPYAGIRLQ EVPDLLEKGE RLSQPPICTI DVYMVMVKCW 240

MIDENIRPTF KELASEF 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 1.

SMARTs

SM00261	; FU; 3.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013