EKS-LAC-00117

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00117

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MLCK	394.1	2.9E-118	492	745	254

Status

Unreviewed

Ensembl Protein

ENSLACP00000004235

UniProt Accession

H3A3L4;

Protein Name

Protein Synonyms/Alias

Gene Name

MYLK3

Gene Synonyms/Alias

MYLK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000003769	ENSLACP00000004235	ENSLACT00000004272

Organism

Latimeria chalumnae

Functional Description

Protein Length

797

Protein Sequence
(FASTA)

MDKKLNLLNE KVDKLVDFQG EVMKKLEVMH QDTGDWKKSI EKRTVAADGH KDRKDGHESC 60

SCGPKSEIKA LCIELLKLMK TVHQDSKQQS EKIDRMEKDV TTVEKAVTFM GETFKNSNIV 120

EFILKGIVPW KKGSVLDSFE RKDKSEDKFG KPKQGLSNRG VQAEKTKPDL KKREDNSIDE 180

RKDSICEKNL GKEVGKSESI KASNGRAGTI KGSDQAEVVD VPHQQLTDVS SQEVDSPDSH 240

DSCYRQPKAD TDSKKFFNVT VTRKAKDSTS RTRGLTRRMR CELCQRSDTE NWKPRQGGTH 300

TTLGPKFSIL SHMNCNYTQC VHCFIPNQRI YFVTPYNKAI SRRSSSTLQK VVPEEQGNLC 360

VTEEPKNAVD SKKQTKEKHG QKDDDSVGFQ KKLKNDLRRN SIMNTTETPK LKEPEKDSKL 420

NDLSKAEAKA IETENGKQDK ALGMQSTEEG NETSKKQDLV IIDDSPSPPA PFEHRIVRAK 480

LEAVTTLYEI NQQELLGGGR FGQVHKCVEM STSLTLAAKI IKVKGAKDRE VVKNEINIMN 540

QLNHVNLIQL YDAYESKNNL TLIMEYVDGG ELFDRIINEN YTLTELDAII FTKQICEGVN 600

YLHQQYILHL DLKPENILCV NHTGNQIKII DFGLARRYKP QEKLKVHFGT PEFLAPEVVN 660

YDHVSFSTDM WSMGIITYML LSGLSPFLGE TETETMNNIV QCNWCFDAEA FEHVSEEAKD 720

FISKLIVKEK CVRVNATQCL KHDWLNNLPE KAKKCKVRLK SQVLLQRYMA QRHWKKHFHV 780

VAAANRLRKL HCFSLGS 797

Nucleotide Sequence
(FASTA)

