EKS-LAC-00505

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00505

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RIPK	288.2	6.6E-86	20	286	267

Status

Unreviewed

Ensembl Protein

ENSLACP00000011259

UniProt Accession

H3ANN8;

Protein Name

Protein Synonyms/Alias

Gene Name

RIPK1

Gene Synonyms/Alias

RIPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000009905	ENSLACP00000011259	ENSLACT00000011343

Organism

Latimeria chalumnae

Functional Description

Protein Length

667

Protein Sequence
(FASTA)

RSVSMSLDKI IHMSSSELLD KEPLDAGGFG MVSLCCHRSY GLVVLKTVYT GPQRTEYNST 60

LLEEGKMMCK LSHDRVIKLL GIILEEGNYS LVMEFMGKGN LWKVLQSVPV LLSVKGRIIL 120

EIIEGMTYLN KQGVVHKDLK PENFLVNDDF HIKIADLGVA TFKTWSKLTK EENNRLRKVN 180

KASVSKTHNN AGTLSYIAPE HLKSVNTKPS EKSDVYSFGI VIWVILTRKE PYENAMNENQ 240

VYHCVLEGNR PDMAEVPSDS PEEISNLMQQ CWDTDCAKRP TFFNTECDCK FRPFYTQRLQ 300

EHVNADVEIM KREYPAPKEF VKRLQSLQFD CVPIESMPTD DPNSLHSSQG ATVRTVDEAL 360

FSPCTRGNPV ESEFTVDATE GGPSLEEKLQ EESNYHLYGN RMDRPESKVM EKFIEEKNRR 420

VSHDPFKQQI RLSNSNTNLV LVPTWSLYFF PPSYFVVEHG VYNTPPPNQM HFPLGLVQKR 480

KLEKNRNKSW FCLSPSPRLL VSNTGPTFNF TSPSRDGREA EAMTQLYIGE ANGIQIGNNN 540

VMSIGSQRYN ALVPSPQRTV ANEFKNLEVL DLYPIENEHL DLLQDNIAKQ WKWLARKLGL 600

TQGDIDEIDH DYDRDGLREK MYQMLQKWKM REGLKGATVG KLARVLLPQN PDLVHQLQRK 660

YHSQDLK 667

Nucleotide Sequence
(FASTA)

