EKS-LAC-00313

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00313

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	185.7	1.2E-54	649	761	113

Status

Unreviewed

Ensembl Protein

ENSLACP00000004336

UniProt Accession

H3A3W5;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB4

Gene Synonyms/Alias

ERBB4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000003856	ENSLACP00000004336	ENSLACT00000004374

Organism

Latimeria chalumnae

Functional Description

Protein Length

789

Protein Sequence
(FASTA)

MGNLEITSID RNRDLSFLRS VREVTGYVLV ALNQFKYLPL ENLRIIRGTK LYEDRYALAI 60

FLNYRKDGNF GLRELGLKNL TEILNGGVYV DQNKFLCFAD TIHWQDIVRN SRTSENLVIS 120

SNGSVGCGRC HSSCVGRCWG PTQSHCQSLT KTVCAEQCDG RCYGPYVSDC CHRECAGGCS 180

GPKDTDCFAC TNFNDSGACV TQCPQPFVYN PTTFQLEQNP KAKYTYGAFC VKKCPHNFVV 240

DHSSCVRACP SNKMELEENG IKMCKPCTDI CPKACDGIGT GSLQSAQTVD SSNIDKFVNC 300

TKINGNLVFL ITGIEGDVYH NIEALDPEKL NVFRTVREIT GFLNIQSWPK NMSDFNVFSN 360

LVTIGGRVLY SGISLLILKQ QGITSLQLQS LKEISAGNVY ITDNHNLCYY HTINWTALFR 420

TNTQKQVIRN NKIAKNCTAE KMVCDPLCSS DGCWGPGPDQ CLSCHFFRRG RTCINSCNLY 480

EGEFREFANG SVCVECDSQC EKMEDNILTC YGPGPEHCTK CFHFKDGPNC VEKCPDGLQG 540

ANSFIFKYAD DNQECHPCHS NCTQGCRGSL IQDCIGLMDR TPLIAAGVIG GLFIVVIVGL 600

TVAVYVRRKS IKKKRALRRF LETELVEPLT PSGTAPNQAQ LRILKETELK RVKVLGSGAF 660

GIVYKGIWVP EGETVKIPVA IKILNETTGP KANVEFMDEA LIMASMDHPH LVRLLGVCLS 720

PTIQLVTQLM PHGCLLDYVH EHKDNIGSQL LLNWCVQIAK VSFVLSSLSS LLCLNAVSRQ 780

CPQSKNLFY 789

Nucleotide Sequence
(FASTA)

