EKS-LAC-00287

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00287

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	468.6	8.0E-141	204	491	288

Status

Unreviewed

Ensembl Protein

ENSLACP00000008196

UniProt Accession

H3AEX6;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1

Gene Synonyms/Alias

TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000007257	ENSLACP00000008197	ENSLACT00000008263
ENSLACG00000007257	ENSLACP00000008196	ENSLACT00000008262

Organism

Latimeria chalumnae

Functional Description

Protein Length

502

Protein Sequence
(FASTA)

MDGGARYYSL ALLSLLMGAA LPGTTALQCH CHHCTQNNLT CETDGLCLAS VTRTEEKVVY 60

NSMCIAREEL IPKDRPFICA PSSKDGISMV ADCCDTDFCN KVKPFPPLPA PTGRNTPSNL 120

GPVGLAAAIA GPVCVVCILL MLTLYICHNR SVIHQRVPNE EDPSLDRPFI SEGTTLKDLI 180

YDMTTSGSGS GLPLLVQRTI ARTIVLQESI GKGRFGEVWR GKWRGEEVAV KIFSSREERS 240

WFREAEIYQT VMLRHENILG FIAADNKDNG TWTQLWLVSD YHEHGSLFDY LNRHTVNVEG 300

MIKLALSTAS GLAHLHMEIV GTQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVRHDSA 360

TDTIDIAPNH RVGTKRYMAP EVLDDSINMK HFESFKRADI YAMGLVFWEV ARRCTSGGIH 420

EDYQLPYYDL VPSDPSVEEM RKVVCEQKLR PNIPNRWQSC EALRVMAKIM RECWYTNGAA 480

RLTALRVKKT LSQLSQQEGI KM 502

Nucleotide Sequence
(FASTA)

ATGGATGGCG GTGCCCGTTA TTATTCTCTC GCCTTATTGT CGCTGCTGAT GGGGGCCGCT 60

TTACCGGGGA CAACCGCATT ACAGTGTCAT TGCCACCACT GCACGCAAAA CAATCTGACC 120

TGTGAGACAG ATGGGCTGTG TCTTGCCTCG GTGACTCGAA CAGAAGAAAA AGTAGTGTAC 180

AACAGCATGT GCATAGCACG GGAAGAACTG ATTCCTAAAG ACAGGCCCTT CATCTGTGCA 240

CCCTCTTCCA AAGATGGAAT CAGTATGGTG GCTGACTGCT GTGACACGGA CTTCTGCAAT 300

AAAGTAAAAC CTTTTCCACC ATTGCCAGCC CCTACAGGAA GAAATACTCC CTCAAACTTG 360

GGCCCTGTGG GTTTAGCTGC AGCCATTGCT GGACCAGTCT GTGTCGTTTG TATTTTGCTC 420

ATGCTGACTC TGTACATCTG CCATAATCGC TCTGTAATTC ATCAGCGTGT TCCAAATGAA 480

GAAGATCCTT CCTTGGACCG GCCTTTCATC TCAGAGGGCA CCACCTTAAA AGATTTAATT 540

TATGACATGA CAACTTCTGG TTCTGGCTCA GGTTTGCCTC TACTTGTACA AAGGACAATT 600

GCAAGAACCA TTGTCCTGCA GGAGAGTATT GGGAAGGGCC GCTTTGGAGA GGTCTGGCGG 660

GGAAAGTGGA GAGGGGAAGA AGTTGCAGTG AAAATTTTCT CATCTCGGGA AGAGCGTTCT 720

TGGTTTCGTG AAGCAGAGAT TTACCAGACA GTGATGTTAA GACATGAAAA TATTCTTGGA 780

TTTATTGCAG CAGACAATAA AGATAATGGT ACCTGGACTC AGCTGTGGTT GGTATCAGAT 840

TATCATGAAC ATGGCTCCCT GTTTGACTAC CTTAACAGAC ACACAGTTAA TGTGGAGGGG 900

ATGATCAAAC TGGCTCTTTC CACAGCCAGT GGACTTGCAC ATCTGCATAT GGAGATTGTT 960

GGTACACAAG GCAAACCTGC TATTGCTCAT AGGGATCTGA AGTCCAAAAA CATTTTAGTA 1020

AAAAAGAATG GAACCTGCTG CATTGCAGAT TTAGGACTGG CAGTAAGACA TGATTCAGCT 1080

ACTGACACAA TTGACATTGC TCCAAACCAC AGAGTGGGAA CGAAAAGATA TATGGCCCCA 1140

GAGGTGCTTG ACGATTCTAT AAATATGAAG CATTTTGAGT CATTCAAGCG AGCTGACATC 1200

TATGCCATGG GTTTAGTATT CTGGGAAGTA GCTCGCAGAT GTACAAGTGG CGGAATCCAT 1260

GAAGACTATC AGCTGCCTTA TTATGACCTG GTACCTTCAG ATCCTTCAGT TGAGGAAATG 1320

AGGAAAGTAG TTTGCGAACA GAAGTTACGG CCAAACATTC CTAATAGGTG GCAGAGCTGT 1380

GAAGCGCTCC GTGTAATGGC CAAAATAATG CGCGAGTGTT GGTACACCAA TGGGGCAGCC 1440

CGGCTGACAG CTTTACGTGT GAAGAAAACA CTATCACAAC TGAGTCAACA GGAAGGCATA 1500

AAAATGTAA 1509

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 204   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  263

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 264   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRHTVNVEGMIKLALSTASGLAHLHMEIVGTQ  323

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 324   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  381

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WEva+Rc++ ++++e+y+lp+++ v+sdPs+eem

Q: 382   VLDDSINMKHFESFKRADIYAMGLVFWEVARRCTS-GGIHEDYQLPYYDLVPSDPSVEEM  440

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+klrP+ip++w+++eal++++k+++ecW+++++aRltalrvkk+l

Q: 441   RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYTNGAARLTALRVKKTL  491

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR HTVNVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEVARR CTSGGIHEDY QLPYYDLVPS DPSVEEMRKV 240

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYTNGAARLT ALRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013