EKS-LAC-00220

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00220

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	451.5	9.7E-136	13	297	285

Status

Unreviewed

Ensembl Protein

ENSLACP00000021928

UniProt Accession

H3AIY0;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL5

Gene Synonyms/Alias

CDKL5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000008468	ENSLACP00000021928	ENSLACT00000026107
ENSLACG00000008468	ENSLACP00000009601	ENSLACT00000009675
ENSLACG00000008468	ENSLACP00000009602	ENSLACT00000009676

Organism

Latimeria chalumnae

Functional Description

Protein Length

992

Protein Sequence
(FASTA)

MKIPDIGNVM NKFEVLGIVG EGAYGVVLKC RHKETNEIVA IKKFKDSEEN EEVKETTLRE 60

LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL EEMPNGVPPE KVRNYIYQLI 120

KAIHWCHKND IVHRDIKPEN LLISHNDILK LCDFGFARNL SEGSNANYTE YVATRWYRSP 180

ELLLGAPYGK AVDMWSVGCI LGELSDGQPL FPGESEIDQL FTIQRVLGPL SPEQMKLFYS 240

NPRFHGLRFP AVSHPQTLER RYLGIISGVL LDLMKNLLKL NPSERYLTDQ SLNHPAFQTQ 300

RLLDRSGSSS PARSTKRKPY HVENSTLSNR NPASKGAGMQ SHHRSNSKDM QTLGVGLQRG 360

EDVLPTDNFL NGNVVVNALS PTLHTKNYQQ TNRTPSGNRD LGGNLPHLLS PKEAKAKTEF 420

DFNLDQKGSD GPGAKYLKST SRSQQSRHTF LDVSQNRTGT LQPSDKHNRH SYIDAVQGNM 480

SQSSKNVMSY LTLSKSHGVL TDSKSVGNLI DARGQLEEAN SRYFPSSCLD LNSSTSPTPP 540

RHTDNRTSLS PSGRNNARMD GTLDSRRPPN RHPKTIEEIK LPAEHIEGGH SHSLSAPHES 600

FPYGLGYTSP FSSQQRPHRH SMYVTRDRPR VQGSEGGLNI GQGMPSRASS LQLLSPQLQH 660

RTLARHSVGS SREDCADDIS RNDQPSVEMS HSRPSIKDSN RDNAALFQRQ KSEVGGYHEN 720

HPEDGSSTKE NRHMYTDAVP RRVGSFYRVP SPRPEGTFLD NPVSTRAPVL PPEGNSMSNH 780

SKRQTTFDSW KTSEDVVLSN PPEPGKGKEK QGFFRAIKKK KKKSQTMPSS DGQDRLALQK 840

AIRSSSHQSS RQKDWRSEKA ADVQTQSQPL KSLRKLLHLS TPSNHSAPSE LRFQPLPSQP 900

TKASFTEGRI HPAVQTPSTN VRQDTQSKSR QTFQLPGQLE PTWHIPPVNR TGSDGTSFSD 960

QMASKTGQNG HSFNRTGRLR MPNLNDLKET AL 992

Nucleotide Sequence
(FASTA)

