EKS-LAC-00419

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00419

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	540.2	2.7E-162	556	890	335

Status

Unreviewed

Ensembl Protein

ENSLACP00000004383

UniProt Accession

H3A412;

Protein Name

Protein Synonyms/Alias

Gene Name

KIT

Gene Synonyms/Alias

KIT;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000003897	ENSLACP00000004383	ENSLACT00000004421

Organism

Latimeria chalumnae

Functional Description

Protein Length

937

Protein Sequence
(FASTA)

VEKGGSIQLQ CKNESQVKWY WQRGTELASI DNRYIKSGKN GLDEVFIKPA DSSFTARYIC 60

KNERTLTNNS AYVFVKDPAN LFLDPEYRFI DVDEGQDITI ECRVTDPDIT NFTLKRCGSA 120

SLPQELKFIP DVETGITIKS LQLNFAGSYV CSAKKNGKVQ ESKIYTIKVM PVEKSPANVT 180

LSKSSQLLKE GEKFQVTCFI QCIRVHGIRY AVWTPKPIVT LTKAIQFLPC NQYRGYRKNL 240

TLTISSARVN NSGTFKCIVQ NVMGISNATV SLKVVGRGFI QFSVPENTTV SVNAGESFVL 300

SVNFQAYPKP DKSYWTYMNW NMQNTSDHFI RSKMLNNNWY INELHLIRLK EKEGGIYSFF 360

ASNSDANSSV TFHVHINSKP EILTSEGPNK GKVRCVAEGF PLPNISWYQC SGPEKRCIEM 420

SSASQKDMQP TYRLLTSPPF GKITVESTLN VSSLQNNITI QCFASNTVGH SNAIFRNRVA 480

EKPTIHELFT PLLIVFAVAL SVLCIIVVVL FYKCLQKPKY EVQWKVVEGI NGNNYVYIDP 540

SQLPYDYKWE FPREKLRLGK TLGAGAFGKV VEATAYGLSK ADTVITVAVK MLKPSALYTE 600

KEALMSELKV LSYLGQHMNI VNLLGACTVG GPTLVITEYC CFGDLLNFLR RKRDYFVCSD 660

PSEGLAELAL YINVLQQRSL ASDGNTGYME MNSGIPRVTP ICSNTDKRRS LSFIDQVIHS 720

EMLEEDTIAV NTEDLLSFSY QVAKGMDFLA TKNCIHRDLA ARNILLTHGR IAKICDFGLA 780

RDIRNDSNYV VKGNARLPVK WMAPESIFEC VYTFESDVWS YGILLWEIFS LGSSPYPGMP 840

VDSKFYRMIK DGYRMLSPEF APAEVYDVMK GCWDSDPFQR PAFQEIVKVI ERLISESTMH 900

VSTPFSNRET FMTHSSRLNS IGSSNASTQP LLVHDDS 937

Nucleotide Sequence
(FASTA)

