EKS-LAC-00154

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00154

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Csk	438.3	7.4E-132	195	440	246

Status

Unreviewed

Ensembl Protein

ENSLACP00000008750

UniProt Accession

H3AGI0;

Protein Name

Protein Synonyms/Alias

Gene Name

CSK

Gene Synonyms/Alias

CSK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000007735	ENSLACP00000008750	ENSLACT00000008818
ENSLACG00000007735	ENSLACP00000008751	ENSLACT00000008819

Organism

Latimeria chalumnae

Functional Description

Protein Length

450

Protein Sequence
(FASTA)

MSGIQEIWAS GTECIAKYNF QGAASQDLPF SKGDVLTIVG VTKDPNWYRA KNRVDREGII 60

PANYVQKREG VRSSTKLSLM PWFHGKIPRD QAERLLYPPE TGLFLVREST NYPGDYTLCV 120

SCDGKVEHYR IIYSSSKLTI DEEEYFDNLM QLVEHYTKDA DGLCTRLIKP KVMEGTVAAQ 180

DEFLRSGWAL NRKDLQLFQT IGKGEFGDVV LGEYKGNKVA VKCIKNDATA QAFIAEASVM 240

TQLCHENLVR LWGVILEDRG CLFIVTEYMA KGSLVDYLRS RGRSVLGSDC LLNFTFDVCK 300

AMEYLEDNNF VHRDLAARNV LVSENSKAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE 360

KKFSTKSDVW SYGILLWEIF SFGRVPYPRI ALKDVVPRVE KGYKMDSPDG CPSTVYELMK 420

QCWTLDTAKR PSFKQLKEQL EHIIENKLYL 450

Nucleotide Sequence
(FASTA)

ATGTCTGGAA TACAGGAAAT TTGGGCGTCT GGCACAGAAT GCATAGCCAA ATACAATTTC 60

CAAGGGGCAG CATCGCAAGA CCTTCCCTTC AGCAAAGGAG ATGTCCTCAC TATCGTCGGG 120

GTAACAAAGG ATCCAAACTG GTACAGAGCA AAAAACCGAG TTGACCGTGA AGGTATAATC 180

CCAGCTAACT ATGTGCAAAA AAGGGAAGGA GTGAGGTCCA GCACAAAACT CAGTCTCATG 240

CCCTGGTTTC ATGGGAAGAT CCCCCGCGAC CAAGCGGAGA GACTGCTGTA TCCCCCCGAG 300

ACCGGATTGT TTCTCGTGCG GGAGAGCACC AACTACCCCG GGGACTACAC GCTGTGCGTC 360

AGCTGTGATG GCAAGGTGGA ACATTACCGC ATCATCTACT CCTCTAGCAA ATTGACCATT 420

GATGAAGAAG AGTACTTTGA CAACCTCATG CAGCTTGTAG AGCACTATAC CAAAGACGCA 480

GACGGACTGT GTACCCGACT CATCAAGCCC AAAGTGATGG AAGGCACGGT GGCTGCCCAG 540

GATGAATTCT TAAGAAGCGG CTGGGCACTG AATCGGAAAG ATCTTCAGCT GTTCCAGACC 600

ATCGGGAAAG GAGAGTTTGG AGATGTGGTG CTGGGGGAAT ACAAAGGCAA TAAGGTAGCA 660

GTCAAGTGCA TTAAGAATGA TGCCACGGCG CAGGCCTTTA TCGCAGAGGC CTCAGTAATG 720

ACGCAGCTCT GTCATGAGAA TCTGGTTCGA CTCTGGGGTG TGATCCTGGA AGACCGAGGG 780

TGTCTCTTTA TAGTAACAGA GTATATGGCA AAGGGCAGCT TAGTAGATTA TCTGAGATCA 840

AGAGGGCGGT CTGTGTTGGG TAGCGACTGT CTTTTAAACT TTACTTTCGA TGTTTGCAAA 900

GCGATGGAAT ACCTGGAAGA CAATAACTTT GTCCACCGAG ATCTGGCTGC TCGGAATGTC 960

CTGGTCTCAG AAAACAGCAA AGCCAAAGTT AGCGATTTTG GTCTCACGAA AGAAGCTTCG 1020

TCCACACAAG ACACGGGGAA GTTACCAGTG AAGTGGACAG CACCAGAAGC ACTTCGAGAA 1080

AAGAAATTTT CTACAAAGTC AGATGTATGG AGTTATGGAA TCCTCTTGTG GGAAATCTTT 1140

TCATTTGGCC GGGTGCCCTA TCCCAGAATT GCTCTGAAGG ACGTGGTTCC CCGGGTAGAG 1200

AAAGGGTACA AAATGGACTC CCCGGACGGC TGTCCCAGCA CGGTGTACGA GCTGATGAAG 1260

CAGTGCTGGA CCCTGGACAC GGCCAAGCGA CCCTCCTTCA AGCAGTTAAA GGAACAGTTA 1320

GAACATATCA TCGAAAACAA GCTGTACCTT TAA 1353

Domain Profile

S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60

         l+l +tigkgefgdv+lgey+g+kvavk+ikndataqaf++easvmt+l henlv+l gv

Q: 195   LQLFQTIGKGEFGDVVLGEYKGNKVAVKCIKNDATAQAFIAEASVMTQLCHENLVRLWGV  254

         6899********************************************************

S: 61    ileek.glylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrd  119

         ile++  l++vtey+akgslvdylrsrgr++l++++ll+f++dv+++meyle +++vhrd

Q: 255   ILEDRgCLFIVTEYMAKGSLVDYLRSRGRSVLGSDCLLNFTFDVCKAMEYLEDNNFVHRD  314

         ****9779****************************************************

S: 120   laarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgi  179

         laarnvlvse+  akvsdfgl+ke+s+++d+gklpvkwtapeal+ekkfstksdvws+gi

Q: 315   LAARNVLVSENSKAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSYGI  374

         ************************************************************

S: 180   llweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfa  239

         llweifsfgrvpypri+lkdvv++vekgykm++p+gcp++vyelmk++w l++akrpsf+

Q: 375   LLWEIFSFGRVPYPRIALKDVVPRVEKGYKMDSPDGCPSTVYELMKQCWTLDTAKRPSFK  434

         ************************************************************

S: 240   klkekl  245

         +lke+l

Q: 435   QLKEQL  440

         ***997

Domain Sequence
(FASTA)

LQLFQTIGKG EFGDVVLGEY KGNKVAVKCI KNDATAQAFI AEASVMTQLC HENLVRLWGV 60

ILEDRGCLFI VTEYMAKGSL VDYLRSRGRS VLGSDCLLNF TFDVCKAMEY LEDNNFVHRD 120

LAARNVLVSE NSKAKVSDFG LTKEASSTQD TGKLPVKWTA PEALREKKFS TKSDVWSYGI 180

LLWEIFSFGR VPYPRIALKD VVPRVEKGYK MDSPDGCPST VYELMKQCWT LDTAKRPSFK 240

QLKEQL 246

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013