EKS-LAC-00322

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00322

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	356.7	8.2E-107	270	521	252

Status

Unreviewed

Ensembl Protein

ENSLACP00000008886

UniProt Accession

H3AGW5;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK1

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000007848	ENSLACP00000008886	ENSLACT00000008955

Organism

Latimeria chalumnae

Functional Description

Protein Length

545

Protein Sequence
(FASTA)

MSDNGEVEDK PPAPPMRNTS TMIGSSSKDS GTLNHGSKPL PPNPEEKKKK DRSIRSIFPG 60

AGDKTNKKKE KERPEISLPS DFEHTIHVGF DAVTGEFTGM PEQWARLLQT SNITKSEQKK 120

NPQAVLDVLK FYDSKETSNS QKYMSFTDKT TDGYNSLNTL NAKAVSESPA VPPVSEDDDE 180

DDVTPPPVIA PRPEHTKSVY TRSVIDPIPL PPTKDAATSP ISPSSENSTT PSNTLQRNAE 240

KQRKKTKMSD EEILEKLRSI VSVGDPKKKY TRFEKIGQGA SGTVYTAIDI ATGQEVAIKQ 300

MNLQQQPKKE LIINEILVMR ENKNPNIVNY LDSYLVGDEL WVVMEYLAGG SLTDVVTETC 360

MDEGQIAAVC RECLQALEFL HSNQVIHRDI KSDNILLGMD GSVKLTDFGF CAQITPEQSK 420

RSTMVGTPYW MAPEVVTRKA YGPKVDIWSL GIMAIEMIEG EPPYLNENPL RALYLIATNG 480

TPELQNPEKL SSIFRDFLNR CLEMDVEKRG SAKELLQHPF LKLAKPLASL TPLIIAAKEA 540

AKSNR 545

Nucleotide Sequence
(FASTA)

ATGTCTGATA ATGGTGAAGT TGAAGACAAG CCTCCAGCCC CACCTATGAG AAACACCAGC 60

ACCATGATTG GCAGCAGCAG CAAAGACTCG GGGACCCTAA ACCACGGTTC CAAACCTCTC 120

CCTCCGAATC CCGAGGAGAA GAAAAAGAAA GACCGGTCCA TCCGATCCAT CTTCCCGGGA 180

GCTGGAGATA AAACTAATAA GAAGAAGGAA AAAGAGCGAC CCGAAATCTC CTTGCCATCG 240

GATTTTGAGC ATACAATACA TGTTGGCTTT GATGCAGTCA CAGGGGAGTT CACTGGTATG 300

CCGGAACAGT GGGCCCGATT GCTACAAACC TCAAACATTA CAAAGTCCGA GCAGAAGAAA 360

AACCCGCAGG CGGTTCTAGA TGTCTTAAAA TTCTACGATT CAAAAGAGAC TTCCAATAGC 420

CAAAAATACA TGAGTTTTAC AGATAAGACT ACAGATGGCT ATAACTCATT AAATACACTG 480

AATGCAAAAG CTGTATCCGA GTCCCCTGCT GTTCCACCAG TATCGGAGGA TGATGATGAA 540

GATGATGTCA CTCCTCCTCC AGTGATAGCA CCTCGTCCAG AACACACTAA ATCGGTCTAT 600

ACCCGCTCTG TGATAGACCC TATTCCCCTG CCTCCCACCA AAGACGCAGC CACCTCTCCA 660

ATCTCCCCAT CTTCTGAAAA CAGCACAACA CCATCCAACA CCCTACAGAG AAATGCAGAG 720

AAACAGAGGA AGAAGACCAA GATGTCCGAT GAGGAGATTC TAGAAAAACT AAGAAGTATA 780

GTCAGTGTGG GAGATCCTAA GAAGAAATAT ACGAGGTTTG AAAAGATTGG ACAGGGGGCG 840

TCGGGGACAG TGTACACAGC AATAGATATA GCGACAGGAC AAGAGGTTGC AATCAAACAG 900

ATGAATTTAC AACAGCAGCC CAAGAAAGAG TTGATCATTA ATGAAATTCT TGTAATGAGG 960

GAAAACAAGA ACCCAAACAT TGTAAATTAT TTAGACAGTT ATCTTGTAGG GGATGAATTG 1020

TGGGTGGTTA TGGAGTACCT GGCAGGAGGG TCTTTAACGG ATGTCGTCAC TGAAACCTGT 1080

ATGGATGAAG GGCAGATAGC AGCTGTGTGC CGAGAGTGTC TGCAAGCACT GGAGTTCCTT 1140

CATTCAAACC AGGTCATTCA CAGAGACATC AAAAGTGACA ACATTCTGCT GGGGATGGAC 1200

GGCTCTGTGA AACTAACTGA TTTTGGTTTC TGCGCTCAGA TTACACCGGA GCAGAGTAAA 1260

CGAAGCACAA TGGTCGGCAC ACCTTACTGG ATGGCTCCTG AAGTGGTAAC TCGGAAAGCG 1320

TATGGGCCAA AAGTAGACAT CTGGTCACTG GGAATCATGG CGATTGAGAT GATTGAAGGA 1380

GAACCGCCTT ACCTAAATGA AAACCCTCTC CGAGCATTAT ATCTTATTGC TACCAATGGT 1440

ACGCCGGAGC TTCAGAACCC AGAGAAGCTT TCATCCATAT TCAGAGATTT CTTGAACCGC 1500

TGTCTTGAAA TGGATGTGGA AAAGAGAGGC TCTGCTAAGG AGCTGCTCCA GCACCCATTC 1560

CTAAAGTTGG CAAAGCCTCT CGCCAGTCTG ACTCCACTGA TCATAGCCGC AAAAGAGGCA 1620

GCAAAAAGCA ACCGTTAA 1638

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         y+ +e+ig+Ga+g+vy+a ++ tg+ vaik++nl++q+k+e++++ei v+++ k+pniv+

Q: 270   YTRFEKIGQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVN  329

         7889********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         yl+s+l+ +elw+vmeylagGsl+d+v+   ++ ++E qia+++re+l+aLe+lHs++vi

Q: 330   YLDSYLVGDELWVVMEYLAGGSLTDVVT---ETCMDEGQIAAVCRECLQALEFLHSNQVI  386

         ****************************...9****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180

         Hrdik++niLl ++g+VkL+dfg++aq++ +++kr+t+vgtpywmAPEv++  +k Y  k

Q: 387   HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT--RKAYGPK  444

         ***************************************************..9******

S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240

         +DiwslGI+aie++egepP+ +++pl+al++i++n +p+l++++k+s+ f++f+++cl+

Q: 445   VDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSSIFRDFLNRCLEM  504

         ************************************************************

S: 241   npekRpsasellkhkFl  257

         ++ekR sa+ell+h+Fl

Q: 505   DVEKRGSAKELLQHPFL  521

         ****************7

Domain Sequence
(FASTA)

YTRFEKIGQG ASGTVYTAID IATGQEVAIK QMNLQQQPKK ELIINEILVM RENKNPNIVN 60

YLDSYLVGDE LWVVMEYLAG GSLTDVVTET CMDEGQIAAV CRECLQALEF LHSNQVIHRD 120

IKSDNILLGM DGSVKLTDFG FCAQITPEQS KRSTMVGTPY WMAPEVVTRK AYGPKVDIWS 180

LGIMAIEMIE GEPPYLNENP LRALYLIATN GTPELQNPEK LSSIFRDFLN RCLEMDVEKR 240

GSAKELLQHP FL 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013