EKS-LAC-00475

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00475

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	411.8	1.5E-123	26	321	296

Status

Unreviewed

Ensembl Protein

ENSLACP00000002488

UniProt Accession

H2ZYL7;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK9

Gene Synonyms/Alias

MAPK9;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000002222	ENSLACP00000002488	ENSLACT00000002508

Organism

Latimeria chalumnae

Functional Description

Protein Length

424

Protein Sequence
(FASTA)

MNESKSDSQF YSVQVADSTF TVLKRYQQLK PIGSGAQGIV CSAFDAILSI HVAVKKLSRP 60

FQNQTHAKRA YRELVLLKCV NHKNIINLLN VFTPQKSLEE FQDVYLVMEL MDANLCQVIH 120

MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTACTNF 180

MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGELVK GCVIFQGTDH IDQWNKVIEQ 240

LGTPSAEFMK KLQPTVRNYV ENRPKYPGVR FEELFPDWIF PSESERDKLK ISQARDLLCK 300

MLVVDPDKRI SVDEALHHPY ISVWYDAAEA EAPPPQIYDA QLEEREHTIE EWKELIYKEV 360

LDWEERSKNG VVKDQPSDAA VNSNTSPSQS SSINDLSSMS TERTLASDTD SSIDAPAGSL 420

EGCR 424

Nucleotide Sequence
(FASTA)

ATGAATGAAA GTAAATCTGA CAGCCAGTTC TATAGTGTGC AGGTTGCAGA CTCCACATTC 60

ACTGTACTCA AACGCTACCA GCAGCTGAAG CCCATTGGGT CAGGAGCTCA GGGCATTGTC 120

TGTTCCGCCT TCGATGCGAT TCTTAGTATC CATGTTGCTG TGAAGAAACT AAGTCGTCCT 180

TTCCAGAACC AAACTCATGC CAAGAGGGCC TACAGGGAGC TTGTTCTGCT AAAATGTGTC 240

AATCATAAAA ACATTATTAA TTTGTTGAAT GTATTTACAC CACAAAAGTC ACTAGAAGAA 300

TTTCAAGATG TATACTTGGT TATGGAACTG ATGGATGCTA ACCTGTGCCA AGTAATTCAC 360

ATGGAGCTGG ACCATGAACG AATGTCATAT CTTCTATATC AGATGCTGTG TGGTATCAAG 420

CATCTTCATT CTGCTGGCAT CATCCACAGA GATTTGAAAC CTAGCAATAT AGTAGTGAAA 480

TCTGATTGTA CACTGAAGAT CTTAGACTTT GGCCTGGCAA GGACAGCATG CACTAATTTT 540

ATGATGACCC CATATGTAGT AACACGATAT TACAGAGCTC CAGAGGTTAT CCTCGGGATG 600

GGCTACAAAG AAAATGTTGA TATCTGGTCA GTGGGGTGCA TCATGGGAGA ATTGGTGAAA 660

GGTTGTGTGA TATTCCAAGG CACTGATCAT ATTGATCAGT GGAATAAAGT TATTGAACAG 720

TTAGGTACGC CATCTGCTGA GTTCATGAAG AAACTGCAGC CCACAGTGAG GAACTATGTG 780

GAAAACCGTC CGAAGTATCC AGGAGTGCGG TTTGAGGAGC TGTTCCCTGA TTGGATCTTC 840

CCCTCTGAGT CTGAGCGAGA CAAATTAAAA ATAAGTCAAG CTAGAGATTT GCTGTGTAAA 900

ATGTTGGTAG TCGATCCAGA CAAGCGTATC TCTGTAGATG AAGCTTTGCA CCATCCGTAT 960

ATCTCTGTCT GGTATGATGC AGCTGAAGCA GAGGCGCCAC CACCACAGAT CTATGATGCA 1020

CAGTTGGAAG AGAGAGAGCA TACTATAGAA GAATGGAAAG AACTGATTTA TAAGGAAGTT 1080

TTGGACTGGG AAGAGAGAAG CAAGAATGGA GTTGTAAAAG ATCAGCCTTC AGATGCAGCA 1140

GTGAATAGCA ACACCAGTCC CTCCCAGTCG TCTTCCATCA ACGACCTGTC CTCCATGTCA 1200

ACTGAGCGGA CTCTGGCCTC CGACACCGAC AGCAGCATTG ATGCACCAGC CGGATCGCTT 1260

GAAGGATGCC GGTGA 1275

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v+sa+d+  + +va+kklsrpfq++t+akr++REl llk+++h+Ni

Q: 26    YQQLKPIGSGAQGIVCSAFDAILSIHVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNI  85

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 86    INLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLYQMLCGIKHLHS  144

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFM--MTPYVVTRYYRAPEVILG-MG  201

         ********************************99976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++El++g ++f+g+d+idq++k++e+lgtps+ef+kk++  ++rny+

Q: 202   YKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQP-TVRNYV  260

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++   feelfp+            + ++a+dLl k+Lv+dpdkRisv+eaL+hpY

Q: 261   ENRPKYPGVRFEELFPDwifpseserdklKISQARDLLCKMLVVDPDKRISVDEALHHPY  320

         ****************************999*****************************

S: 289   l  289

Q: 321   I  321

Domain Sequence
(FASTA)

YQQLKPIGSG AQGIVCSAFD AILSIHVAVK KLSRPFQNQT HAKRAYRELV LLKCVNHKNI 60

INLLNVFTPQ KSLEEFQDVY LVMELMDANL CQVIHMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART ACTNFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GELVKGCVIF QGTDHIDQWN KVIEQLGTPS AEFMKKLQPT VRNYVENRPK 240

YPGVRFEELF PDWIFPSESE RDKLKISQAR DLLCKMLVVD PDKRISVDEA LHHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013