GTGGAAAAAG GGGGCTCCAT TCAGCTTCAG TGTAAAAATG AGTCCCAGGT GAAGTGGTAT 60

TGGCAGAGGG GTACAGAGCT TGCCAGTATT GATAACCGAT ACATTAAGTC TGGCAAGAAT 120

GGCTTGGATG AAGTGTTTAT CAAACCTGCA GATTCTTCAT TTACAGCCAG ATATATTTGC 180

AAAAATGAGA GAACCTTGAC TAACAACTCT GCTTATGTGT TTGTAAAAGA TCCAGCAAAT 240

CTTTTTCTTG ATCCTGAATA TCGATTTATT GATGTGGATG AAGGCCAAGA CATTACTATT 300

GAATGCCGTG TGACAGACCC AGATATTACC AATTTTACAT TGAAAAGGTG TGGTAGTGCA 360

TCGCTTCCTC AGGAACTGAA ATTCATTCCA GACGTAGAGA CAGGAATAAC TATAAAAAGC 420

CTGCAGTTGA ATTTTGCAGG ATCTTATGTG TGTTCAGCAA AGAAAAATGG AAAAGTACAA 480

GAGTCAAAGA TTTATACTAT AAAAGTAATG CCTGTTGAAA AATCACCTGC AAATGTTACA 540

CTATCTAAAA GTTCACAGCT TCTAAAAGAA GGAGAAAAAT TTCAGGTTAC ATGCTTCATA 600

CAATGTATCC GTGTCCATGG TATTCGTTAT GCAGTGTGGA CTCCTAAACC GATTGTCACT 660

TTAACAAAGG CCATCCAGTT CCTCCCATGC AACCAATATC GTGGCTATCG AAAGAATTTA 720

ACACTCACTA TCAGTTCTGC AAGGGTGAAC AATTCTGGCA CTTTTAAATG CATAGTGCAA 780

AATGTCATGG GGATATCAAA TGCCACAGTG TCCCTGAAAG TTGTTGGTAG AGGATTCATT 840

CAGTTTTCAG TTCCTGAGAA CACCACAGTC AGTGTGAATG CTGGAGAAAG CTTTGTTCTG 900

TCAGTCAATT TTCAGGCATA CCCAAAACCA GACAAAAGTT ACTGGACCTA TATGAATTGG 960

AATATGCAAA ATACATCGGA TCATTTTATC AGATCAAAGA TGTTGAACAA TAATTGGTAT 1020

ATCAACGAGC TTCACCTCAT CAGGTTAAAG GAAAAAGAAG GAGGCATTTA TTCATTTTTT 1080

GCATCCAATT CTGATGCTAA CTCCTCAGTA ACATTTCATG TGCATATAAA CTCTAAACCG 1140

GAAATACTTA CTTCTGAGGG GCCCAACAAG GGTAAGGTGC GCTGTGTGGC AGAAGGATTC 1200

CCCCTTCCAA ATATATCTTG GTATCAGTGT TCTGGCCCCG AAAAACGATG CATAGAGATG 1260

TCGTCTGCTT CACAAAAGGA CATGCAGCCT ACCTATCGGT TACTAACAAG TCCACCATTT 1320

GGAAAGATTA CGGTTGAGAG CACACTGAAT GTTAGCTCGT TGCAAAACAA TATTACAATA 1380

CAGTGCTTTG CTTCCAACAC AGTTGGCCAC AGTAATGCCA TTTTCAGGAA TAGAGTTGCA 1440

GAAAAACCCA CAATCCATGA ACTCTTCACA CCATTGCTTA TAGTATTTGC AGTAGCACTG 1500

AGTGTGCTGT GCATCATTGT AGTAGTCCTC TTCTATAAGT GTCTACAGAA ACCTAAGTAT 1560

GAGGTTCAGT GGAAAGTCGT TGAAGGAATA AATGGCAACA ACTATGTATA TATCGACCCT 1620

AGTCAACTGC CATATGACTA CAAATGGGAG TTTCCCAGAG AAAAGCTACG ACTTGGGAAA 1680

ACACTTGGTG CTGGAGCTTT TGGAAAAGTA GTTGAAGCTA CTGCCTATGG TTTATCAAAA 1740

GCTGACACTG TGATAACAGT GGCAGTTAAA ATGTTGAAAC CAAGCGCTCT TTATACAGAG 1800

AAAGAAGCCT TAATGTCAGA ACTCAAAGTG CTCAGTTACC TTGGCCAGCA CATGAACATT 1860

GTTAATCTTC TTGGAGCATG CACTGTGGGA GGTCCTACTC TGGTTATCAC CGAATACTGC 1920

TGTTTTGGTG ACCTTTTGAA TTTTTTGAGA AGAAAGAGAG ATTACTTTGT TTGTTCAGAC 1980

CCCAGTGAAG GTCTTGCAGA GTTGGCCCTT TACATTAATG TGCTCCAACA GCGCAGCCTC 2040

GCGTCGGATG GAAATACTGG TTACATGGAA ATGAATTCAG GAATTCCCAG AGTTACTCCC 2100

ATATGTTCCA ATACAGACAA AAGAAGATCC CTCAGTTTCA TTGACCAAGT TATTCATAGC 2160

GAAATGCTGG AGGAAGACAC AATAGCTGTG AACACTGAAG ATCTCTTAAG TTTTTCATAT 2220

CAAGTTGCAA AGGGCATGGA CTTCCTTGCC ACTAAAAATT GCATACACAG GGACCTGGCT 2280

