EKS-LAC-00383

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00383

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	440.9	1.5E-132	269	518	250

Status

Unreviewed

Ensembl Protein

ENSLACP00000007324

UniProt Accession

H3ACF3;

Protein Name

Protein Synonyms/Alias

Gene Name

SRC

Gene Synonyms/Alias

SRC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000006496	ENSLACP00000007324	ENSLACT00000007384

Organism

Latimeria chalumnae

Functional Description

Protein Length

535

Protein Sequence
(FASTA)

MGSSKSKPKE PGQRSRSLDG AILSGTDSTN HGASSSQQSQ TPNKNAAADT ANPSSRDIAE 60

GKLFGGVSTS DTTSPQHSGQ MTGGVTTFVA LYDYESRTAT DLSFKKGERL QIVNNTEGDW 120

WLAHSLTSGK TGYIPSNYVA PSNSIQAEEW YFGKITRRES ERFLLNPENP RGTYLVRESE 180

TTKGAYCLSV SDFDSVKGLN VKHYKIRKLD SGGFYITSRT QFNSLQQLVA YYSKHADGLC 240

YRLTSICPTS KPQTQGLAKD AWEIPRESLR LDVKLGQGCF GEVWKGTWNG TTRVAIKTLK 300

PGTMSPEAFL QEAQVMKKLR HEKLVQLYAV VSEEPIYIVT EFMNRGSLLD FLKGEMGKYL 360

MLPQLVDMAA QIASGMAYVE RMNYVHRDLR AANILVGENL VCKVADFGLA RLIEDNEYTA 420

RQGAKFPIKW TAPEAALYGR FTIKSDVWSF GILLTELTTK GRVPYPGMVN REVLDQVERG 480

YRMHCPPECP ESLHDLMLQC WRKDPEERPT FEYLQSFLED YFTSTEPQYQ PGENL 535

Nucleotide Sequence
(FASTA)

ATGGGCAGCA GTAAGAGTAA ACCGAAAGAG CCTGGGCAGA GGAGCAGGAG TCTTGATGGT 60

GCCATCTTGT CTGGAACTGA TAGTACAAAC CATGGAGCCT CCTCATCTCA ACAGTCCCAG 120

ACTCCCAACA AAAATGCAGC AGCTGATACT GCCAATCCCT CCTCTCGGGA CATAGCTGAG 180

GGCAAACTGT TTGGAGGGGT CAGTACTTCA GACACGACAT CACCTCAGCA CTCAGGACAA 240

ATGACTGGTG GAGTTACCAC ATTTGTGGCA TTGTATGACT ATGAGTCCAG GACAGCAACT 300

GACCTCTCCT TTAAGAAGGG TGAACGGCTA CAGATTGTCA ACAACACGGA AGGGGACTGG 360

TGGCTTGCCC ACTCACTGAC CTCTGGAAAA ACAGGCTATA TTCCCAGCAA TTACGTAGCT 420

CCTTCTAACT CCATCCAAGC AGAAGAGTGG TATTTTGGGA AGATTACCCG TCGGGAATCT 480

GAGAGGTTTC TGCTGAATCC TGAAAACCCA CGAGGCACTT ACTTGGTCAG GGAGAGTGAA 540

ACTACTAAAG GTGCATATTG CCTTTCTGTC TCTGACTTCG ACAGTGTGAA AGGTTTGAAT 600

GTAAAACACT ATAAAATTCG TAAACTGGAC AGTGGTGGCT TCTACATTAC ATCTCGTACT 660

CAGTTTAACA GTCTGCAGCA ACTGGTGGCC TATTACTCAA AGCATGCTGA TGGCTTGTGT 720

TATCGGTTGA CGAGTATTTG TCCAACTTCC AAACCCCAAA CCCAGGGGCT AGCAAAGGAT 780

GCCTGGGAAA TCCCCAGGGA GTCACTCCGA CTGGACGTGA AGCTTGGGCA GGGTTGTTTT 840

GGAGAAGTCT GGAAGGGAAC CTGGAATGGC ACCACAAGGG TAGCAATCAA GACTTTGAAA 900

CCTGGAACCA TGTCTCCTGA AGCCTTTTTA CAGGAAGCTC AGGTCATGAA GAAACTTCGA 960

CATGAGAAAT TGGTACAGCT GTATGCTGTA GTCTCAGAAG AACCAATTTA CATTGTCACA 1020

GAGTTCATGA ACAGAGGAAG TTTATTGGAT TTCCTTAAAG GTGAAATGGG AAAATATTTG 1080

ATGCTTCCTC AACTGGTCGA CATGGCTGCT CAGATTGCAT CTGGCATGGC GTATGTAGAA 1140

CGAATGAACT ACGTCCACAG GGACCTCAGG GCAGCAAATA TCCTAGTGGG AGAGAACCTG 1200

GTCTGTAAAG TAGCTGACTT TGGCCTTGCT AGATTAATAG AGGACAATGA GTACACAGCT 1260

AGACAAGGTG CCAAGTTTCC TATCAAATGG ACAGCACCAG AGGCCGCTCT TTATGGCCGA 1320

TTTACAATAA AGTCTGATGT CTGGTCATTT GGAATCCTGT TGACAGAACT GACTACAAAG 1380

GGTAGAGTAC CCTATCCAGG GATGGTAAAC CGGGAAGTGT TGGACCAGGT GGAGCGTGGA 1440

TACAGAATGC ACTGTCCGCC AGAGTGCCCT GAATCTTTGC ATGACCTCAT GCTTCAGTGC 1500

TGGCGAAAGG ATCCTGAAGA GAGACCCACT TTTGAGTACC TGCAGTCCTT TCTAGAAGAT 1560

TATTTCACAT CTACGGAGCC TCAGTACCAG CCAGGGGAAA ACCTCTAG 1608

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l  klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly

Q: 269   LRLDVKLGQGCFGEVWKGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  328

         57889*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m++Gslldflk e gk+l lp+lvd+aaq+a+Gmay+e++n++hr

Q: 329   AVVSE-EPIYIVTEFMNRGSLLDFLKGEMGKYLMLPQLVDMAAQIASGMAYVERMNYVHR  387

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvge+lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 388   DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  447

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte++tkG+vPypGm n+evl+qvergyr+ +p ecpe+l++l+l+cw+kdpee

Q: 448   WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMHCPPECPESLHDLMLQCWRKDPEE  507

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq++l

Q: 508   RPTFEYLQSFL  518

         ********986

Domain Sequence
(FASTA)

LRLDVKLGQG CFGEVWKGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60

AVVSEEPIYI VTEFMNRGSL LDFLKGEMGK YLMLPQLVDM AAQIASGMAY VERMNYVHRD 120

LRAANILVGE NLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMHCPPE CPESLHDLML QCWRKDPEER 240

PTFEYLQSFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013