EKS-LAC-00455

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00455

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	493.1	2.2E-148	76	342	267

Status

Unreviewed

Ensembl Protein

ENSLACP00000006622

UniProt Accession

H3AAF1;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPB

Gene Synonyms/Alias

CDC42BPB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000005873	ENSLACP00000006622	ENSLACT00000006676

Organism

Latimeria chalumnae

Functional Description

Protein Length

1713

Protein Sequence
(FASTA)

MSAKVRLKKL EQLVLDGPQK NESAMSVETL LDILICLYKE CSNSPLRREK YVNEFLEWAK 60

PFTNLVKDMR LHRDDFEIIK VIGRGAFGEV AVVKMKNTER VYAMKILNKW EMLKRAETAC 120

FHEERNVLVN GDCQWITTLH YAFQDDNYLY LVMDYYVGGD LLTLLSKFED RLPEDMAKFY 180

VAEMVLAIHS IHQLHYVHRD IKPDNVLLDV NGHIRLADFG SCLKMNTDGS VQSSVAVGTP 240

DYISPEILQA MEDGMGKYGP ECDWWSLGVC MYEMLYGETP FYAESLVETY GKIMNHEERF 300

QFPSHITDVS EDAKDLIQQL ICRRERRLGQ NGIGDFKKHP FFVGIDWDNI RNRGAPYIPE 360

VSSPSDTSNF DVDDDVLKNP EIVPPASHTG FSGLHLPFVG FTYTTESCLS DRGNMKGAIH 420

GTAVADTDVQ RDLENSLQVE AYERRIRRLE QEKLELTRKL QESTQTIQSL HGSPRGLGSV 480

NRDKEIKKLN EEIERLKKKL ADSDRLEQKL EDAVTLQQEY EDSTIKLKVL EKQVKTLKQD 540

KEDIHKQLVE ALERLKSQAK ELKDAHQQRK LAMQEFSELN ETMADLRSQK QKFSRQLRDK 600

EEEMEVVMQK IDTMRQEIRK AEKARKELEI QLEDTTAEAS KERKLREHSE LYSKQLESKL 660

EALKVRQGGR TAGDASEHQQ ELSKIKSELE KKILFYEEEL LRREASHASE IKNLKKEMHD 720

TESQTLAQQK EIMMLKDKLE KARRERQSEM EEAVGTLKDK YLREKNMLIE ENKKLTVETD 780

RLGSFVDKLT SENRQLEDAF QDLATKKESV AHWEAQIAEI IQWVSDEKDA RGYLQALASK 840

MTEELESLRS SSLGSRTLDP LWKVRRSQKL DMSARLELQS ALDAELRAKQ LVQEELRKVK 900

ASNISYESKL KEADTRNRQL LEEVEALKKE IEESRSRADK GLKLPDFQDS IFEYFNTSPL 960

THDLTFRTSS ITEPDASGTK PEVPLSPSVS VPTEQQDEPI KVQHTAPSVP VPSRSTSINI 1020

PKPRAHQLTV KNFSSPTQCS HCTSLMVGLV RQGYACDVCS FTCHVSCKDS TPQVCPVPPE 1080

QAKRPLGIDV QRGIGTAYKG YVRIPKPTGV KKGWQRAYAF VCDCKLFLYD VPEGKSTQCG 1140

VVASQVLDLS RDKEFSVSSV LASDVIHATR KDIPCIFRVT SSLLASPSKT YSLLILTESE 1200

TEKRKWVGIL EGLQTILYKN KLRNRPVHVA QEAYDSTLPL IKTTLAAAII DRDRVALGTE 1260

EGLFVVEVTR DVITRAADCK KVYQIELVSK DKIVILICGR SHHVHLYPWT SLDGSEGSFD 1320

IKLPETKGCQ IITTGTLRQG ILTCLFVAVK RQVLCYEINR TKPFHKKFNE VQAPGIVQWM 1380

AMFKDKLCVG YQSGFSLLNI QGDGPSVSLV NPNDASLAFL SQCPVDALCA MELVNEEYLL 1440

CFSHMGVYVD LQGRRSRTQE LMWPATPVAC SCSLSFVTVY SDYGVDVFDA NTMEWVQTIA 1500

LRKIRPLNID GTLNLLNSEP PRLIYFKNSY SEGKELCVPE TSDNSKKQML RTRSKRRFIF 1560

KVPEEERLQQ RREMLRDPEL RSKMISNPTN FNHVAHMGPG DGMQVLMDLP LMGRPIVSKI 1620

KRHPAAVSAV FKLKHAHSHF INSENSGAGD LGGATSSRNI SEFEPDFEKE PDSDSTKHST 1680

PSNSSNPSGP PSPNSPHRSQ LTLDGLDQST CDA 1713

Nucleotide Sequence
(FASTA)

