EKS-LAC-00474

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00474

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	412.8	7.9E-124	42	334	293

Status

Unreviewed

Ensembl Protein

ENSLACP00000004198

UniProt Accession

H3A3H7;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK7

Gene Synonyms/Alias

MAPK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000003734	ENSLACP00000004198	ENSLACT00000004235

Organism

Latimeria chalumnae

Functional Description

Protein Length

927

Protein Sequence
(FASTA)

MAAPHKEEEQ GKREAAQAMA AKNLAFLKAR SLDVAFEVGD EYEIIETIGT GAYGVVSSAR 60

RRSTGQQVAI KKIPNAFDVV TNAKRTLREL KILKHFKHDN IIAIKDILKP SVPNSEFKSV 120

YVVLDLMESD LHQIIHSSQP LTLEHVRYFL YQLLRGLKYI HSANVIHRDL KPSNLLINEN 180

CELKIGDFGM ARGLCTKPDE YKYFMTEYVA TRWYRAPELM LSLHKYTQAI DMWSVGCIFA 240

EMLGRKQLFP GKNYIHQLQL IMTVLGTPSN EVIHSIGADR VRAYIQSLPS RQPVPWETLY 300

QGADKKALGL LAKMLRFDPK DRISVLDALK HPFLSKYHDP DDEPNCVPAF DFDFDKQVLT 360

KEQIKEAIIR EINDFHEKRE GIRRQISFKP FLRPAGAPHA DTELLDIQQL VSLASGRIPK 420

GERGLEPCCD VDMPSANSVS ERMDFALDSS SRFAQPETID LTSPMETVAK PPAQEEDTGR 480

KPEGPAVKTE PEVVPKKEGA ISDDTKAALK AAILKSALRN KNKDAVITSL ETPDVRKPVT 540

AQERQREREE KRKRRQERAK EREKKQKEKE RKEMKKDDTF GGLKLTENDK NLLERWKKMR 600

DETSQPPQNG PGTGETNGGQ VTVPPSHNIT QPVFSVQNNI TLLPIVGEQK TTTAIAAVSQ 660

ALVPNPSASA GVVHYYPAQP GAFPIGAPNS VLVAAPAHPD GALAKGDCLM TSSHINMAPD 720

MGVKYTPDTR SGCPMSRQLA SNYSQKGPGF SGREGLSLEP SVFLQDLGPA QPKPTLEPSQ 780

NLTSIYAMGH ASQSTGQKAP GMSQHPTVSI SSSDTSNSNS PDINLVTQQL SKSQVEDLLP 840

PVFSVTPKGS GAGYGVGFDL EEFLNQSFDM VGENRESQGD SAPLSASLLA DWLEVHRMNP 900

ADMESLQQEL QLGSPMILSD IPDLRAL 927

Nucleotide Sequence
(FASTA)

