EKS-LAC-00295

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00295

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	387.1	5.6E-116	244	537	294

Status

Unreviewed

Ensembl Protein

ENSLACP00000004469

UniProt Accession

H3A497;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2

Gene Synonyms/Alias

TGFBR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000003976	ENSLACP00000004468	ENSLACT00000004507
ENSLACG00000003976	ENSLACP00000004469	ENSLACT00000004508

Organism

Latimeria chalumnae

Functional Description

Protein Length

567

Protein Sequence
(FASTA)

IGRGESPKYN CMHVVHRTQQ KNPPPPIFPP NDNSWLGENG GMNLPNLCLF CDLEPTNCEA 60

QGSCKPTCNR TSICEDPQEV CIAIWRKKGT NVTIETVCHD PKKKLHGFDI EDFESNTCEM 120

KEKKVPDWQV YMCACLGEEC NGDLIFTKIH GTSPENLNLF IIKVTVISLL PPLVIAITVI 180

TTFYCYRIQR RRKLNKEWEK DKKPLKHPNM DCSDPCALMI DDDRSDISST CANNINHNTE 240

LLPIELDTLV GKGRFAEVYK AKLKHNTSEQ FETVAVKIFP YEEYASWKTE KETFSDINLK 300

HENILQFLTA EERKTELGKQ YWLITAFHSK GNLQEYLTRH IISWEDLWKL GGSLARGIAH 360

LHSDRTTCGR PKIPIVHRDL KSSNILVKND LTCCLCDFGL SLKLEPSLSM DDLANSGQVG 420

TARYMAPEVL ESRINLENTE AFKQTDIYSM ALVLWEIASR CNAIGEVKDY EPPFGSKVRE 480

HPCVESMKDN VLRDRGRPEI SSSWLNHQGM QVVCETIVEC WDHDPEARLT AHCVAERFSE 540

LEHLDKLSGR SCSEEKIPED CSESDGK 567

Nucleotide Sequence
(FASTA)