ATGTCAGCGA AGGTGCGGCT GAAGAAATTG GAACAATTGG TCCTTGATGG ACCTCAGAAG 60

AATGAAAGTG CAATGAGTGT GGAGACTCTC TTGGATATCT TGATTTGCCT CTATAAGGAG 120

TGTAGTAATT CCCCTTTAAG GAGAGAAAAA TATGTGAACG AATTCCTAGA ATGGGCAAAA 180

CCATTTACGA ATTTGGTGAA GGACATGCGA CTTCATCGTG ATGACTTTGA AATTATAAAA 240

GTTATTGGCA GAGGGGCATT TGGTGAGGTT GCAGTAGTTA AAATGAAAAA CACGGAGCGT 300

GTGTATGCAA TGAAAATCTT AAATAAATGG GAAATGCTAA AAAGAGCAGA GACGGCGTGT 360

TTTCATGAAG AAAGAAATGT TCTAGTGAAT GGGGACTGTC AGTGGATTAC TACATTGCAT 420

TATGCATTCC AAGATGATAA CTATTTGTAT TTAGTAATGG ATTACTATGT GGGTGGTGAT 480

CTGCTGACAT TGCTCAGTAA GTTTGAAGAT CGGCTTCCTG AAGATATGGC GAAGTTCTAC 540

GTGGCTGAAA TGGTGCTAGC TATCCACTCC ATTCATCAAC TTCATTATGT ACACAGGGAT 600

ATAAAGCCCG ATAATGTCCT CTTGGATGTG AATGGTCACA TACGTCTGGC AGACTTTGGC 660

TCATGTCTGA AGATGAACAC TGATGGATCT GTGCAATCCT CTGTAGCTGT GGGTACCCCT 720

GACTACATTT CCCCTGAGAT ATTACAGGCA ATGGAAGATG GCATGGGAAA ATATGGGCCA 780

GAATGTGATT GGTGGTCTCT TGGGGTCTGC ATGTATGAAA TGTTGTATGG GGAAACTCCA 840

TTCTATGCAG AGTCATTGGT GGAAACATAT GGGAAGATTA TGAATCATGA AGAACGCTTC 900

CAGTTCCCTT CTCACATCAC AGATGTATCT GAAGACGCTA AAGATTTAAT CCAACAACTT 960

ATCTGTCGCA GGGAACGACG ACTAGGACAG AATGGAATTG GTGATTTTAA AAAACACCCA 1020

TTTTTTGTAG GGATTGACTG GGATAATATT CGTAACAGGG GAGCACCTTA CATCCCAGAA 1080

GTCAGCAGCC CTTCTGACAC ATCAAACTTT GATGTAGATG ATGATGTTTT AAAGAACCCA 1140

GAAATTGTGC CGCCAGCTTC TCACACTGGC TTTTCTGGAT TACATTTACC ATTTGTTGGT 1200

TTTACATATA CAACTGAAAG TTGTTTGTCA GACAGAGGTA ATATGAAGGG TGCCATACAT 1260

GGCACAGCTG TCGCAGACAC AGATGTACAA AGAGATTTAG AGAACAGTCT GCAGGTAGAG 1320

GCTTATGAGA GGAGGATACG ACGGCTTGAA CAAGAAAAAC TGGAACTCAC CAGAAAATTG 1380

CAAGAGTCTA CACAAACTAT TCAGTCACTG CATGGTTCAC CACGGGGATT AGGATCTGTT 1440

AACAGAGATA AAGAAATAAA AAAACTAAAT GAAGAAATTG AGCGCTTAAA GAAAAAATTA 1500

GCAGATTCAG ATCGGTTAGA ACAGAAACTT GAAGATGCAG TAACTCTTCA ACAGGAATAT 1560

