EKS-LAC-00163

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00163

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	504.1	1.4E-151	690	995	306

Status

Unreviewed

Ensembl Protein

ENSLACP00000010012

UniProt Accession

H3AK41;

Protein Name

Protein Synonyms/Alias

Gene Name

LATS2

Gene Synonyms/Alias

LATS2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000008825	ENSLACP00000010012	ENSLACT00000010089

Organism

Latimeria chalumnae

Functional Description

Protein Length

1108

Protein Sequence
(FASTA)

MRPKTFPATS YAGNSRQRLQ EIREGLKQPS KPSDQVVLGG SGSETQLDPK APSVKEPARQ 60

QLRPPAKFGP YQKALREIRN SLMPFATCVE VNKQMLQELV NAGCDQEMAI RALKQTGSRS 120

IEAALDYISK MGYLDPRNEQ IVRVIKQTSP DKKGGPNSID RRPSFEGSNN SMPSYQMGTP 180

VYEGTGFNEV PRQYMNIPNM NYLLSPSQSA TVNSPMQRPS ASGPHATLGG HQQKPYPANK 240

EPAIVNYSTP NHSTQPLQMH GTHTSSTPHY MRQHMIVQAE QIGYGVQRSP SFQNKMQQEG 300

NYGNLQGTGP VAQNNSNHPL APTSLYVPQP HHRQTSPTSH QVHQMARASA FGNDYSDVSQ 360

AVMTPSRNSL NMDLYDISNS QVQQWQTSSP SRRGSIQSPG VDTPPRQHVP YRTDAQVPSR 420

TNSFNNQHQQ VAVGVRQALP NKADPNLNLP NTITTVTSAP ILQPVKSIRV MRPEPQTAVG 480

PSHPGWLAAQ AQPVDSLEIT EQHPLKVSGT AAYGLEHVDY NIQEPRCPPP PYPKHLLLQN 540

SSEQFDSSLC TGTEQGLRGV PTLNCDKTED DNDKRSDKSK KGSKTEKPGK DKKQIQTSPV 600

PVRKNAKDEE KRESRIKSYS PFAFKFYMEQ HVENIMKTYQ QKLNRRLQLE QEMAKAGLSE 660

GEQEQMRKIL YQKESNYNRL KRAKMDKSMF VKIKKLGTGA FGEVCLTLKV DTNALYAMKT 720

LRKKDVLNRN QVAHVKAERD ILAEADNEWV VKLYYSFQDK ENLYFVMDYI PGGDMMNLLM 780

RMGVFPEHLA RFYIAELTLA IESVHKMGFI HRDIKPDNIL IDLDGHIKLT DFGLCTGFRW 840

THNSKYYQKG NHVRQDSMEP SDLWEDLSNC KCGDRLKLLQ QRAAKQHQRC LAHSLVGTPN 900

YIAPEVLLRK GYTQLCDWWS VGVILFEMLV GQPPFLAPSP AETQFKVINW ENTLHIPPQV 960

KLSTEATDLI TNLCCAAEDR LGRNGADEIK AHPFFTSIDF SLDIRRQPAP YVPKISHAMD 1020

TSNFDPDEED SPWNDSTDSA KTWDTLTSTN NKHPEHAFYE FTFRRFFDDN GYPFRCPKPL 1080

GTTEIQNEME SGNKDATGQA EGFLPVYV 1108

Nucleotide Sequence
(FASTA)

