EKS-LAC-00501

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00501

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	381.4	1.9E-114	18	272	255

Status

Unreviewed

Ensembl Protein

ENSLACP00000008927

UniProt Accession

H3AH06;

Protein Name

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000007884	ENSLACP00000008927	ENSLACT00000008996

Organism

Latimeria chalumnae

Functional Description

Protein Length

892

Protein Sequence
(FASTA)

MLPLKDAEIG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKAVTH PRLCQYIDIT 60

RGKHERLVVV AEHYENSLEE LLKEGNPVSC AKILHIAYEA LEGLEYMNKH GLVHRALSPQ 120

NILMDREGHI KLAKFGLYHM TAHGADVDFP IGYPSYLAPE VIAQGIRKPT DHSQSEKCLP 180

SGPKSDVWSL GIILFELCVG RKVLQNIDLS ERLKFIITLG CVDDIVTVLA EEHGCHDTIK 240

ELPENIIALL RKCLSFQPSQ RPTAAALLHD SVLSTVSPLH KPYQRPASLF SSSLRCADLT 300

LPEDISELCK GLPSKFFFFK SLASVHVCVC VGGNLEIEIL MKKIISCRGG TLCIVNFLLE 360

DGESFGQGRD RSFLLDHTTV TLSLCQLRNR LKDVAGETFY PLLEDDQSSL PQSSSSNELS 420

AAAALPLIIR ERDTEYQLHR IILFDRLLKA YPYKKNQVWK EARVDVPPPV RGLTWAALLG 480

VEGDIQARYD AIDKDTPIPT DRQIEVDIPR CHQYDELLSS PEGHTKFRRV LKAWVVSHPN 540

LVYWQGLDSL CAPFLYLNFN NEALAYACMS AFIPKYLYNF FLKDNSHVIQ EYLTVFSQMI 600

AFHDPELSNH LNEIGFIPDL YAIPWFLTMF THVFPLHKIF HLWDTLLLGN SSFPFCIGVA 660

ILQQLRDRLL ANGFNECILL FSDLPEVDIE RCVRESINLF CWTPKSATYR QHGQPPKPAP 720

ENGGVSRTAS YYSADYQDMP KTDLSREAVK LIELKTEVTP RISAEDLIDL CELTGPCLYK 780

TPTKKTKSSK PKLLVVDIRN SEDFNRGHIS GSINIPYSLA FGADGDLVQC AATTTLQSFK 840

GRVIVIVGLV MKNAASFAAH LVKLGYPRVC ILDGGINKMK PTGLLTVPSP QI 892

Nucleotide Sequence
(FASTA)