GAAGATTCCA CAATCAAACT AAAAGTACTT GAAAAACAAG TCAAAACTCT CAAGCAAGAC 1620

AAGGAGGACA TTCACAAACA ACTTGTTGAA GCCCTTGAAA GGTTGAAGTC TCAGGCCAAA 1680

GAACTGAAGG ATGCCCATCA GCAGAGGAAG TTGGCAATGC AGGAATTTTC GGAACTGAAT 1740

GAAACAATGG CAGACCTGCG CTCTCAGAAA CAGAAGTTCT CCCGGCAACT GCGTGACAAA 1800

GAGGAAGAAA TGGAAGTGGT CATGCAGAAA ATTGACACTA TGCGACAGGA AATCCGCAAA 1860

GCTGAGAAGG CCAGAAAAGA GCTGGAAATT CAGCTTGAAG ACACTACAGC AGAAGCATCA 1920

AAGGAGCGAA AACTTCGAGA ACACAGTGAG CTTTACTCCA AACAGCTGGA AAGTAAGCTG 1980

GAAGCACTCA AGGTAAGGCA AGGAGGTCGG ACAGCAGGGG ATGCATCAGA ACACCAGCAA 2040

GAACTGTCCA AGATTAAGTC CGAGTTGGAG AAGAAAATCT TGTTCTATGA GGAGGAACTG 2100

CTACGACGGG AGGCCTCCCA TGCTTCTGAA ATCAAAAATC TAAAGAAGGA AATGCATGAC 2160

ACTGAAAGCC AAACCTTAGC CCAGCAAAAA GAGATCATGA TGTTAAAAGA CAAACTGGAA 2220

AAAGCAAGGA GGGAAAGGCA AAGTGAGATG GAGGAGGCAG TAGGAACGCT AAAGGATAAG 2280

TACCTCCGAG AGAAAAACAT GCTTATTGAG GAGAACAAGA AATTAACTGT AGAGACTGAT 2340

AGGCTTGGCT CATTTGTGGA TAAACTGACA TCCGAGAATA GGCAGCTGGA GGATGCATTC 2400

CAGGATCTTG CAACTAAAAA AGAATCAGTA GCTCACTGGG AAGCTCAGAT TGCTGAGATT 2460

ATACAGTGGG TAAGTGATGA AAAGGATGCT CGTGGGTACC TCCAGGCTTT GGCTTCCAAG 2520

ATGACAGAAG AACTTGAGTC CCTTAGAAGC TCCAGTTTAG GCTCAAGGAC TCTGGACCCA 2580

TTGTGGAAGG TACGCCGCAG TCAGAAGTTG GATATGTCTG CCAGGCTGGA GTTACAGTCT 2640

GCTCTAGATG CAGAATTACG TGCCAAACAA TTAGTTCAGG AAGAACTAAG AAAGGTTAAA 2700

GCATCCAATA TATCTTACGA AAGTAAGCTA AAGGAGGCCG ATACAAGGAA CCGGCAACTA 2760

TTGGAGGAGG TTGAAGCTTT GAAGAAGGAG ATTGAGGAAA GCAGATCTAG AGCAGATAAA 2820

GGTCTTAAAC TTCCAGATTT CCAGGACTCA ATTTTTGAGT ATTTTAACAC ATCCCCTCTT 2880

ACGCATGATT TAACGTTTAG AACAAGCTCC ATTACTGAGC CTGATGCTTC AGGCACCAAA 2940

CCAGAAGTTC CTCTGTCCCC TTCAGTTTCT GTGCCTACAG AGCAACAAGA TGAGCCAATC 3000

AAGGTTCAAC ACACAGCACC ATCTGTTCCT GTACCATCTC GGTCTACTTC TATAAACATA 3060

CCAAAGCCTA GAGCTCATCA GCTAACTGTG AAGAACTTTT CAAGCCCTAC TCAATGTAGT 3120