GCAAGGAATA TTCTTTTGAC TCATGGTCGA ATAGCAAAAA TTTGTGATTT TGGCCTTGCT 2340

AGAGATATAA GGAATGACTC CAACTATGTG GTCAAAGGCA ATGCTCGTCT TCCTGTAAAG 2400

TGGATGGCAC CAGAGAGCAT ATTTGAGTGT GTGTACACAT TTGAAAGTGA TGTTTGGTCT 2460

TATGGCATAC TACTATGGGA AATCTTCTCT CTTGGTAGCA GTCCTTATCC TGGGATGCCA 2520

GTAGATTCCA AGTTCTACAG GATGATTAAA GATGGCTATA GGATGCTTAG CCCTGAATTT 2580

GCACCAGCTG AAGTGTATGA TGTAATGAAA GGTTGCTGGG ATTCTGATCC TTTTCAGAGA 2640

CCTGCATTTC AAGAAATCGT GAAGGTGATT GAGCGGCTGA TTTCAGAGAG CACAATGCAT 2700

GTAAGTACAC CATTCAGCAA TAGGGAGACA TTCATGACAC ATTCATCACG TTTGAACTCC 2760

ATTGGCAGCA GCAATGCTTC TACTCAGCCC CTCCTTGTGC ATGATGACTC A 2811

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         l+lGk+lG+GafGkvveatayGlsk+d+v++vavkmlk++a  +ekealmselk+ls+lG

Q: 556   LRLGKTLGAGAFGKVVEATAYGLSKADTVITVAVKMLKPSALYTEKEALMSELKVLSYLG  615

         789*********************************************************

S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120

         +h+nivnllGact+gGp++viteycc+Gdlln+lrrkr+ f+ +      +++e l   a

Q: 616   QHMNIVNLLGACTVGGPTLVITEYCCFGDLLNFLRRKRDYFVCS------DPSEGLAELA  669

         *****************************************933......3444444444

S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180

         l    ++ ++ sl+s+++  y++++ ++  v++  +++ + ++  s++++ +++++ eed

Q: 670   L--YINVLQQRSLASDGNTGYMEMNSGIPRVTPICSNTDK-RRSLSFIDQVIHSEMLEED  726

         4..2334566778899***************998777655.55689**************

S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240

         + +++ edllsfsyqvakGm+fla+knc+hrdlaarn+llt+G+++kicdfGlardi++d

Q: 727   TIAVNTEDLLSFSYQVAKGMDFLATKNCIHRDLAARNILLTHGRIAKICDFGLARDIRND  786

         ************************************************************

S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300

         snyvvkGnarlpvkwmapesif+++yt++sdvwsyGillweifslGs+pypg++vdskfy

Q: 787   SNYVVKGNARLPVKWMAPESIFECVYTFESDVWSYGILLWEIFSLGSSPYPGMPVDSKFY  846

         ************************************************************

S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344

         ++ik+Gyrm +p++a++e+y++m+ cw+++p +rp+f+++v+++

Q: 847   RMIKDGYRMLSPEFAPAEVYDVMKGCWDSDPFQRPAFQEIVKVI  890

         ****************************************9875

Domain Sequence
(FASTA)

LRLGKTLGAG AFGKVVEATA YGLSKADTVI TVAVKMLKPS ALYTEKEALM SELKVLSYLG 60

QHMNIVNLLG ACTVGGPTLV ITEYCCFGDL LNFLRRKRDY FVCSDPSEGL AELALYINVL 120

QQRSLASDGN TGYMEMNSGI PRVTPICSNT DKRRSLSFID QVIHSEMLEE DTIAVNTEDL 180

LSFSYQVAKG MDFLATKNCI HRDLAARNIL LTHGRIAKIC DFGLARDIRN DSNYVVKGNA 240

RLPVKWMAPE SIFECVYTFE SDVWSYGILL WEIFSLGSSP YPGMPVDSKF YRMIKDGYRM 300

LSPEFAPAEV YDVMKGCWDS DPFQRPAFQE IVKVI 335

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

Created Date

20-Feb-2013