EKS-LAC-00417
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LAC-00417
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR600.11.7E-180603960358
StatusUnreviewed
Ensembl ProteinENSLACP00000010339
UniProt AccessionH3AL18;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLACG00000009105ENSLACP00000010339ENSLACT00000010417
OrganismLatimeria chalumnae
Functional Description
Protein Length1094
Protein Sequence
(FASTA)
NEPTWSLSFL LISFLPGPQL AACQLQNPHI VPNKEELIVE PFSSFTLTCT GESEVKWRYP 60
TIGNPDDEVT VRAEENNSGN FVTSLQVFSA SGTQTGSYIC YYPPNGSNIQ GEDMEIEGTE 120
IYVYVPDPTV VFVPIKQYEE FIFAPEGELV TIPCRITDPT LSVTLRNLDL NEVIHGLYDS 180
KQGFIGKFLP GPYTCEVTIN GTDIEFETQF LVQTWKAAPD LHVEVTTTKT VLKAGESITV 240
TCVVTENEMV HQNWIYPGEA KERGEKSYEE SKNPMKLVYT LIIPNATVKD TGVYECVVKH 300
VKDDVKEVKH VDIIVHDKGF IELEPMFGPM EFTDLHEVKQ FAVNIHAYPP PGVTWKKNDL 360
TPIEELTEIS TATKKINEVR RYQSNLTLIR AKEEDKGEYT IVVYNEDATQ NYTFLVMVKV 420
PSLILDLNLE NHHGSESGQS VLCKTGGVPM PDVEWTICKD IVKCANDTSL WTVLPMNSTE 480
TKIEETYFDD KNEMESKVTF QKLEETMIAR CIARNELATV TRELKLVAHP LRSELTVAAA 540
VLVLLVIVII SLIVLVIIWK QKPRYEIRWR VIEPISPNGH EYIYVDPMQL PYDSRWEFPR 600
DGLVLGRILG SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARSSEKQA LMSELKIMTH 660
LGPHLNILNL LGACTKSGPI YIITEYCFYG DLVNYLHKNR DNFFCRHPDK MKKDLDIFGI 720
NPADESTRSY VILSFENNGD YMDMKQADTT QYVPMLERKD SSKYSDIQRS MYDHPPSHKK 780
KSLTESEVKS LLSDDNSEGL SFMDLLSFTY QVARGMEFLA SKNCVHRDLA ARNVLLAQGK 840
IVKICDFGLA RDIMHDSNYV SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS 900
LGGTPYPGMM VDSSFYNKIK SGYRMTKPEH ATSEVYDIMV KCWNSEPDKR PSFVHLSDIV 960
GNLLPKEYKK SYEKVHHDFL KSDHPAVTRV RSNSDAYIGV TYKNEDKLKD RESGYDEQRL 1020
SADSGYIIPL PDIEPVSEDD MGKRNRHRSK RGKKSYLQTG SSSSTFIKRG DETIEDAEGM 1080
DDVEYSDLVE DSFL 1094
Nucleotide Sequence
(FASTA)
AATGAACCAA CCTGGAGCCT TTCTTTTCTG CTTATCTCCT TTCTTCCAGG GCCTCAACTG 60
GCTGCATGCC AGTTGCAAAA CCCTCATATA GTTCCAAACA AAGAAGAGCT AATTGTGGAG 120
CCGTTTTCTT CCTTTACCCT GACCTGCACT GGAGAGAGTG AGGTGAAGTG GAGATACCCC 180
ACCATTGGCA ATCCTGATGA TGAGGTCACT GTCCGGGCTG AAGAGAACAA CAGTGGAAAC 240
TTTGTGACTT CTCTGCAGGT TTTCAGTGCT TCAGGGACCC AAACGGGATC ATACATTTGC 300
TACTATCCCC CTAATGGTTC AAATATTCAG GGTGAAGACA TGGAGATTGA GGGAACGGAG 360
ATTTATGTTT ATGTCCCAGA TCCAACTGTT GTCTTTGTTC CCATTAAACA ATATGAGGAA 420
TTCATATTTG CTCCAGAGGG GGAACTTGTC ACTATACCAT GTCGTATCAC TGACCCAACT 480
CTTTCTGTCA CCTTAAGAAA CCTTGACCTT AATGAGGTGA TTCATGGTCT CTATGACAGC 540
AAGCAAGGCT TCATTGGGAA GTTTCTGCCA GGGCCATACA CTTGTGAAGT AACCATCAAT 600
GGCACAGATA TTGAATTTGA AACACAATTT CTTGTACAAA CATGGAAAGC TGCACCAGAC 660
