EKS-LAC-00158

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00158

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	543.2	1.1E-163	468	746	279

Status

Unreviewed

Ensembl Protein

ENSLACP00000007448

UniProt Accession

H3ACS7;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR2

Gene Synonyms/Alias

FGFR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000006604	ENSLACP00000007448	ENSLACT00000007510

Organism

Latimeria chalumnae

Functional Description

Protein Length

810

Protein Sequence
(FASTA)

FICLLLISNK FSPFPSPPFP LSPSLLNFAE LPTKHLISQP EVYSVYPGDL LQLHCQLKET 60

VKISWTKDGV QLRPNNRTVI IGEYLQIKNA TPKDSGLYAC TAIKTPDTHY FIVNVTDTIS 120

SGDDEDDNNG SEDIFADSNQ MKIGAPYWTQ PQKMEKKLHA VPAANTVKFR CPAAGNPTPS 180

LRWLRNGVEF KQENRIGGYK VRSQHWTLVM ESVVPSDKGN YTCIVENEFG SINHTYHLDV 240

VERSPHRPIL QAGLPANVTT IVGGNAKFEC KVYSDAQPHI QWLKHVEKNG SSYGPNGSSF 300

IQVLKTAGVN TTDKEIESLY LWNVTFEDAG EYTCLAGNSI GITFHSAWLT VLPEPGIKTG 360

ITSPDYLEIA IYCIGVFLIS CMVVTVIVCR MKSTAKKPDF NSQPAVHKLT KRIPLHRQVS 420

ADSSSSMNSN TPLVRITAHF SSDAPALAGV SEYELPEDPR WEFARDKLTL GKPLGEGCFG 480

QVVMAEALGV DKDKPKEATT VAVKMLKADD ATEKDLSDLV SEMEMMKMIG KHKNIINLLG 540

ACTQDGPLYV IVEFAAKGNL REYLRARRPP GMEYTFDILN RVPDEQLTFK DLLSCTYQVA 600

RGMEYLASQK CIHRDLAARN VLVTESNVMK IADFGLARDV HNIDYYKKTT NGRLPVKWMA 660

PEALFDRVYT HQSDVWSFGV LMWEIFTLGG SPYPGIPVEE LFKLLKEGHR MDKPANCTNE 720

LYMMMRDCWH AVPSQRPTFK QLVEDLDRIL TLTTNEEYLD LTTPLEQYSP SYPDTRSSCS 780

SGDDSVFSHD PTPDEPCIPK YQHMNGSVKT 810

Nucleotide Sequence
(FASTA)