ATGGATAAAA AACTAAACCT TCTGAATGAA AAAGTTGATA AATTAGTGGA CTTCCAAGGG 60

GAAGTCATGA AGAAATTGGA AGTCATGCAC CAAGATACAG GAGACTGGAA GAAAAGCATT 120

GAGAAACGAA CAGTAGCTGC TGATGGCCAC AAAGACAGAA AAGATGGCCA TGAAAGTTGT 180

TCCTGTGGTC CTAAAAGTGA AATCAAAGCC TTATGCATAG AGCTTTTGAA GTTGATGAAA 240

ACTGTGCATC AGGATTCCAA ACAGCAAAGT GAAAAAATAG ACCGTATGGA AAAAGATGTT 300

ACAACGGTGG AAAAGGCTGT AACGTTTATG GGAGAAACCT TCAAGAATTC TAACATAGTG 360

GAATTTATTC TCAAAGGCAT TGTACCTTGG AAAAAAGGAA GTGTGCTCGA TTCTTTTGAG 420

CGAAAAGATA AATCTGAAGA TAAGTTTGGT AAACCAAAAC AAGGACTTAG CAACAGAGGA 480

GTTCAAGCAG AGAAAACAAA ACCTGACTTA AAAAAAAGAG AAGACAATAG TATTGATGAA 540

AGAAAAGATT CTATATGTGA GAAGAACTTG GGTAAAGAAG TTGGGAAAAG TGAAAGCATA 600

AAAGCAAGTA ATGGTAGAGC TGGAACAATT AAAGGTTCTG ATCAAGCTGA AGTAGTGGAT 660

GTACCACATC AACAACTGAC GGATGTTTCT AGCCAAGAAG TGGACTCCCC AGATTCCCAT 720

GATTCATGCT ATCGACAACC AAAGGCTGAC ACTGACAGCA AAAAGTTCTT CAATGTTACG 780

GTCACAAGAA AAGCCAAAGA CAGCACCTCT AGGACCAGAG GACTTACAAG AAGAATGAGG 840

TGTGAGTTAT GTCAAAGGTC AGACACTGAA AACTGGAAAC CCCGGCAGGG TGGCACACAC 900

ACAACGTTGG GACCCAAATT TTCAATCCTA TCACACATGA ATTGTAATTA TACACAGTGT 960

GTTCATTGTT TCATCCCTAA CCAGAGGATT TATTTTGTTA CCCCTTATAA CAAAGCAATA 1020

AGCCGTAGGA GTTCCAGCAC CCTGCAGAAA GTTGTACCTG AAGAACAGGG CAACTTGTGT 1080

GTGACTGAAG AGCCAAAAAA TGCAGTGGAC AGCAAAAAAC AAACCAAAGA AAAACATGGT 1140

CAAAAGGACG ACGACTCTGT TGGCTTCCAA AAGAAACTTA AAAACGATCT CAGGAGAAAC 1200

AGTATAATGA ATACAACAGA GACACCAAAG CTAAAAGAAC CAGAAAAAGA CTCAAAATTA 1260

AATGACTTGT CAAAAGCGGA AGCAAAGGCA ATAGAAACTG AGAATGGAAA ACAGGACAAA 1320

GCTTTAGGAA TGCAAAGCAC AGAAGAAGGT AATGAAACAT CAAAAAAACA AGATTTGGTT 1380

ATAATAGATG ACAGCCCATC TCCCCCAGCA CCATTTGAAC ATCGAATAGT GAGAGCCAAA 1440

CTAGAAGCTG TAACCACATT ATATGAAATA AACCAGCAGG AGCTGTTGGG AGGGGGGCGT 1500

TTTGGACAAG TTCACAAGTG TGTGGAGATG TCAACAAGTC TGACTTTGGC AGCCAAAATA 1560

ATAAAAGTGA AAGGTGCAAA GGACAGGGAA GTAGTGAAGA ACGAAATAAA TATCATGAAT 1620

CAACTAAACC ATGTGAATTT GATCCAGCTT TACGATGCAT ATGAATCCAA GAACAATCTC 1680

ACCCTGATTA TGGAATATGT TGATGGCGGA GAGCTGTTTG ATCGTATCAT CAATGAAAAT 1740

TACACTCTAA CAGAATTAGA TGCAATTATA TTCACAAAGC AGATATGTGA AGGAGTCAAC 1800

TACTTGCATC AACAATATAT TCTTCATTTG GATCTTAAGC CAGAAAATAT CTTGTGTGTA 1860

AACCACACGG GAAATCAAAT TAAAATTATT GACTTTGGAC TAGCCAGGAG GTACAAGCCT 1920

CAAGAGAAGC TGAAAGTTCA TTTTGGTACT CCAGAATTCT TGGCCCCAGA AGTAGTGAAT 1980

TATGACCACG TTTCATTCTC TACAGACATG TGGAGTATGG GAATTATCAC ATATATGCTG 2040

CTTAGTGGAT TATCTCCTTT TCTCGGAGAA ACTGAAACTG AAACAATGAA CAACATTGTC 2100

CAGTGCAACT GGTGCTTTGA TGCAGAAGCA TTTGAACATG TCTCTGAAGA GGCAAAAGAC 2160

TTCATCTCAA AACTCATTGT GAAAGAAAAA TGTGTCAGAG TGAATGCAAC CCAGTGCTTG 2220

AAACATGATT GGTTAAATAA CTTGCCCGAG AAGGCGAAGA AATGCAAAGT GCGGCTCAAA 2280

TCCCAGGTGC TGTTGCAGAG GTACATGGCT CAGCGGCACT GGAAAAAACA TTTTCATGTG 2340

GTTGCTGCTG CCAATCGGTT AAGAAAACTC CACTGCTTCA GTTTGGGGAG TTGA 2394

Domain Profile

S: 3     ikeelgkGkfgvvvkavekstgkklaakivkvrkekdkeevkkEieilnqlrHekliqly  62

         ++e lg G+fg+v+k+ve st  +laaki+kv+ +kd+e vk+Ei+i+nql+H +liqly

Q: 492   QQELLGGGRFGQVHKCVEMSTSLTLAAKIIKVKGAKDREVVKNEINIMNQLNHVNLIQLY  551

         6899********************************************************

S: 63    dafeskeeivlvlElveggelferiveedyeltEeevvlfvrqvlealeylHkkgivHld  122

         da+esk++++l++E+v+ggelf+ri++e+y+ltE + + f++q++e+++ylH+++i+Hld

Q: 552   DAYESKNNLTLIMEYVDGGELFDRIINENYTLTELDAIIFTKQICEGVNYLHQQYILHLD  611

         ************************************************************

S: 123   lkpenillqskkskqiKlidFGlarklkkkeklkvlfgtpefvaPEvvnkepvslatDmW  182

         lkpenil+++++++qiK+idFGlar++k++eklkv+fgtpef+aPEvvn++ vs++tDmW

Q: 612   LKPENILCVNHTGNQIKIIDFGLARRYKPQEKLKVHFGTPEFLAPEVVNYDHVSFSTDMW  671

         ************************************************************

S: 183   svGvityvLlsGlsPFlgdndeetlenvssakydfdeeafkevseeakdFiskllvkekk  242

         s+G+ity+LlsGlsPFlg++++et++n+ ++++ fd+eaf++vseeakdFiskl+vkek

Q: 672   SMGIITYMLLSGLSPFLGETETETMNNIVQCNWCFDAEAFEHVSEEAKDFISKLIVKEKC  731

         ************************************************************

S: 243   kRmsaeeaLkhkwl  256

          R++a+++Lkh wl

Q: 732   VRVNATQCLKHDWL  745

         *************8

Domain Sequence
(FASTA)

QQELLGGGRF GQVHKCVEMS TSLTLAAKII KVKGAKDREV VKNEINIMNQ LNHVNLIQLY 60

DAYESKNNLT LIMEYVDGGE LFDRIINENY TLTELDAIIF TKQICEGVNY LHQQYILHLD 120

LKPENILCVN HTGNQIKIID FGLARRYKPQ EKLKVHFGTP EFLAPEVVNY DHVSFSTDMW 180

SMGIITYMLL SGLSPFLGET ETETMNNIVQ CNWCFDAEAF EHVSEEAKDF ISKLIVKEKC 240

VRVNATQCLK HDWL 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013