EKS-LAC-00168

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00168

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	615.6	1.1E-185	437	716	280

Status

Unreviewed

Ensembl Protein

ENSLACP00000009084

UniProt Accession

H3AHG3;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK2

Gene Synonyms/Alias

TLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000008019	ENSLACP00000009084	ENSLACT00000009153

Organism

Latimeria chalumnae

Functional Description

Protein Length

747

Protein Sequence
(FASTA)

SHQTIYAVSP MRVCLLMNVF LFQGPVNDSS NQSLCSVGSL SDKELETPEK KQNDQRNRKR 60

KAEPFDASQG KGTPRGHKIS DYFEFAGGSG PGTSPGRSVP PVARSSPQHS LSNPSPSAIC 120

QQLFNHSQAS LLHYRGLFTL ISTTISYAYC PPPPKKKQKN FKTHGLIMNF NTLKNPQGSP 180

SSVGSGNTDY SCSSQRQISL QHKLTQSDLT MEKLAALENN KNSDLEKKEG RIDDLLRANC 240

DLRRQIDEQQ KMLERYKERL NRCVTMSRKL LIEKSKQEKM ACRDKSMQDR LRLGHFTTVR 300

HGASFTEQWT DGYAFQNLIK QQERINAQRE DIERQRKLLA KRKPPAMGQT PPANNEQKPR 360

KNKTNGAENE TLSLAEYHEQ EEIFKLRLGH LKKEEAEIQA ELERLERVRN LHIRELKRIH 420

NEDNSQFKDH PTLNDRYLLL HLLGRGGFSE VYKAFDLTEQ RYVAVKIHQL NKNWRDEKKE 480

NYHKHACREY RIHKELDHPR IVKLYDYFSL DTDSFCTVLE YCEGNDLDFY LKQHKLMSEK 540

EARSIIMQIV SALKYLNEIK PPIIHYDLKP GNILLVNGTA CGEIKITDFG LSKIMDDDSY 600

NSVDGMELTS QGAGTYWYLP PECFVVGKEP PKISNKVDVW SVGVIFYQCL YGRKPFGHNQ 660

SQQDILQENT ILKATEVQFP PKPVVTPEAK AFTRRCLAYR KEDRIDVQLL ASDPYLMPHI 720

RKSVSSNAPA GAAIASTSGS SSSSVSN 747

Nucleotide Sequence
(FASTA)

