EPS-LAC-00074

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-LAC-00074

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/PTEN	298.0	3.6E-89	14	184	171

Status

Unreviewed

Ensembl Protein

ENSLACP00000006424

UniProt Accession

H3A9V3;

Protein Name

Protein Synonyms/Alias

Gene Name

PTEN

Gene Synonyms/Alias

PTEN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000005701	ENSLACP00000006424	ENSLACT00000006477

Organism

Latimeria chalumnae

Functional Description

Protein Length

404

Protein Sequence
(FASTA)

MTAIIKEIVS RNKRRYQEDG FDLDLTYIYP NIIAMGFPAE RLEGVYRNNI DDVVRFLDSK 60

HKNHYKIYNL CAERHYDATK FNCRVAQYPF EDHNPPQLEL IKPFCEDLDK WLSEDDNHVA 120

AIHCKAGKGR TGVMICAYLL HRSKFLKAQE ALDFYGEVRT RDKKGVTIPS QRRYVYYYSY 180

LLKHQLDYKP VALLFHKLAF ETIPMFSGGT CNPLFVVYQL KVKIYTSPLG PTRREEKYMH 240

FEFPQPLPVC GDIKVEFFHK QNKMMKKEKM FHFWINTFFI PGPEENSDKV ENGSVVGEKE 300

LDGIYSTERS DNDKEYLILT LAKNDLDKAN KDKANKSFSP NFKVKLFFTK TVEEPSNSEA 360

SSSTSVTPDV SDNEPDHYRY SDTTDSDPEN EPFDEDQHPQ ITKV 404

Nucleotide Sequence
(FASTA)

ATGACTGCCA TCATCAAAGA AATCGTCAGC AGAAACAAAA GAAGATACCA AGAGGATGGC 60

TTCGACTTGG ATTTAACCTA TATTTATCCA AACATCATTG CTATGGGATT TCCAGCAGAA 120

AGACTTGAAG GTGTATACAG AAACAACATT GATGATGTAG TAAGGTTCTT GGATTCAAAG 180

CATAAAAACC ATTATAAGAT ATACAACCTA TGTGCAGAAA GACATTATGA TGCCACCAAA 240

TTTAATTGTA GAGTTGCACA ATATCCTTTT GAAGACCATA ATCCACCACA GCTAGAGTTA 300

ATCAAACCTT TCTGTGAAGA CCTTGACAAA TGGCTAAGTG AAGATGACAA TCATGTTGCA 360

GCAATTCACT GTAAAGCTGG AAAGGGACGA ACTGGTGTAA TGATATGTGC ATATTTGCTA 420

CATCGAAGCA AATTCCTAAA GGCACAAGAA GCCTTAGACT TTTATGGTGA AGTGAGGACC 480

AGAGACAAGA AGGGAGTAAC GATTCCCAGC CAGAGGCGCT ATGTATATTA CTACAGCTAT 540

CTGTTGAAGC ACCAGTTGGA CTACAAACCA GTGGCACTGT TGTTTCACAA GTTGGCGTTT 600

GAAACAATTC CAATGTTTAG TGGTGGAACA TGCAATCCTC TGTTTGTGGT CTATCAGTTA 660

AAGGTGAAGA TTTACACCTC TCCTCTGGGA CCCACAAGAC GTGAAGAAAA ATACATGCAC 720

TTTGAGTTTC CGCAGCCCTT GCCAGTGTGT GGTGACATAA AGGTGGAGTT CTTTCACAAG 780

CAGAACAAGA TGATGAAAAA GGAAAAAATG TTCCACTTTT GGATAAATAC ATTCTTCATA 840

CCAGGACCTG AAGAAAATTC AGACAAAGTT GAAAATGGCA GTGTGGTTGG AGAAAAAGAA 900

CTTGATGGGA TTTACAGTAC TGAGCGTTCT GATAATGACA AGGAGTATCT TATCCTCACA 960

TTGGCAAAAA ATGATCTAGA TAAAGCGAAT AAGGACAAGG CCAACAAATC CTTTTCTCCA 1020

AACTTCAAGG TAAAGCTTTT CTTCACAAAA ACAGTTGAAG AGCCATCGAA CTCTGAGGCC 1080

AGCAGTTCAA CTTCAGTAAC GCCGGATGTT AGTGATAATG AACCTGATCA TTATAGATAT 1140

TCAGACACCA CTGACTCTGA CCCAGAAAAT GAACCTTTTG ATGAAGATCA GCATCCACAG 1200

ATAACAAAAG TCTGA 1215

Domain Profile

S: 1     rrltedgfdldltyvteriiavsfPaeareevyrnnlrevvrlldskhrnkyklynlcse  60

         rr++edgfdldlty++++iia++fPae+ e+vyrnn+++vvr+ldskh+n+yk+ynlc+e

Q: 14    RRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAE  73

         79**********************************************************

S: 61    rrydltklnakvaefgiedlnaPaleklvsickeldeWlseddenvvvlhckggkgrlGv  120

         r+yd tk+n++va++++ed+n+P+le ++++c++ld+Wlsedd++v+++hck+gkgr+Gv

Q: 74    RHYDATKFNCRVAQYPFEDHNPPQLELIKPFCEDLDKWLSEDDNHVAAIHCKAGKGRTGV  133

         ************************************************************

S: 121   ivcayllaseisakadealdtfgerrtredkvagvkqPsqrryvsyfsqllkg  173

         ++cayll++ +++ka+eald++ge+rtr++k  gv++Psqrryv+y+s+llk

Q: 134   MICAYLLHRSKFLKAQEALDFYGEVRTRDKK--GVTIPSQRRYVYYYSYLLKH  184

         *******************************..*****************985

Domain Sequence
(FASTA)

RRYQEDGFDL DLTYIYPNII AMGFPAERLE GVYRNNIDDV VRFLDSKHKN HYKIYNLCAE 60

RHYDATKFNC RVAQYPFEDH NPPQLELIKP FCEDLDKWLS EDDNHVAAIH CKAGKGRTGV 120

MICAYLLHRS KFLKAQEALD FYGEVRTRDK KGVTIPSQRR YVYYYSYLLK H 171

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0016314	; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800	; F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004725	; F:protein tyrosine phosphatase activity
GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0046855	; P:inositol phosphate dephosphorylation
GO:0030336	; P:negative regulation of cell migration
GO:0008285	; P:negative regulation of cell proliferation
GO:0051895	; P:negative regulation of focal adhesion assembly
GO:0051898	; P:negative regulation of protein kinase B signaling cascade
GO:0035335	; P:peptidyl-tyrosine dephosphorylation
GO:0046856	; P:phosphatidylinositol dephosphorylation
GO:0031647	; P:regulation of protein stability

KEGG

InterPros

IPR017361	; Bifunc_PIno_P3_Pase/Pase_PTEN.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR014019	; Phosphatase_tensin-typ.
IPR014020	; Tensin_phosphatase_C2-dom.
IPR016130	; Tyr_Pase_AS.

Pfam

PF00782	; DSPc; 1.
PF10409	; PTEN_C2; 1.

SMARTs

Prosites

PS51182	; C2_TENSIN; 1.
PS51181	; PPASE_TENSIN; 1.
PS00383	; TYR_PHOSPHATASE_1; 1.

Prints

Created Date

20-Feb-2013