CTTCATGTTG AAGTGACGAC CACCAAAACA GTCCTGAAAG CAGGCGAGAG CATCACGGTC 720
ACATGTGTTG TCACTGAGAA TGAAATGGTT CATCAAAACT GGATCTACCC AGGAGAAGCG 780
AAAGAAAGAG GAGAAAAAAG TTATGAGGAA AGCAAAAATC CGATGAAACT GGTGTATACT 840
CTAATTATTC CAAATGCAAC TGTGAAAGAC ACTGGAGTTT ATGAATGCGT TGTCAAACAT 900
GTAAAAGATG ATGTCAAAGA AGTAAAACAC GTGGATATTA TAGTACATGA TAAGGGATTC 960
ATTGAACTTG AACCTATGTT TGGACCAATG GAGTTTACAG ATTTGCATGA AGTGAAGCAG 1020
TTTGCAGTCA ATATACATGC TTACCCACCT CCAGGGGTCA CGTGGAAGAA GAATGACTTG 1080
ACACCAATCG AAGAGCTAAC AGAAATTTCA ACTGCTACAA AGAAAATAAA TGAAGTCAGA 1140
AGGTATCAAA GTAACCTAAC GCTGATTCGT GCAAAAGAAG AAGACAAAGG GGAGTATACA 1200
ATTGTGGTTT ACAATGAAGA TGCAACTCAA AACTATACTT TTCTAGTCAT GGTTAAAGTT 1260
CCCTCTTTAA TTCTTGACTT AAATCTTGAA AACCACCATG GCTCAGAGAG CGGGCAGTCA 1320
GTGCTGTGTA AGACAGGAGG TGTACCTATG CCTGATGTGG AATGGACCAT TTGCAAAGAC 1380
ATTGTAAAGT GTGCAAATGA CACATCATTG TGGACAGTAC TTCCAATGAA TTCCACTGAA 1440
ACCAAAATTG AAGAAACCTA TTTTGATGAT AAAAATGAAA TGGAAAGCAA GGTGACTTTT 1500
CAGAAACTGG AAGAAACCAT GATTGCTCGA TGTATTGCAA GAAATGAACT TGCGACTGTG 1560
ACAAGAGAAC TGAAACTAGT TGCTCACCCC TTGCGTTCTG AATTGACTGT GGCAGCTGCA 1620
GTCTTGGTTC TACTGGTCAT TGTTATCATT TCCCTCATAG TTCTTGTCAT TATTTGGAAA 1680
CAGAAACCCA GGTATGAGAT CAGATGGAGA GTCATTGAAC CCATTAGCCC TAATGGACAT 1740
GAATACATTT ACGTAGACCC TATGCAGTTA CCATATGATT CCAGATGGGA ATTTCCTAGA 1800
GATGGGCTTG TTCTTGGTCG GATCCTTGGC TCTGGGGCTT TTGGCAAAGT GGTTGAAGGA 1860
ACTGCCTATG GGTTAAGTCG CTCCCAGCCA GTAATGAAAG TTGCTGTGAA AATGTTAAAG 1920
CCCACAGCGA GATCCAGTGA GAAACAGGCC CTGATGTCTG AACTCAAAAT AATGACTCAT 1980
TTGGGACCTC ATCTGAACAT TCTTAACCTG TTAGGTGCTT GCACAAAATC AGGCCCAATA 2040
TACATTATTA CTGAATATTG CTTCTATGGT GATCTTGTCA ACTACTTGCA CAAGAACAGG 2100
GACAACTTCT TTTGCCGACA CCCTGACAAA ATGAAGAAGG ATCTTGATAT ATTTGGCATC 2160
AATCCAGCTG ATGAAAGCAC TAGAAGTTAT GTTATATTGT CATTTGAAAA CAATGGAGAC 2220
TACATGGATA TGAAGCAAGC AGATACAACA CAATATGTAC CAATGCTGGA GAGAAAGGAT 2280
AGTTCCAAGT ATTCAGATAT CCAAAGATCA ATGTATGACC ACCCTCCATC TCACAAAAAG 2340
AAATCATTGA CAGAATCAGA AGTCAAAAGT CTGCTCTCTG ATGACAACTC TGAAGGACTT 2400
AGTTTTATGG ACTTGTTGAG TTTCACTTAC CAGGTAGCAC GAGGGATGGA ATTCTTGGCT 2460
TCTAAAAATT GTGTGCATCG TGACTTGGCA GCTCGTAACG TTCTCCTGGC ACAAGGAAAG 2520
ATAGTGAAAA TCTGTGATTT TGGTCTGGCT AGGGACATTA TGCATGACTC CAACTATGTC 2580
TCTAAAGGCA GCACTTTTCT TCCTGTGAAA TGGATGGCAC CCGAGAGCAT TTTTGACAAC 2640
CTGTACACAA CACTGAGTGA TGTATGGTCT TATGGCATTT TGCTGTGGGA AATCTTTTCT 2700
CTTGGGGGAA CACCATACCC AGGAATGATG GTTGATTCCA GCTTTTACAA CAAAATTAAA 2760
AGTGGTTACA GAATGACAAA ACCTGAACAT GCAACCAGTG AAGTTTATGA CATCATGGTA 2820
AAGTGTTGGA ACAGTGAACC TGACAAGAGA CCATCATTTG TTCACCTGAG CGATATTGTT 2880
