EKS-LAC-00072

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00072

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	336.9	1.1E-100	9	295	287

Status

Unreviewed

Ensembl Protein

ENSLACP00000005801

UniProt Accession

H3A830;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK4

Gene Synonyms/Alias

CDK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000005150	ENSLACP00000005801	ENSLACT00000005851
ENSLACG00000005150	ENSLACP00000022211	ENSLACT00000026075

Organism

Latimeria chalumnae

Functional Description

Protein Length

306

Protein Sequence
(FASTA)

MASEVKTLYE PVAKIGGGAY GTVYKARDLQ SGKFVALKSV KVHTTEEGLP LSTVREVALL 60

KRLEHFDHPN IVRLMDVCAT TRTDSELRVT LVFEHVDQDL RTYLEKAPNP GVPADTIKDL 120

MRQFLKGLEF LHLNCVVHRD LKPENILVTS RGEVKLADFG LARTYSCHMA LTPVVVTLWY 180

RSPEVLLHLP YATSVDMWSA GCIFAEMFRR KPLFCGNSEV DQLGKVFDMI GLPPEEEWPR 240

EVVLPYSSFT QRLPQPFRMF VPEIDEFGGS LLLEMLTFSP DKRISAFNAL QHPYFKDHGA 300

EGIRTN 306

Nucleotide Sequence
(FASTA)

ATGGCTAGTG AAGTCAAAAC TCTTTACGAG CCTGTAGCTA AGATTGGAGG AGGAGCATAT 60

GGTACAGTTT ATAAAGCAAG AGATCTACAG AGTGGAAAAT TTGTGGCTCT TAAAAGTGTC 120

AAAGTACACA CAACTGAAGA AGGACTACCG CTGTCCACAG TCCGAGAAGT TGCTCTGCTG 180

AAACGATTGG AACATTTTGA TCACCCAAAT ATTGTCCGGC TCATGGATGT CTGTGCAACA 240

ACAAGAACTG ACAGTGAACT GAGGGTGACA TTGGTGTTTG AACATGTGGA TCAGGACCTC 300

AGGACTTACT TAGAAAAAGC GCCAAATCCT GGAGTACCTG CTGACACCAT CAAGGACCTC 360

ATGCGCCAGT TCTTGAAGGG CCTGGAATTC CTCCATCTAA ATTGTGTGGT GCATCGGGAC 420

CTGAAGCCAG AGAACATCTT GGTAACAAGT CGAGGGGAGG TTAAGCTAGC GGATTTTGGA 480

TTGGCTCGAA CTTACAGCTG TCACATGGCT CTCACCCCGG TGGTAGTGAC GTTGTGGTAC 540

CGGTCCCCAG AAGTGCTCCT TCACTTGCCT TATGCTACCT CTGTTGATAT GTGGAGTGCT 600

GGTTGCATAT TTGCAGAAAT GTTTAGGAGA AAGCCTTTGT TTTGTGGGAA TTCCGAAGTT 660

GACCAATTAG GCAAGGTCTT TGACATGATT GGCCTACCAC CAGAGGAGGA ATGGCCTCGA 720

GAAGTGGTGT TGCCATACTC TTCCTTTACC CAACGCTTAC CACAGCCCTT TAGGATGTTT 780

GTACCTGAAA TTGATGAGTT TGGAGGAAGT CTACTCCTGG AGATGTTAAC TTTCAGCCCT 840

GATAAAAGGA TTTCTGCCTT CAATGCCCTG CAGCACCCGT ATTTCAAGGA CCATGGAGCT 900

GAGGGCATAA GAACCAATTA G 921

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkel...kh  57

         ye ++kig G+yg+vyka+d ++g++vAlK++++++ +eg+p +++rE++llk+l   +h

Q: 9     YEPVAKIGGGAYGTVYKARDLQSGKFVALKSVKVHTTEEGLPLSTVREVALLKRLehfDH  68

         8899**************************************************977789

S: 58    knivkLlevva....kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqllegl  113

         +niv+L++v+a     ++ +++Lvfe+++qdL ++l+k ++ +++ +++k l++q+l+gl

Q: 69    PNIVRLMDVCAttrtDSELRVTLVFEHVDQDLRTYLEKAPNPGVPADTIKDLMRQFLKGL  128

         ***********8765455789***************************************

S: 114   aylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLl  173

         ++lH n ++HRDlKp+N+L++++g++klaDfGlar++s ++  +t++vvTlwYr+Pe+Ll

Q: 129   EFLHLNCVVHRDLKPENILVTSRGEVKLADFGLARTYSCHMA-LTPVVVTLWYRSPEVLL  187

         *************************************99998.*****************

S: 174   gakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpe  233

             Y t+vD+Ws+gci+ae+++rkplf g+se+dql ++f+++g p e++wp+   lp

Q: 188   HL-PYATSVDMWSAGCIFAEMFRRKPLFCGNSEVDQLGKVFDMIGLPPEEEWPREVVLPY  246

         87.5******************************************************98

S: 234   ykksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

            sf+++ ++ ++  v++++e + +ll ++l+++p+kRisa +alqh+yf

Q: 247   S--SFTQRLPQPFRMFVPEIDEFGGSLLLEMLTFSPDKRISAFNALQHPYF  295

         5..699999*****************************************9

Domain Sequence
(FASTA)

YEPVAKIGGG AYGTVYKARD LQSGKFVALK SVKVHTTEEG LPLSTVREVA LLKRLEHFDH 60

PNIVRLMDVC ATTRTDSELR VTLVFEHVDQ DLRTYLEKAP NPGVPADTIK DLMRQFLKGL 120

EFLHLNCVVH RDLKPENILV TSRGEVKLAD FGLARTYSCH MALTPVVVTL WYRSPEVLLH 180

LPYATSVDMW SAGCIFAEMF RRKPLFCGNS EVDQLGKVFD MIGLPPEEEW PREVVLPYSS 240

FTQRLPQPFR MFVPEIDEFG GSLLLEMLTF SPDKRISAFN ALQHPYF 287

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013