ATGAGGCCAA AGACTTTTCC TGCCACATCA TATGCTGGAA ACAGTCGGCA GCGGCTGCAG 60

GAGATACGGG AAGGGTTAAA ACAGCCTTCT AAGCCTTCAG ATCAGGTTGT GCTTGGTGGA 120

TCAGGCAGTG AAACTCAGCT TGACCCTAAA GCTCCGTCAG TGAAGGAACC AGCCAGGCAG 180

CAACTAAGAC CACCAGCAAA GTTTGGGCCT TACCAGAAAG CCCTTAGAGA AATTAGAAAC 240

TCTCTGATGC CTTTTGCTAC CTGTGTGGAA GTAAATAAGC AGATGCTGCA AGAACTGGTG 300

AATGCAGGAT GTGATCAGGA AATGGCTATC AGGGCTCTCA AGCAGACTGG GAGCAGAAGC 360

ATTGAAGCAG CTTTGGACTA CATAAGCAAG ATGGGGTACT TGGACCCTAG AAATGAACAG 420

ATAGTGCGTG TCATAAAGCA AACATCACCA GATAAGAAAG GTGGACCGAA CTCTATAGAT 480

CGTAGGCCAA GTTTTGAAGG ATCTAATAAC TCAATGCCTT CCTACCAGAT GGGCACGCCA 540

GTGTATGAAG GGACAGGCTT CAATGAAGTC CCTAGGCAAT ACATGAATAT TCCCAATATG 600

AACTACTTAC TTTCACCTTC ACAGTCTGCA ACCGTAAATT CTCCAATGCA AAGGCCATCT 660

GCATCAGGAC CTCATGCAAC GCTTGGGGGA CATCAGCAAA AACCATATCC AGCTAATAAG 720

GAACCAGCCA TTGTCAACTA CTCTACCCCT AATCACAGTA CCCAGCCTTT ACAAATGCAT 780

GGAACTCATA CCTCTAGCAC TCCACATTAC ATGAGGCAGC ATATGATTGT TCAAGCGGAA 840

CAAATAGGAT ATGGTGTTCA GAGAAGCCCC TCATTCCAAA ACAAGATGCA ACAAGAGGGA 900

AATTATGGAA ATCTTCAGGG CACAGGACCA GTAGCCCAAA ATAACTCCAA CCACCCATTG 960

GCTCCAACAA GTCTGTATGT ACCACAGCCT CATCACAGGC AAACAAGTCC TACCTCTCAT 1020

CAGGTGCATC AGATGGCTCG AGCTTCAGCA TTTGGAAATG ATTATTCAGA TGTTTCTCAA 1080

GCTGTAATGA CTCCATCTAG AAATAGCTTA AACATGGACC TCTATGACAT TAGTAATTCT 1140

CAAGTCCAAC AGTGGCAAAC ATCCTCCCCT TCCAGACGTG GTTCTATACA AAGCCCAGGA 1200

GTCGACACAC CACCAAGGCA ACATGTTCCT TATAGAACAG ATGCTCAAGT GCCAAGTAGA 1260

ACTAATTCCT TCAACAACCA GCATCAACAG GTAGCTGTAG GTGTGAGGCA GGCCCTTCCC 1320

AATAAAGCAG ACCCTAATTT GAACCTTCCT AACACTATAA CCACAGTAAC ATCAGCACCT 1380

ATTCTACAAC CTGTAAAAAG CATACGGGTA ATGAGGCCAG AACCTCAGAC AGCTGTAGGA 1440

CCTTCACACC CAGGATGGCT GGCTGCGCAG GCCCAGCCTG TGGACAGCTT AGAAATTACT 1500

GAACAGCATC CACTTAAAGT AAGTGGGACA GCAGCCTATG GACTTGAACA TGTTGACTAC 1560

AATATTCAAG AGCCTAGGTG TCCTCCACCA CCATACCCTA AGCACCTGTT ACTACAAAAT 1620

AGTTCAGAGC AGTTTGACAG TAGCTTGTGC ACTGGCACAG AGCAAGGCCT GCGAGGAGTT 1680

CCTACCTTAA ACTGCGACAA AACTGAAGAT GACAACGATA AAAGAAGTGA CAAAAGTAAA 1740

AAGGGTAGTA AAACAGAGAA ACCTGGAAAA GATAAGAAAC AAATACAGAC ATCTCCTGTA 1800

CCAGTGCGCA AAAATGCCAA AGATGAGGAA AAAAGAGAGT CTAGAATCAA GAGTTATTCA 1860

CCTTTTGCTT TTAAGTTCTA CATGGAACAG CATGTGGAGA ACATCATGAA AACATATCAG 1920

CAAAAACTAA ATAGAAGGCT ACAGCTTGAG CAGGAAATGG CAAAGGCAGG CCTTTCTGAA 1980

GGTGAGCAAG AACAGATGAG GAAAATTCTT TACCAGAAAG AATCCAACTA CAACCGACTA 2040

AAAAGAGCCA AGATGGACAA GTCTATGTTT GTTAAAATTA AAAAACTGGG TACGGGTGCT 2100

TTTGGTGAAG TTTGCCTCAC TCTTAAAGTG GACACCAATG CTTTGTATGC AATGAAAACC 2160

CTGAGAAAGA AAGATGTTTT AAACAGAAAC CAGGTGGCTC ATGTGAAAGC AGAGAGGGAT 2220

ATTTTGGCTG AGGCAGACAA CGAGTGGGTG GTCAAACTTT ACTATTCTTT CCAAGACAAA 2280

GAAAACTTGT ACTTTGTGAT GGACTACATC CCTGGTGGAG ACATGATGAA TCTCCTTATG 2340

CGGATGGGGG TCTTTCCAGA GCATTTAGCT AGATTCTACA TTGCAGAGCT TACTTTAGCC 2400

ATAGAGAGTG TCCACAAAAT GGGATTTATT CACAGAGACA TTAAACCTGA TAACATTTTG 2460

ATAGATCTTG ATGGTCATAT TAAACTTACA GATTTTGGAC TTTGCACTGG ATTTAGGTGG 2520

