EKS-LAC-00293

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00293

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	418.8	1.2E-125	191	478	288

Status

Unreviewed

Ensembl Protein

ENSLACP00000002565

UniProt Accession

H2ZYU4;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2A

Gene Synonyms/Alias

ACVR2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000002290	ENSLACP00000002565	ENSLACT00000002585

Organism

Latimeria chalumnae

Functional Description

Protein Length

512

Protein Sequence
(FASTA)

MGAATKLSFA VFLISCSSGA ILGRSETQEC IFYNANWEKD KTNHSGIEPC YGDKDKRQHC 60

FATWKNISGS IEIVKQGCWL DDINCYDKND CIEKKENLDV FFCCCEGNMC NERFFYNPEM 120

GSIPPPNPVP PKPSLFNTLL YSLVPIMGIA MIVLFLFWMY RHHKLAYPPV LVPTQDPGLP 180

PPSPMLGLKP LQLLEIKARG RFGCVWKAQL LHEYVAVKIF PIQDRQSWQN EYEVYSLPGM 240

KHENILQFIG AEKRGTNIDV ELWLITTFHE KGSLTDYLKA NIVTWNDLCH IAETMARGLA 300

YLHEDILGLK DGHKPAVAHR DIKSKNVLLK SNLTACIADF GLALKFEAGK SAGDTHGQVG 360

TRRYMAPEVL EGAINFQRDA FLRIDMYAIG LVLWELASRC TAADGPVDEY MLPFEEEVGQ 420

HPSLEDMQEV VVHKKVRPVL KECWQKHPGM AMLCETIEEC WDHDAEARLS AGCVEERIIQ 480

MQRLTNIITT EDIVTVVTMV TNVDFPPKES SL 512

Nucleotide Sequence
(FASTA)

ATGGGAGCTG CTACAAAGTT GTCCTTTGCA GTTTTTCTCA TTTCTTGTTC TTCAGGGGCT 60

ATCCTTGGTC GATCAGAAAC ACAAGAGTGC ATCTTCTACA ATGCAAACTG GGAAAAAGAT 120

AAAACAAATC ACAGTGGCAT TGAACCCTGT TATGGTGATA AAGATAAAAG ACAGCATTGT 180

TTTGCTACGT GGAAGAATAT TTCAGGTTCA ATTGAAATTG TGAAACAAGG CTGCTGGTTG 240

GATGATATCA ACTGCTATGA CAAGAATGAT TGCATAGAGA AAAAGGAGAA TCTTGATGTG 300

TTTTTCTGCT GTTGTGAAGG CAACATGTGC AATGAAAGGT TCTTCTATAA TCCAGAGATG 360

GGATCCATAC CACCTCCTAA TCCAGTTCCA CCTAAACCAT CTTTGTTCAA TACATTGCTT 420

TATTCATTGG TGCCCATTAT GGGGATTGCT ATGATTGTGC TCTTTTTATT CTGGATGTAC 480

AGACATCACA AGCTTGCATA TCCTCCAGTG CTTGTGCCAA CCCAGGACCC TGGCCTGCCC 540

CCACCGTCTC CCATGCTGGG TCTGAAACCA CTGCAGCTAC TGGAAATTAA GGCCAGAGGG 600

CGTTTTGGTT GTGTATGGAA AGCACAACTA CTACATGAAT ATGTAGCTGT CAAAATCTTT 660

CCAATCCAGG ACAGACAATC ATGGCAGAAT GAATATGAAG TCTACAGTTT ACCTGGAATG 720

AAACATGAGA ATATCTTGCA ATTCATTGGT GCTGAAAAGA GAGGCACAAA TATTGATGTG 780

GAGTTATGGT TAATAACAAC CTTTCATGAA AAGGGTTCAC TGACTGATTA CCTGAAGGCT 840

AACATTGTAA CCTGGAATGA CTTATGTCAT ATTGCTGAAA CCATGGCAAG AGGCCTGGCT 900

TACCTTCATG AAGATATACT AGGTCTAAAA GATGGACATA AACCTGCCGT AGCCCACAGA 960

GACATCAAAA GCAAAAATGT ACTGTTGAAA AGCAACCTTA CAGCTTGTAT AGCTGACTTT 1020

GGGCTTGCAT TGAAATTCGA AGCTGGAAAG TCTGCTGGTG ACACCCATGG TCAGGTTGGT 1080

ACTCGACGTT ACATGGCCCC AGAGGTGCTT GAGGGTGCTA TCAATTTCCA GAGAGATGCA 1140

TTCTTAAGGA TAGACATGTA TGCAATTGGA TTAGTATTGT GGGAGCTGGC ATCACGATGC 1200

ACTGCCGCAG ATGGGCCAGT TGACGAATAC ATGTTGCCAT TTGAAGAGGA GGTTGGCCAG 1260

CATCCATCCC TTGAAGACAT GCAGGAGGTT GTGGTACATA AAAAAGTGAG ACCTGTTTTG 1320

AAAGAATGCT GGCAGAAACA TCCGGGAATG GCAATGTTAT GTGAAACTAT AGAAGAATGC 1380

TGGGATCATG ATGCAGAGGC CAGATTATCT GCTGGCTGTG TAGAAGAACG AATTATTCAA 1440

ATGCAAAGAC TGACAAACAT CATAACTACA GAAGACATTG TTACAGTAGT CACTATGGTG 1500

ACAAATGTGG ACTTTCCCCC AAAAGAGTCC AGTCTATGA 1539

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw++E e+y+++ ++henilqfi+

Q: 191   LQLLEIKARGRFGCVWKAQLLHEYVAVKIFPIQDRQSWQNEYEVYSLPGMKHENILQFIG  250

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ ++  +el+l+t++hekgsL+dyLk++++++++l+++a+++a+Gla+LHe+i g k

Q: 251   AEKRGTNIDVELWLITTFHEKGSLTDYLKANIVTWNDLCHIAETMARGLAYLHEDILGLK  310

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +Kpa+aHRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d  ++ qvGt+RYmaPE

Q: 311   DGHKPAVAHRDIKSKNVLLKSNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPE  368

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ +af r+D+Y++gLvlWE+asRc+++d+ v+ey+lpfee+vg++Psle+m

Q: 369   VLEGAINFQR-DAFLRIDMYAIGLVLWELASRCTAADGPVDEYMLPFEEEVGQHPSLEDM  427

         *********9.9************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +evvv+kk+rP ++e w+k++ +++l++++eecWd+d+eaRl+a +v++r+

Q: 428   QEVVVHKKVRPVLKECWQKHPGMAMLCETIEECWDHDAEARLSAGCVEERI  478

         ************************************************985

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL LHEYVAVKIF PIQDRQSWQN EYEVYSLPGM KHENILQFIG 60

AEKRGTNIDV ELWLITTFHE KGSLTDYLKA NIVTWNDLCH IAETMARGLA YLHEDILGLK 120

DGHKPAVAHR DIKSKNVLLK SNLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDA FLRIDMYAIG LVLWELASRC TAADGPVDEY MLPFEEEVGQ HPSLEDMQEV 240

VVHKKVRPVL KECWQKHPGM AMLCETIEEC WDHDAEARLS AGCVEERI 288

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013