ATGAAGATTC CTGACATTGG TAATGTGATG AATAAATTTG AGGTCCTTGG GATTGTAGGT 60

GAAGGTGCCT ATGGTGTGGT ACTAAAATGC AGGCACAAGG AGACAAATGA AATTGTGGCC 120

ATCAAGAAGT TTAAAGACAG TGAAGAAAAT GAAGAAGTCA AAGAAACAAC CCTGCGAGAG 180

CTTAAGATGC TTCGTACGCT AAAGCAAGAA AATATAGTGG AACTTAAGGA AGCTTTTAGA 240

AGAAGAGGAA AACTTTACTT AGTGTTTGAA TATGTGGAAA AGAATATGCT TGAATTACTT 300

GAAGAAATGC CAAATGGGGT TCCACCCGAG AAAGTAAGAA ACTATATCTA CCAGCTAATC 360

AAGGCAATTC ACTGGTGCCA CAAGAATGAC ATTGTTCATA GAGATATCAA GCCAGAGAAT 420

CTCCTAATCA GCCACAATGA CATTCTGAAA CTGTGCGACT TTGGTTTTGC TCGGAATTTG 480

TCAGAAGGCA GTAATGCAAA CTACACAGAA TATGTGGCCA CCAGGTGGTA CCGTTCACCA 540

GAGTTGTTGC TTGGAGCACC CTACGGAAAG GCTGTAGATA TGTGGTCTGT GGGTTGTATT 600

CTTGGGGAAC TGAGTGATGG GCAGCCCCTC TTTCCAGGAG AAAGTGAAAT TGACCAGCTT 660

TTCACCATCC AGAGGGTGCT AGGACCACTG TCGCCAGAGC AGATGAAACT TTTCTACAGC 720

AACCCTCGCT TTCATGGATT ACGGTTTCCA GCAGTCAGCC ATCCTCAGAC CCTTGAAAGA 780

AGATATCTGG GAATAATTAG TGGAGTTTTG CTAGATCTCA TGAAGAATTT GTTAAAATTG 840

AATCCATCCG AGAGATATCT GACAGATCAA AGTTTGAACC ACCCTGCGTT TCAAACCCAG 900

AGACTGCTTG ATCGTTCTGG AAGCTCATCG CCTGCACGGT CAACTAAGAG AAAACCTTAC 960

CATGTGGAAA ACAGCACTTT ATCAAACAGA AATCCTGCAA GCAAAGGGGC AGGCATGCAG 1020

TCCCATCACA GATCAAACAG TAAGGACATG CAGACCTTGG GAGTTGGCTT ACAGAGAGGG 1080

GAAGACGTTC TTCCTACTGA CAACTTTTTA AATGGAAATG TAGTTGTGAA TGCACTTAGC 1140

CCAACATTGC ACACAAAGAA CTATCAGCAG ACCAACCGAA CGCCATCTGG CAACAGGGAT 1200

CTAGGTGGCA ACTTGCCGCA TCTTCTCAGC CCAAAGGAAG CGAAAGCAAA AACAGAATTT 1260

GATTTTAACT TGGACCAAAA GGGCTCAGAT GGTCCAGGGG CAAAATACCT GAAGTCCACT 1320

TCACGCTCAC AGCAAAGTAG ACATACCTTT CTGGATGTAT CGCAAAACAG AACTGGAACC 1380

CTGCAGCCTA GTGATAAACA CAATCGCCAC AGCTATATAG ATGCAGTGCA GGGAAATATG 1440

TCTCAGTCCT CCAAGAATGT CATGTCATAT TTGACACTAT CAAAAAGTCA TGGTGTTCTA 1500

ACTGATTCAA AGTCTGTAGG GAACCTCATT GATGCCAGAG GTCAACTGGA GGAGGCAAAC 1560

TCTAGATACT TCCCATCCAG CTGCTTGGAT CTGAATTCCT CAACCAGCCC TACGCCACCT 1620

CGGCACACAG ATAATAGAAC TTCATTAAGT CCATCTGGGA GGAATAATGC TAGAATGGAT 1680

GGTACTCTCG ACTCTCGCAG GCCACCAAAC AGACATCCCA AAACCATTGA GGAGATCAAG 1740

CTACCTGCTG AGCACATAGA AGGTGGGCAT TCCCATTCGC TGTCTGCTCC ACATGAGTCT 1800

TTTCCCTATG GATTGGGTTA CACAAGCCCC TTCTCTTCTC AGCAGCGTCC TCATAGGCAC 1860

TCTATGTATG TAACCAGGGA CAGACCACGA GTGCAGGGCT CAGAGGGGGG CTTGAACATA 1920

GGGCAAGGAA TGCCTTCAAG AGCAAGCAGC TTACAGCTCC TTTCCCCACA GCTTCAGCAT 1980

AGGACACTCG CCAGACATTC TGTGGGATCC TCTCGTGAAG ACTGTGCAGA TGATATCAGC 2040

AGGAATGACC AACCCTCAGT GGAAATGAGC CACTCCAGAC CATCAATCAA GGATTCCAAC 2100

AGAGATAATG CAGCGTTATT TCAACGCCAA AAGTCTGAGG TTGGGGGTTA TCATGAGAAT 2160

CATCCAGAGG ACGGATCATC CACAAAAGAG AATAGACATA TGTATACAGA TGCTGTCCCT 2220

