EPS-LAC-00021

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-LAC-00021

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	103.2	1.3E-29	4	139	136

Status

Unreviewed

Ensembl Protein

ENSLACP00000008316

UniProt Accession

H3AF95;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP12

Gene Synonyms/Alias

DUSP12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000007360	ENSLACP00000008316	ENSLACT00000008382

Organism

Latimeria chalumnae

Functional Description

Protein Length

308

Protein Sequence
(FASTA)

MISVRAGLFL GTVADLSDSE RLNEAGITHV LTVDSEEPSP LPGLRHKFVF ALDEAGTDLL 60

SALDDCVDFI QNALATGRAA VLVHCHAGVS RCAAVVTAYL MKKEQLAFQD AYNKVQSVKP 120

DVKVNDEFVR QLELYEAMGC EVDRTSIAYK QYRLQKVTEK YPELQNLPPE VFAADPTAGN 180

QVQTSEALYR CRKCRRSLFR GSSILSHTFG TGPVAFAHKR MVPQVSGGDN KKCTSYFIEP 240

VQWMEPALIG VMDGQLLCPK CSSKLGSFSW YGEQCSCACW VTPAFQIHKN RVDEVKQMQI 300

PGLQKGSG 308

Nucleotide Sequence
(FASTA)

ATGATTTCTG TGCGGGCTGG GTTGTTCCTG GGGACAGTGG CAGATCTGTC GGACTCTGAG 60

CGGCTGAATG AGGCTGGAAT CACCCACGTC CTCACCGTCG ATTCTGAGGA GCCTAGCCCG 120

CTGCCTGGCC TCCGCCACAA GTTTGTTTTC GCCCTGGATG AGGCTGGCAC TGACCTGCTG 180

AGTGCGCTGG ATGACTGTGT GGATTTCATC CAGAATGCGC TGGCCACAGG CAGAGCTGCA 240

GTCCTGGTCC ACTGTCATGC AGGAGTGAGT CGATGTGCTG CTGTAGTCAC AGCATATTTA 300

ATGAAGAAGG AGCAGCTGGC TTTTCAAGAT GCTTATAATA AAGTCCAGAG TGTGAAGCCA 360

GATGTCAAAG TGAATGATGA GTTTGTGCGT CAGCTGGAAC TGTACGAAGC CATGGGTTGC 420

GAGGTGGATC GGACGAGCAT TGCCTATAAA CAGTATCGTT TGCAGAAAGT CACTGAAAAA 480

TACCCTGAGC TACAGAACTT GCCGCCTGAG GTATTTGCAG CCGATCCTAC AGCTGGCAAC 540

CAAGTCCAGA CGAGTGAAGC TCTGTACAGA TGTAGGAAGT GTCGCCGGTC CTTATTCCGA 600

GGTTCCAGCA TCTTAAGTCA CACATTTGGA ACTGGACCTG TGGCCTTTGC CCATAAAAGA 660

ATGGTTCCCC AAGTAAGCGG TGGGGACAAC AAGAAGTGCA CATCATATTT TATTGAGCCA 720

GTGCAGTGGA TGGAGCCAGC ATTGATTGGA GTTATGGATG GGCAGCTTCT GTGTCCGAAG 780

TGCAGTTCGA AGTTGGGTTC CTTCAGCTGG TACGGAGAGC AGTGCTCTTG CGCTTGCTGG 840

GTGACTCCGG CCTTTCAGAT TCACAAGAAT CGTGTAGATG AGGTCAAGCA AATGCAGATC 900

CCGGGACTTC AGAAAGGAAG CGGCTGA 927

Domain Profile

S: 5     ilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvdDsd  64

         + +gl+lg  a+  d   L+++git+v+++  +          l   g + k + + D+

Q: 4     VRAGLFLGTVADLSDSERLNEAGITHVLTVDSEEPS------PL--PGLRHKFVFALDEA  55

         789**************************9988777......33..5778889999****

S: 65    vtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAieav  123

          tdll+ +d +++fi++a  + + +vlvHC+aGvsR a++v+aYLmk e+l+++dA+++v

Q: 56    GTDLLSALDDCVDFIQNAlATGRAAVLVHCHAGVSRCAAVVTAYLMKKEQLAFQDAYNKV  115

         ******************7778899***********************************

S: 124   krkrpsiepnegfleQLlelekkl  147

         ++ +p ++ n++f++QL ++e ++

Q: 116   QSVKPDVKVNDEFVRQLELYEAMG  139

         *********************997

Domain Sequence
(FASTA)

VRAGLFLGTV ADLSDSERLN EAGITHVLTV DSEEPSPLPG LRHKFVFALD EAGTDLLSAL 60

DDCVDFIQNA LATGRAAVLV HCHAGVSRCA AVVTAYLMKK EQLAFQDAYN KVQSVKPDVK 120

VNDEFVRQLE LYEAMG 136

Keyword

Complete proteome; Hydrolase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0004725	; F:protein tyrosine phosphatase activity
GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0035335	; P:peptidyl-tyrosine dephosphorylation

KEGG

InterPros

IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR016278	; DUSP12.
IPR000387	; Tyr/Dual-specificity_Pase.
IPR016130	; Tyr_Pase_AS.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS00383	; TYR_PHOSPHATASE_1; 1.
PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

Created Date

20-Feb-2013