EKS-LAC-00479

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00479

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	341.0	5.9E-102	20	316	297

Status

Unreviewed

Ensembl Protein

ENSLACP00000001703

UniProt Accession

H2ZWD2;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK6

Gene Synonyms/Alias

MAPK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000001524	ENSLACP00000001703	ENSLACT00000001716

Organism

Latimeria chalumnae

Functional Description

Protein Length

721

Protein Sequence
(FASTA)

MAEKFESLMN IHGFDLGSRY MDLKPLGYGG NGLVFSAVDN DCDKRVAVKK IVLTDPQSVK 60

HALREIKIIR RLDHDNIVKV FEVLGPNGRL LTEDVVSFTE LNCVYIVQEY METDLARLLQ 120

QGPLLEEHAR LFMYQLLRGL KYIHSANVLH RDLKPANLFI NTEDLVLKIG DFGLARIMDP 180

HYSHKGHLSE GLVTKWYRSP RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ 240

MQLILESIPV IHEEDLQELL GVIPVYIEND MTEPHKPLAQ LLPGISPEAL DFLAQILTFN 300

PMDRLTAEEA LSHPYMSIYS FPLDEPISNH PFHIEDEVDD ILLMDESHSH VYNWERYHES 360

QFSDHDWSLH NNFETDEVQR DPRALSDVTE EEEVQVDPRK YLDGDREKYL EDPAFDSHFS 420

TEPCWQHSDH HENKYCDLEC SHTCNYKVRS PLYLDNLVWR DSEVNHYYEP KLIIDLSNWK 480

EQSKEKVDKK GKSKCEKNGL VKAQIALQEA SQQLVEKEKN PGFDFDSFIA GTIKLSLQTE 540

VSDVDKLNGL NSSVSQLELK TSISKSVSQE KEEKGIANLA QLGGWNQTPW DSQYGHIDDA 600

DECFLIDQFC CDVRKDEQLE REITYTSYLD KFFSKKEDVE MAELEPVEDR KLGGKDREES 660

LIGKNGEIML SKQFECIGIP SFHSPVSSPL KSIQATLTPS SVRSSPQIPH KTYSSILKHL 720

N 721

Nucleotide Sequence
(FASTA)