ATGCTGCCAT TAAAAGATGC CGAAATTGGG GCCTTCACCT TCTTTGCTTC AGCGCTTCCG 60

CATGACGTGT GCGGGAGCAA TGGCCTTCCC CTCACACCCA ACTCCATCAA AATCCTGGGA 120

CGCTTCCAAA TCTTGAAGGC TGTCACCCAC CCCAGGCTTT GCCAGTATAT AGACATCACC 180

AGGGGTAAAC ATGAACGGCT GGTGGTGGTT GCGGAACATT ATGAAAATAG TCTTGAAGAG 240

TTGCTGAAGG AGGGGAACCC TGTAAGCTGT GCGAAGATCC TCCATATAGC CTATGAGGCA 300

CTAGAAGGGT TGGAATACAT GAACAAACAC GGGCTGGTTC ACAGAGCATT GTCTCCGCAG 360

AATATTCTCA TGGATCGAGA GGGTCATATT AAGCTGGCAA AGTTCGGGTT GTATCACATG 420

ACTGCCCACG GTGCTGATGT AGACTTTCCC ATTGGGTACC CATCATACTT GGCACCTGAG 480

GTCATTGCCC AGGGTATTAG GAAGCCCACC GATCATAGCC AGAGTGAGAA GTGTCTTCCC 540

TCGGGGCCCA AGTCTGACGT GTGGTCTCTT GGTATAATAC TGTTTGAACT CTGTGTGGGA 600

AGAAAAGTGT TGCAGAACAT AGATCTGTCT GAAAGGCTGA AGTTTATAAT TACATTAGGT 660

TGTGTTGATG ACATAGTGAC GGTGCTGGCT GAAGAGCATG GCTGCCATGA TACAATTAAG 720

GAATTACCTG AAAACATTAT CGCTCTGTTG AGGAAATGCC TTAGTTTCCA GCCATCCCAA 780

AGGCCTACTG CAGCTGCATT GCTTCATGAC AGTGTACTCA GCACGGTGTC CCCTTTGCAT 840

AAACCCTACC AGAGACCTGC CAGTCTGTTT TCCTCTTCTC TGAGATGTGC TGACTTAACA 900

CTCCCCGAGG ACATCAGTGA GCTTTGTAAA GGGCTGCCTT CAAAATTCTT TTTCTTTAAA 960

TCTCTTGCCT CTGTGCATGT GTGTGTGTGT GTGGGAGGGA ACCTTGAAAT TGAAATACTG 1020

ATGAAAAAAA TTATATCCTG CAGAGGTGGT ACTCTCTGCA TAGTAAATTT TCTGTTGGAA 1080

GATGGTGAAA GCTTTGGACA AGGAAGAGAC AGAAGTTTCC TTTTAGATCA CACGACAGTC 1140

ACTTTATCCC TGTGCCAGCT GAGAAACAGA CTTAAAGACG TTGCTGGAGA AACATTCTAT 1200

CCTTTGTTGG AAGACGATCA ATCAAGCCTG CCCCAGTCGA GCAGTAGCAA TGAACTGTCT 1260

GCAGCTGCCG CTTTACCCCT CATTATCCGT GAGAGGGACA CGGAGTACCA GCTCCACCGA 1320

ATCATTTTGT TTGATAGACT GTTAAAGGCT TACCCTTACA AGAAGAATCA AGTCTGGAAG 1380

GAAGCAAGAG TTGATGTTCC TCCTCCAGTC AGAGGCTTGA CTTGGGCTGC TTTGCTCGGA 1440

GTAGAGGGAG ACATTCAAGC AAGATATGAT GCCATTGATA AGGATACTCC TATCCCTACT 1500

GATCGGCAGA TTGAGGTGGA TATTCCACGC TGCCATCAGT ATGATGAGCT GCTGTCATCA 1560

CCAGAGGGCC ATACGAAGTT CAGGCGGGTA TTGAAAGCCT GGGTAGTCTC CCATCCTAAT 1620

CTAGTCTACT GGCAAGGGCT GGATTCCCTG TGTGCGCCAT TCCTCTATTT AAACTTTAAT 1680

AATGAAGCTT TAGCTTATGC CTGTATGTCT GCTTTTATTC CCAAGTACCT GTATAACTTC 1740

TTTTTAAAGG ACAACTCGCA TGTTATTCAG GAGTACCTGA CGGTATTTTC TCAGATGATT 1800

GCTTTCCATG ACCCAGAACT AAGTAACCAT CTCAATGAGA TTGGCTTCAT TCCAGATCTG 1860

TACGCTATTC CATGGTTTCT CACAATGTTT ACACATGTGT TTCCATTGCA CAAGATTTTC 1920

CATCTATGGG ATACTCTGCT CTTGGGAAAC TCCTCCTTTC CTTTCTGTAT CGGGGTGGCC 1980

ATCCTGCAGC AGCTGAGAGA CAGACTGCTG GCCAATGGGT TCAACGAGTG CATCCTTCTC 2040

TTCTCTGATT TACCAGAAGT TGATATTGAG CGCTGCGTCC GAGAGTCCAT TAACCTTTTC 2100

TGTTGGACAC CAAAGAGCGC CACCTACAGA CAGCACGGTC AGCCGCCCAA ACCTGCTCCT 2160

GAGAACGGTG GGGTCAGCAG GACTGCTTCT TACTATTCTG CAGACTATCA GGACATGCCA 2220

AAGACGGACC TGTCTCGTGA AGCAGTAAAG TTGATTGAAC TGAAAACTGA GGTGACACCC 2280

CGTATTTCTG CAGAAGACTT GATTGACCTG TGTGAGCTGA CTGGACCCTG CCTCTACAAG 2340

ACCCCCACCA AGAAAACGAA ATCCAGCAAG CCCAAACTGC TAGTGGTTGA CATTCGCAAC 2400

AGTGAGGACT TCAACCGTGG CCATATTTCT GGCAGCATAA ATATTCCTTA CAGTTTAGCA 2460

TTTGGAGCAG ACGGTGACTT GGTTCAGTGT GCTGCTACCA CCACTCTGCA GAGCTTCAAG 2520

GGGAGAGTCA TCGTCATTGT TGGACTTGTG ATGAAAAACG CAGCCAGTTT TGCAGCTCAT 2580

CTGGTGAAAC TGGGTTACCC ACGCGTCTGT ATCCTAGACG GAGGCATCAA CAAGATGAAG 2640

CCAACTGGCT TGCTGACTGT GCCCTCTCCG CAGATTTGA 2679

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk ++h+rLcqY+di+rgkher++vvaeh+e s

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKAVTHPRLCQYIDITRGKHERLVVVAEHYENS  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         Le+llke++pvs++++l+iaye l+gl+y+nkh++vhral+p++il+dr+g+ +kLak+G

Q: 78    LEELLKEGNPVSCAKILHIAYEALEGLEYMNKHGLVHRALSPQNILMDREGH-IKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+ta+G+dvdfpigy+sylaPe+i+q+         ++k l++++ksDvWsLg+il+e

Q: 137   LYHMTAHGADVDFPIGYPSYLAPEVIAQGirkptdhsqSEKCLPSGPKSDVWSLGIILFE  196

         ************************************************************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l++g+k+ +++dlserlk++ +l++vd+ + +laee++c+d ik+l+e+++all+kCL++

Q: 197   LCVGRKVLQNIDLSERLKFIITLGCVDDIVTVLAEEHGCHDTIKELPENIIALLRKCLSF  256

         ************************************************************

S: 232   lpskRpspdellkekv  247

          ps+Rp+   ll++ v

Q: 257   QPSQRPTAAALLHDSV  272

         ***********99987

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKA VTHPRLCQYI DITRGKHERL VVVAEHYENS 60

LEELLKEGNP VSCAKILHIA YEALEGLEYM NKHGLVHRAL SPQNILMDRE GHIKLAKFGL 120

YHMTAHGADV DFPIGYPSYL APEVIAQGIR KPTDHSQSEK CLPSGPKSDV WSLGIILFEL 180

CVGRKVLQNI DLSERLKFII TLGCVDDIVT VLAEEHGCHD TIKELPENII ALLRKCLSFQ 240

PSQRPTAAAL LHDSV 255

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013