EKS-LAC-00273

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00273

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	417.1	3.1E-125	42	294	253

Status

Unreviewed

Ensembl Protein

ENSLACP00000004640

UniProt Accession

H3A4R9;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK1

Gene Synonyms/Alias

PLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000004130	ENSLACP00000004640	ENSLACT00000004679

Organism

Latimeria chalumnae

Functional Description

Protein Length

595

Protein Sequence
(FASTA)

MTTVAGKPLS KQSAPSVADP TKTVAVKEIP DILVDPRTKK KYVRGKFLGK GGFAKCYEIT 60

DMETKEVFAG KIVPKSMLMK PHQKEKMSME ISLHKSLSHP HVVGFHGFFE DNDFVFVVLE 120

LCRRRSLLEL HKRRKAVTEP EARYFLRQTI LGCQFLHGSR VIHRDLKLGN LFLNDDMEVK 180

IGDFGLATKV EYDGERKKTL CGTPNYIAPE VLGKKGHSFE VDIWSLGCIM YTLLVGKPPF 240

ETSCLKETYL RIKKNEYSVP KHINPVATAL IQKMLRADPT TRPTIDDLLN DDFFTSGYVP 300

NRLPTTCLTV PPRFSIAPNS IDASIRKPLT AINKENPVLS EKLGKVEDKE EMQYRELGEP 360

TGCYLSDMLE QLNSVNMARP SERPLIRQEE AEDPASIPIF WVSKWVDYSD KYGLGYQLCD 420

NSVGVLFNDS TRLIMYNDGD SLQYIERNYS ESYLNMRSFP TSLSKKITLL KYFRNYMSEH 480

LLKAGANITP REGDELARMP YLRTWFRTRS AIVIHLSNGT VQINFFQDHT KIILCPLMAA 540

VTYIDENRDF RVYKLSLIEE HGCCKELASR LRYARTMVEK LMGSKPGSAR MKTLA 595

Nucleotide Sequence
(FASTA)