CACTGTACAT CCTTAATGGT TGGACTTGTA CGACAGGGCT ATGCCTGTGA TGTGTGTTCA 3180

TTCACTTGTC ACGTTTCCTG TAAGGACAGT ACACCTCAGG TCTGCCCTGT TCCTCCAGAG 3240

CAAGCCAAGA GACCTCTTGG GATAGATGTG CAGAGAGGGA TAGGAACTGC TTACAAAGGC 3300

TATGTCCGGA TTCCGAAGCC AACAGGAGTG AAGAAAGGTT GGCAGCGAGC TTATGCGTTT 3360

GTCTGCGACT GTAAGCTCTT TCTGTATGAT GTGCCAGAAG GGAAGTCAAC TCAGTGTGGA 3420

GTTGTTGCCA GTCAGGTGTT GGACCTGAGT AGGGATAAGG AGTTTTCTGT GAGTTCTGTG 3480

CTGGCATCTG ATGTCATACA TGCCACCCGA AAGGATATCC CTTGCATTTT CAGGGTGACA 3540

TCTTCACTGT TGGCTTCGCC TTCGAAGACC TACTCACTTC TTATCCTAAC GGAGAGCGAG 3600

ACTGAAAAAA GAAAGTGGGT TGGAATCCTG GAGGGACTGC AAACCATCCT ATACAAAAAC 3660

AAGCTAAGGA ATAGGCCTGT GCATGTTGCA CAAGAAGCCT ATGATAGCAC ACTGCCTCTT 3720

ATTAAAACAA CATTAGCTGC TGCTATTATA GATCGTGATC GTGTAGCGCT TGGCACAGAA 3780

GAAGGACTGT TTGTGGTTGA GGTTACACGT GATGTGATTA CCCGAGCTGC TGACTGTAAA 3840

AAGGTGTATC AAATTGAGCT GGTTTCCAAA GACAAAATTG TTATCCTCAT CTGTGGCCGT 3900

AGCCATCATG TTCATCTTTA TCCATGGACC TCTCTTGATG GGTCAGAAGG TAGCTTTGAC 3960

ATTAAGCTCC CTGAAACAAA AGGCTGTCAG ATCATTACAA CTGGCACTCT GCGGCAGGGC 4020

ATCTTGACCT GTCTGTTTGT GGCTGTGAAG AGGCAGGTCC TTTGCTATGA GATTAACAGA 4080

ACTAAACCCT TCCACAAAAA ATTCAATGAA GTTCAGGCCC CAGGGATTGT GCAATGGATG 4140

GCAATGTTTA AAGACAAACT CTGCGTAGGC TACCAGTCTG GCTTCTCACT GCTAAATATC 4200

CAGGGAGATG GACCTTCTGT AAGCCTGGTA AATCCCAATG ACGCCTCACT TGCATTCCTC 4260

TCGCAGTGTC CTGTTGATGC TCTTTGTGCA ATGGAGCTCG TTAATGAGGA GTACCTGCTT 4320

TGCTTCAGCC ATATGGGAGT GTATGTCGAC TTACAGGGTC GAAGGTCACG CACACAGGAG 4380

CTAATGTGGC CTGCAACTCC TGTGGCCTGC AGTTGCAGCT TATCCTTTGT AACAGTGTAC 4440

AGTGATTATG GTGTTGATGT GTTTGATGCA AACACTATGG AATGGGTCCA AACCATTGCT 4500

TTGAGAAAGA TACGACCATT AAATATCGAT GGGACCTTAA ATCTTCTCAA CTCAGAGCCC 4560

CCTCGGTTGA TATATTTCAA GAATAGTTAT TCAGAAGGAA AGGAACTCTG TGTGCCAGAA 4620

ACTTCAGATA ATAGTAAAAA GCAAATGCTC AGAACCCGAA GTAAGAGAAG ATTTATCTTT 4680