GGAAATCTGT TACCTAAGGA ATACAAGAAG AGCTATGAAA AGGTCCACCA TGACTTCCTG 2940
AAGAGTGACC ACCCTGCTGT TACCCGTGTG AGGTCCAACT CTGATGCCTA CATTGGTGTC 3000
ACTTACAAGA ATGAGGATAA ACTGAAGGAC CGAGAGAGTG GCTATGATGA ACAAAGACTG 3060
AGCGCAGACA GTGGCTATAT TATCCCTCTG CCTGATATTG AACCAGTCTC GGAAGATGAC 3120
ATGGGGAAGA GAAACAGGCA CAGGTCTAAG AGAGGAAAGA AATCATATCT TCAGACTGGC 3180
TCTAGCAGTT CCACTTTCAT CAAGCGAGGA GATGAGACCA TTGAAGATGC TGAAGGGATG 3240
GATGACGTTG AATATTCAGA CCTTGTGGAG GATAGTTTCC TGTAA 3285
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 603   LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  662
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+ni+nllGactk+Gpiy+iteyc+yGdl+nyl+++r++f+ ++ +k    +++ld+++
Q: 663   PHLNILNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDNFFCRHPDK---MKKDLDIFG  719
         ********************************************9999...678899999
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         + +ad+s+rs+++ls+e++++y+d+k++                +sd+++s +d++ s+k
Q: 720   InPADESTRSYVILSFENNGDYMDMKQAdttqyvpmlerkdsskYSDIQRSMYDHPPSHK  779
         989************************9********************************
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         kks++e+evk+ l++++se+l+++dllsf+yqva+Gmeflaskncvhrdlaarnvll++G
Q: 780   KKSLTESEVKSLLSDDNSEGLSFMDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG  839
         ************************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif
Q: 840   KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  899
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         slG+tpypg++vds fy++ik+Gyrm++p++at+e+y+im+kcw++ep krpsf +l+ +
Q: 900   SLGGTPYPGMMVDSSFYNKIKSGYRMTKPEHATSEVYDIMVKCWNSEPDKRPSFVHLSDI  959
         *********************************************************987
S: 344   l  344
         +
Q: 960   V  960
         5
Domain Sequence
(FASTA)
LVLGRILGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNILNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDN FFCRHPDKMK KDLDIFGINP 120
ADESTRSYVI LSFENNGDYM DMKQADTTQY VPMLERKDSS KYSDIQRSMY DHPPSHKKKS 180
LTESEVKSLL SDDNSEGLSF MDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV 240
KICDFGLARD IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG ILLWEIFSLG 300
GTPYPGMMVD SSFYNKIKSG YRMTKPEHAT SEVYDIMVKC WNSEPDKRPS FVHLSDIV 358
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003006; Ig/MHC_CS.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00290; IG_MHC; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
Created Date20-Feb-2013