ATGACTACAG TAGCAGGAAA ACCGTTGTCC AAACAGTCCG CACCAAGCGT TGCGGATCCA 60

ACAAAAACGG TTGCGGTTAA AGAAATCCCA GATATCCTGG TGGATCCCAG AACCAAGAAG 120

AAATACGTGC GGGGGAAGTT CTTGGGGAAA GGGGGCTTTG CGAAATGCTA CGAGATCACG 180

GACATGGAGA CCAAGGAAGT TTTCGCCGGG AAGATTGTGC CAAAGTCCAT GCTGATGAAG 240

CCGCACCAGA AGGAGAAGAT GTCGATGGAA ATCTCCCTCC ATAAGAGCCT TAGCCACCCT 300

CATGTAGTGG GATTTCATGG CTTTTTCGAA GATAATGATT TCGTGTTCGT TGTGCTGGAG 360

CTGTGTAGGA GAAGATCCCT GCTCGAGCTG CATAAGAGAA GAAAAGCTGT TACAGAGCCA 420

GAAGCTCGTT ATTTCCTGAG GCAGACAATC CTTGGCTGTC AGTTTTTACA TGGAAGCCGA 480

GTGATCCACA GAGACTTGAA GCTTGGAAAC TTGTTCCTCA ATGATGATAT GGAAGTCAAA 540

ATAGGTGATT TTGGTTTAGC AACAAAAGTA GAATATGATG GGGAGCGGAA GAAGACGCTG 600

TGTGGAACAC CAAATTACAT TGCACCGGAA GTGCTGGGCA AGAAAGGACA TAGCTTTGAA 660

GTTGACATTT GGTCTCTTGG CTGTATTATG TACACTTTAC TGGTAGGCAA GCCTCCATTT 720

GAAACTTCCT GTTTGAAGGA AACTTACCTG AGAATAAAGA AGAATGAGTA CTCTGTTCCC 780

AAGCACATCA ACCCTGTAGC AACTGCTCTC ATCCAGAAGA TGTTGAGAGC TGATCCAACC 840

ACACGGCCCA CTATTGATGA CCTATTGAAT GATGACTTTT TCACCTCAGG GTATGTCCCT 900

AACCGGCTGC CTACTACATG TCTGACTGTC CCTCCAAGAT TTTCTATTGC TCCTAATAGT 960

ATTGATGCCA GCATCAGAAA ACCTTTGACT GCAATTAATA AAGAAAATCC TGTGTTAAGT 1020

GAGAAATTGG GGAAGGTAGA AGATAAGGAA GAAATGCAAT ACAGAGAACT GGGAGAACCT 1080

ACCGGCTGCT ATCTGTCAGA CATGTTGGAG CAGCTTAACA GTGTTAATAT GGCCAGACCA 1140

TCTGAAAGAC CTTTAATAAG ACAAGAAGAA GCTGAAGATC CTGCCAGCAT TCCAATCTTC 1200

TGGGTCAGCA AATGGGTGGA TTATTCTGAC AAATATGGTT TGGGTTACCA GCTATGTGAT 1260

AACAGTGTTG GTGTGCTCTT TAATGACTCT ACTCGACTAA TTATGTACAA CGATGGGGAC 1320

AGCCTGCAGT ATATAGAGCG AAACTATAGT GAATCGTACC TTAATATGAG GTCATTTCCT 1380

ACTAGTTTGT CAAAAAAGAT CACCCTGTTG AAATATTTCC GTAACTACAT GAGTGAACAC 1440

TTGTTGAAGG CTGGTGCAAA TATTACCCCA CGAGAAGGAG ACGAACTGGC CCGAATGCCT 1500

TACCTCCGAA CTTGGTTCCG GACAAGAAGT GCAATCGTAA TTCACTTGAG CAATGGCACA 1560

GTGCAGATCA ACTTTTTTCA AGACCACACA AAAATCATTC TGTGTCCCTT GATGGCTGCT 1620

GTTACCTACA TTGATGAGAA TCGGGACTTC CGCGTGTATA AGCTGAGCCT CATTGAGGAA 1680

CATGGATGCT GTAAGGAACT AGCCAGCCGC CTGCGCTATG CCCGCACTAT GGTGGAGAAA 1740

CTTATGGGCT CCAAGCCTGG ATCTGCCCGA ATGAAGACTT TGGCATGA 1788

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y rgk+lGkGgfakcye++d+etkevfa k+vpks+l+k++q+ek+++ei++h+sl+h++

Q: 42    YVRGKFLGKGGFAKCYEITDMETKEVFAGKIVPKSMLMKPHQKEKMSMEISLHKSLSHPH  101

         89**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v ++ ffed+++v++vlelc+rrsl el+krrka+tepe+ry+lrq + g+++lh  r+

Q: 102   VVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKAVTEPEARYFLRQTILGCQFLHGSRV  161

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         +hrdlklgnlfln+++evkigdfGlat++e+++erkktlcGtPnyiaPevl kkghs+ev

Q: 162   IHRDLKLGNLFLNDDMEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLGKKGHSFEV  221

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         diWslGci+ytllvGkPPfet++lkety +ikk+eys+P+++++ a+ li+k+l+++P+

Q: 222   DIWSLGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSVPKHINPVATALIQKMLRADPTT  281

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp+++++l+d+f+

Q: 282   RPTIDDLLNDDFF  294

         ************8

Domain Sequence
(FASTA)

YVRGKFLGKG GFAKCYEITD METKEVFAGK IVPKSMLMKP HQKEKMSMEI SLHKSLSHPH 60

VVGFHGFFED NDFVFVVLEL CRRRSLLELH KRRKAVTEPE ARYFLRQTIL GCQFLHGSRV 120

IHRDLKLGNL FLNDDMEVKI GDFGLATKVE YDGERKKTLC GTPNYIAPEV LGKKGHSFEV 180

DIWSLGCIMY TLLVGKPPFE TSCLKETYLR IKKNEYSVPK HINPVATALI QKMLRADPTT 240

RPTIDDLLND DFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013