CGAAGAGTTG GGAGCTTTTA TAGAGTTCCA TCTCCACGAC CTGAGGGAAC ATTCCTTGAT 2280

AATCCTGTGT CGACCAGGGC ACCTGTGCTG CCACCAGAGG GCAATTCCAT GTCAAACCAC 2340

TCGAAAAGAC AGACAACCTT TGATTCATGG AAGACTTCTG AGGATGTTGT CCTCAGCAAC 2400

CCCCCTGAGC CAGGGAAAGG AAAAGAAAAG CAGGGGTTTT TCAGAGCAAT AAAAAAGAAG 2460

AAGAAAAAAT CCCAAACAAT GCCTAGTAGC GATGGACAGG ATCGACTTGC ATTGCAGAAA 2520

GCCATCCGTT CTTCCAGCCA TCAGAGTAGC AGGCAGAAAG ACTGGCGCTC TGAGAAAGCA 2580

GCAGACGTCC AGACTCAGAG CCAGCCTTTG AAATCTCTTC GAAAGCTTCT ACATCTTTCT 2640

ACTCCATCGA ATCACTCTGC TCCCTCTGAA CTACGCTTTC AGCCTTTACC TAGCCAGCCA 2700

ACCAAAGCTT CCTTCACTGA AGGTCGAATT CACCCTGCTG TTCAGACTCC TAGCACCAAT 2760

GTACGCCAGG ACACTCAGTC CAAAAGCAGA CAGACCTTTC AGCTTCCTGG CCAGTTAGAA 2820

CCAACTTGGC ACATTCCTCC AGTAAACAGG ACTGGTAGTG ATGGGACTTC CTTTTCTGAC 2880

CAGATGGCCT CCAAGACTGG CCAGAACGGC CACAGTTTTA ACAGGACAGG CCGTCTGAGA 2940

ATGCCAAATT TGAATGACCT AAAAGAGACA GCTCTGTAG 2979

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         +e lg vGeG+yGvvlkcr+k+t++ivaikkf++se+++evk+++lre+k+l++lk+en+

Q: 13    FEVLGIVGEGAYGVVLKCRHKETNEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI  72

         799*********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         v+l+e+frr+ klylvfeyv+k++l+ le++pnGv+ e+v++++yq++kai++chkn+i+

Q: 73    VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVRNYIYQLIKAIHWCHKNDIV  132

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarlla.apgdvytdyvatrwyrapellvgdtkyGks  179

         hrdikpen+lis+++++klcdfGfar+l+ +++++yt+yvatrwyr+pell+g + yGk+

Q: 133   HRDIKPENLLISHNDILKLCDFGFARNLSeGSNANYTEYVATRWYRSPELLLG-APYGKA  191

         ****************************98999********************.9*****

S: 180   vdvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpe  239

         vd+w++Gc+l el++G+plfpg+s++dql++i+++lG+l+p+++k+f++n++f+G+++p+

Q: 192   VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQRVLGPLSPEQMKLFYSNPRFHGLRFPA  251

         ************************************************************

S: 240   vedleslekkyp.klnevlldllkkclkldpaerlsceellkheyf  284

         v+++++le++y   ++ vlldl+k++lkl+p+er+++++ l+h+ f

Q: 252   VSHPQTLERRYLgIISGVLLDLMKNLLKLNPSERYLTDQSLNHPAF  297

         ***********98899***************************987

Domain Sequence
(FASTA)

FEVLGIVGEG AYGVVLKCRH KETNEIVAIK KFKDSEENEE VKETTLRELK MLRTLKQENI 60

VELKEAFRRR GKLYLVFEYV EKNMLELLEE MPNGVPPEKV RNYIYQLIKA IHWCHKNDIV 120

HRDIKPENLL ISHNDILKLC DFGFARNLSE GSNANYTEYV ATRWYRSPEL LLGAPYGKAV 180

DMWSVGCILG ELSDGQPLFP GESEIDQLFT IQRVLGPLSP EQMKLFYSNP RFHGLRFPAV 240

SHPQTLERRY LGIISGVLLD LMKNLLKLNP SERYLTDQSL NHPAF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013