EKS-LAC-00239

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00239

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	384.6	2.8E-115	70	364	295

Status

Unreviewed

Ensembl Protein

ENSLACP00000007289

UniProt Accession

H3ACB8;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K1

Gene Synonyms/Alias

MAP2K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000006464	ENSLACP00000007289	ENSLACT00000007349

Organism

Latimeria chalumnae

Functional Description

Protein Length

396

Protein Sequence
(FASTA)

MPRKGKPMPI QLNPTPDGST INGTSSAETN LEALQKKLEE LELDEQQRKR LEAFLTQKQK 60

VGELKDDDFE KICELGAGNG GVVFKVSHKP SSLIMARKLI HLEIKPAIRN QIIRELQVLH 120

ECNSPYIVGF YGAFYSDGEI SICMEHMDGG SLDQVLKKAG RIPEQILGKV SIAVIKGLTY 180

LREKHKIMHR DVKPSNILVN SRGEIKLCDF GVSGQLIDSM ANSFVGTRSY MSPERLQGTH 240

YSVQSDIWSM GLSLVEMAVG RYPIPPPDPK ELEQIFGCPV EGDSTSSETS ARPRPPGHPM 300

SSFGPDSRPP MAIFELLDYI VNEPPPKLPS NVFSSEFQDF VNKCLIKNPA ERADLKQLMA 360

QAFIKRSDAE EVDFAGWLCT TIGLNQPSTP THAAGV 396

Nucleotide Sequence
(FASTA)

ATGCCAAGGA AGGGCAAGCC TATGCCAATC CAGCTGAATC CCACTCCGGA TGGATCAACT 60

ATAAACGGAA CCAGCTCTGC AGAGACAAAT CTTGAGGCTC TGCAGAAGAA GCTAGAAGAA 120

CTAGAGTTGG ATGAACAGCA GCGCAAGCGT CTGGAGGCTT TCCTTACCCA GAAACAAAAA 180

GTTGGGGAGT TAAAGGATGA CGACTTTGAA AAGATCTGTG AGCTTGGAGC AGGGAATGGT 240

GGTGTGGTTT TTAAAGTATC ACACAAACCA TCCAGCCTCA TCATGGCAAG AAAGTTAATT 300

CATCTGGAGA TCAAGCCAGC CATTAGAAAC CAGATCATCC GAGAGCTGCA GGTTCTCCAT 360

GAGTGTAACT CTCCATATAT CGTGGGCTTT TATGGAGCAT TTTATAGTGA TGGAGAGATC 420

AGTATTTGTA TGGAACATAT GGATGGTGGC TCTTTGGATC AAGTGTTGAA AAAAGCTGGA 480

AGAATCCCAG AGCAAATTTT GGGCAAAGTC AGCATAGCGG TAATAAAAGG ATTGACTTAC 540

CTGAGAGAAA AGCACAAGAT AATGCATAGA GATGTCAAGC CATCTAATAT TTTGGTAAAC 600

TCTCGAGGTG AGATCAAGCT ATGTGATTTT GGTGTCAGTG GACAATTGAT AGATTCTATG 660

GCAAACTCCT TTGTTGGGAC AAGGTCCTAT ATGTCTCCTG AAAGACTACA AGGTACTCAT 720

TACTCAGTGC AGTCAGACAT CTGGAGTATG GGGCTCTCGC TTGTGGAAAT GGCTGTAGGT 780

AGATACCCAA TTCCACCTCC TGACCCGAAG GAACTAGAAC AGATCTTTGG GTGCCCTGTA 840

GAGGGAGACT CAACATCATC TGAAACCTCA GCAAGACCAA GACCCCCAGG TCATCCTATG 900

AGTTCCTTTG GCCCAGACAG TAGACCACCA ATGGCAATTT TTGAACTGCT GGATTATATA 960

GTCAATGAGC CGCCTCCCAA ACTGCCCAGT AATGTTTTCA GTTCCGAATT CCAGGATTTT 1020

GTTAACAAAT GCTTAATAAA AAATCCAGCT GAGAGGGCAG ACTTGAAGCA GCTCATGGCT 1080

CAAGCTTTCA TTAAGAGATC AGACGCTGAA GAGGTGGATT TTGCAGGCTG GCTGTGTACA 1140

ACCATAGGCT TAAACCAACC TAGTACACCA ACACATGCTG CTGGAGTGTA A 1191

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61

         ek+ elGaGnggvV kv+hk+s+ i+a+K i+leik+++++qi+rel+vl+++ nspyiv

Q: 70    EKICELGAGNGGVVFKVSHKPSSLIMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV  128

         7899*************************************************.******

S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121

         +fyGaf+s+g++sicme+mdg+sld+vlkk    ++ripe++lgk+++av+k+l+yl+ek

Q: 129   GFYGAFYSDGEISICMEHMDGGSLDQVLKK----AGRIPEQILGKVSIAVIKGLTYLREK  184

         *****************************9....8*************************

S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181

         +ki+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv

Q: 185   HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSV  243

         ******************************************************.*****

S: 182   ksdvWslGltlvelatgrypyeklke..................................  207

         +sd+Ws+Gl+lve+a+gryp+++++

Q: 244   QSDIWSMGLSLVEMAVGRYPIPPPDPkeleqifgcpvegdstssetsarprppghpmssf  303

         **********************998889********************************

S: 208   .........ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkhaf  258

                  i+ell++ivne+ppklp++ fs+efq+fv+kCl+k+++eR++lk+l+++af

Q: 304   gpdsrppmaIFELLDYIVNEPPPKLPSNVFSSEFQDFVNKCLIKNPAERADLKQLMAQAF  363

         **********************************************************99

S: 259   i  259

Q: 364   I  364

Domain Sequence
(FASTA)

EKICELGAGN GGVVFKVSHK PSSLIMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60

FYGAFYSDGE ISICMEHMDG GSLDQVLKKA GRIPEQILGK VSIAVIKGLT YLREKHKIMH 120

RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS 180

MGLSLVEMAV GRYPIPPPDP KELEQIFGCP VEGDSTSSET SARPRPPGHP MSSFGPDSRP 240

PMAIFELLDY IVNEPPPKLP SNVFSSEFQD FVNKCLIKNP AERADLKQLM AQAFI 295

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013