EKS-LAC-00290

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00290

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	443.6	3.4E-133	153	441	289

Status

Unreviewed

Ensembl Protein

ENSLACP00000009358

UniProt Accession

H3AI87;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1C

Gene Synonyms/Alias

ACVR1C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000008255	ENSLACP00000009358	ENSLACT00000009429

Organism

Latimeria chalumnae

Functional Description

Protein Length

453

Protein Sequence
(FASTA)

DGACRTSVML TNGKEEVIKS CVSLPELNAQ VFCHSSNNVT KIECCFTDFC NNITLRLSTG 60

KNNIKIWGPV QLTAIIAVPV CLLSLALMVT VFTCHGRQRA NTKAKKHSLE EVLPDHTFIS 120

SGKSLKDLIC DLTTSGSGSG LPLLVQRTIA RTIVLQEIVG KGRFGEVWRG KWRGEDVAVK 180

IFSTRDERSW FREAEIYQTV MLRNENILGF IAADNKVDNG TWTQLWLVSD YHEHGSLFDY 240

LNRYTVTLDG VIKLSLSIAS GLAHLHMEIV GTQGKPAIAH RDFKSKNILV KSNGTCAIAD 300

LGLAVKHDLE TNTVDIPLNH RVGTKRYMAP EILDDTINTS IFESFKRADI YSLGLVYWEI 360

ARRCSIEGSI HEEYQLPYYD LVPSDPSVED MRKTVCEQKL RPNIPNQWQS YETLRVMGKV 420

MCECWYANSA ARLTALRIKK TVSQLSTQED MKI 453

Nucleotide Sequence
(FASTA)

GATGGCGCAT GCAGGACATC AGTCATGCTA ACTAATGGCA AAGAAGAGGT GATAAAGTCC 60

TGTGTATCTC TTCCTGAACT GAATGCTCAA GTCTTTTGTC ATAGCTCTAA TAATGTGACA 120

AAAATAGAAT GCTGTTTCAC AGACTTTTGC AACAACATAA CACTCCGCCT ATCTACAGGT 180

AAAAATAATA TAAAAATTTG GGGACCAGTG CAGCTAACAG CAATAATAGC TGTACCAGTT 240

TGTCTCCTGT CTTTGGCTTT AATGGTAACT GTCTTTACTT GTCATGGCAG ACAGCGTGCC 300

AATACCAAAG CCAAAAAGCA CAGTTTGGAA GAAGTCTTAC CTGACCACAC CTTTATAAGT 360

TCTGGGAAAA GTCTGAAAGA TCTTATTTGT GATCTAACCA CATCTGGCTC AGGATCAGGT 420

TTACCATTAC TTGTCCAAAG AACTATAGCA CGGACAATAG TTCTTCAAGA AATAGTTGGA 480

AAGGGTCGTT TTGGTGAAGT CTGGCGTGGG AAGTGGCGTG GGGAAGATGT GGCTGTGAAA 540

ATCTTCTCTA CTAGAGATGA AAGGTCTTGG TTTAGGGAGG CAGAGATTTA CCAAACTGTC 600

ATGCTAAGGA ATGAAAATAT CTTGGGATTT ATTGCTGCTG ACAACAAAGT AGATAATGGA 660

ACGTGGACTC AGCTATGGCT AGTGTCTGAC TACCATGAGC ATGGATCACT GTTTGACTAC 720

TTGAATCGAT ACACTGTGAC CTTAGATGGT GTTATAAAGC TATCCCTGTC AATAGCCAGT 780

GGACTAGCAC ATCTGCATAT GGAGATAGTT GGTACACAAG GTAAACCTGC TATTGCCCAT 840

CGAGACTTCA AATCCAAAAA TATTTTAGTA AAAAGCAATG GAACTTGTGC CATTGCTGAT 900

CTTGGTCTGG CTGTAAAACA TGATTTAGAA ACAAACACAG TCGATATACC TCTAAATCAC 960

CGAGTGGGAA CAAAACGGTA TATGGCTCCA GAGATACTAG ATGATACCAT AAACACAAGC 1020

ATCTTTGAGT CATTCAAGCG TGCTGATATA TATTCCCTGG GTCTGGTGTA TTGGGAGATA 1080

GCACGAAGGT GTTCAATTGA AGGTAGTATC CATGAAGAGT ACCAGTTGCC TTATTATGAT 1140

TTGGTACCTT CTGATCCTTC AGTAGAAGAC ATGAGAAAAA CTGTTTGTGA GCAGAAGCTT 1200

AGACCAAACA TTCCAAACCA GTGGCAAAGC TATGAGACCC TCCGAGTCAT GGGTAAAGTA 1260

ATGTGTGAAT GTTGGTATGC AAATTCAGCA GCTCGACTGA CAGCGCTCCG CATTAAGAAG 1320

ACTGTTTCTC AGCTTAGCAC ACAAGAAGAC ATGAAAATCT AG 1362

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e++gkGr+geVw++k+rge+vAvKifst+de+sw+rE+eiyqtv+lr enil+fia

Q: 153   IVLQEIVGKGRFGEVWRGKWRGEDVAVKIFSTRDERSWFREAEIYQTVMLRNENILGFIA  212

         5789********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

         ad+  +++++t+l+lv++yhe+gsL+dyL+r+t++++ +++l ls+asGlahLH+eivgt

Q: 213   ADNkVDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTLDGVIKLSLSIASGLAHLHMEIVGT  272

         ***99*******************************************************

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         +g  KpaiaHRD+kskNilvk+++tc+iaDlGLa+k++ e++++d+  n++vGtkRYmaP

Q: 273   QG--KPAIAHRDFKSKNILVKSNGTCAIADLGLAVKHDLETNTVDIPLNHRVGTKRYMAP  330

         **..********************************************************

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         E+l++++n++ fe+fkraD+YslgLv+WE+a+Rc+ +++++eey+lp+++ v+sdPs+e+

Q: 331   EILDDTINTSIFESFKRADIYSLGLVYWEIARRCSIEGSIHEEYQLPYYDLVPSDPSVED  390

         ************************************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         m+++v+e+klrP+ip++w++ e+l+++ k++ ecW+a+++aRltalr+kk+

Q: 391   MRKTVCEQKLRPNIPNQWQSYETLRVMGKVMCECWYANSAARLTALRIKKT  441

         *************************************************98

Domain Sequence
(FASTA)

IVLQEIVGKG RFGEVWRGKW RGEDVAVKIF STRDERSWFR EAEIYQTVML RNENILGFIA 60

ADNKVDNGTW TQLWLVSDYH EHGSLFDYLN RYTVTLDGVI KLSLSIASGL AHLHMEIVGT 120

QGKPAIAHRD FKSKNILVKS NGTCAIADLG LAVKHDLETN TVDIPLNHRV GTKRYMAPEI 180

LDDTINTSIF ESFKRADIYS LGLVYWEIAR RCSIEGSIHE EYQLPYYDLV PSDPSVEDMR 240

KTVCEQKLRP NIPNQWQSYE TLRVMGKVMC ECWYANSAAR LTALRIKKT 289

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013