EKS-LAC-00416

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00416

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	391.5	2.1E-117	314	579	266

Status

Unreviewed

Ensembl Protein

ENSLACP00000001911

UniProt Accession

H2ZWZ0;

Protein Name

Protein Synonyms/Alias

Gene Name

TYRO3

Gene Synonyms/Alias

TYRO3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000001709	ENSLACP00000001911	ENSLACT00000001925

Organism

Latimeria chalumnae

Functional Description

Protein Length

690

Protein Sequence
(FASTA)

GVNQTTAFSC EAHNAKGVST SRTSHIRVKV SPDTPSDLQV TNVTSSSVSL AWKPMFDGHS 60

ALQSCGVQVA ERQRERKHFA VKTVAVPPFN YTFQSLKFFT GYSVQLRCSN EVGTSPYTDW 120

VDFQTLEMAP SVAPQNITFH YGGSWLSLEW EEVAKEEMNG ALLGYEVKWI KDGLYQKGLQ 180

TAGNQANITK LSVFQNLTLQ VCAMTSAGCG PWSDSIMVLL PLKNTRTRPL HPTTEYIGAL 240

YRIPRCLMVS CVFSVCLCRT AFGPAPSEPV VHFSAARSYN RQGAGIIEAT LSSLGVSDAL 300

KEKLEDVLIP VQYLTLGITL GKGEFGSVKE ARLKLEDGAV QRVAVKTLKA DITCSSDIED 360

FLREAAFMKD FDHPNVLKLI GVSLESRPQR RLPVPMVILP FMKHGDLHTF LLLSRLGETP 420

FTLPVQTLIK FMIDISSGME YLGSKNFIHR DLASRNCMLS EDMSVCVADF GLSKKIYSGD 480

YYRQGSASKL PVKWIALESL ADNIYTVCSD VFRALFPLFH ACSRSFTYFV DFGCSSIITP 540

FTKGNVLLQY PRLILYLYEI MFRCWNPQPK MRPNFTALKR ELEKILGRLS LVTDDKDLLY 600

VNVGDTGAGA TGTEPALFTA CWEKEDQQEE QEGALSFLGS SSAVTSGYRY VLDPIGLGTD 660

EGREEHLGTQ MNEAAGLLHA EQDKEPIFNC 690

Nucleotide Sequence
(FASTA)

