EKS-LAC-00480
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LAC-00480
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK329.81.5E-9822312291
StatusUnreviewed
Ensembl ProteinENSLACP00000022074
UniProt AccessionH3AH38;
Protein Name
Protein Synonyms/Alias
Gene NameMAPK4
Gene Synonyms/Alias MAPK4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLACG00000007912ENSLACP00000008960ENSLACT00000009029
ENSLACG00000007912ENSLACP00000008959ENSLACT00000009028
ENSLACG00000007912ENSLACP00000022074ENSLACT00000026089
OrganismLatimeria chalumnae
Functional Description
Protein Length578
Protein Sequence
(FASTA)
MAEKCDCIAN IHGYDLGGRF VEFKALGYGA NGLVLSAVDS KRCQKVAVKK ISVGDSQSMK 60
HALREIKIIR RLDHENVVKV FDVLGPQGAD LPGDVYKISV AYIVQEHMET DLARLLEQGP 120
LTEDHAKLFV YQLLRGLKYI HSANVLHRDL KPANIFINTE DLVLKIGDFG LARIVDQHYS 180
HKGYLSEGLV TKWYRSPRLL LSPNNYTKAI DMWATGCILA EMLTGRMLFA GADELEQMQL 240
FLETIPVIRE EDKEELLKVM PTYINSTWEV KRPLRKLLAE VSGEAIDFLG KILTFNPMDR 300
LTAEVALEHP YMSPYCCPED EPTAQHPFRI EDEIDDILLM EGSQSQISNW ERYPSSLSSD 360
LDWLRDKYND MSDVQRDPRA GSGSIVEEVQ VDPRKYSQSS SERFLEQSHS SMDRVCEMDY 420
GRSCDYKVGS PSYLDKLLWR DNKPHHYSEP KLILDLSHWK RTTIPPSGGI LLEEERSDLF 480
LEITHWVAST QSRLECHSPL PEIQEHSRPS SPRDPGSKEI SNGAQSQFDL DVFISRALKL 540
CGKSEDLADS KVSEINGACI SEHPNEIVKA EVYKKKRW 578
Nucleotide Sequence
(FASTA)
ATGGCGGAGA AGTGTGACTG TATTGCCAAC ATACATGGCT ATGACTTAGG TGGCCGCTTT 60
GTAGAGTTCA AAGCCTTGGG CTATGGTGCC AATGGGTTGG TTCTCTCCGC TGTTGACAGT 120
AAAAGGTGCC AGAAAGTGGC GGTGAAGAAG ATCTCTGTTG GCGATTCCCA GAGCATGAAG 180
CACGCCTTGC GAGAGATCAA GATCATCCGC AGGCTAGACC ACGAAAATGT CGTGAAGGTG 240
TTTGATGTGC TCGGGCCACA AGGTGCTGAC CTCCCAGGGG ATGTTTATAA GATCAGCGTG 300
GCATACATAG TCCAAGAACA CATGGAGACA GACCTAGCCC GACTTTTGGA GCAGGGACCT 360
TTAACCGAGG ACCATGCCAA GCTCTTCGTG TACCAGCTGC TCCGTGGGCT GAAATACATA 420
CACTCAGCAA ATGTGCTGCA CAGGGACCTC AAACCGGCCA ACATTTTCAT TAACACTGAA 480
GACTTGGTTC TCAAGATTGG AGACTTTGGA CTGGCAAGGA TTGTGGATCA ACATTATTCA 540
CATAAAGGCT ACCTGTCTGA AGGGCTGGTG ACAAAATGGT ACCGGTCTCC ACGCCTCCTC 600
CTCTCCCCCA ACAACTACAC CAAAGCAATT GACATGTGGG CCACCGGGTG CATCCTGGCT 660
GAAATGCTAA CCGGGAGGAT GCTATTTGCT GGTGCCGATG AGCTGGAACA AATGCAGTTG 720
TTTTTGGAGA CGATCCCTGT CATCCGAGAA GAGGACAAGG AGGAGCTCCT CAAGGTCATG 780
CCAACCTACA TCAACAGCAC GTGGGAGGTG AAGAGACCTC TGAGAAAACT GCTTGCTGAA 840
GTAAGTGGAG AAGCCATTGA TTTCCTGGGG AAGATCCTGA CCTTTAACCC AATGGATCGG 900
CTAACCGCTG AGGTCGCCCT GGAGCATCCC TATATGAGCC CTTATTGTTG CCCCGAGGAC 960
GAGCCGACGG CACAGCACCC CTTCAGGATC GAGGATGAGA TTGACGATAT CTTGCTGATG 1020
GAAGGCAGCC AGAGCCAGAT CTCCAACTGG GAGAGGTATC CCTCAAGTCT GTCTTCTGAT 1080
TTGGATTGGC TGCGTGATAA GTATAATGAC ATGAGTGATG TGCAGCGAGA CCCAAGGGCA 1140
GGTTCCGGGT CCATTGTAGA GGAGGTCCAG GTGGATCCCC GCAAGTATTC CCAAAGCAGC 1200
TCAGAGCGGT TCCTGGAGCA GTCCCACTCT TCCATGGACC GGGTATGTGA AATGGATTAC 1260
GGTCGATCTT GTGATTATAA AGTTGGATCT CCGTCATACC TCGACAAGCT TCTGTGGAGA 1320
GACAACAAGC CCCACCACTA CTCTGAGCCC AAGCTTATCT TAGACTTGTC CCACTGGAAA 1380
AGGACCACCA TACCACCCTC TGGGGGCATC CTGCTTGAGG AAGAACGTTC AGACCTCTTT 1440
