EKS-LAC-00384

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00384

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	439.9	3.0E-132	250	500	251

Status

Unreviewed

Ensembl Protein

ENSLACP00000006462

UniProt Accession

H3A9Z1;

Protein Name

Protein Synonyms/Alias

Gene Name

LYN

Gene Synonyms/Alias

LYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000005733	ENSLACP00000006462	ENSLACT00000006515

Organism

Latimeria chalumnae

Functional Description

Protein Length

515

Protein Sequence
(FASTA)

MGCVKSKSFM NSGEDGINKK NQPVRTTEQT IYVRDPTSNN RQMPHSNTDS HLLPGQRFKH 60

LDEEAKGGNI FVALYPYEAM HPDDLGFKKG DKLKVLEEQG EWWKARSLTT KKEGFIPSNY 120

VARINSMETE EWFFKDITRK DAERQLLAPG NKPGAFLIRE SETSKGSYSL SMRDYDPQQG 180

DVIKHYKIRS LDNGGVYISP RITFQDISSM IKHYRKQSDG LCRKLESPCI SPKPQMPWDK 240

DAWEISRDSI KLVKRLGAGQ FGEVWMGYYK NTTKVAVKTL KPGTMSVQAF LEEANLMKTL 300

QHDRLVRLYA VVTKEDPIYI IAEFMANGSL LDFLKSEEGG RVLLPKLIDF SAQIAEGMAY 360

IERKNYIHRD LRAANVLVSE TLLCKIADFG LARVIEDNEY TAREGAKFPI KWTAPEAINF 420

GSFTIKSDVW SFGILLYEII TYGKIPYPGM SNSDVISSIQ RGYRMPRPEN CPDELYEVME 480

GCWKNKAEDR PTFDYLQSVL EDFYTATEGQ YQQQP 515

Nucleotide Sequence
(FASTA)

ATGGGATGTG TAAAATCAAA GTCATTCATG AACTCGGGTG AAGATGGGAT AAATAAGAAG 60

AATCAACCAG TACGTACAAC TGAACAAACT ATATATGTGA GAGATCCAAC CTCCAATAAC 120

CGGCAAATGC CGCATTCAAA CACTGATTCA CATCTCCTTC CTGGTCAGAG GTTCAAACAC 180

CTCGATGAAG AAGCAAAGGG TGGAAACATA TTTGTAGCCT TGTACCCTTA TGAAGCAATG 240

CATCCAGATG ATTTGGGCTT CAAGAAAGGT GACAAGTTGA AGGTGCTTGA GGAGCAAGGA 300

GAATGGTGGA AAGCCAGATC CCTCACAACA AAGAAAGAAG GCTTTATTCC CAGCAACTAT 360

GTTGCAAGAA TAAACTCCAT GGAAACGGAA GAATGGTTCT TTAAAGATAT TACCAGGAAA 420

GATGCAGAAA GACAGCTTTT GGCACCAGGA AACAAGCCAG GGGCGTTCCT TATAAGAGAA 480

AGTGAAACAT CAAAAGGCAG CTACTCACTT TCTATGAGAG ATTATGATCC ACAACAGGGT 540

GATGTCATTA AACACTACAA AATCCGGAGT CTTGACAATG GTGGAGTTTA CATCTCTCCA 600

AGAATTACTT TCCAGGACAT TAGCAGCATG ATTAAGCATT ACCGAAAGCA ATCAGATGGT 660

CTCTGCAGAA AACTAGAATC ACCATGTATT AGTCCTAAAC CACAGATGCC GTGGGATAAA 720

GATGCCTGGG AAATTTCACG GGATTCTATA AAGTTAGTGA AGAGGCTTGG AGCTGGGCAG 780

TTTGGAGAAG TATGGATGGG TTACTACAAA AATACTACAA AAGTAGCAGT AAAAACCTTA 840

AAGCCAGGCA CCATGTCTGT GCAGGCTTTT CTTGAAGAAG CTAACCTCAT GAAGACACTT 900

CAGCATGATA GGCTCGTGAG ACTTTATGCT GTGGTCACAA AGGAAGATCC AATTTATATT 960

ATTGCGGAAT TCATGGCTAA TGGCAGTTTG TTAGACTTCT TAAAGAGTGA GGAAGGAGGC 1020

CGTGTCCTGC TACCAAAATT GATTGATTTT TCAGCACAAA TTGCTGAGGG AATGGCCTAC 1080

ATTGAAAGGA AGAATTACAT CCATCGAGAT CTTCGAGCAG CAAATGTGCT GGTTTCAGAG 1140

ACACTGCTGT GTAAAATTGC AGATTTTGGC CTGGCTAGAG TAATTGAAGA TAATGAGTAC 1200

ACTGCTCGAG AAGGTGCAAA ATTTCCAATT AAGTGGACTG CTCCTGAGGC TATTAACTTT 1260

GGATCGTTCA CTATTAAGTC CGATGTGTGG TCCTTTGGAA TCCTTCTATA TGAAATTATT 1320

ACATATGGAA AAATCCCGTA TCCAGGTATG AGCAATTCTG ATGTCATATC ATCCATTCAA 1380

CGTGGGTATC GGATGCCACG GCCAGAGAAT TGCCCAGATG AGCTCTATGA AGTAATGGAG 1440

GGCTGCTGGA AGAACAAAGC AGAAGACCGA CCCACGTTTG ACTACCTACA AAGTGTGCTA 1500

GAAGACTTCT ACACTGCAAC AGAAGGCCAA TATCAGCAAC AGCCTTAA 1548

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +klvk+lG+GqfGevw+g++k+++kvavktlk+gt+s +afleea+++k+l+h++lv+ly

Q: 250   IKLVKRLGAGQFGEVWMGYYKNTTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDRLVRLY  309

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++e+Piyi++e+ma+Gslldflk+eeg ++ lpkl+d++aq+aeGmay+e+kn+ihr

Q: 310   AVVTKEDPIYIIAEFMANGSLLDFLKSEEGGRVLLPKLIDFSAQIAEGMAYIERKNYIHR  369

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+nvlv+e+l++k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv

Q: 370   DLRAANVLVSETLLCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV  429

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGill+ei+t+Gk+PypGm+n++v+++++rgyr+prpe+cp+elye+++ cwk+++e+

Q: 430   WSFGILLYEIITYGKIPYPGMSNSDVISSIQRGYRMPRPENCPDELYEVMEGCWKNKAED  489

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtf++lq+vl

Q: 490   RPTFDYLQSVL  500

         ********986

Domain Sequence
(FASTA)

IKLVKRLGAG QFGEVWMGYY KNTTKVAVKT LKPGTMSVQA FLEEANLMKT LQHDRLVRLY 60

AVVTKEDPIY IIAEFMANGS LLDFLKSEEG GRVLLPKLID FSAQIAEGMA YIERKNYIHR 120

DLRAANVLVS ETLLCKIADF GLARVIEDNE YTAREGAKFP IKWTAPEAIN FGSFTIKSDV 180

WSFGILLYEI ITYGKIPYPG MSNSDVISSI QRGYRMPRPE NCPDELYEVM EGCWKNKAED 240

RPTFDYLQSV L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013