EKS-LAC-00062

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00062

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	389.6	9.1E-117	142	423	282

Status

Unreviewed

Ensembl Protein

ENSLACP00000022784

UniProt Accession

H3A0N3;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK18

Gene Synonyms/Alias

CDK18;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000002862	ENSLACP00000003204	ENSLACT00000003234
ENSLACG00000002862	ENSLACP00000022784	ENSLACT00000026645

Organism

Latimeria chalumnae

Functional Description

Protein Length

472

Protein Sequence
(FASTA)

MNKMKNFKRR FSLSVPRTET IEESLAEFTE QINQINNKKN EGIVHENLQL SNLNHDFRAE 60

QASVSPSDDS QSPAPIRYKN SRQRRFSMED ISKRFSLPMD IRLPQEFLQK LQLESPELPK 120

PLSRMSRRAS LSDIGFGKLE TYIKLDKLGE GTYATVFKGR SKLTENLVAL KEIRLEHEEG 180

APCTAIREVS LLKNLKHANI VTLHDIIHTE RSLTLVFEYL DSDLKQYLDN CGNLMSMHNV 240

KIFMFQLLRG LAYCHKRKIL HRDLKPQNLL INERGELKLA DFGLARAKSV PTKTYSNEVV 300

TLWYRPPDVL LGSTEYSTQI DMWGVGCILY EMVTGRPMFP GSTIKEELHL IFRLLGTPTE 360

ETWPGITSNE EFNAYHFPQY KPQALISHVP RLDSEGLDLL ANLLLYEARS RISAEIALQH 420

SYFKTFGESV HSLADNVSVF SLKEIQLKKD PGYRGSGYPH SSRGKNRRQS IF 472

Nucleotide Sequence
(FASTA)

ATGAACAAGA TGAAAAACTT TAAACGGCGT TTTTCGCTCT CAGTTCCCAG AACTGAAACA 60

ATTGAAGAAT CTCTTGCAGA ATTTACAGAG CAGATAAACC AAATTAATAA CAAGAAAAAC 120

GAAGGCATTG TTCATGAAAA CCTACAGCTA AGCAACCTGA ATCATGACTT CAGGGCAGAG 180

CAAGCCTCAG TCTCCCCTTC TGACGACAGC CAGTCTCCAG CACCAATTCG TTACAAAAAC 240

AGTAGACAAC GCAGGTTCTC TATGGAGGAC ATCAGTAAAC GCTTCTCTCT CCCAATGGAT 300

ATTCGTCTCC CACAGGAATT CCTCCAGAAA CTGCAGCTGG AAAGTCCTGA GTTACCTAAA 360

CCACTGAGCA GGATGTCTCG AAGAGCCTCA CTGTCTGACA TTGGCTTTGG AAAGCTAGAA 420

ACTTACATAA AACTGGACAA ACTTGGGGAG GGCACCTATG CAACAGTCTT TAAAGGAAGA 480

AGTAAACTCA CGGAGAATTT GGTGGCTCTA AAGGAGATCC GTCTGGAACA TGAAGAGGGG 540

GCGCCGTGCA CTGCCATAAG GGAAGTTTCT CTCTTGAAGA ACCTGAAGCA TGCCAACATT 600

GTTACCTTAC ATGACATCAT CCACACAGAG CGCTCCCTAA CGCTAGTCTT TGAATACCTG 660

GACAGTGACC TAAAACAGTA CCTGGACAAC TGCGGCAATC TAATGAGCAT GCACAATGTC 720

AAGATCTTCA TGTTTCAACT CCTACGTGGA TTGGCCTATT GCCACAAGAG GAAGATACTC 780

CACCGGGACC TGAAACCACA GAACCTCTTA ATCAACGAGC GAGGAGAGTT AAAATTAGCT 840

GATTTTGGTC TAGCAAGAGC AAAGTCTGTC CCTACAAAGA CCTATTCAAA TGAGGTGGTC 900

ACTCTGTGGT ACCGACCTCC TGATGTGTTA CTGGGATCTA CGGAGTACTC TACCCAGATT 960

GATATGTGGG GAGTGGGCTG TATTCTGTAT GAAATGGTCA CAGGAAGGCC AATGTTTCCT 1020

GGGTCCACCA TAAAAGAAGA GCTTCACTTA ATATTCAGAC TTCTAGGTAC TCCCACTGAA 1080

GAAACATGGC CTGGAATTAC ATCAAATGAA GAATTTAATG CATATCATTT TCCTCAGTAC 1140

AAGCCCCAAG CACTAATAAG CCACGTACCA AGGTTGGACT CAGAAGGCCT TGATCTCCTT 1200

GCAAACCTTT TACTGTATGA AGCAAGGAGC CGGATCTCCG CTGAAATAGC ACTGCAACAT 1260

TCTTATTTCA AAACGTTTGG GGAGAGCGTG CACAGCCTGG CTGACAATGT CTCTGTTTTC 1320

TCTCTGAAGG AGATCCAGCT CAAGAAGGAC CCTGGGTACC GAGGTTCTGG CTACCCACAC 1380

TCATCACGAG GAAAGAACAG AAGACAAAGT ATATTTTAG 1419

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y kl+k+geGty++v+k+++k t+++vAlK+irle+e eg p+ta+rE+sllk+lkh+ni

Q: 142   YIKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANI  200

         7799********************************9.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L+++++ ++++l+Lvfe+l++dLk++l+++ +  +s+++vk +++qll+glay+H++k

Q: 201   VTLHDIIH-TERSLTLVFEYLDSDLKQYLDNCGN-LMSMHNVKIFMFQLLRGLAYCHKRK  258

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLi+++g+lklaDfGlara s+p+kty++evvTlwYr+P++Llg++eYst

Q: 259   ILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYST  318

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksfp  239

         ++D+W+vgcil e++t +p+f+g++ +++l+ if+llgtp+e++wp++++ +e++ ++fp

Q: 319   QIDMWGVGCILYEMVTGRPMFPGSTIKEELHLIFRLLGTPTEETWPGITSNEEFNaYHFP  378

         *******************************************************99***

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         ++k++ l ++v++l++++ldll +ll ++ ++Risa+ alqh+yf

Q: 379   QYKPQALISHVPRLDSEGLDLLANLLLYEARSRISAEIALQHSYF  423

         ********************************************9

Domain Sequence
(FASTA)

YIKLDKLGEG TYATVFKGRS KLTENLVALK EIRLEHEEGA PCTAIREVSL LKNLKHANIV 60

TLHDIIHTER SLTLVFEYLD SDLKQYLDNC GNLMSMHNVK IFMFQLLRGL AYCHKRKILH 120

RDLKPQNLLI NERGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTQID 180

MWGVGCILYE MVTGRPMFPG STIKEELHLI FRLLGTPTEE TWPGITSNEE FNAYHFPQYK 240

PQALISHVPR LDSEGLDLLA NLLLYEARSR ISAEIALQHS YF 282

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013