GGTGTGAACC AAACAACTGC TTTCTCCTGC GAGGCCCACA ATGCAAAGGG AGTCTCCACC 60

TCCAGAACCT CTCACATTCG GGTTAAAGTT TCACCAGATA CACCTTCTGA CCTCCAGGTC 120

ACCAACGTCA CTAGCAGCAG CGTCAGTCTT GCCTGGAAGC CAATGTTTGA TGGACACTCC 180

GCCCTTCAGT CCTGTGGTGT TCAGGTTGCT GAGAGGCAAA GGGAGAGAAA ACACTTTGCT 240

GTGAAAACTG TAGCCGTTCC CCCGTTCAAC TACACCTTCC AGAGCCTGAA GTTTTTCACA 300

GGCTACAGTG TGCAGCTTCG GTGCAGCAAT GAGGTTGGGA CGTCCCCGTA CACCGACTGG 360

GTGGACTTTC AAACGCTGGA GATGGCTCCC AGTGTTGCTC CCCAGAACAT CACATTTCAC 420

TACGGAGGTT CTTGGCTCTC TCTGGAATGG GAAGAGGTAG CAAAGGAGGA AATGAATGGG 480

GCTTTACTTG GATACGAGGT GAAGTGGATC AAGGATGGTC TTTATCAGAA AGGCCTTCAG 540

ACTGCAGGAA ACCAAGCCAA CATCACGAAG CTGAGCGTGT TTCAGAACCT GACGCTGCAG 600

GTCTGCGCGA TGACGTCAGC TGGCTGTGGT CCGTGGAGTG ACTCCATAAT GGTTCTTCTT 660

CCACTCAAAA ACACTCGTAC AAGACCTTTG CACCCAACTA CTGAATATAT TGGTGCTTTG 720

TATCGTATTC CTCGATGTTT GATGGTATCA TGTGTCTTCT CTGTCTGTCT GTGCAGGACT 780

GCGTTTGGAC CTGCCCCGAG TGAACCAGTG GTCCATTTCA GCGCTGCTCG CTCGTACAAC 840

AGACAGGGGG CGGGGATTAT TGAAGCCACA CTGAGCAGTT TGGGGGTCAG TGATGCTCTG 900

AAGGAAAAAC TGGAAGATGT TCTAATTCCT GTACAGTACC TTACCTTGGG AATCACCTTA 960

GGAAAAGGGG AGTTTGGATC AGTGAAGGAA GCCCGGTTGA AGCTGGAGGA CGGAGCCGTT 1020

CAGAGAGTTG CTGTGAAAAC TCTGAAAGCT GACATCACTT GTTCCAGTGA TATTGAGGAT 1080

TTTCTACGAG AAGCGGCTTT TATGAAGGAC TTTGATCACC CGAACGTCCT CAAGCTGATC 1140

GGAGTGAGTC TGGAAAGCCG ACCCCAGCGC CGTCTCCCCG TTCCGATGGT AATCTTGCCC 1200

TTCATGAAGC ACGGCGACCT CCACACTTTC CTCTTGCTGT CCCGCTTAGG AGAAACCCCT 1260

TTTACATTGC CTGTGCAAAC GCTGATAAAG TTTATGATTG ACATTTCCAG CGGTATGGAG 1320

TACCTGGGCA GTAAAAACTT CATCCACAGA GACCTTGCCA GCCGCAACTG CATGTTGAGT 1380

GAGGACATGA GTGTTTGTGT CGCAGATTTT GGACTCTCTA AGAAAATCTA CAGCGGCGAT 1440

TATTACCGAC AGGGCAGCGC ATCCAAATTA CCAGTAAAGT GGATCGCACT GGAGAGCCTG 1500

GCGGACAACA TCTACACCGT GTGCAGCGAC GTGTTTCGCG CACTTTTTCC GCTGTTTCAT 1560

GCTTGCTCAC GCTCTTTCAC GTATTTTGTG GATTTTGGTT GTTCATCCAT AATTACACCT 1620

TTTACAAAGG GGAATGTTTT GCTTCAGTAT CCCCGACTGA TCCTCTATCT CTACGAAATC 1680

ATGTTCCGGT GTTGGAACCC CCAGCCCAAG ATGCGGCCTA ACTTCACAGC ATTGAAACGG 1740

GAACTGGAGA AGATACTGGG GAGGCTATCC TTGGTGACAG ACGACAAGGA CCTGCTGTAT 1800

GTCAATGTTG GAGACACTGG GGCAGGGGCC ACTGGGACTG AGCCAGCATT GTTCACTGCA 1860

TGCTGGGAGA AAGAGGATCA GCAGGAGGAA CAAGAGGGTG CGTTGTCCTT CCTAGGTTCC 1920

TCCAGTGCAG TTACAAGTGG CTATCGCTAT GTGCTGGACC CTATAGGGCT CGGAACTGAT 1980

GAGGGGAGAG AAGAGCATCT GGGAACACAA ATGAATGAAG CAGCAGGGCT TCTTCATGCA 2040

GAACAGGATA AAGAGCCTAT TTTTAACTGT 2070

Domain Profile

S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60

         l+lg +lg+gefgsv+e++lk edg++++vavktlk+di+++s+ie+fl+eaa mk+fdh

Q: 314   LTLGITLGKGEFGSVKEARLKLEDGAVQRVAVKTLKADITCSSDIEDFLREAAFMKDFDH  373

         689*********************************************************

S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120

         pnv++l+gvsles+ + rlp p+vilpfmk+gdlh+fll srlge p+ lp+qtl+kfm+

Q: 374   PNVLKLIGVSLESRPQRRLPVPMVILPFMKHGDLHTFLLLSRLGETPFTLPVQTLIKFMI  433

         ************************************************************

S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180

         di+sgmeyl s+nfihrdla+rncml+edm+vcvadfglskkiysgdyyrqg ++klpvk

Q: 434   DISSGMEYLGSKNFIHRDLASRNCMLSEDMSVCVADFGLSKKIYSGDYYRQGSASKLPVK  493

         ************************************************************

S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240

         wia+eslad++yt+ sdv+     ++   +r  t +     + i   + +gn l q +

Q: 494   WIALESLADNIYTVCSDVFRALFPLFHACSRSFTYFVDFGCSSIITPFTKGNVLLQYPRL  553

         ************************************************************

S: 241   ldelydlmyrcweadpkdrpsfsvlr  266

         +  ly++m+rcw+ +pk rp f+ l+

Q: 554   ILYLYEIMFRCWNPQPKMRPNFTALK  579

         **********************9986

Domain Sequence
(FASTA)

LTLGITLGKG EFGSVKEARL KLEDGAVQRV AVKTLKADIT CSSDIEDFLR EAAFMKDFDH 60

PNVLKLIGVS LESRPQRRLP VPMVILPFMK HGDLHTFLLL SRLGETPFTL PVQTLIKFMI 120

DISSGMEYLG SKNFIHRDLA SRNCMLSEDM SVCVADFGLS KKIYSGDYYR QGSASKLPVK 180

WIALESLADN IYTVCSDVFR ALFPLFHACS RSFTYFVDFG CSSIITPFTK GNVLLQYPRL 240

ILYLYEIMFR CWNPQPKMRP NFTALK 266

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Gallus gallus"; ?>Meleagris gallopavo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013