EKS-LAC-00180

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00180

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	476.2	3.2E-143	247	505	259

Status

Unreviewed

Ensembl Protein

ENSLACP00000003162

UniProt Accession

H3A0J1;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCB

Gene Synonyms/Alias

PRKCB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000002827	ENSLACP00000003162	ENSLACT00000003192
ENSLACG00000002827	ENSLACP00000003163	ENSLACT00000003193

Organism

Latimeria chalumnae

Functional Description

Protein Length

578

Protein Sequence
(FASTA)

DPRSRHMFKI HSYSSPTFCD HCGSLLYGLI HQGMKCDTCM MNVHKRCVMN VPSLCGTDHT 60

ERRGRIYIKA HINNETLVVV VKEARNLVPM DPNGLSDPYV KLKLIPDPKG ESKQKTKTIK 120

CSLNPDWNET FKFSLLKESD KDRRLSVEIW DWDLTSRNDF MGALSFGISE LQKAGVDGWF 180

KLLSQEEGEY FNVPVPPEGE EGNEELRKKF ERAKIGPGSK ATEDKVKNSS SKFGNNGNRD 240

RIKLSDFNFL MVLGKGSFGK VLLVERKGTD ELYAVKILKK DVVIQDDDVE CTMVEKRVLA 300

LSGKPPFLTH LHSCFQTMER LYFVMEYISG GDLMYQIQQA GKFKEPHAVF YAAEIAIGLF 360

YLHSKGIVYR DLKLDNVMLD SEGHIKIADF GMCKENMWDG VTTKTFCGTP DYIAPEIIAY 420

QPYGKSVDWW AFGVLLYEML AGQPPFDGED EDELFQSIME HNVAYPKSMS KEAVAICKGL 480

MTKHPGKRLG CGPEGERDIK EHAFFRYIDW EKLEQKEIQP PFKPKTCGRK AENFDRFFTR 540

HPPVLTPPDQ EVIMNIDQSE FEGFSFVNHE FIKPEVKS 578

Nucleotide Sequence
(FASTA)

