EKS-LAC-00148

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00148

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/Akt	501.4	6.2E-151	148	406	259

Status

Unreviewed

Ensembl Protein

ENSLACP00000005002

UniProt Accession

H3A5T1;

Protein Name

Protein Synonyms/Alias

Gene Name

AKT1

Gene Synonyms/Alias

AKT1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000004447	ENSLACP00000005003	ENSLACT00000005047
ENSLACG00000004447	ENSLACP00000005002	ENSLACT00000005046

Organism

Latimeria chalumnae

Functional Description

Protein Length

478

Protein Sequence
(FASTA)

MNEVAIVKEG WLHKRGEYIK TWRPRYFLLK TDGTFIGYKE RPQDVDQLES PLNNFSVAQC 60

QLMKTERPKP NTFIIRCLQW TTVIERTFHV DTPEEREEWT KAIQTVADRL KKQEEEMMDF 120

NSPSDNSDAG EMEVSLTRPK HRVTMHDFEY LKLLGKGTFG KVILVKEKAT GRYYAMKILK 180

KEVIVAKDEV AHTLTENRVL QNSKHPFLTG LKHSFQTHDR LCFVMEYANG GELFFHLSRE 240

RVFSEDRARF YGAEIVSALD YLHSEKNVVY RDLKLENLML DKDGHIKITD FGLCKEGIKD 300

GATMKTFCGT PEYLAPEVLE DNDYDRAVDW WGLGVVMYEM MCGRLPFYNQ DHEKLFELIL 360

MEEIRFPRTL SPEAKSLLSG LLKKDPKQRL GGGPDDAKEI MHHKFFAGIV WQDVYERKLV 420

PRFKPQVTSE TDTRYFDEEF TAQTITITPP DQDDNMEFVD NERRPHFPQF SYSASGTA 478

Nucleotide Sequence
(FASTA)

ATGAATGAAG TAGCAATAGT GAAGGAAGGA TGGCTTCATA AGCGAGGAGA ATATATAAAA 60

ACATGGAGAC CAAGGTATTT TCTGTTGAAG ACAGACGGAA CTTTTATTGG GTACAAGGAA 120

CGGCCACAGG ATGTTGACCA GCTTGAATCT CCTTTAAATA ATTTCTCTGT TGCACAGTGC 180

CAGCTGATGA AGACAGAACG ACCAAAACCA AACACATTCA TCATTCGTTG CCTGCAGTGG 240

ACCACAGTAA TTGAGAGAAC ATTTCACGTT GATACTCCAG AAGAACGAGA AGAATGGACC 300

AAAGCCATCC AAACCGTAGC AGACCGCCTG AAAAAACAAG AGGAAGAGAT GATGGACTTT 360

AATTCTCCTA GTGATAATTC AGATGCTGGA GAAATGGAAG TTTCCCTGAC CCGACCAAAA 420

CACAGAGTAA CTATGCATGA TTTTGAATAT CTTAAACTAC TTGGAAAAGG TACATTTGGA 480

AAAGTGATCT TAGTTAAAGA AAAGGCAACA GGACGCTATT ATGCCATGAA GATTCTTAAG 540

AAAGAAGTAA TTGTAGCAAA GGATGAAGTA GCACATACTC TCACAGAAAA TCGGGTGTTA 600

CAAAATTCTA AACATCCATT CTTAACAGGT TTAAAGCATT CCTTTCAGAC ACATGACCGT 660

TTGTGCTTCG TCATGGAGTA TGCTAATGGG GGAGAGTTAT TCTTCCACTT GTCAAGAGAG 720

CGTGTCTTTT CTGAAGATCG CGCTCGCTTC TACGGAGCAG AAATTGTGTC GGCACTAGAT 780

TACCTGCATT CAGAAAAGAA TGTAGTTTAT AGAGATCTGA AGTTGGAAAA TCTTATGTTG 840

GACAAGGATG GTCACATTAA AATAACAGAC TTCGGCCTTT GTAAGGAGGG TATAAAGGAT 900

GGTGCAACAA TGAAAACATT TTGTGGAACC CCTGAATATT TGGCGCCAGA GGTTCTTGAA 960

GACAATGATT ATGACCGTGC AGTAGATTGG TGGGGCCTAG GAGTTGTAAT GTACGAAATG 1020

ATGTGTGGTC GACTCCCCTT CTACAATCAG GACCATGAGA AACTCTTTGA GCTCATCCTT 1080

ATGGAGGAGA TCCGATTCCC ACGAACCTTA TCACCTGAAG CTAAATCTCT CCTGTCTGGG 1140

CTGCTAAAAA AGGACCCCAA GCAAAGGTTA GGTGGGGGCC CCGATGATGC TAAGGAGATC 1200

ATGCACCACA AATTTTTTGC TGGAATTGTA TGGCAAGACG TGTACGAGAG AAAGCTTGTT 1260

CCTCGATTTA AGCCTCAAGT TACTTCTGAA ACAGATACAA GATATTTTGA TGAAGAATTT 1320

ACAGCACAAA CAATTACTAT CACTCCACCT GATCAAGATG ACAATATGGA ATTTGTAGAT 1380

AATGAAAGAC GACCACATTT CCCCCAGTTT TCCTACTCGG CCAGTGGAAC AGCTTAA 1437

Domain Profile

S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60

         f++lkllGkGtfGkvilv+ekat+++ya+kilkkevivakdevahtlte+rvl+++khpf

Q: 148   FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSKHPF  207

         9***********************************************************

S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhs.kd  119

         l+ lk+sfqt+++lc+v+ey+nGGelffhls+ervfsedrarfygaeivsaldylhs k+

Q: 208   LTGLKHSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSeKN  267

         ********************************************************9789

S: 120   vvyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygka  179

         vvyrdlklenl+ldkdGhikitdfGlcke+ikdg+++ktfcGtpeylapevled+dy++a

Q: 268   VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYDRA  327

         ************************************************************

S: 180   vdwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpk  239

         vdwwglGvv+yem+cGrlpfyn+dheklfelil+ee++fpr+ls+eaksllsGllkkdpk

Q: 328   VDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLSPEAKSLLSGLLKKDPK  387

         ************************************************************

S: 240   krlGggkddakeireheff  258

         +rlGgg+ddakei++h+ff

Q: 388   QRLGGGPDDAKEIMHHKFF  406

         ******************9

Domain Sequence
(FASTA)

FEYLKLLGKG TFGKVILVKE KATGRYYAMK ILKKEVIVAK DEVAHTLTEN RVLQNSKHPF 60

LTGLKHSFQT HDRLCFVMEY ANGGELFFHL SRERVFSEDR ARFYGAEIVS ALDYLHSEKN 120

VVYRDLKLEN LMLDKDGHIK ITDFGLCKEG IKDGATMKTF CGTPEYLAPE VLEDNDYDRA 180

VDWWGLGVVM YEMMCGRLPF YNQDHEKLFE LILMEEIRFP RTLSPEAKSL LSGLLKKDPK 240

QRLGGGPDDA KEIMHHKFF 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013