AGAAGTGTAA GCATGTCGCT GGATAAGATC ATTCATATGA GCTCCTCTGA GCTCCTGGAC 60

AAAGAGCCAC TGGATGCTGG TGGATTTGGC ATGGTGTCAT TATGTTGTCA CAGAAGCTAT 120

GGGCTTGTTG TGTTAAAAAC CGTGTACACC GGCCCACAGC GCACAGAGTA CAACAGCACC 180

CTCCTTGAGG AAGGTAAAAT GATGTGTAAG CTCAGTCATG ATCGGGTTAT AAAGTTGCTT 240

GGAATTATTC TGGAAGAAGG CAACTACTCC CTTGTCATGG AGTTCATGGG AAAGGGGAAC 300

TTGTGGAAGG TGCTTCAGTC AGTTCCTGTT CTGCTATCTG TAAAAGGAAG AATAATTTTG 360

GAAATTATTG AAGGAATGAC TTATTTAAAT AAGCAGGGTG TTGTTCACAA AGACCTTAAG 420

CCAGAAAATT TTCTGGTAAA TGATGATTTC CATATTAAGA TTGCAGATCT GGGTGTAGCC 480

ACCTTCAAAA CTTGGAGCAA GTTGACAAAA GAGGAGAACA ACAGACTTAG GAAGGTGAAC 540

AAGGCGTCAG TCAGCAAAAC CCACAACAAC GCAGGCACGC TCTCTTACAT AGCACCAGAG 600

CACTTGAAAT CGGTCAATAC AAAACCCAGT GAGAAGTCGG ACGTCTACAG CTTTGGCATT 660

GTAATCTGGG TCATCCTGAC CCGTAAAGAA CCATATGAAA ATGCAATGAA TGAAAATCAA 720

GTTTATCACT GTGTGTTGGA AGGTAACCGG CCAGATATGG CCGAGGTTCC TTCTGATTCG 780

CCAGAGGAAA TTTCTAACTT AATGCAGCAA TGCTGGGATA CTGACTGTGC AAAAAGGCCA 840

ACTTTTTTCA ATACAGAATG TGATTGTAAA TTTCGGCCTT TCTATACCCA GCGCTTGCAA 900

GAACACGTGA ATGCAGATGT GGAAATAATG AAGAGAGAAT ACCCCGCTCC AAAAGAATTT 960

GTGAAAAGGC TGCAGTCACT TCAGTTTGAC TGTGTTCCAA TAGAAAGTAT GCCTACAGAT 1020

GATCCAAACT CCCTGCATAG TTCTCAAGGC GCCACTGTCA GAACTGTAGA TGAAGCCCTG 1080

TTTTCACCGT GCACAAGAGG TAACCCTGTT GAGAGTGAGT TTACTGTTGA TGCTACTGAA 1140

GGAGGCCCGA GTCTGGAAGA GAAACTACAG GAGGAGTCTA ACTATCACCT GTATGGCAAC 1200

CGCATGGATA GACCAGAAAG CAAGGTTATG GAAAAGTTCA TAGAGGAAAA AAACAGAAGA 1260

GTTTCCCATG ATCCATTTAA GCAACAGATT AGATTAAGTA ACTCTAATAC TAACCTAGTA 1320

TTAGTACCTA CTTGGTCGCT TTATTTTTTT CCTCCCTCTT ACTTTGTGGT GGAACACGGT 1380

GTTTATAACA CCCCCCCCCC CAACCAAATG CATTTTCCTT TGGGGCTTGT ACAGAAAAGA 1440

AAATTGGAAA AAAATCGAAA TAAATCCTGG TTCTGCTTAT CCCCCTCCCC AAGGCTGCTT 1500

GTGTCTAACA CTGGTCCCAC ATTTAATTTC ACCAGTCCCA GCCGTGATGG GCGGGAGGCA 1560

GAGGCAATGA CACAGTTGTA CATTGGAGAA GCTAATGGAA TACAGATTGG GAATAACAAC 1620

GTTATGAGCA TTGGAAGCCA ACGTTACAAT GCTCTTGTGC CGTCTCCACA ACGAACCGTG 1680

GCCAATGAAT TTAAAAATTT GGAAGTTTTG GATTTATATC CAATTGAAAA TGAGCATCTC 1740

GACCTGCTCC AAGACAATAT AGCAAAACAA TGGAAGTGGC TCGCTCGTAA ACTTGGCTTG 1800

ACACAGGGAG ACATTGATGA AATTGACCAT GACTATGACA GAGATGGGCT AAGGGAAAAA 1860

ATGTATCAGA TGTTGCAAAA GTGGAAGATG AGAGAAGGGT TGAAAGGGGC CACTGTTGGA 1920

AAACTAGCAA GGGTGCTCCT TCCCCAAAAC CCAGACTTGG TCCATCAGCT TCAGAGAAAG 1980

TATCATAGCC AAGATTTAAA ATGA 2004

Domain Profile

S: 3     elelvgsGgfgkvfkarhrkwrvevavkslvlktdaldserkelleeakkmeklrfsyvl  62

         + e ++ Ggfg v+ + hr++++ v+++  v++++++++++++llee+k+m kl +++v+

Q: 20    DKEPLDAGGFGMVSLCCHRSYGLVVLKT--VYTGPQRTEYNSTLLEEGKMMCKLSHDRVI  77

         67889******************99999..******************************

S: 63    kllGvikeeeklglvmeymenGsLeklLkseielpwplkfRilkevvlgmnyLhslkPpl  122

         kllG+i ee++++lvme+m +G+L k+L+s  ++ +++k Ri+ e+++gm+yL +++  +

Q: 78    KLLGIILEEGNYSLVMEFMGKGNLWKVLQSV-PVLLSVKGRIILEIIEGMTYLNKQG--V  134

         *****************************98.**********************999..*

S: 123   lhkDLkpeniLlDnelhvkiaDfGlskfm.......eessqskevsssa......egGtl  169

         +hkDLkpen L++ ++h+kiaD+G+++f        ee+++ ++v++++      + Gtl

Q: 135   VHKDLKPENFLVNDDFHIKIADLGVATFKtwskltkEENNRLRKVNKASvskthnNAGTL  194

         ****************************55999*9955555555554444455569****

S: 170   aYlaPelleevnkkaseksDvYsfaiviWavlakkepyeeeknslqiiivvkkgnRPele  229

         +Y+aPe+l+ vn k+seksDvYsf+iviW +l++kepye+++n+ q+  +v +gnRP+++

Q: 195   SYIAPEHLKSVNTKPSEKSDVYSFGIVIWVILTRKEPYENAMNENQVYHCVLEGNRPDMA  254

         ************************************************************

S: 230   evseelPrevpqlieLmkrcWeadpeeRPsFleie  264

         ev++++P+e   + +Lm++cW++d  +RP+F + e

Q: 255   EVPSDSPEE---ISNLMQQCWDTDCAKRPTFFNTE  286

         *******88...999****************8765

Domain Sequence
(FASTA)

DKEPLDAGGF GMVSLCCHRS YGLVVLKTVY TGPQRTEYNS TLLEEGKMMC KLSHDRVIKL 60

LGIILEEGNY SLVMEFMGKG NLWKVLQSVP VLLSVKGRII LEIIEGMTYL NKQGVVHKDL 120

KPENFLVNDD FHIKIADLGV ATFKTWSKLT KEENNRLRKV NKASVSKTHN NAGTLSYIAP 180

EHLKSVNTKP SEKSDVYSFG IVIWVILTRK EPYENAMNEN QVYHCVLEGN RPDMAEVPSD 240

SPEEISNLMQ QCWDTDCAKR PTFFNTE 267

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000488	; Death.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR025735	; RHIM_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00531	; Death; 1.
PF00069	; Pkinase; 1.
PF12721	; RHIM; 1.

SMARTs

SM00005

; DEATH; 1.

Prosites

PS50017	; DEATH_DOMAIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013