EKS-LAC-00471

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00471

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	448.6	9.5E-135	63	347	285

Status

Unreviewed

Ensembl Protein

ENSLACP00000001774

UniProt Accession

H2ZWK3;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK14

Gene Synonyms/Alias

MAPK14;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000001584	ENSLACP00000001774	ENSLACT00000001787

Organism

Latimeria chalumnae

Functional Description

Protein Length

399

Protein Sequence
(FASTA)

MANPPFPGYY NVRNPDPRCG QVQLCCVDRV GGREEEQRGA GSHRPEFYRQ ELNKTVWEVP 60

RRYENLSPVG SGAYGSVCSA CDTQSGLRVA VKKLSRPFQS IIHAKRTYRE LRLLKHMKHE 120

NVIGLLDVFT PSQSLEEFND VYLVTHLMGA DLNNIVKCQK LTDDHVQFLI YQILRGLKYI 180

HSAGIIHRDL KPSNLAVNED CELKILDFGL ARHTDDEMTG YVATRWYRAP EIMLNWMHYN 240

QTVDIWSVGC IMAELLTGRT LFPGTDHIDQ LKLIMMLVGT PGSDLLMKIS SESARNYIQS 300

LPFMPKRSFE DVFIGANPLA VDLLEKMLVL DTDKRITAAE ALAHPYFAQY HDPEDEPEAE 360

PYDQSFESRE LEIEEWKRLT YEEVLSFEPP PLDTEEMES 399

Nucleotide Sequence
(FASTA)

ATGGCGAATC CACCTTTTCC CGGTTATTAC AATGTGCGGA ATCCCGATCC GCGTTGCGGC 60

CAAGTGCAGC TGTGCTGTGT GGATCGGGTT GGAGGCCGCG AAGAGGAGCA GCGCGGCGCC 120

GGTTCTCACC GGCCCGAATT TTACCGACAG GAGCTCAATA AAACTGTCTG GGAGGTTCCG 180

CGGCGCTACG AGAATCTGTC GCCCGTTGGA TCGGGCGCTT ACGGTTCTGT TTGCTCAGCG 240

TGTGACACAC AGTCTGGATT GCGGGTGGCT GTGAAGAAAT TGTCAAGGCC ATTTCAGTCC 300

ATCATCCACG CGAAGCGGAC ATACCGAGAA CTACGACTTC TCAAACACAT GAAACATGAA 360

AACGTGATTG GCTTACTGGA TGTTTTCACA CCTTCACAGT CACTGGAGGA GTTTAACGAT 420

GTGTACTTGG TGACACACCT GATGGGGGCA GATCTAAACA ACATTGTTAA ATGTCAGAAA 480

TTAACCGATG ATCACGTCCA GTTCCTCATC TATCAGATAC TCCGAGGATT AAAGTATATC 540

CATTCAGCTG GTATCATTCA CAGAGATCTG AAGCCCAGCA ATCTGGCGGT GAACGAGGAT 600

TGTGAGTTAA AGATCCTTGA CTTTGGCTTG GCACGTCATA CAGATGATGA AATGACAGGA 660

TATGTTGCTA CCAGGTGGTA TCGAGCACCA GAGATTATGT TGAACTGGAT GCACTACAAT 720

CAGACAGTGG ATATTTGGTC CGTTGGATGC ATCATGGCAG AATTATTGAC AGGAAGGACA 780

CTCTTTCCCG GCACAGATCA TATCGATCAG TTGAAGCTCA TAATGATGCT GGTCGGAACC 840

CCAGGGTCTG ACCTCTTGAT GAAAATATCA TCGGAGTCTG CTAGGAACTA TATTCAGTCT 900

CTGCCATTTA TGCCAAAGAG GAGTTTTGAA GATGTCTTCA TTGGAGCTAA TCCACTGGCT 960

GTTGATTTGC TGGAGAAGAT GCTTGTGCTG GACACAGATA AGAGGATCAC AGCAGCTGAG 1020

GCCCTGGCGC ACCCCTACTT TGCACAGTAT CATGATCCGG AAGATGAACC AGAAGCAGAA 1080

CCCTATGATC AGTCCTTCGA AAGCAGGGAA CTTGAAATAG AAGAGTGGAA GAGACTGACA 1140

TATGAGGAAG TTTTGAGCTT TGAGCCACCA CCACTGGATA CAGAAGAAAT GGAGTCCTGA 1200

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         ye+l+p+g+Gayg v+sa d++++ rva+kklsrpfq+ ++akrt+REl+llk++kheN+

Q: 63    YENLSPVGSGAYGSVCSACDTQSGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV  122

         8999********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i lldvftp+++lee++dvYlvt+lm++dL++++k qkl+d+h+++l+yqilrglky+Hs

Q: 123   IGLLDVFTPSQSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHS  182

         ************************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsNl+vnedcelkildFGlar++d+e    +t+yvatrwYraPei+l++++

Q: 183   AGIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE----MTGYVATRWYRAPEIMLNWMH  238

         **********************************9....*********************

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI+aElltg++lfpg+d+idql++i+ ++gtp ++ l+ki+se+arnyi

Q: 239   YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIMMLVGTPGSDLLMKISSESARNYI  298

         ************************************************************

S: 241   kslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         +slp ++k++fe++f  a++ a+dLlek+Lvld+dkRi+++eaL+hpY+

Q: 299   QSLPFMPKRSFEDVFIGANPLAVDLLEKMLVLDTDKRITAAEALAHPYF  347

         ************************************************6

Domain Sequence
(FASTA)

YENLSPVGSG AYGSVCSACD TQSGLRVAVK KLSRPFQSII HAKRTYRELR LLKHMKHENV 60

IGLLDVFTPS QSLEEFNDVY LVTHLMGADL NNIVKCQKLT DDHVQFLIYQ ILRGLKYIHS 120

AGIIHRDLKP SNLAVNEDCE LKILDFGLAR HTDDEMTGYV ATRWYRAPEI MLNWMHYNQT 180

VDIWSVGCIM AELLTGRTLF PGTDHIDQLK LIMMLVGTPG SDLLMKISSE SARNYIQSLP 240

FMPKRSFEDV FIGANPLAVD LLEKMLVLDT DKRITAAEAL AHPYF 285

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013