EKS-LAC-00159
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LAC-00159
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR531.53.9E-160472747276
StatusUnreviewed
Ensembl ProteinENSLACP00000010918
UniProt AccessionH3AMP7;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR4
Gene Synonyms/Alias FGFR4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLACG00000009607ENSLACP00000010918ENSLACT00000010999
ENSLACG00000009607ENSLACP00000021882ENSLACT00000025634
ENSLACG00000009607ENSLACP00000010919ENSLACT00000011000
OrganismLatimeria chalumnae
Functional Description
Protein Length810
Protein Sequence
(FASTA)
MQSMCKLCFS ILALANLVVT HPPISDATEK IIPEEVLENQ TSDTTEHLLL DPGDVMKLIC 60
DTNRTVDINW YKEASHLLPG DRIQIQQNIL EITDMTYDDS GLYLCVVRGT GEILRNFTII 120
VVDSLASGDD DEDNGRDEVT GDEDRTYFRR APYWTHPQRM EKRLHAVPAG NTVKFRCPAM 180
GYPTPTIQWL KNGREFRGEH RIGGIKLRHQ HWSLVMESVV PSDRGNYTCV VENKYGSINH 240
SYLLDVLERS PHRPILQAGL PANTTVVVGS DVEFYCKVYS DAQPHIQWLK HIEVNGSRYG 300
VDGVPYVQVL KTADINSSEV EVLYLRKVSF EDAGEYTCLA GNSIGFSYQS AWLTVLPEKE 360
LVKEIEVSET KYTDIIIYTS VSLAIVMATV IVILCRMQAH ASKEPIDSLP VQKLSKFPLR 420
RQFSLESNSS GKSSASLVRV ARLSSSCTPM LAGVMEFELP LDPKWEFSRD KLILGKQLGE 480
GCFGQVVRAE ASGLDKESPD RTATVAVKML KDDATDKDLA DLISEMEMMK IMDKHKNIIN 540
LLGVCTQDGP VYVIVEYASK GNLREYLRAR RPPGMDYTFD VTKVPEEQLT FKDLVSCAYQ 600
VARGMEYLAS KRCIHRDLAA RNVLVTEDSV VKIADFGLAR GIHNIDYYKK TTNGRLPVKW 660
MAPEALFDRV YTHQSDVWSF GVLMWEIFTL GGSPYPGIPV EELFKLLKEG HRMDKPSNCT 720
HELYLLMREC WHAIPSQRPT FRQLVMELDR VLSAVSDEYL DLSTPFEQYS PSCEDTSSTC 780
SSNDSVFTHD PLPSDPCLFP YHDVKSRIRT 810
Nucleotide Sequence
(FASTA)
ATGCAATCCA TGTGTAAACT TTGCTTCAGT ATTCTTGCTT TGGCTAATCT TGTGGTCACA 60
CACCCACCAA TTTCAGATGC CACAGAAAAG ATAATACCAG AAGAAGTGCT AGAAAACCAA 120
ACATCAGATA CAACAGAGCA CCTTCTATTA GACCCAGGTG ATGTGATGAA ACTGATCTGT 180
GACACAAACC GCACTGTGGA CATTAATTGG TACAAGGAGG CAAGTCATTT GCTACCAGGT 240
GATCGCATCC AGATCCAGCA AAACATACTG GAAATTACTG ATATGACCTA TGATGACTCT 300
GGCCTATACC TTTGTGTTGT ACGTGGCACA GGCGAGATCT TGCGCAACTT CACCATAATA 360
GTTGTTGATT CTTTAGCATC AGGTGATGAT GATGAAGATA ATGGAAGGGA TGAGGTTACA 420
GGAGACGAAG ACAGAACGTA CTTCAGAAGA GCTCCCTATT GGACACATCC CCAGCGAATG 480
GAGAAACGTC TTCATGCAGT TCCAGCAGGA AATACAGTAA AGTTTCGCTG TCCAGCCATG 540
GGATATCCAA CCCCCACAAT CCAGTGGCTT AAGAATGGAC GAGAATTTCG TGGTGAGCAC 600
CGCATTGGAG GAATCAAGCT CCGCCATCAA CACTGGAGCC TAGTCATGGA GAGTGTGGTG 660
CCATCTGACC GTGGAAATTA CACCTGTGTG GTAGAAAACA AATATGGGAG CATCAATCAC 720
AGCTACCTCC TGGATGTCCT TGAGAGATCT CCACATAGAC CAATCCTGCA GGCTGGGTTG 780
CCTGCTAATA CTACTGTGGT GGTTGGCAGT GATGTAGAGT TTTACTGTAA GGTTTACAGT 840
GATGCCCAGC CTCATATTCA GTGGCTCAAA CACATTGAAG TAAATGGAAG CAGATATGGA 900
GTAGATGGAG TCCCCTATGT GCAAGTTCTT AAGACAGCAG ACATTAACAG TTCTGAAGTA 960
GAAGTTTTAT ATCTTCGCAA AGTTTCATTT GAAGATGCTG GAGAGTACAC CTGCTTGGCA 1020
GGAAATTCCA TTGGGTTCTC TTATCAATCA GCTTGGCTCA CTGTCTTACC AGAAAAAGAG 1080
CTAGTGAAAG AGATCGAGGT ATCTGAGACA AAGTACACGG ACATCATTAT ATACACCTCA 1140
GTGTCTCTTG CTATTGTCAT GGCAACTGTA ATTGTGATCT TGTGCAGAAT GCAGGCTCAT 1200
GCTAGCAAAG AGCCCATTGA TAGCCTTCCA GTACAGAAGC TGTCCAAGTT TCCCCTCCGT 1260
AGACAGTTCT CTCTGGAGTC CAACTCTTCT GGAAAATCCA GTGCATCTCT TGTGAGGGTT 1320
