EKS-LAC-00119

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00119

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MLCK	373.8	4.6E-112	180	420	241

Status

Unreviewed

Ensembl Protein

ENSLACP00000002878

UniProt Accession

H2ZZQ7;

Protein Name

Protein Synonyms/Alias

Gene Name

MYLK4

Gene Synonyms/Alias

MYLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000002572	ENSLACP00000002878	ENSLACT00000002901

Organism

Latimeria chalumnae

Functional Description

Protein Length

460

Protein Sequence
(FASTA)

MKEYSPDVVE QATPCLLEDS NKKAVDNESR PPDIQNELNQ NLQQKYKEIE KETSALRVAT 60

TEPEPEPAGD LSQNIDHSIS SKRRVTEEDL VKDDNKKSRR DSSIEGYGPP EEPNQSSCVT 120

EGTLEPSSNI DEENNNQVVP TIEDLEIEID DSPPPPAPFD HRIVSAKPAQ INNYFSIDRT 180

DILGGGRFGQ VHKCMEKSTG LTLAAKIIKV RGAKEKEEVK NEIQVMNQLN HVNLIQLYAA 240

FESKNDIALV MEYVEGGELF DRIIDENYNL TEMDTVLFIK QICEGVQYMH QMYILHLDLK 300

PENILCISRS ERKIKIIDFG LARSRYKPRE KLKVNFGTPE FLAPEVVNYD FVSFPTDMWS 360

MGVIAYMLLS GLSPFLGEDD SETLNNILAC KWDFEDPEFQ NVSEDAKEFI SKLLIKEKTM 420

AFKFCSSLGY FSCWMEEGKP YWSKDKIYSI QSLIMKTVHD 460

Nucleotide Sequence
(FASTA)

ATGAAAGAGT ATAGCCCTGA TGTGGTGGAA CAAGCAACAC CTTGCCTCTT GGAAGATTCC 60

AATAAAAAGG CTGTTGATAA TGAATCCAGA CCTCCAGATA TCCAGAATGA GTTGAACCAA 120

AATTTACAGC AAAAGTACAA AGAAATCGAA AAGGAAACCA GTGCCCTGAG AGTGGCAACA 180

ACGGAGCCGG AGCCAGAACC AGCAGGAGAT CTGTCACAGA ATATTGACCA CAGCATTAGC 240

AGTAAACGAA GAGTAACTGA AGAAGACTTG GTGAAAGACG ACAACAAAAA GAGTAGGAGA 300

GACTCCAGCA TTGAAGGCTA TGGGCCCCCT GAGGAGCCAA ACCAATCCAG CTGTGTGACA 360

GAAGGGACAT TGGAGCCATC CAGCAACATT GATGAAGAGA ATAATAATCA GGTTGTCCCA 420

ACTATAGAAG ATCTGGAGAT TGAAATTGAT GACAGCCCAC CTCCCCCAGC CCCCTTTGAC 480

CATCGGATTG TTTCTGCAAA ACCAGCACAA ATAAACAACT ATTTTAGTAT CGATAGAACG 540

GACATTCTGG GAGGTGGTCG ATTTGGTCAA GTCCATAAAT GTATGGAAAA ATCAACAGGT 600

CTCACTTTGG CAGCCAAAAT TATTAAAGTC AGAGGTGCCA AGGAAAAGGA AGAGGTTAAG 660

AATGAGATCC AGGTCATGAA TCAATTGAAC CATGTCAATC TTATCCAGTT GTATGCTGCC 720

TTTGAATCCA AAAATGACAT TGCACTCGTC ATGGAATATG TGGAAGGAGG AGAGCTGTTC 780

GATAGGATCA TTGACGAAAA CTACAATTTA ACTGAAATGG ACACAGTACT GTTTATTAAG 840

CAGATTTGTG AAGGGGTTCA GTACATGCAC CAGATGTACA TTCTTCATTT AGACTTGAAG 900

CCTGAGAATA TTTTGTGTAT CAGTCGATCT GAAAGGAAAA TAAAGATAAT TGATTTTGGA 960

CTGGCAAGAA GCAGATATAA ACCAAGAGAA AAACTAAAGG TAAACTTTGG GACTCCAGAA 1020

TTTCTCGCTC CTGAAGTTGT GAATTACGAT TTTGTCTCAT TCCCTACTGA CATGTGGAGT 1080

ATGGGAGTCA TTGCCTATAT GCTGCTAAGT GGATTGTCCC CTTTTCTGGG AGAAGATGAC 1140

AGTGAGACCT TGAATAACAT CCTGGCTTGT AAGTGGGACT TTGAAGACCC TGAGTTTCAA 1200

AATGTCTCTG AAGATGCCAA GGAGTTTATC TCAAAGCTTT TAATCAAAGA AAAAACCATG 1260

GCTTTCAAAT TCTGCAGTTC CTTGGGATAT TTCTCCTGTT GGATGGAAGA AGGGAAGCCG 1320

TATTGGTCCA AAGATAAAAT CTACAGTATA CAGTCACTGA TTATGAAAAC AGTGCATGAC 1380

Domain Profile

S: 4     keelgkGkfgvvvkavekstgkklaakivkvrkekdkeevkkEieilnqlrHekliqlyd  63

         ++ lg G+fg+v+k++ekstg +laaki+kvr +k+keevk+Ei+++nql+H +liqly+

Q: 180   TDILGGGRFGQVHKCMEKSTGLTLAAKIIKVRGAKEKEEVKNEIQVMNQLNHVNLIQLYA  239

         6789********************************************************

S: 64    afeskeeivlvlElveggelferiveedyeltEeevvlfvrqvlealeylHkkgivHldl  123

         afesk++i lv+E+veggelf+ri++e+y+ltE+++vlf++q++e+++y+H+++i+Hldl

Q: 240   AFESKNDIALVMEYVEGGELFDRIIDENYNLTEMDTVLFIKQICEGVQYMHQMYILHLDL  299

         ************************************************************

S: 124   kpenillqskkskqiKlidFGlar.klkkkeklkvlfgtpefvaPEvvnkepvslatDmW  182

         kpenil+ s++ ++iK+idFGlar ++k++eklkv+fgtpef+aPEvvn+++vs+ tDmW

Q: 300   KPENILCISRSERKIKIIDFGLARsRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMW  359

         ***********************978**********************************

S: 183   svGvityvLlsGlsPFlgdndeetlenvssakydfdeeafkevseeakdFiskllvkekk  242

         s+Gvi+y+LlsGlsPFlg++d+etl+n+ ++k+df++ +f++vse+ak+Fiskll+kek+

Q: 360   SMGVIAYMLLSGLSPFLGEDDSETLNNILACKWDFEDPEFQNVSEDAKEFISKLLIKEKT  419

         *********************************************************997

S: 243   k  243

Q: 420   M  420

Domain Sequence
(FASTA)

TDILGGGRFG QVHKCMEKST GLTLAAKIIK VRGAKEKEEV KNEIQVMNQL NHVNLIQLYA 60

AFESKNDIAL VMEYVEGGEL FDRIIDENYN LTEMDTVLFI KQICEGVQYM HQMYILHLDL 120

KPENILCISR SERKIKIIDF GLARSRYKPR EKLKVNFGTP EFLAPEVVNY DFVSFPTDMW 180

SMGVIAYMLL SGLSPFLGED DSETLNNILA CKWDFEDPEF QNVSEDAKEF ISKLLIKEKT 240

M 241

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013