EKS-LAC-00394

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00394

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	304.5	7.1E-91	17	258	242

Status

Unreviewed

Ensembl Protein

ENSLACP00000003944

UniProt Accession

H3A2S2;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000003510	ENSLACP00000003943	ENSLACT00000003979
ENSLACG00000003510	ENSLACP00000003944	ENSLACT00000003980

Organism

Latimeria chalumnae

Functional Description

Protein Length

438

Protein Sequence
(FASTA)

MSSLGASFVQ IKFDDLQFFE SCGGGSFGSV YRAIWISQDK EVAVKKLLKI EKEAEILSVL 60

SHKNIIQFYG AVLESPNYCI VTEYASGGSL YDYLSSTKSE EMDMDLVMTW AMDIGKGLHY 120

LHMEAPVKVI HRDLKSRNVV ISPDRILKIC DFGASRFHSH TTHMSLVGTF PWMAPEVIQS 180

FPVSETCDTY SYGVVLWEML TREIPFKGLE GLQVAWLVVE KNERLTIPSS CPVSFAELMW 240

QCWETDAKKR PMFKQILLTL ESMSNDSKLP EQCNSFLHNK AEWRCEIEAT LDRLKKLERD 300

LSTKEQELKE RERRLKVWEQ KLIEQSCTPL FLPVAARVSE ECFFESKTEE SNSTEMSCQI 360

STTSNGEVDG MNQSLQAMMK GFGDIFSMNL AGPVMQSGMQ INMQAKQNSS KTTSVRKGKK 420

INMAMAFGHF SWSDDSDN 438

Nucleotide Sequence
(FASTA)

ATGTCGTCCC TTGGTGCATC TTTTGTACAA ATCAAATTTG ATGACCTGCA GTTTTTTGAA 60

AGCTGTGGCG GAGGAAGTTT TGGAAGTGTT TATCGAGCTA TATGGATATC ACAGGACAAG 120

GAGGTGGCTG TAAAAAAACT TTTAAAAATA GAGAAAGAGG CAGAGATTTT AAGTGTTCTT 180

AGTCATAAGA ACATTATACA GTTCTATGGA GCAGTTCTAG AATCTCCCAA TTACTGTATA 240

GTAACAGAAT ATGCCTCTGG AGGATCCTTG TATGACTATT TATCCAGTAC TAAAAGTGAA 300

GAAATGGACA TGGATCTTGT TATGACTTGG GCGATGGATA TAGGCAAAGG CTTGCACTAC 360

TTACATATGG AAGCTCCAGT AAAGGTAATC CACAGAGACC TCAAGTCTAG AAATGTTGTG 420

ATATCTCCTG ACAGAATATT AAAGATCTGT GACTTTGGTG CCTCAAGATT TCACTCCCAT 480

ACAACACACA TGTCTTTAGT AGGAACCTTT CCTTGGATGG CTCCAGAGGT TATACAGAGT 540

TTCCCAGTAT CTGAAACCTG TGACACTTAT TCATATGGTG TGGTTTTGTG GGAAATGCTA 600

ACAAGAGAGA TCCCTTTCAA AGGCTTGGAA GGACTACAGG TAGCTTGGCT TGTAGTGGAG 660

AAGAACGAGA GATTAACCAT TCCAAGTAGT TGCCCTGTAA GTTTTGCAGA ATTGATGTGG 720

CAGTGTTGGG AAACTGATGC AAAGAAAAGG CCAATGTTTA AGCAGATTCT GTTGACCCTG 780

GAATCAATGT CAAATGACAG CAAGCTTCCA GAGCAGTGTA ATTCCTTCCT GCATAACAAG 840

GCAGAGTGGA GATGTGAAAT TGAGGCCACT CTAGACAGAC TAAAGAAACT GGAGCGTGAC 900

CTGAGCACTA AAGAGCAGGA GCTGAAGGAA AGGGAGAGAC GGTTAAAGGT GTGGGAGCAG 960

AAACTGATAG AACAATCCTG CACTCCTCTT TTCTTACCTG TTGCTGCAAG AGTTTCTGAG 1020

GAGTGTTTCT TTGAATCTAA GACAGAGGAA TCAAACAGTA CAGAGATGTC TTGTCAAATC 1080

TCAACCACCA GTAACGGGGA GGTAGATGGC ATGAACCAGA GTCTGCAGGC TATGATGAAG 1140

GGCTTTGGGG ATATCTTCTC AATGAACCTA GCAGGACCTG TCATGCAGTC TGGAATGCAG 1200

ATAAACATGC AAGCCAAACA GAATTCTTCC AAAACCACCT CTGTCAGGAA AGGAAAGAAA 1260

ATCAACATGG CCATGGCTTT TGGTCACTTC AGTTGGTCAG ATGATAGTGA CAATTGA 1317

Domain Profile

S: 2     eleeligsgafgkvykakwrkke..vavKklreeaeekekleklereakllsklshpnii  59

         ++ e +g g+fg+vy+a w +++  vavKkl +          +e+ea++ls lsh+nii

Q: 17    QFFESCGGGSFGSVYRAIWISQDkeVAVKKLLK----------IEKEAEILSVLSHKNII  66

         67799**************665444****9987..........899**************

S: 60    ellGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseap  119

         +++G++le+pn+++v+ey++ggsL+++l++++++e+d++ +++wa++i +G++YLh eap

Q: 67    QFYGAVLESPNYCIVTEYASGGSLYDYLSSTKSEEMDMDLVMTWAMDIGKGLHYLHMEAP  126

         ************************************************************

S: 120   kkiihrdLksknvLlseekktlkicdFGtarelskstkmsaagtlawmaPEvlkeekvse  179

         +k+ihrdLks+nv++ + ++ lkicdFG +r++s++t+ms  gt+ wmaPEv+++ +vse

Q: 127   VKVIHRDLKSRNVVI-SPDRILKICDFGASRFHSHTTHMSLVGTFPWMAPEVIQSFPVSE  185

         ***************.********************************************

S: 180   ksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwne  239

         ++D +SygvvLWe+ltre+P+k+l+ l++a+ v++k++rl+ipsscp ++++Lm +cw++

Q: 186   TCDTYSYGVVLWEMLTREIPFKGLEGLQVAWLVVEKNERLTIPSSCPVSFAELMWQCWET  245

         ************************************************************

S: 240   dpekRpsfseivk  252

         d++kRp f++i+

Q: 246   DAKKRPMFKQILL  258

         **********985

Domain Sequence
(FASTA)

QFFESCGGGS FGSVYRAIWI SQDKEVAVKK LLKIEKEAEI LSVLSHKNII QFYGAVLESP 60

NYCIVTEYAS GGSLYDYLSS TKSEEMDMDL VMTWAMDIGK GLHYLHMEAP VKVIHRDLKS 120

RNVVISPDRI LKICDFGASR FHSHTTHMSL VGTFPWMAPE VIQSFPVSET CDTYSYGVVL 180

WEMLTREIPF KGLEGLQVAW LVVEKNERLT IPSSCPVSFA ELMWQCWETD AKKRPMFKQI 240

LL 242

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00454

; SAM; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013