AAGGTACCTG AAGAAGAGAG ATTACAACAG AGAAGAGAAA TGCTGCGAGA CCCGGAGCTG 4740

AGGTCCAAGA TGATATCTAA TCCAACGAAC TTCAACCATG TAGCACACAT GGGACCAGGG 4800

GATGGAATGC AAGTGCTCAT GGATCTACCA CTGATGGGGC GGCCCATTGT CAGCAAAATC 4860

AAACGACATC CTGCAGCGGT TTCAGCTGTT TTCAAGCTGA AGCATGCTCA TTCACACTTC 4920

ATTAATTCTG AAAATAGTGG TGCTGGAGAC TTAGGAGGAG CCACGTCATC ACGTAACATT 4980

TCAGAGTTTG AACCTGATTT TGAAAAAGAG CCTGATTCGG ATTCAACAAA ACACTCAACC 5040

CCATCTAACA GCTCAAACCC AAGTGGACCC CCAAGCCCAA ACTCCCCACA TAGGAGCCAG 5100

CTTACACTAG ATGGTTTAGA TCAATCAACC TGTGACGCAT GA 5142

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         fei+kviGrGafgevavv++k+te+vyamkil+k+e+lkrae+a+f+eer+vlv++d++w

Q: 76    FEIIKVIGRGAFGEVAVVKMKNTERVYAMKILNKWEMLKRAETACFHEERNVLVNGDCQW  135

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqd++ylylvm+y+vGGdlltllsk+ed+lpe++a+fy+ae+vla++s+h+l+

Q: 136   ITTLHYAFQDDNYLYLVMDYYVGGDLLTLLSKFEDRLPEDMAKFYVAEMVLAIHSIHQLH  195

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrdikpdn+lld++Ghi+ladfGsclk+n+dg+v+ssvavGtpdyispe+l+a+e+g+

Q: 196   YVHRDIKPDNVLLDVNGHIRLADFGSCLKMNTDGSVQSSVAVGTPDYISPEILQAMEDGM  255

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nh+e+++fp++  +vse+akd

Q: 256   GKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHItDVSEDAKD  315

         *************************************************988********

S: 240   likklltsreerlgregiedlkkhpff  266

         li++l+++re+rlg++gi d+kkhpff

Q: 316   LIQQLICRRERRLGQNGIGDFKKHPFF  342

         **************************9

Domain Sequence
(FASTA)

FEIIKVIGRG AFGEVAVVKM KNTERVYAMK ILNKWEMLKR AETACFHEER NVLVNGDCQW 60

ITTLHYAFQD DNYLYLVMDY YVGGDLLTLL SKFEDRLPED MAKFYVAEMV LAIHSIHQLH 120

YVHRDIKPDN VLLDVNGHIR LADFGSCLKM NTDGSVQSSV AVGTPDYISP EILQAMEDGM 180

GKYGPECDWW SLGVCMYEML YGETPFYAES LVETYGKIMN HEERFQFPSH ITDVSEDAKD 240

LIQQLICRRE RRLGQNGIGD FKKHPFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013