GCTCGTTTGT CCTCCAGTTG TACACCAATG CTTGCAGGGG TCATGGAATT TGAGCTGCCA 1380
CTCGATCCAA AATGGGAATT TTCCAGAGAC AAGTTGATAC TAGGCAAACA ACTTGGTGAA 1440
GGTTGTTTTG GTCAAGTTGT ACGAGCAGAG GCCAGTGGGC TTGACAAAGA GAGTCCAGAC 1500
AGAACAGCTA CTGTAGCAGT CAAGATGCTG AAAGATGATG CAACCGATAA GGACCTGGCC 1560
GATCTCATCT CTGAAATGGA AATGATGAAG ATAATGGATA AACACAAAAA CATCATCAAC 1620
CTGCTTGGGG TCTGCACCCA AGATGGCCCT GTGTATGTGA TTGTGGAGTA TGCTTCAAAA 1680
GGAAATCTGC GTGAGTACTT GAGGGCACGA CGACCACCTG GCATGGATTA TACCTTTGAT 1740
GTCACTAAAG TACCAGAGGA ACAGCTTACC TTTAAAGACT TGGTTTCCTG TGCCTACCAA 1800
GTTGCACGAG GCATGGAATA CTTGGCATCT AAAAGGTGTA TTCATCGAGA TTTAGCTGCC 1860
AGGAATGTGC TAGTAACAGA AGACAGTGTT GTGAAAATTG CAGACTTTGG TTTGGCCAGG 1920
GGTATCCATA ATATAGACTA CTACAAAAAA ACAACTAATG GACGTTTGCC AGTGAAATGG 1980
ATGGCGCCAG AGGCTTTGTT TGACAGAGTG TACACGCACC AGAGTGATGT CTGGTCTTTT 2040
GGAGTGCTGA TGTGGGAAAT TTTTACTCTT GGAGGGTCAC CATATCCTGG AATCCCAGTA 2100
GAAGAACTCT TTAAACTCCT GAAAGAGGGT CACAGAATGG ACAAACCTTC AAATTGTACA 2160
CATGAACTGT ATTTGTTGAT GCGGGAGTGC TGGCATGCCA TCCCTTCACA GAGACCTACT 2220
TTTAGACAGT TAGTCATGGA GCTTGACAGG GTACTATCTG CAGTTTCAGA TGAGTACTTG 2280
GACCTTTCCA CACCATTTGA ACAGTATTCG CCTTCTTGTG AAGATACGAG CAGCACATGC 2340
TCTTCCAATG ATTCTGTCTT TACTCATGAT CCCTTACCAT CTGATCCTTG TTTATTCCCC 2400
TATCATGATG TCAAATCCAG GATAAGGACT TGA 2433
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l lgk+lGeG+fGqvv+aea gldk+ +++++tvavkmlk+datdkdladl+seme++k+
Q: 472   LILGKQLGEGCFGQVVRAEASGLDKESPDRTATVAVKMLKDDATDKDLADLISEMEMMKI  531
         689*********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         + khkniinllG+ctq+Gp+yviveya+kGnlre+lrarrp+g++++ d +k++eeqlt+
Q: 532   MDKHKNIINLLGVCTQDGPVYVIVEYASKGNLREYLRARRPPGMDYTFDVTKVPEEQLTF  591
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ayqvarGmeylask+cihrdlaarnvlvted+v+kiadfGlar++h+idyykkt
Q: 592   KDLVSCAYQVARGMEYLASKRCIHRDLAARNVLVTEDSVVKIADFGLARGIHNIDYYKKT  651
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh
Q: 652   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  711
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlved  276
         rm+kp++ct+ely lmrecwha +s+rptf+qlv +
Q: 712   RMDKPSNCTHELYLLMRECWHAIPSQRPTFRQLVME  747
         *********************************976
Domain Sequence
(FASTA)
LILGKQLGEG CFGQVVRAEA SGLDKESPDR TATVAVKMLK DDATDKDLAD LISEMEMMKI 60
MDKHKNIINL LGVCTQDGPV YVIVEYASKG NLREYLRARR PPGMDYTFDV TKVPEEQLTF 120
KDLVSCAYQV ARGMEYLASK RCIHRDLAAR NVLVTEDSVV KIADFGLARG IHNIDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPSNCTH ELYLLMRECW HAIPSQRPTF RQLVME 276
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00141
EKS-CAP-00150
EKS-DAR-00435
EKS-EQC-00148
EKS-FEC-00139
EKS-GAM-00077
EKS-GAA-00174
EKS-ICT-00143
EKS-LOA-00148
EKS-MOD-00149
EKS-MUM-00154
EKS-MUP-00154
EKS-MYL-00158
EKS-ORN-00184
EKS-ORL-00172
EKS-SAH-00144
EKS-SUS-00130
EKS-TAG-00178
EKS-TAR-00193
EKS-TEN-00185
EKS-XET-00138
EKS-XIM-00178
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008284; P:positive regulation of cell proliferation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013