EKS-LAC-00288

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00288

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	455.1	1.1E-136	234	521	288

Status

Unreviewed

Ensembl Protein

ENSLACP00000001526

UniProt Accession

H2ZVV5;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1B

Gene Synonyms/Alias

BMPR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000001364	ENSLACP00000001526	ENSLACT00000001539

Organism

Latimeria chalumnae

Functional Description

Protein Length

532

Protein Sequence
(FASTA)

MGWLEEPSWQ IHFSLIMLLS LQTKANLLDN MLLRSSGKLN LENRKEDGES KVPVPAQKML 60

WCYCHHHCPE DSVNNTCRTD GFCFTIIEED ESGVPIVTSG CLGWEGSDFQ CRDTPRSHQR 120

RAIECCTDQD FCNKDLSPTL PPLNTRDLVD GSIHNMALLI SVTVCSIILA LIIIYCYFRY 180

KRQEPRPRYS IGLEQDETFI PPGESLKDLI EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI 240

GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 300

SWTQLYLITD YHENGSLYDY LKSTTLDTKA MLKLAYSAVS GLCHLHTEIF GTQGKPAIAH 360

RDLKSKNLLV KKNGTCCIAD LGLAVKFISD TNEVDIPPNT RVGTKRYMAP EVLDETLNRN 420

HFQSYIMADM YSFGLILWEI ARRCVSGGIV EEYQLPYHDQ VPNDPSYEDM REVVCIKRLR 480

PSFPNRWSSD ECLRQMGKLM TECWAHNPAS RLTALRVKKT LAKMSESQDI KL 532

Nucleotide Sequence
(FASTA)

ATGGGTTGGC TTGAAGAACC AAGTTGGCAG ATTCACTTTT CCTTGATCAT GCTGCTTTCC 60

CTGCAGACTA AGGCCAACCT CCTCGACAAC ATGTTGCTGC GGAGTTCGGG AAAGCTGAAT 120

TTGGAGAACA GGAAGGAGGA TGGCGAGAGC AAGGTGCCTG TGCCAGCTCA GAAGATGCTG 180

TGGTGCTACT GCCATCACCA CTGCCCCGAG GACTCTGTCA ACAATACCTG CAGGACAGAT 240

GGTTTTTGCT TCACTATTAT AGAAGAAGAT GAGTCGGGAG TTCCAATAGT CACCTCTGGA 300

TGCCTGGGTT GGGAAGGATC AGACTTTCAG TGTCGGGATA CTCCAAGGTC TCACCAGAGG 360

AGAGCAATCG AATGTTGCAC TGACCAAGAT TTTTGTAATA AGGACCTCAG TCCTACACTG 420

CCGCCATTGA ATACCCGAGA TCTGGTGGAT GGAAGCATTC ATAATATGGC CTTATTAATC 480

TCTGTGACTG TGTGCAGTAT CATCCTAGCC CTGATCATCA TATACTGCTA CTTCAGGTAT 540

AAGAGACAAG AACCAAGACC TCGTTACAGC ATAGGGCTGG AGCAAGATGA GACCTTCATC 600

CCTCCCGGAG AATCCCTCAA GGACCTCATT GAACAGTCTC AGAGCTCAGG CAGTGGTTCC 660

GGGCTCCCTC TACTGGTCCA AAGGACGATA GCCAAGCAAA TTCAGATGGT GAAGCAAATT 720

GGAAAGGGCC GGTATGGAGA AGTCTGGATG GGGAAGTGGC GAGGGGAGAA GGTGGCGGTG 780

AAAGTGTTTT TCACTACAGA GGAGGCCAGC TGGTTCAGGG AGACTGAGAT TTATCAGACC 840

GTCCTCATGA GGCACGAGAA CATCCTGGGC TTCATTGCCG CTGATATCAA GGGCACGGGG 900

TCGTGGACGC AGCTTTACCT GATCACAGAC TACCATGAGA ACGGCTCTCT GTACGACTAC 960

CTGAAATCCA CCACACTGGA CACCAAGGCC ATGCTGAAGC TGGCCTACTC CGCGGTCAGC 1020

GGCCTGTGCC ACTTACACAC TGAGATCTTT GGCACGCAGG GGAAGCCGGC CATTGCTCAC 1080

CGGGACCTGA AAAGCAAAAA CCTCTTGGTG AAGAAAAACG GAACCTGTTG TATAGCAGAT 1140

TTAGGCTTGG CAGTTAAATT CATCAGCGAT ACGAATGAAG TAGACATCCC CCCTAACACC 1200

AGAGTGGGCA CTAAGCGGTA CATGGCTCCA GAGGTACTGG ATGAGACCCT CAACCGGAAT 1260

CATTTCCAGT CCTATATCAT GGCAGACATG TACAGCTTTG GACTGATCCT TTGGGAGATT 1320

GCCAGGAGAT GTGTGTCTGG AGGCATAGTA GAAGAATATC AGCTACCTTA TCATGACCAG 1380

GTACCCAATG ATCCCTCCTA TGAAGATATG AGAGAAGTTG TGTGCATCAA GAGGTTACGG 1440

CCCTCTTTCC CCAATCGATG GAGCAGCGAT GAGTGCCTAA GGCAGATGGG AAAACTTATG 1500

ACAGAATGCT GGGCCCACAA TCCTGCTTCT CGCCTAACAG CCCTTCGGGT GAAGAAGACA 1560

CTTGCCAAAA TGTCAGAGTC ACAGGACATT AAGCTCTGA 1599

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 234   IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  293

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+dyLk++tld++ +l+la+s++sGl+hLH+ei+gt+

Q: 294   ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDTKAMLKLAYSAVSGLCHLHTEIFGTQ  353

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskN+lvkk++tcciaDlGLa+k+ ++++e+d+  n++vGtkRYmaPE

Q: 354   G--KPAIAHRDLKSKNLLVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMAPE  411

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aD+Ys+gL+lWE+a+Rc + +++veey+lp++++v++dPs+e+m

Q: 412   VLDETLNRNHFQSYIMADMYSFGLILWEIARRCVS-GGIVEEYQLPYHDQVPNDPSYEDM  470

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +evv+ k+lrP++p++w+++e+l+++ kl++ecW+++p++Rltalrvkk+l

Q: 471   REVVCIKRLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL  521

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDTKAMLK LAYSAVSGLC HLHTEIFGTQ 120

GKPAIAHRDL KSKNLLVKKN GTCCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMAPEVL 180

DETLNRNHFQ SYIMADMYSF GLILWEIARR CVSGGIVEEY QLPYHDQVPN DPSYEDMREV 240

VCIKRLRPSF PNRWSSDECL RQMGKLMTEC WAHNPASRLT ALRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013