EKS-LAC-00325

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00325

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	345.9	1.7E-103	29	280	252

Status

Unreviewed

Ensembl Protein

ENSLACP00000002903

UniProt Accession

H2ZZT1;

Protein Name

Protein Synonyms/Alias

Gene Name

STK4

Gene Synonyms/Alias

STK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000002595	ENSLACP00000002902	ENSLACT00000002925
ENSLACG00000002595	ENSLACP00000002903	ENSLACT00000002926

Organism

Latimeria chalumnae

Functional Description

Protein Length

487

Protein Sequence
(FASTA)

LERIVAFNIC RQLKKLSEDS LTKQPEEVFD VLEKLGEGSY GSVYKAIYKE NGQVVAIKQV 60

PVESDLQEII KEISIMQQCD SPHVVKYYGS YFKNRDLWIV MEYCGAGSVS DIIRLRNKTL 120

TEEEIATIVK STLKGLEYLH FMRKIHRDIK AGNILLNTEG QAKLADFGVA GQLTDTMAKR 180

NTVIGTPFWM APEVIQEIGY NCVADIWSLG ITAIEMAEGK PPYADIHPMR AIFMIPTNLP 240

PTFRKPELWS DKFIDFVKQC LIKNPEQRGT ATQLLQHPFV KTAKPESILR AMINEAMDIK 300

EKRQEAQQRE IDHEEEENSD EDDTNSGTMV RAHGENSGTI RTTSTSYGDT ADTLDDTMAS 360

QLGTMVINKE EEEEEEEGTM KRRDETMQPA KPSFLKYFEQ KEKENQMNSY GSQKGLGQSH 420

NASEWKVPQD GDYEFLKNWS VDDLQQRLAS LDPMMEREIE EIRQRYDSKR QPILDAIEAK 480

KRRQQNF 487

Nucleotide Sequence
(FASTA)

CTGGAGAGGA TTGTAGCTTT CAACATCTGC AGGCAATTAA AGAAGCTCAG TGAAGACAGT 60

CTGACTAAAC AACCTGAAGA GGTTTTTGAT GTATTAGAGA AACTTGGAGA AGGATCCTAT 120

GGTAGTGTAT ATAAAGCTAT TTATAAAGAA AATGGTCAAG TTGTGGCAAT TAAACAGGTT 180

CCTGTGGAGT CAGACCTGCA GGAGATTATT AAAGAAATAT CTATTATGCA ACAATGTGAC 240

AGTCCTCATG TGGTGAAGTA CTATGGCAGC TATTTTAAGA ACAGAGATCT GTGGATAGTG 300

ATGGAATATT GTGGTGCAGG CTCTGTGTCC GATATTATTC GCTTAAGGAA TAAAACATTA 360

ACAGAAGAAG AAATAGCAAC AATAGTAAAG TCTACCTTGA AAGGACTAGA ATATCTGCAC 420

TTCATGAGAA AAATCCACAG AGATATCAAA GCTGGAAATA TATTATTAAA CACAGAGGGA 480

CAAGCTAAAC TGGCAGATTT TGGCGTAGCA GGTCAGCTTA CGGATACAAT GGCTAAAAGG 540

AACACTGTAA TTGGAACACC ATTTTGGATG GCTCCAGAAG TAATACAGGA GATTGGTTAT 600

AACTGTGTAG CAGACATCTG GTCACTAGGA ATAACCGCAA TAGAGATGGC AGAAGGAAAG 660

CCTCCTTATG CTGATATTCA TCCAATGAGG GCAATTTTCA TGATCCCTAC GAATTTACCG 720

CCAACATTTC GAAAACCTGA ATTGTGGTCC GATAAATTTA TAGATTTTGT AAAGCAGTGT 780

TTAATAAAGA ACCCTGAACA AAGAGGCACT GCCACTCAAC TACTGCAGCA CCCTTTTGTG 840

AAGACTGCAA AACCAGAGTC AATTTTACGA GCTATGATCA ATGAGGCAAT GGATATTAAA 900

GAAAAACGAC AAGAGGCACA GCAGCGTGAA ATAGATCATG AGGAGGAAGA GAACTCGGAT 960

GAAGATGATA CGAACTCTGG TACAATGGTG CGAGCCCATG GAGAGAACTC GGGTACAATA 1020

CGAACAACCA GTACGAGTTA TGGGGATACA GCAGATACTT TAGACGATAC AATGGCATCC 1080

CAGCTAGGGA CCATGGTAAT AAACAAAGAG GAGGAGGAGG AGGAAGAGGA GGGAACCATG 1140

AAAAGAAGAG ATGAGACCAT GCAGCCAGCA AAACCATCGT TCCTCAAGTA CTTTGAGCAA 1200

AAGGAGAAAG AAAACCAAAT GAATAGTTAT GGCAGCCAAA AAGGATTGGG TCAGTCGCAT 1260

AATGCATCAG AATGGAAAGT CCCTCAGGAC GGAGACTACG AATTTTTAAA GAATTGGAGT 1320

GTGGATGATT TGCAGCAGAG ACTGGCTTCA CTGGACCCCA TGATGGAACG GGAAATTGAG 1380

GAGATCCGGC AGCGGTACGA TTCTAAACGA CAACCAATCC TCGATGCAAT TGAGGCCAAG 1440

AAACGCAGAC AACAGAACTT CTAA 1464

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +++le++g+G++g+vy+a  k++g++vaik++ +e+  +l+e++keis+++++++p++v+

Q: 29    FDVLEKLGEGSYGSVYKAIYKENGQVVAIKQVPVES--DLQEIIKEISIMQQCDSPHVVK  86

         7899*******************************7..9*********************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y++s++k+++lw+vmey+ +Gs+sd+++  ++++l+Ee+ia+i++++lk+LeylH +++i

Q: 87    YYGSYFKNRDLWIVMEYCGAGSVSDIIR-LRNKTLTEEEIATIVKSTLKGLEYLHFMRKI  145

         ****************************.99*****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180

         Hrdika+niLl++eg+ kL+dfgva ql++t++kr+tv+gtp+wmAPEvi+  e gY++

Q: 146   HRDIKAGNILLNTEGQAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ--EIGYNCV  203

         ***************************************************..9******

S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240

         aDiwslGItaie+aeg+pP++d++p++a+++i++n pp++++++ +s++f +fv++cl k

Q: 204   ADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNLPPTFRKPELWSDKFIDFVKQCLIK  263

         ************************************************************

S: 241   npekRpsasellkhkFl  257

         npe+R +a++ll+h+F+

Q: 264   NPEQRGTATQLLQHPFV  280

         ****************7

Domain Sequence
(FASTA)

FDVLEKLGEG SYGSVYKAIY KENGQVVAIK QVPVESDLQE IIKEISIMQQ CDSPHVVKYY 60

GSYFKNRDLW IVMEYCGAGS VSDIIRLRNK TLTEEEIATI VKSTLKGLEY LHFMRKIHRD 120

IKAGNILLNT EGQAKLADFG VAGQLTDTMA KRNTVIGTPF WMAPEVIQEI GYNCVADIWS 180

LGITAIEMAE GKPPYADIHP MRAIFMIPTN LPPTFRKPEL WSDKFIDFVK QCLIKNPEQR 240

GTATQLLQHP FV 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR011524	; SARAH.
IPR024205	; SARAH_domain.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF11629	; Mst1_SARAH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50951	; SARAH; 1.

Prints

Created Date

20-Feb-2013