ATGGCGGCAC CGCACAAGGA AGAGGAGCAG GGGAAACGGG AAGCCGCACA GGCAATGGCG 60

GCCAAGAACC TGGCCTTCCT GAAGGCACGG TCCCTCGATG TAGCCTTTGA GGTGGGCGAC 120

GAATACGAGA TCATCGAGAC AATCGGCACT GGCGCCTATG GGGTGGTGTC GTCGGCCCGG 180

CGCAGGTCCA CAGGCCAACA AGTTGCTATA AAGAAGATTC CCAACGCCTT CGACGTGGTG 240

ACGAATGCCA AGCGAACCCT GCGGGAGCTG AAGATCCTTA AACACTTTAA ACACGACAAC 300

ATCATCGCCA TTAAAGATAT CTTGAAGCCC AGCGTCCCGA ACTCAGAGTT CAAATCTGTG 360

TATGTTGTGC TGGATCTTAT GGAAAGTGAC CTGCATCAGA TTATCCACTC CTCTCAGCCA 420

CTGACGCTGG AGCACGTCCG CTATTTCTTG TATCAGCTGC TGCGGGGCCT GAAGTATATC 480

CACTCAGCCA ACGTGATCCA CCGGGATCTC AAGCCCTCCA ACCTGCTGAT CAACGAGAAC 540

TGCGAGTTGA AGATTGGCGA CTTTGGCATG GCCAGGGGCC TGTGCACCAA GCCGGACGAG 600

TACAAGTACT TCATGACAGA GTATGTGGCG ACGCGCTGGT ATCGGGCGCC AGAGCTCATG 660

CTGTCGCTCC ACAAATACAC GCAGGCCATC GACATGTGGT CGGTGGGCTG CATCTTCGCT 720

GAGATGCTGG GCCGCAAGCA GCTCTTCCCG GGCAAGAACT ACATCCACCA GCTGCAGCTG 780

ATCATGACAG TATTGGGGAC GCCGTCCAAT GAGGTGATCC ACTCCATCGG GGCCGACCGG 840

GTTCGGGCGT ACATCCAGAG TTTACCCTCC CGCCAGCCGG TCCCCTGGGA GACCCTGTAC 900

CAGGGAGCTG ACAAGAAAGC GCTGGGACTG TTGGCCAAGA TGCTGCGCTT TGACCCCAAG 960

GACCGGATCT CAGTCCTGGA TGCCCTCAAG CACCCGTTTT TGTCCAAGTA CCACGATCCC 1020

GACGATGAGC CCAACTGCGT GCCGGCCTTC GACTTTGATT TTGACAAGCA GGTGTTGACC 1080

AAGGAGCAGA TCAAAGAGGC CATCATCAGG GAGATCAACG ACTTCCATGA GAAGAGGGAA 1140

GGGATCCGCC GTCAGATCAG CTTCAAGCCC TTCCTCCGAC CTGCTGGGGC ACCACATGCT 1200

GACACCGAGT TGTTGGACAT ACAGCAGCTA GTCTCCCTGG CCTCTGGGAG GATTCCAAAG 1260

GGTGAACGAG GCCTGGAGCC CTGCTGCGAT GTGGACATGC CCAGCGCCAA CTCGGTGAGC 1320

GAGCGGATGG ACTTTGCCCT GGACTCGTCC TCCCGGTTTG CCCAGCCTGA GACTATTGAT 1380

TTGACGTCGC CCATGGAGAC TGTGGCGAAG CCACCTGCCC AAGAAGAGGA CACCGGGAGG 1440

AAGCCAGAAG GGCCTGCTGT GAAGACTGAA CCAGAGGTGG TGCCGAAGAA GGAAGGGGCC 1500

ATCTCAGATG ACACAAAGGC TGCTCTCAAA GCCGCCATAT TAAAATCAGC CCTTCGTAAC 1560

AAGAATAAAG ACGCAGTTAT TACCAGCCTT GAAACACCAG ATGTCCGGAA GCCGGTGACG 1620

GCTCAGGAGC GCCAGCGAGA GCGGGAAGAG AAACGGAAGC GACGACAAGA GAGAGCGAAG 1680

GAGCGGGAGA AGAAGCAGAA GGAAAAAGAG CGCAAGGAGA TGAAGAAGGA TGACACCTTT 1740

GGCGGACTGA AGCTGACGGA GAACGACAAA AATCTGCTGG AGCGCTGGAA GAAAATGAGG 1800

GATGAAACCA GCCAGCCGCC ACAGAATGGC CCTGGGACAG GCGAGACGAA TGGCGGCCAG 1860

GTCACAGTGC CGCCCAGCCA CAACATAACG CAGCCAGTAT TCAGCGTCCA GAATAACATC 1920

ACGCTGTTGC CGATTGTGGG GGAGCAAAAG ACTACCACGG CAATCGCCGC GGTGTCGCAA 1980

GCACTCGTGC CAAACCCCAG TGCCTCTGCC GGTGTGGTGC ATTATTACCC GGCTCAGCCA 2040

GGGGCTTTTC CCATTGGGGC CCCCAATTCT GTGCTGGTGG CAGCACCAGC GCACCCGGAT 2100

GGTGCCCTTG CTAAAGGAGA CTGCTTGATG ACCTCTAGCC ACATCAACAT GGCGCCTGAC 2160

