EKS-LAC-00277

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00277

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	468.1	1.7E-140	211	524	314

Status

Unreviewed

Ensembl Protein

ENSLACP00000004361

UniProt Accession

H3A3Z0;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK2

Gene Synonyms/Alias

DYRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000003878	ENSLACP00000004361	ENSLACT00000004399

Organism

Latimeria chalumnae

Functional Description

Protein Length

590

Protein Sequence
(FASTA)

MLTRKPSATV YPAGRGGEGG SQVQSSPGVG AGDRRTAVTD PPSPVGLPPL RNSNTHTVGG 60

NKHTMNDHMH VGSHGQIHVQ QLFEDNSNKR TVLAAQPNGL TTVGKTGLPA VQDRQLDSSH 120

RRQGSSTSLK SADGIMKVKA TQMTPEQAMK QYMHKLTAFE HHEIFNYPEI YFVGPNAKKR 180

PGVVGGSNNG GYDDDQGSYI HVPHDHVAYR YEVLKIIGKG SFGQVVKAYD HKTHQHIALK 240

MVRNEKRFHR QAAEEIRILE HLRKQDKDNN MNVIHMLENF TFRNHICMTF ELLSMNLYEL 300

IKKNKFQGFS LPLVRKFAHS ILQCLDALHK NRIIHCDLKP ENILLKQQGR SGIKVIDFGS 360

SCYEHQRVYT YIQSRFYRAP EVILGGRYGM PIDMWSLGCI LAELLTGYPL LPGEDEGDQL 420

ACMIELLGMP SQKLIDSSKR AKNFVSSKGY PRYCTVTTLP DGSVVLNGGR SRRGKVRGSP 480

GSKEWVTALK GCDDPLFLGF LKQCLEWDPA LRMTPSQALR HPWLRRRLPK PPTGEKTSVK 540

RIAESTGAIT SISKLPPTSG SASKLRTNLA QMTDANGNIQ QRTVLPKLVS 590

Nucleotide Sequence
(FASTA)