TTTATATGCT TACTACTAAT ATCTAACAAA TTCTCTCCTT TTCCTTCTCC ACCCTTTCCA 60

CTCTCCCCTT CCCTCTTAAA CTTTGCAGAG CTGCCAACTA AACACCTAAT TTCTCAGCCA 120

GAAGTGTATT CAGTGTACCC TGGGGATCTT CTTCAGTTGC ATTGTCAGTT GAAAGAGACA 180

GTGAAGATCA GTTGGACTAA AGATGGGGTG CAATTGCGGC CCAACAATAG AACAGTCATT 240

ATTGGGGAGT ACTTGCAAAT TAAAAATGCT ACGCCCAAGG ATTCAGGCCT CTATGCTTGT 300

ACTGCTATTA AGACACCAGA TACCCATTAC TTCATTGTAA ATGTTACAGA CACAATCTCA 360

TCGGGGGATG ATGAAGATGA CAACAATGGC TCAGAGGACA TCTTTGCTGA TAGTAACCAG 420

ATGAAAATAG GAGCTCCGTA TTGGACACAG CCCCAAAAGA TGGAAAAAAA GCTGCATGCA 480

GTCCCAGCGG CAAACACAGT TAAATTCCGC TGTCCAGCTG CGGGAAACCC AACACCAAGT 540

CTGCGATGGT TAAGGAATGG CGTAGAGTTT AAGCAGGAAA ATCGGATAGG TGGATATAAG 600

GTTCGATCCC AGCATTGGAC TCTCGTTATG GAAAGTGTTG TCCCATCAGA TAAAGGAAAT 660

TATACTTGTA TAGTAGAGAA TGAATTTGGA TCAATCAACC ACACATATCA CTTAGATGTA 720

GTTGAGCGGT CACCACACAG ACCTATTCTC CAGGCTGGAC TCCCGGCAAA TGTCACTACA 780

ATTGTAGGAG GAAATGCAAA GTTTGAATGT AAAGTATACA GTGATGCTCA GCCTCATATC 840

CAGTGGTTAA AACATGTAGA AAAGAATGGC AGCAGTTATG GCCCTAATGG GTCTTCTTTT 900

ATTCAGGTTT TAAAGACTGC CGGGGTTAAC ACCACGGACA AGGAGATTGA GTCTCTCTAT 960

TTATGGAATG TTACTTTTGA GGATGCTGGG GAGTATACAT GCTTGGCGGG TAATTCTATT 1020

GGGATCACCT TTCACTCTGC ATGGTTGACA GTTCTGCCAG AGCCTGGAAT AAAAACAGGG 1080

ATTACCTCAC CTGACTACCT GGAGATAGCC ATCTACTGTA TTGGGGTCTT TCTCATCTCC 1140

TGTATGGTGG TGACAGTTAT TGTGTGTCGC ATGAAGAGTA CTGCCAAGAA GCCAGACTTC 1200

AACAGTCAGC CCGCAGTACA CAAGCTGACC AAGCGCATCC CCCTGCACAG ACAGGTTTCA 1260

GCAGACTCAA GCTCCTCAAT GAACTCAAAC ACTCCTTTAG TGAGGATAAC TGCCCATTTC 1320

TCCTCTGATG CACCAGCTCT AGCAGGTGTT TCTGAATATG AACTACCTGA AGATCCTAGA 1380

TGGGAATTTG CAAGAGATAA GTTGACACTG GGTAAACCCC TTGGGGAAGG CTGCTTTGGA 1440

CAAGTTGTCA TGGCTGAAGC TCTGGGAGTT GACAAAGACA AGCCCAAAGA AGCAACTACT 1500

GTGGCTGTGA AAATGCTGAA AGCAGATGAT GCTACAGAGA AAGATCTCTC TGATCTTGTG 1560

TCTGAGATGG AAATGATGAA GATGATAGGA AAGCACAAAA ATATAATTAA TCTTTTAGGA 1620

GCCTGCACAC AAGATGGGCC TTTATATGTA ATAGTTGAGT TTGCTGCTAA AGGTAACCTT 1680

CGTGAGTACT TGCGTGCACG GAGGCCTCCA GGGATGGAGT ACACTTTTGA TATTCTTAAT 1740

CGAGTTCCAG ATGAACAGTT GACATTCAAG GATTTGTTAT CATGCACTTA CCAGGTGGCA 1800

AGGGGTATGG AGTACCTCGC ATCACAAAAA TGCATTCATC GAGACTTGGC AGCTAGAAAT 1860

GTTTTAGTGA CAGAGAGTAA CGTAATGAAA ATTGCAGACT TTGGCTTGGC CAGAGATGTC 1920

CATAATATTG ATTATTACAA AAAAACAACA AATGGTCGTC TTCCTGTAAA ATGGATGGCT 1980

CCTGAAGCTC TTTTTGATAG AGTTTACACA CACCAAAGTG ATGTATGGTC ATTTGGTGTG 2040

CTAATGTGGG AGATCTTCAC ATTGGGGGGG TCTCCTTACC CAGGAATCCC AGTAGAGGAA 2100

CTTTTTAAGC TGCTGAAGGA GGGACACAGA ATGGACAAAC CTGCCAATTG CACGAATGAG 2160

CTATATATGA TGATGAGGGA CTGTTGGCAT GCTGTACCTT CCCAAAGACC AACTTTCAAA 2220

CAGCTGGTTG AAGACTTAGA CCGAATTCTA ACATTAACTA CCAATGAGGA ATATTTGGAC 2280

CTCACTACAC CTCTTGAACA GTATTCTCCC AGTTACCCTG ATACACGGAG TTCATGCTCT 2340

TCAGGAGATG ATTCTGTGTT TTCCCATGAT CCCACACCTG ATGAACCTTG TATTCCTAAA 2400

TACCAACATA TGAATGGCAG TGTCAAAACA TGA 2433

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlk.edatdkdladlvsemevlk  59

         l+lgk+lGeG+fGqvv+aea+g+dkdk+k+++tvavkmlk +dat+kdl+dlvseme++k

Q: 468   LTLGKPLGEGCFGQVVMAEALGVDKDKPKEATTVAVKMLKaDDATEKDLSDLVSEMEMMK  527

         79*************************************95579****************

S: 60    liGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdk.skaseeql  118

         +iGkhkniinllGactq+Gplyvive+aakGnlre+lrarrp+g+e++ d  +++++eql

Q: 528   MIGKHKNIINLLGACTQDGPLYVIVEFAAKGNLREYLRARRPPGMEYTFDIlNRVPDEQL  587

         *************************************************964799*****

S: 119   tekdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyyk  178

         t+kdl+s++yqvarGmeylas+kcihrdlaarnvlvte nv+kiadfGlardvh+idyyk

Q: 588   TFKDLLSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNVMKIADFGLARDVHNIDYYK  647

         ************************************************************

S: 179   kttnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllke  238

         kttnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllke

Q: 648   KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE  707

         ************************************************************

S: 239   Ghrmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         Ghrm+kpa+ct+ely++mr+cwha++s+rptfkqlvedl

Q: 708   GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  746

         *************************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA LGVDKDKPKE ATTVAVKMLK ADDATEKDLS DLVSEMEMMK 60

MIGKHKNIIN LLGACTQDGP LYVIVEFAAK GNLREYLRAR RPPGMEYTFD ILNRVPDEQL 120

TFKDLLSCTY QVARGMEYLA SQKCIHRDLA ARNVLVTESN VMKIADFGLA RDVHNIDYYK 180

KTTNGRLPVK WMAPEALFDR VYTHQSDVWS FGVLMWEIFT LGGSPYPGIP VEELFKLLKE 240

GHRMDKPANC TNELYMMMRD CWHAVPSQRP TFKQLVEDL 279

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013