TCCCATCAGA CCATCTATGC AGTATCACCA ATGAGAGTTT GCTTGTTGAT GAATGTCTTT 60

CTCTTTCAGG GTCCAGTCAA TGATTCCTCC AACCAGAGTT TGTGCAGCGT GGGCTCTCTG 120

AGTGACAAGG AGTTAGAGAC TCCTGAGAAG AAGCAGAATG ATCAGAGAAA CAGGAAAAGA 180

AAAGCAGAAC CTTTTGATGC TAGTCAAGGA AAGGGCACAC CCAGGGGACA TAAAATAAGT 240

GATTACTTTG AGTTTGCTGG TGGCAGTGGT CCAGGTACCA GTCCGGGTAG GAGTGTCCCG 300

CCAGTTGCCC GGTCATCACC CCAACATTCC TTATCAAACC CTTCACCTTC TGCTATATGT 360

CAACAACTGT TCAATCATAG CCAAGCTTCC CTCTTGCATT ACAGGGGTCT GTTTACCCTC 420

ATTAGCACAA CAATTTCGTA TGCTTATTGC CCCCCCCCCC CCAAAAAAAA ACAAAAAAAC 480

TTCAAAACAC ATGGTCTCAT TATGAATTTT AACACATTAA AAAATCCGCA AGGCAGCCCA 540

TCTTCTGTAG GATCTGGGAA CACCGATTAT TCCTGCAGTT CCCAGAGACA GATCTCTCTC 600

CAGCACAAAC TGACACAGTC TGACCTCACA ATGGAAAAGC TAGCAGCCCT AGAAAACAAC 660

AAGAACTCTG ACCTGGAGAA GAAAGAGGGC AGGATAGACG ATTTATTAAG GGCAAACTGT 720

GACCTAAGAC GACAGATAGA TGAACAACAA AAGATGCTGG AGAGATATAA AGAACGGTTA 780

AATAGATGTG TCACCATGAG TAGGAAGCTG CTAATAGAAA AGTCTAAACA AGAGAAGATG 840

GCATGTCGAG ATAAAAGCAT GCAGGACCGG CTGAGGCTGG GACACTTTAC TACAGTCAGG 900

CATGGAGCCT CCTTTACTGA ACAGTGGACA GATGGATATG CATTTCAGAA CCTCATCAAA 960

CAACAAGAGC GAATCAATGC ACAAAGAGAG GACATTGAGC GCCAGCGAAA GCTCCTAGCA 1020

AAACGAAAAC CACCAGCCAT GGGTCAAACC CCACCTGCAA ATAATGAGCA GAAACCACGC 1080

AAAAACAAAA CCAATGGTGC AGAAAATGAA ACATTATCAT TAGCAGAGTA CCATGAACAG 1140

GAGGAGATTT TTAAGCTCCG GTTAGGTCAT CTGAAAAAGG AAGAGGCAGA GATACAGGCT 1200

GAGCTGGAGC GGCTGGAGAG AGTCCGAAAT CTCCACATCC GGGAACTCAA AAGGATACAC 1260

AATGAAGATA ACTCTCAATT TAAAGATCAT CCAACACTAA ATGACAGGTA CCTGTTGTTA 1320

CATCTGCTAG GTAGAGGTGG TTTTAGCGAG GTATATAAGG CCTTTGATTT AACAGAACAA 1380

AGATATGTAG CTGTGAAGAT TCACCAGTTA AATAAAAACT GGAGAGATGA GAAAAAAGAG 1440

AATTATCACA AACATGCCTG TAGAGAATAC CGAATTCATA AAGAACTGGA TCATCCTCGG 1500

ATAGTAAAGC TATATGATTA CTTTTCACTC GATACAGACT CGTTTTGTAC TGTACTGGAG 1560

TACTGTGAGG GAAACGACTT AGATTTCTAC CTGAAACAGC ACAAGTTGAT GTCTGAGAAA 1620

GAAGCACGCT CTATCATTAT GCAGATAGTC AGTGCACTGA AATACCTGAA TGAGATTAAG 1680

CCACCCATTA TCCACTATGA TCTTAAACCA GGTAACATTT TGCTTGTAAA TGGTACAGCG 1740

TGTGGTGAAA TCAAAATCAC AGATTTTGGT CTCTCAAAGA TCATGGATGA TGACAGTTAC 1800

AATTCAGTGG ATGGAATGGA GTTGACGTCA CAAGGAGCTG GAACTTACTG GTATTTGCCT 1860

CCAGAGTGCT TTGTGGTTGG GAAGGAGCCC CCTAAGATCT CTAATAAAGT AGATGTTTGG 1920

TCAGTAGGAG TCATCTTCTA CCAGTGTCTG TATGGACGGA AGCCATTTGG CCATAACCAA 1980

TCCCAGCAGG ACATTCTGCA GGAGAACACC ATTCTTAAAG CTACAGAGGT GCAGTTCCCT 2040

CCCAAACCAG TTGTCACTCC TGAAGCCAAG GCATTTACAC GACGTTGCCT GGCATACCGG 2100

AAGGAGGACC GGATAGATGT GCAGCTGCTG GCTTCTGACC CCTACCTGAT GCCTCACATC 2160

CGGAAGTCTG TGTCAAGCAA TGCTCCTGCA GGGGCAGCCA TAGCATCTAC TTCTGGATCA 2220

TCCAGTAGCA GTGTTTCAAA CTGA 2244

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqryvavkihqlnk+w+dekkeny+kha+reyrihkel

Q: 437   YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL  496

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtdsfctvley+egndldfylkqhkl+sekearsiimqivsalkyl

Q: 497   DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVSALKYL  556

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy+s+dg+eltsqgagty

Q: 557   NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY  616

         ************************************************************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvifyqclyg+kpfghnqsqqdil+entilkate

Q: 617   WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE  676

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvv++eakaf rrclayrkedridvq la+d+yl

Q: 677   VQFPPKPVVTPEAKAFTRRCLAYRKEDRIDVQLLASDPYL  716

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LTEQRYVAVK IHQLNKNWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDSFC TVLEYCEGND LDFYLKQHKL MSEKEARSII MQIVSALKYL 120

NEIKPPIIHY DLKPGNILLV NGTACGEIKI TDFGLSKIMD DDSYNSVDGM ELTSQGAGTY 180

WYLPPECFVV GKEPPKISNK VDVWSVGVIF YQCLYGRKPF GHNQSQQDIL QENTILKATE 240

VQFPPKPVVT PEAKAFTRRC LAYRKEDRID VQLLASDPYL 280

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013