CTGGAGATTA CCCATTGGGT GGCAAGCACC CAGTCAAGGC TCGAGTGTCA CAGCCCTCTT 1500
CCAGAGATCC AGGAGCACAG TCGACCATCT TCCCCTCGTG ACCCAGGGTC CAAAGAAATT 1560
AGCAACGGGG CGCAATCTCA GTTTGACTTG GATGTTTTTA TTTCCAGGGC ATTGAAGCTA 1620
TGTGGGAAAT CTGAGGACCT AGCAGATAGC AAAGTCAGTG AGATAAATGG GGCCTGCATC 1680
TCAGAGCACC CTAATGAAAT TGTTAAAGCA GAGGTCTACA AAAAGAAGAG GTGGTAG 1737
Domain Profile
S: 3     slkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiik  62
         + k lg Ga+g+v+savd+++ ++va+kk+s    +++s+k++lRE+k++++l+heN++k
Q: 22    EFKALGYGANGLVLSAVDSKRCQKVAVKKIS--VGDSQSMKHALREIKIIRRLDHENVVK  79
         6789***************************..99*************************
S: 63    lldvftpee.....eleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglky  117
         ++dv+ p+      ++ +++  Y+v+e metdL++++++  l+++h+kl++yq+lrglky
Q: 80    VFDVLGPQGadlpgDVYKISVAYIVQEHMETDLARLLEQGPLTEDHAKLFVYQLLRGLKY  139
         ********988888999*******************************************
S: 118   lHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwYraPei  174
         +Hsanv+HrDlKP+N+++n++   lki dFGlar+ d+++++k  l+e ++t+wYr+P++
Q: 140   IHSANVLHRDLKPANIFINTEDLvLKIGDFGLARIVDQHYSHKgyLSEGLVTKWYRSPRL  199
         *******************876449**************999999***************
S: 175   llslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiese  234
         lls ++ytka+D+W+ GCIlaE+ltg++lf+g+de++q+++ le+++  +ee+ +++ + 
Q: 200   LLSPNNYTKAIDMWATGCILAEMLTGRMLFAGADELEQMQLFLETIPVIREEDKEELLKV  259
         **********************************************************95
S: 235   earnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289
          + +yi+s+++ k+ ++++l+ + s ea+d+l k+L+++p++R+++e aLehpY+
Q: 260   -MPTYINSTWEVKR-PLRKLLAEVSGEAIDFLGKILTFNPMDRLTAEVALEHPYM  312
         .*********9988.9**************************************7
Domain Sequence
(FASTA)
EFKALGYGAN GLVLSAVDSK RCQKVAVKKI SVGDSQSMKH ALREIKIIRR LDHENVVKVF 60
DVLGPQGADL PGDVYKISVA YIVQEHMETD LARLLEQGPL TEDHAKLFVY QLLRGLKYIH 120
SANVLHRDLK PANIFINTED LVLKIGDFGL ARIVDQHYSH KGYLSEGLVT KWYRSPRLLL 180
SPNNYTKAID MWATGCILAE MLTGRMLFAG ADELEQMQLF LETIPVIREE DKEELLKVMP 240
TYINSTWEVK RPLRKLLAEV SGEAIDFLGK ILTFNPMDRL TAEVALEHPY M 291
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00440
EKS-ANC-00458
EKS-BOT-00472
EKS-CAJ-00477
EKS-CAF-00471
EKS-CAP-00503
EKS-DAR-00882
EKS-EQC-00459
EKS-FEC-00449
EKS-GAM-00277
EKS-GAA-00574
EKS-GOG-00460
EKS-HOS-00479
EKS-ICT-00446
EKS-LOA-00476
EKS-MAM-00468
EKS-MIM-00087
EKS-MOD-00464
EKS-MUM-00503
EKS-MUP-00463
EKS-MYL-00464
EKS-NOL-00429
EKS-OCP-00123
EKS-ORN-00596
EKS-ORA-00404
EKS-ORC-00446
EKS-ORL-00543
EKS-OTG-00479
EKS-PAT-00442
EKS-PES-00414
EKS-POA-00457
EKS-RAN-00485
EKS-SAH-00441
EKS-SUS-00412
EKS-TAR-00587
EKS-TEN-00586
EKS-XET-00620
EKS-XIM-00588
Gene Ontology
GO:0005524; F:ATP binding
GO:0004707; F:MAP kinase activity
GO:0000165; P:MAPK cascade
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR008350; MAPK_ERK3/4.
IPR000719; Prot_kinase_cat_dom.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR01771; ERK3ERK4MAPK.
Created Date20-Feb-2013