ATGGGGGTCA AGTACACCCC AGACACAAGG TCAGGTTGCC CCATGTCAAG ACAGCTGGCC 2220

AGCAACTATT CACAGAAAGG CCCAGGCTTC AGTGGACGGG AAGGCCTCAG TCTCGAGCCC 2280

TCAGTGTTTC TACAGGATTT AGGACCAGCT CAGCCAAAAC CGACACTAGA GCCATCTCAA 2340

AACCTGACCA GTATTTACGC AATGGGACAT GCATCCCAGT CAACGGGGCA GAAAGCCCCA 2400

GGAATGAGCC AGCATCCAAC AGTGTCCATC TCATCCTCGG ATACCTCTAA CTCAAATTCT 2460

CCCGACATCA ACCTTGTGAC CCAACAGCTT TCAAAATCCC AGGTGGAGGA CCTGCTGCCC 2520

CCTGTCTTCT CGGTCACCCC CAAGGGTAGC GGAGCCGGCT ATGGAGTGGG CTTCGACCTG 2580

GAGGAGTTCC TCAATCAGTC CTTCGATATG GTCGGAGAAA ACAGAGAAAG CCAAGGTGAC 2640

TCGGCCCCCC TGTCTGCGTC CCTGCTTGCT GATTGGCTGG AGGTGCACCG CATGAACCCG 2700

GCTGACATGG AGTCTCTGCA GCAGGAACTG CAGCTGGGCT CTCCCATGAT CCTCTCTGAT 2760

ATCCCCGACC TTCGGGCCCT C 2781

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         ye ++++g+Gaygvv sa +++t+++vaikk+ ++f+  t+akrtlRElk+lk++kh+Ni

Q: 42    YEIIETIGTGAYGVVSSARRRSTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNI  101

         77899*******************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylH  119

         i + d+++p+   +e+k+vY+v +lme+dL+++i+s+  l+ eh++++lyq+lrglky+H

Q: 102   IAIKDILKPSVPNSEFKSVYVVLDLMESDLHQIIHSSqPLTLEHVRYFLYQLLRGLKYIH  161

         ***********************************9889*********************

S: 120   sanviHrDlKPsNllvnedcelkildFGlarsadkekekk...lteyvatrwYraPeill  176

         sanviHrDlKPsNll+ne+celki dFG+ar   ++ ++    +teyvatrwYraPe++l

Q: 162   SANVIHRDLKPSNLLINENCELKIGDFGMARGLCTKPDEYkyfMTEYVATRWYRAPELML  221

         *******************************955554433478*****************

S: 177   slkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseea  236

         sl++yt+a+D+WsvGCI+aE+l +k+lfpgk++i+ql++i++vlgtps+e++++i  +++

Q: 222   SLHKYTQAIDMWSVGCIFAEMLGRKQLFPGKNYIHQLQLIMTVLGTPSNEVIHSIGADRV  281

         ************************************************************

S: 237   rnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         r+yi+slp+++  ++e+l++ a+++al Ll k+L +dp++Risv +aL+hp+l

Q: 282   RAYIQSLPSRQPVPWETLYQGADKKALGLLAKMLRFDPKDRISVLDALKHPFL  334

         ***************************************************97

Domain Sequence
(FASTA)

YEIIETIGTG AYGVVSSARR RSTGQQVAIK KIPNAFDVVT NAKRTLRELK ILKHFKHDNI 60

IAIKDILKPS VPNSEFKSVY VVLDLMESDL HQIIHSSQPL TLEHVRYFLY QLLRGLKYIH 120

SANVIHRDLK PSNLLINENC ELKIGDFGMA RGLCTKPDEY KYFMTEYVAT RWYRAPELML 180

SLHKYTQAID MWSVGCIFAE MLGRKQLFPG KNYIHQLQLI MTVLGTPSNE VIHSIGADRV 240

RAYIQSLPSR QPVPWETLYQ GADKKALGLL AKMLRFDPKD RISVLDALKH PFL 293

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013