ATGGCGGAAA AGTTTGAAAG TTTAATGAAC ATACATGGTT TTGATTTGGG TTCCCGTTAC 60

ATGGACTTGA AGCCACTGGG CTATGGTGGA AATGGCTTAG TTTTTTCTGC CGTTGATAAT 120

GACTGTGACA AAAGAGTTGC TGTCAAAAAA ATTGTCCTCA CTGACCCCCA GAGTGTTAAA 180

CATGCCCTGC GTGAGATCAA AATAATTAGG CGACTTGATC ATGATAATAT TGTGAAAGTC 240

TTTGAGGTTC TTGGCCCTAA TGGGAGACTG CTAACTGAGG ATGTGGTTTC TTTTACGGAA 300

CTAAATTGTG TTTACATTGT CCAAGAGTAC ATGGAGACTG ACTTGGCCAG GCTGCTACAA 360

CAGGGGCCCC TACTAGAGGA GCATGCCAGG CTCTTCATGT ACCAGCTTCT TCGTGGCCTC 420

AAGTACATTC ATTCAGCCAA TGTCCTGCAC AGAGATCTTA AACCAGCAAA TCTCTTTATT 480

AACACTGAGG ACCTGGTGCT GAAAATTGGA GATTTTGGTC TTGCACGTAT CATGGATCCC 540

CACTACTCCC ATAAGGGCCA TTTGTCTGAA GGATTAGTTA CCAAATGGTA TAGATCTCCC 600

CGCCTTCTTC TTTCACCTAA TAACTACACC AAAGCCATTG ACATGTGGGC TGCTGGTTGC 660

ATCTTTGCAG AAATGCTAAC TGGAAAAACT CTATTTGCAG GTGCCCATGA GCTGGAGCAG 720

ATGCAGCTGA TTCTTGAGTC TATTCCTGTC ATCCATGAAG AAGACCTCCA GGAGCTTCTT 780

GGTGTCATCC CAGTTTACAT TGAAAATGAT ATGACTGAGC CACATAAACC ACTAGCACAG 840

CTACTTCCAG GAATCAGTCC TGAAGCCCTA GATTTCCTTG CGCAAATATT GACCTTTAAT 900

CCTATGGACA GACTGACTGC AGAAGAAGCT TTGTCCCATC CATACATGAG CATCTACTCT 960

TTTCCACTTG ATGAGCCCAT TTCAAATCAT CCTTTTCACA TTGAAGATGA AGTAGATGAT 1020

ATTTTGCTTA TGGATGAGAG CCACAGCCAT GTCTACAATT GGGAAAGATA TCATGAAAGC 1080

CAGTTCTCAG ATCATGACTG GTCTCTACAT AACAATTTTG AGACAGATGA AGTCCAGCGT 1140

GACCCAAGGG CTTTGTCGGA CGTCACAGAA GAGGAAGAAG TGCAAGTAGA CCCTCGTAAA 1200

TACTTGGATG GAGATCGAGA AAAGTATTTA GAAGACCCTG CTTTTGACTC TCACTTTTCC 1260

ACTGAGCCTT GTTGGCAACA CTCGGATCAC CATGAAAACA AATACTGTGA TTTAGAGTGT 1320

AGCCACACTT GTAACTACAA AGTGAGATCT CCACTTTACC TTGATAACTT AGTTTGGCGG 1380

GATAGTGAAG TTAACCATTA CTATGAGCCC AAGCTTATTA TAGATCTGTC TAACTGGAAA 1440

GAGCAGAGCA AAGAGAAGGT AGACAAGAAG GGCAAATCAA AATGTGAAAA AAATGGTTTG 1500

GTGAAAGCTC AGATAGCTCT ACAGGAAGCA TCTCAGCAAC TGGTTGAAAA GGAAAAGAAT 1560

CCAGGTTTTG ACTTTGATTC TTTTATTGCA GGAACCATTA AGCTCAGTTT GCAGACGGAG 1620

GTTTCTGATG TTGATAAGTT AAATGGCTTA AACAGTTCAG TATCACAACT TGAATTAAAA 1680

ACCTCAATAT CCAAATCTGT CAGCCAGGAG AAAGAGGAAA AGGGAATAGC CAATCTGGCT 1740

CAGCTAGGAG GTTGGAACCA AACTCCTTGG GATAGCCAGT ATGGCCATAT AGATGATGCA 1800

GATGAATGCT TCCTCATAGA CCAATTTTGT TGCGATGTTA GGAAAGATGA GCAGTTAGAA 1860

AGAGAAATTA CCTACACCAG TTACTTGGAC AAGTTCTTTA GCAAGAAGGA GGATGTTGAA 1920

ATGGCAGAAC TTGAGCCAGT TGAAGACAGG AAACTGGGGG GAAAGGACAG AGAGGAAAGC 1980

CTCATAGGTA AAAATGGAGA GATCATGTTA AGCAAGCAGT TTGAATGCAT AGGCATTCCC 2040

TCATTTCACA GTCCTGTTAG TTCACCTCTC AAGTCAATTC AGGCCACTTT AACACCTTCT 2100

TCAGTAAGAT CTTCCCCTCA GATTCCTCAT AAGACGTATA GCAGCATTTT GAAACATCTA 2160

AACTAA 2166

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkplg G +g+v+savd+++++rva+kk++  +++ +s+k++lRE+k++++l+h+Ni

Q: 20    YMDLKPLGYGGNGLVFSAVDNDCDKRVAVKKIV--LTDPQSVKHALREIKIIRRLDHDNI  77

         7899****************************9..9************************

S: 61    iklldvftpee........eleelkdvYlvtelmetdLkkviksqklsdehiklllyqil  112

         +k+++v+ p+         +++el+ vY+v+e+metdL++++++  l +eh++l++yq+l

Q: 78    VKVFEVLGPNGrlltedvvSFTELNCVYIVQEYMETDLARLLQQGPLLEEHARLFMYQLL  137

         **********99999988889999************************************

S: 113   rglkylHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwY  169

         rglky+Hsanv+HrDlKP+Nl++n++   lki dFGlar++d+++++k  l+e ++t+wY

Q: 138   RGLKYIHSANVLHRDLKPANLFINTEDLvLKIGDFGLARIMDPHYSHKghLSEGLVTKWY  197

         ************************876449**************999999**********

S: 170   raPeillslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflk  229

         r+P++lls ++ytka+D+W++GCI+aE+ltgk+lf+g++e++q+++ile ++  +ee+l+

Q: 198   RSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVIHEEDLQ  257

         ************************************************************

S: 230   kieseearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         ++    +  yi++ +++++k++++l+p  s+eald+l ++L+++p++R+++eeaL+hpY+

Q: 258   ELLGV-IPVYIENDMTEPHKPLAQLLPGISPEALDFLAQILTFNPMDRLTAEEALSHPYM  316

         ***95.*****************************************************7

Domain Sequence
(FASTA)

YMDLKPLGYG GNGLVFSAVD NDCDKRVAVK KIVLTDPQSV KHALREIKII RRLDHDNIVK 60

VFEVLGPNGR LLTEDVVSFT ELNCVYIVQE YMETDLARLL QQGPLLEEHA RLFMYQLLRG 120

LKYIHSANVL HRDLKPANLF INTEDLVLKI GDFGLARIMD PHYSHKGHLS EGLVTKWYRS 180

PRLLLSPNNY TKAIDMWAAG CIFAEMLTGK TLFAGAHELE QMQLILESIP VIHEEDLQEL 240

LGVIPVYIEN DMTEPHKPLA QLLPGISPEA LDFLAQILTF NPMDRLTAEE ALSHPYM 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013