GACCCAAGAA GCAGACACAT GTTTAAAATT CACTCCTATT CCAGTCCTAC TTTTTGTGAC 60

CACTGTGGAT CCCTACTCTA CGGCCTCATC CACCAGGGAA TGAAATGTGA CACTTGTATG 120

ATGAATGTTC ATAAGCGCTG TGTGATGAAT GTTCCTAGCC TGTGTGGAAC TGACCATACT 180

GAACGTAGAG GACGTATATA CATCAAAGCA CACATAAACA ATGAAACCCT CGTTGTTGTA 240

GTAAAAGAGG CCAGGAACCT TGTTCCCATG GACCCGAATG GATTGTCAGA TCCCTATGTT 300

AAACTGAAGC TAATTCCAGA TCCAAAAGGT GAAAGTAAGC AGAAGACCAA AACTATTAAA 360

TGTTCTCTAA ATCCGGATTG GAATGAAACT TTCAAATTCA GCCTCCTGAA AGAGTCCGAT 420

AAAGACAGGA GATTGTCTGT TGAGATCTGG GACTGGGACC TGACCAGCAG GAATGACTTC 480

ATGGGAGCAC TGTCGTTTGG AATCTCAGAA CTACAGAAAG CTGGAGTTGA TGGCTGGTTC 540

AAACTGCTAA GTCAGGAGGA AGGAGAGTAC TTCAATGTCC CTGTTCCTCC TGAAGGAGAA 600

GAAGGAAATG AAGAATTAAG GAAAAAATTT GAAAGAGCCA AAATTGGACC AGGGTCAAAG 660

GCAACAGAAG ACAAGGTGAA GAATTCATCG TCTAAATTTG GCAACAATGG AAACCGAGAT 720

CGGATTAAAC TATCTGACTT TAACTTCCTC ATGGTGCTTG GGAAAGGAAG CTTTGGAAAG 780

GTCCTGTTGG TTGAACGAAA AGGAACTGAT GAATTATATG CTGTGAAAAT TCTGAAGAAG 840

GATGTAGTTA TACAAGATGA TGATGTGGAA TGTACTATGG TTGAAAAGAG GGTGTTAGCT 900

CTTTCGGGAA AACCTCCATT CCTAACTCAT CTCCACTCCT GCTTCCAAAC AATGGAGCGT 960

TTGTATTTTG TGATGGAATA CATCAGTGGT GGAGACCTTA TGTACCAGAT CCAGCAAGCT 1020

GGCAAATTCA AAGAGCCTCA TGCTGTGTTC TATGCTGCAG AAATTGCTAT TGGCCTGTTC 1080

TACCTGCACA GTAAAGGCAT CGTTTATCGA GATCTAAAAC TTGATAATGT AATGCTGGAC 1140

TCAGAAGGGC ACATAAAAAT TGCTGACTTT GGTATGTGTA AAGAGAATAT GTGGGATGGA 1200

GTAACAACCA AGACTTTCTG CGGGACACCT GATTACATTG CACCAGAGAT AATTGCATAC 1260

CAGCCTTATG GAAAGTCTGT GGATTGGTGG GCATTTGGTG TCCTGCTGTA TGAAATGCTA 1320

GCTGGACAGC CTCCTTTTGA TGGAGAAGAT GAAGATGAGC TCTTCCAGTC AATTATGGAG 1380

CATAACGTTG CTTATCCCAA ATCAATGTCA AAGGAAGCAG TAGCCATCTG TAAAGGGCTA 1440

ATGACCAAGC ATCCTGGTAA GCGTCTGGGA TGTGGACCAG AAGGTGAGCG GGATATTAAG 1500

GAACATGCTT TCTTTAGATA CATTGATTGG GAGAAACTGG AGCAGAAAGA GATTCAGCCT 1560

CCATTTAAGC CAAAAACTTG TGGCCGGAAA GCTGAAAACT TCGATCGATT TTTCACCCGT 1620

CATCCACCAG TGTTAACACC ACCTGACCAA GAGGTCATCA TGAACATTGA CCAATCAGAA 1680

TTCGAGGGAT TTTCCTTTGT TAACCATGAG TTCATTAAAC CTGAAGTCAA GAGCTAA 1737

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f++l+vlGkGsfgkvll+e+k+tdelya+k+lkkdvv+qdddve+t+vekrvlal+ k+p

Q: 247   FNFLMVLGKGSFGKVLLVERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALSGKPP  306

         99**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl++l+scfqt++rl+fv+ey++GGdlm++iq+a+k+ke++a+fyaaei+++l++lh+kg

Q: 307   FLTHLHSCFQTMERLYFVMEYISGGDLMYQIQQAGKFKEPHAVFYAAEIAIGLFYLHSKG  366

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         i+yrdlkldnv+ld+eGhik+adfG+cke++++g tt+tfcGtPdyiaPei+++++ygks

Q: 367   IVYRDLKLDNVMLDSEGHIKIADFGMCKENMWDGVTTKTFCGTPDYIAPEIIAYQPYGKS  426

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdwwa+Gvllyemlagq+Pf+gededelf+si+e++v+yPks+skeav+i+kgl+tk+p

Q: 427   VDWWAFGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG  486

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlG+ +ege+dikehaff

Q: 487   KRLGCGPEGERDIKEHAFF  505

         ******************9

Domain Sequence
(FASTA)

FNFLMVLGKG SFGKVLLVER KGTDELYAVK ILKKDVVIQD DDVECTMVEK RVLALSGKPP 60

FLTHLHSCFQ TMERLYFVME YISGGDLMYQ IQQAGKFKEP HAVFYAAEIA IGLFYLHSKG 120

IVYRDLKLDN VMLDSEGHIK IADFGMCKEN MWDGVTTKTF CGTPDYIAPE IIAYQPYGKS 180

VDWWAFGVLL YEMLAGQPPF DGEDEDELFQ SIMEHNVAYP KSMSKEAVAI CKGLMTKHPG 240

KRLGCGPEGE RDIKEHAFF 259

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004697	; F:protein kinase C activity
GO:0008270	; F:zinc ion binding
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020477	; C2_dom.
IPR018029	; C2_membr_targeting.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014375	; Protein_kinase_C_a/b/g.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF00168	; C2; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50004	; C2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00360	; C2DOMAIN.
PR00008	; DAGPEDOMAIN.

Created Date

20-Feb-2013