EKS-LAC-00386

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00386

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	431.9	7.8E-130	184	431	248

Status

Unreviewed

Ensembl Protein

ENSLACP00000003363

UniProt Accession

H3A142;

Protein Name

Protein Synonyms/Alias

Gene Name

BLK

Gene Synonyms/Alias

BLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000003007	ENSLACP00000003363	ENSLACT00000003393

Organism

Latimeria chalumnae

Functional Description

Protein Length

447

Protein Sequence
(FASTA)

DGNIYVALYD YFPVNNKDLE LRKGEKVRVL ADKGDWWMAQ SLSSEARGYV PSNFVAKVNT 60

LEVEKWFCKN LSRKDAERLL QTPGNKAGAF LVRESETSKG AYSLSLRDND STHGDVVKHY 120

KIRSLDKGGY YISPKIAFVT IQELVQHYTE HSDGLCQKLV KPCQYQGPQT PWAKDEWEIP 180

RESLKLVKKL GAGQFGEVWM GFYKNSVKVA IKTLKEGNMA PEAFLAEANL MKNLQHDKLV 240

RLHAVVTDEP IYIVTEYMAK GSLLDFLKTD EGNRIQLPIL IDMSAQIAEG MAYIESKNYI 300

HRDLRAANIL VSDTLCCKVA DFGLARIIEN EYMAQEGAKF PIKWTAPEAI NFGVFTIKSD 360

VWSFGVLLTE IITYGRIPYP GMTNPEVIRN LDRGYRMPCP DTCPEELYEL MMKCWRNYPE 420

ERPTFEYLQC VLEDFYTATE GQYQQQP 447

Nucleotide Sequence
(FASTA)

GATGGAAATA TATATGTTGC ACTGTACGAT TATTTTCCAG TAAACAACAA GGACTTGGAG 60

CTTAGAAAAG GGGAGAAAGT GCGAGTCCTT GCAGATAAAG GGGATTGGTG GATGGCCCAG 120

TCTCTCAGCT CAGAAGCAAG GGGATACGTG CCTAGTAATT TCGTCGCAAA AGTGAACACA 180

CTGGAAGTAG AAAAGTGGTT CTGTAAGAAT TTGAGTCGGA AGGATGCTGA GCGACTGCTG 240

CAAACCCCGG GGAACAAGGC GGGGGCCTTC CTCGTCAGGG AGAGCGAGAC CAGCAAAGGT 300

GCCTACTCTC TGTCTTTGAG AGACAACGAC TCGACTCATG GCGATGTAGT TAAACACTAC 360

AAGATTCGGT CGCTAGACAA AGGGGGTTAT TACATTTCGC CAAAAATAGC CTTTGTCACA 420

ATACAGGAAT TAGTGCAGCA TTACACTGAG CATTCAGATG GTTTATGCCA GAAGCTGGTA 480

AAGCCATGCC AGTACCAAGG TCCCCAGACA CCGTGGGCGA AGGACGAGTG GGAGATACCA 540

CGCGAGTCCC TAAAACTGGT GAAAAAACTC GGAGCTGGCC AGTTCGGCGA GGTGTGGATG 600

GGCTTCTACA AGAACAGCGT GAAGGTGGCA ATCAAGACGT TGAAAGAAGG CAACATGGCT 660

CCCGAGGCCT TCCTGGCCGA GGCTAACCTG ATGAAGAACC TTCAGCACGA CAAACTGGTC 720

CGGCTTCATG CCGTTGTGAC CGACGAACCC ATCTACATTG TCACCGAGTA CATGGCCAAA 780

GGCAGTTTGC TGGACTTCCT CAAGACAGAC GAGGGGAACA GAATCCAACT CCCAATACTG 840

ATCGACATGT CAGCACAGAT TGCAGAGGGA ATGGCTTACA TTGAGTCCAA GAACTACATC 900

CACAGAGACC TGCGGGCTGC TAACATCCTG GTATCAGATA CTCTATGCTG CAAAGTCGCT 960

GACTTTGGCC TCGCGAGGAT CATTGAAAAT GAGTACATGG CTCAGGAGGG TGCTAAGTTC 1020

CCAATCAAAT GGACGGCCCC TGAGGCGATA AACTTTGGAG TTTTCACAAT CAAGTCTGAC 1080

GTCTGGTCTT TTGGAGTTCT CCTCACTGAA ATTATAACAT ATGGCAGAAT CCCTTATCCA 1140

GGTATGACTA ACCCTGAAGT CATCCGCAAT CTAGATCGGG GATATCGGAT GCCTTGCCCA 1200

GACACGTGCC CTGAGGAGCT CTACGAACTC ATGATGAAAT GCTGGAGGAA TTACCCCGAG 1260

GAGAGGCCAA CCTTTGAGTA CCTGCAGTGC GTCCTGGAGG ACTTCTACAC GGCAACCGAG 1320

GGGCAGTACC AACAGCAGCC CTAG 1344

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lklvkklG+GqfGevw+g +k+svkva+ktlkeg+++peafl+ea+++k+l+h+klv+l+

Q: 184   LKLVKKLGAGQFGEVWMGFYKNSVKVAIKTLKEGNMAPEAFLAEANLMKNLQHDKLVRLH  243

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv+  ePiyivte+makGslldflk++eg++++lp l+d++aq+aeGmay+e+kn+ihr

Q: 244   AVVTD-EPIYIVTEYMAKGSLLDFLKTDEGNRIQLPILIDMSAQIAEGMAYIESKNYIHR  302

         ***98.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+++l++kvadfGlar+i ++ey+a+egak+PikWtaPeai++g+ftiksdv

Q: 303   DLRAANILVSDTLCCKVADFGLARII-ENEYMAQEGAKFPIKWTAPEAINFGVFTIKSDV  361

         **************************.799******************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfG+lltei+t+G++PypGmtn ev+++++rgyr+p+p++cpeelyel+++cw++ pee

Q: 362   WSFGVLLTEIITYGRIPYPGMTNPEVIRNLDRGYRMPCPDTCPEELYELMMKCWRNYPEE  421

         ************************************************************

S: 241   rPtfetlqev  250

         rPtfe+lq v

Q: 422   RPTFEYLQCV  431

         *******976

Domain Sequence
(FASTA)

LKLVKKLGAG QFGEVWMGFY KNSVKVAIKT LKEGNMAPEA FLAEANLMKN LQHDKLVRLH 60

AVVTDEPIYI VTEYMAKGSL LDFLKTDEGN RIQLPILIDM SAQIAEGMAY IESKNYIHRD 120

LRAANILVSD TLCCKVADFG LARIIENEYM AQEGAKFPIK WTAPEAINFG VFTIKSDVWS 180

FGVLLTEIIT YGRIPYPGMT NPEVIRNLDR GYRMPCPDTC PEELYELMMK CWRNYPEERP 240

TFEYLQCV 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013