ATTGGGAGAG GGGAATCACC AAAATATAAC TGTATGCACG TAGTTCATAG GACACAGCAA 60

AAAAATCCCC CCCCCCCCAT TTTTCCACCT AATGACAACA GCTGGCTTGG TGAAAATGGG 120

GGCATGAATC TTCCAAACCT GTGTCTATTT TGTGACTTGG AGCCTACAAA CTGTGAAGCC 180

CAAGGGTCCT GCAAGCCTAC CTGCAATAGA ACTTCCATCT GTGAGGATCC CCAGGAAGTC 240

TGTATAGCTA TATGGAGAAA GAAAGGTACC AATGTAACCA TAGAAACTGT CTGCCATGAT 300

CCAAAGAAGA AATTGCATGG CTTCGATATA GAGGACTTTG AGTCTAACAC ATGTGAAATG 360

AAAGAAAAGA AAGTGCCCGA CTGGCAGGTT TATATGTGCG CCTGCTTGGG TGAAGAATGT 420

AATGGTGATC TCATCTTTAC AAAAATCCAT GGCACATCCC CAGAAAATTT AAATTTATTT 480

ATCATTAAGG TTACAGTAAT AAGTCTTCTC CCTCCTCTTG TAATCGCCAT TACTGTGATA 540

ACCACATTCT ACTGCTACCG CATCCAAAGA AGACGGAAGC TCAACAAGGA ATGGGAAAAA 600

GACAAAAAGC CACTGAAGCA TCCCAATATG GACTGCAGTG ACCCCTGTGC CCTTATGATA 660

GATGATGACC GTTCTGACAT CAGCTCCACA TGCGCAAACA ACATTAACCA CAACACAGAG 720

TTACTGCCCA TTGAGCTGGA TACCCTTGTG GGGAAGGGTC GTTTTGCTGA GGTTTACAAG 780

GCCAAGCTGA AGCACAACAC ATCAGAGCAG TTTGAAACTG TAGCAGTTAA GATCTTTCCT 840

TATGAGGAAT ATGCCTCTTG GAAGACTGAG AAAGAGACCT TCTCCGATAT CAACTTAAAG 900

CATGAGAATA TTCTTCAGTT CTTAACAGCA GAAGAGCGAA AAACTGAACT GGGAAAACAG 960

TACTGGCTGA TCACTGCCTT CCACTCCAAG GGAAACCTAC AAGAGTACCT CACACGGCAT 1020

ATTATCAGTT GGGAGGACCT CTGGAAGCTG GGTGGGTCAC TGGCTCGAGG TATTGCCCAT 1080

TTGCACAGCG ACCGCACCAC CTGTGGCCGA CCTAAAATAC CCATAGTGCA CAGAGACCTG 1140

AAGAGTTCAA ACATCCTTGT AAAAAATGAC CTAACATGCT GCCTTTGTGA CTTTGGACTG 1200

TCCCTGAAGC TGGAACCTTC CCTCTCTATG GATGATTTAG CTAACAGTGG ACAGGTTGGA 1260

ACAGCCAGGT ACATGGCTCC TGAAGTTTTA GAATCCAGGA TTAATTTAGA AAATACTGAG 1320

GCATTCAAAC AGACTGATAT TTATTCCATG GCTTTAGTCC TGTGGGAAAT TGCTTCACGC 1380

TGCAATGCCA TTGGAGAGGT AAAAGACTAT GAGCCTCCAT TTGGCTCCAA AGTGCGAGAA 1440

CACCCTTGTG TGGAAAGCAT GAAGGACAAT GTCCTGAGGG ACAGAGGGCG TCCTGAGATC 1500

TCCAGCAGCT GGCTGAATCA CCAGGGCATG CAGGTGGTTT GTGAAACCAT TGTTGAATGC 1560

TGGGACCATG ACCCTGAAGC TAGGCTCACT GCGCATTGTG TTGCTGAGCG ATTCAGCGAA 1620

TTGGAGCATC TGGATAAACT CTCTGGGCGA AGCTGTTCTG AAGAGAAAAT ACCGGAAGAT 1680

TGCTCAGAAA GTGATGGCAA GTAG 1704

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr++eV+kakl++      e+vAvKif++e+ aswk+Eke ++ ++l+hen

Q: 244   IELDTLVGKGRFAEVYKAKLKHntseqfETVAVKIFPYEEYASWKTEKETFSDINLKHEN  303

         678899**************999999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         ilqf++a+++++++ ++++l+t++h kg+L++yL+r+++++e+l +l  sla+G+ahLH+

Q: 304   ILQFLTAEERKTELGKQYWLITAFHSKGNLQEYLTRHIISWEDLWKLGGSLARGIAHLHS  363

         ************************************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + ++t+g+ K  i+HRDlks Nilvk+dltcc++D+GL+lkle + +  dla++ qvGt

Q: 364   D-RTTCGRPKIPIVHRDLKSSNILVKNDLTCCLCDFGLSLKLEPSLSMDDLANSGQVGTA  422

         *.67889*****************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle+++nl+++eafk++D+Ys++LvlWE+asRc++  +ev++y++pf ++v+++

Q: 423   RYMAPEVLESRINLENTEAFKQTDIYSMALVLWEIASRCNA-IGEVKDYEPPFGSKVREH  481

         *****************************************.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         P++e+mk+ v++++ rP+i+++w +++ ++++++++ ecWd+dpeaRlta++v++r

Q: 482   PCVESMKDNVLRDRGRPEISSSWLNHQGMQVVCETIVECWDHDPEARLTAHCVAER  537

         *****************************************************987

Domain Sequence
(FASTA)

IELDTLVGKG RFAEVYKAKL KHNTSEQFET VAVKIFPYEE YASWKTEKET FSDINLKHEN 60

ILQFLTAEER KTELGKQYWL ITAFHSKGNL QEYLTRHIIS WEDLWKLGGS LARGIAHLHS 120

DRTTCGRPKI PIVHRDLKSS NILVKNDLTC CLCDFGLSLK LEPSLSMDDL ANSGQVGTAR 180

YMAPEVLESR INLENTEAFK QTDIYSMALV LWEIASRCNA IGEVKDYEPP FGSKVREHPC 240

VESMKDNVLR DRGRPEISSS WLNHQGMQVV CETIVECWDH DPEARLTAHC VAER 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013