ATGGGCAACC TGGAGATTAC CAGCATTGAC CGCAATCGGG ACCTCTCCTT CCTGCGGTCT 60

GTCAGAGAAG TTACTGGTTA TGTCCTCGTG GCTTTGAATC AGTTTAAATA TCTCCCACTG 120

GAAAACCTCC GCATTATCCG AGGGACCAAG CTGTATGAGG ACCGCTATGC ACTGGCGATC 180

TTTCTCAACT ACAGGAAGGA TGGCAACTTT GGGCTGAGGG AGCTGGGCCT TAAGAATCTC 240

ACAGAAATCT TGAATGGTGG CGTGTATGTG GACCAGAACA AGTTCCTCTG TTTTGCTGAC 300

ACGATTCACT GGCAGGACAT TGTGCGCAAC TCTCGCACTT CAGAGAACCT TGTCATTTCT 360

TCCAATGGCA GCGTGGGATG TGGAAGGTGT CACAGTTCCT GTGTTGGCCG ATGTTGGGGA 420

CCAACTCAGA GCCATTGTCA AAGCTTGACA AAGACAGTGT GTGCAGAACA GTGTGACGGT 480

CGATGTTACG GGCCTTATGT CAGTGACTGC TGTCATCGAG AGTGTGCAGG GGGCTGCTCT 540

GGACCCAAAG ACACTGACTG CTTTGCCTGT ACCAACTTCA ATGACAGTGG AGCCTGCGTC 600

ACCCAGTGTC CTCAGCCTTT CGTCTACAAC CCCACCACCT TCCAGCTGGA GCAGAACCCC 660

AAGGCCAAAT ACACCTATGG AGCTTTCTGT GTCAAGAAGT GCCCACATAA CTTTGTGGTT 720

GATCACAGCT CTTGTGTGCG TGCTTGCCCC AGCAACAAGA TGGAGCTTGA AGAAAATGGC 780

ATTAAAATGT GTAAACCTTG CACAGACATT TGTCCGAAAG CATGTGACGG GATTGGGACA 840

GGGAGCCTGC AGTCAGCTCA AACTGTGGAT TCCAGCAACA TTGACAAGTT TGTGAACTGC 900

ACAAAAATAA ATGGGAACCT TGTCTTTCTC ATTACTGGAA TAGAAGGGGA TGTTTACCAC 960

AACATTGAAG CGCTGGACCC AGAGAAACTC AATGTTTTTC GAACAGTCAG AGAGATAACA 1020

GGTTTTTTAA ACATACAATC CTGGCCCAAA AACATGAGTG ATTTCAATGT GTTTTCCAAC 1080

CTGGTTACAA TAGGGGGACG CGTCCTGTAC AGTGGTATAT CTCTGCTGAT TTTGAAGCAA 1140

CAGGGAATAA CGTCTTTACA ACTCCAGTCT CTGAAGGAGA TAAGTGCAGG CAATGTGTAC 1200

ATAACAGACA ACCACAACCT GTGCTACTAC CACACAATCA ACTGGACAGC CCTCTTCCGA 1260

ACTAACACCC AGAAGCAAGT GATACGCAAC AACAAGATTG CTAAAAACTG CACTGCAGAA 1320

AAGATGGTAT GTGACCCCCT GTGTTCAAGT GATGGCTGTT GGGGACCAGG CCCAGATCAG 1380

TGTCTGTCCT GTCATTTTTT CAGAAGAGGA AGGACCTGTA TTAACTCCTG CAACCTGTAT 1440

GAGGGGGAGT TTAGGGAGTT TGCAAATGGA TCGGTCTGTG TTGAATGTGA TTCCCAATGT 1500

GAAAAGATGG AGGATAATAT ATTAACATGC TATGGACCGG GTCCTGAACA CTGCACCAAG 1560

TGTTTTCACT TCAAAGACGG CCCAAACTGC GTGGAGAAGT GTCCTGACGG CCTCCAAGGA 1620

GCCAACAGCT TCATTTTCAA ATATGCTGAC GACAACCAAG AGTGTCACCC TTGCCACTCC 1680

AACTGCACTC AGGGGTGCAG AGGCTCGCTG ATCCAGGACT GCATTGGCCT GATGGATAGG 1740

ACACCGTTGA TTGCTGCTGG AGTCATAGGT GGTCTCTTCA TTGTGGTCAT TGTGGGCCTC 1800

ACAGTTGCAG TTTATGTTCG AAGGAAGAGC ATCAAGAAGA AACGAGCTTT ACGGAGGTTT 1860

CTGGAAACAG AGTTAGTGGA GCCTCTTACC CCAAGTGGCA CTGCGCCCAA CCAAGCACAG 1920

CTCCGCATTC TGAAGGAGAC TGAATTAAAA CGAGTTAAAG TCCTTGGTTC TGGAGCCTTT 1980

GGAATTGTCT ACAAGGGTAT CTGGGTTCCT GAAGGAGAAA CTGTGAAGAT TCCTGTGGCC 2040

ATCAAGATCC TAAATGAGAC AACAGGACCC AAGGCAAATG TGGAATTTAT GGATGAGGCC 2100

TTGATAATGG CCAGTATGGA CCACCCACAC CTGGTACGTC TGCTGGGCGT TTGTTTGAGT 2160

CCCACCATTC AGCTGGTTAC TCAGCTGATG CCCCATGGCT GTCTGCTAGA CTACGTGCAT 2220

GAACACAAGG ATAATATCGG CTCCCAGCTT TTGCTTAACT GGTGTGTTCA GATAGCCAAG 2280

GTAAGCTTTG TACTTTCATC ACTGTCCAGC CTCCTCTGTC TCAATGCTGT TAGTAGGCAG 2340

TGTCCTCAAA GCAAGAATCT GTTTTACTGA 2370

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         lk++kvlGsGafG vykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as+dh

Q: 649   LKRVKVLGSGAFGIVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDH  708

         699*********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakG  113

         ++lvrllg+cls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiak

Q: 709   PHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKV  761

         ***************************************************96

Domain Sequence
(FASTA)

LKRVKVLGSG AFGIVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD EALIMASMDH 60

PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKV 113

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261

; FU; 5.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013