ATGTTAACCA GGAAACCCAG TGCAACTGTC TATCCAGCTG GCAGAGGGGG TGAAGGTGGT 60

TCCCAGGTGC AGTCTTCCCC GGGGGTTGGA GCAGGGGATC GGCGGACTGC AGTGACCGAC 120

CCTCCGTCAC CTGTAGGTCT GCCACCACTC AGGAACAGCA ATACCCACAC GGTTGGAGGC 180

AATAAACATA CAATGAACGA CCATATGCAC GTTGGTAGCC ATGGGCAAAT CCATGTCCAG 240

CAGCTGTTTG AGGACAATAG CAACAAACGG ACTGTACTGG CGGCGCAGCC AAATGGGCTC 300

ACTACAGTCG GCAAGACGGG CTTGCCGGCG GTTCAGGACA GACAGCTGGA CAGTTCCCAT 360

CGACGGCAGG GAAGCTCCAC CTCTCTGAAA TCTGCCGACG GAATCATGAA AGTCAAAGCC 420

ACTCAGATGA CTCCAGAGCA GGCAATGAAG CAATACATGC ATAAGCTAAC CGCGTTTGAG 480

CACCATGAGA TTTTCAACTA TCCCGAAATC TATTTTGTGG GTCCAAATGC AAAGAAACGA 540

CCTGGTGTAG TTGGCGGGTC AAACAATGGG GGCTACGATG ATGATCAGGG CTCTTATATT 600

CATGTGCCCC ATGACCACGT TGCCTATCGG TATGAGGTTT TGAAAATCAT TGGAAAAGGG 660

AGTTTTGGTC AAGTGGTAAA GGCCTATGAC CACAAAACGC ATCAACACAT AGCACTAAAA 720

ATGGTCCGGA ACGAAAAGCG TTTCCATAGG CAGGCAGCGG AAGAAATCCG GATTCTGGAG 780

CACCTGAGGA AGCAGGACAA AGACAACAAC ATGAATGTCA TTCACATGCT GGAGAACTTC 840

ACATTCCGGA ATCATATCTG CATGACGTTT GAGCTGCTGA GCATGAATCT CTACGAGCTC 900

ATTAAAAAAA ACAAATTTCA GGGTTTCAGC CTTCCGCTGG TGCGCAAGTT TGCCCACTCG 960

ATTTTGCAGT GCTTGGACGC TTTGCACAAA AACAGAATTA TTCACTGTGA CCTTAAGCCG 1020

GAGAACATTC TACTAAAGCA GCAGGGCAGG AGCGGGATCA AAGTGATCGA TTTTGGGTCT 1080

AGTTGCTATG AGCATCAGCG AGTCTACACC TACATCCAGT CACGGTTTTA TCGTGCACCT 1140

GAGGTCATCC TTGGAGGCAG GTATGGGATG CCTATTGACA TGTGGAGTTT AGGCTGCATT 1200

TTGGCTGAGC TGTTAACGGG TTACCCTCTC TTACCTGGAG AAGATGAAGG GGACCAGCTG 1260

GCTTGTATGA TTGAACTGCT GGGCATGCCA TCCCAGAAAC TGATCGACTC GTCAAAACGA 1320

GCAAAAAATT TCGTCAGCTC CAAGGGGTAC CCTCGCTACT GCACTGTCAC CACCTTGCCC 1380

GACGGGTCGG TTGTGCTGAA TGGAGGCCGG TCGCGGCGGG GGAAGGTGCG AGGCTCGCCG 1440

GGGAGCAAGG AGTGGGTGAC GGCGTTGAAA GGCTGCGACG ATCCTCTCTT CCTGGGCTTC 1500

TTGAAGCAGT GCTTGGAGTG GGATCCTGCC CTGCGCATGA CGCCCAGCCA GGCCTTGCGG 1560

CATCCCTGGC TGCGGAGACG CTTGCCGAAG CCCCCAACGG GCGAGAAGAC CTCTGTGAAA 1620

AGAATAGCGG AGAGCACTGG TGCTATTACA TCCATTTCCA AATTACCTCC AACTTCGGGC 1680

TCTGCTTCAA AGCTAAGGAC TAATTTGGCA CAGATGACTG ATGCTAATGG AAACATCCAG 1740

CAGAGAACAG TATTGCCAAA ATTGGTTAGC TGA 1773

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl++igkGsfgqVvka+d+kt++++a+k+++n+krf+rqa+eE++iLe+l+k+dk+++

Q: 211   YEVLKIIGKGSFGQVVKAYDHKTHQHIALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNN  270

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le f+frnh+c++fells+nLyel+kknkf+g+sl lvrk+a++il++L++L++

Q: 271   MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHK  330

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         ++iiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg +y

Q: 331   NRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR-VYTYIQSRFYRAPEVILGGRYG  389

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iDmWSlGc+laEl+tG+pL+pGe+e dqla+++e+lg+p++kl++++k+ak+f+++k+

Q: 390   MPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLIDSSKRAKNFVSSKG  449

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+y+++t+  d +++l+ ++++++k r +p+ske+++alk ++d lf  +lk++le+dp

Q: 450   YPRYCTVTTLPDGSVVLNGGRSRRGKVRGSPGSKEWVTALKGCDDPLFLGFLKQCLEWDP  509

         ************************************************************

S: 301   akRitpkealkhpfv  315

         a R+tp++al+hp++

Q: 510   ALRMTPSQALRHPWL  524

         **************6

Domain Sequence
(FASTA)

YEVLKIIGKG SFGQVVKAYD HKTHQHIALK MVRNEKRFHR QAAEEIRILE HLRKQDKDNN 60

MNVIHMLENF TFRNHICMTF ELLSMNLYEL IKKNKFQGFS LPLVRKFAHS ILQCLDALHK 120

NRIIHCDLKP ENILLKQQGR SGIKVIDFGS SCYEHQRVYT YIQSRFYRAP EVILGGRYGM 180

PIDMWSLGCI LAELLTGYPL LPGEDEGDQL ACMIELLGMP SQKLIDSSKR AKNFVSSKGY 240

PRYCTVTTLP DGSVVLNGGR SRRGKVRGSP GSKEWVTALK GCDDPLFLGF LKQCLEWDPA 300

LRMTPSQALR HPWL 314

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013