ACTCACAATT CAAAATACTA TCAAAAAGGG AATCATGTTA GACAAGACAG CATGGAACCA 2580

AGTGATCTTT GGGAAGATTT ATCAAACTGT AAATGTGGCG ACAGGTTAAA GCTCCTGCAA 2640

CAAAGAGCAG CAAAGCAGCA CCAAAGATGT CTGGCACATT CCCTAGTTGG TACTCCGAAC 2700

TACATAGCTC CGGAAGTTCT GCTCCGAAAA GGCTATACGC AGCTGTGCGA CTGGTGGAGC 2760

GTAGGAGTGA TTCTCTTTGA GATGTTAGTC GGACAGCCTC CTTTTCTGGC ACCATCTCCT 2820

GCAGAAACTC AGTTTAAGGT GATTAATTGG GAGAACACAC TTCACATTCC ACCACAGGTC 2880

AAGCTAAGTA CTGAGGCAAC TGATCTAATC ACAAATCTGT GCTGTGCTGC TGAAGACCGG 2940

TTAGGAAGAA ATGGAGCAGA TGAAATAAAG GCTCATCCCT TCTTCACTTC CATAGACTTT 3000

TCCCTCGATA TCCGCAGGCA GCCTGCTCCA TATGTTCCAA AGATCAGCCA TGCAATGGAC 3060

ACCTCAAATT TTGACCCTGA TGAAGAAGAC AGTCCTTGGA ACGATAGTAC TGACTCTGCA 3120

AAGACTTGGG ACACACTGAC TTCCACTAAC AACAAGCACC CAGAACATGC ATTCTACGAG 3180

TTTACGTTTC GAAGGTTTTT TGATGACAAT GGCTACCCAT TTAGATGTCC AAAGCCTTTA 3240

GGAACTACAG AGATTCAGAA TGAGATGGAA TCGGGGAATA AAGATGCAAC AGGTCAAGCC 3300

GAGGGATTTC TACCTGTATA TGTGTAA 3327

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         f k+k++g+GafGev+l  k dt+++ya+k+lrkkd+l++nqvahvkaerdilaead+ew

Q: 690   FVKIKKLGTGAFGEVCLTLKVDTNALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEW  749

         889*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vvklyysfqdkenly+vm+y+PGGd+m ll+++++++e+larfyiael+la+esvhk+Gf

Q: 750   VVKLYYSFQDKENLYFVMDYIPGGDMMNLLMRMGVFPEHLARFYIAELTLAIESVHKMGF  809

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddlease.......  173

         ihrd+kPdn+lid +GhikltdfGlctG+++th+s+yy++ +++++d++e s+

Q: 810   IHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGNHVRQDSMEPSDlwedlsn  869

         **************************************************9999******

S: 174   .....elkvlerrkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyeml  228

              +lk l++r++k+++r+la+slvGtp+yiapevl++kgy++lcdwWs+Gvil+eml

Q: 870   ckcgdRLKLLQQRAAKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEML  929

         ****99******************************************************

S: 229   vGypPflaetpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdei  288

         vG+pPfla +p et+ kvinw++tl++p++v+ls+ea+dli++l++ ae+rlg++G+dei

Q: 930   VGQPPFLAPSPAETQFKVINWENTLHIPPQVKLSTEATDLITNLCCAAEDRLGRNGADEI  989

         ************************************************************

S: 289   kkhpff  294

         k+hpff

Q: 990   KAHPFF  995

         *****9

Domain Sequence
(FASTA)

FVKIKKLGTG AFGEVCLTLK VDTNALYAMK TLRKKDVLNR NQVAHVKAER DILAEADNEW 60

VVKLYYSFQD KENLYFVMDY IPGGDMMNLL MRMGVFPEHL ARFYIAELTL AIESVHKMGF 120

IHRDIKPDNI LIDLDGHIKL TDFGLCTGFR WTHNSKYYQK GNHVRQDSME PSDLWEDLSN 180

CKCGDRLKLL QQRAAKQHQR CLAHSLVGTP NYIAPEVLLR KGYTQLCDWW SVGVILFEML 240

VGQPPFLAPS PAETQFKVIN WENTLHIPPQ VKLSTEATDL ITNLCCAAED RLGRNGADEI 300

KAHPFF 306

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR009060	; UBA-like.
IPR000449	; UBA/transl_elong_EF1B_N.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.
PF00627	; UBA; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013