EKS-LAC-00162

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00162

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	504.8	8.3E-152	713	1018	306

Status

Unreviewed

Ensembl Protein

ENSLACP00000011263

UniProt Accession

H3ANP2;

Protein Name

Protein Synonyms/Alias

Gene Name

LATS1

Gene Synonyms/Alias

LATS1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000009909	ENSLACP00000011263	ENSLACT00000011347

Organism

Latimeria chalumnae

Functional Description

Protein Length

1140

Protein Sequence
(FASTA)

MKRGEKPEGY RQMRPKTFPA SNYTGSSRQM LQEIRESLRN LPKPSDTTKV EQNAVKLAAE 60

DPRHPGRAPP KFGTHHKALQ EIRNSLLPFA NETNSSARGA SEVNRKMLQD LQAAGFDEDM 120

VIRALRQTNS RSLEAAIEYI SKMSYQDPRR EQMVAVVNAG MKLPGPGGVQ SVNRKQSWKG 180

SKESLVPQRH GPSMVDSVVY RSESPSSQTE MVRPLSGSGL AAFTQGHPGN GQRVNPPPPP 240

QVRSVTPPPP PPRGQTPPPR GTTPPPPSWD PNSQPKRYSG SIEYVIPRIS PVPQGAWQDG 300

YSASAMNTSP MMNPSPQGQR GISPVPVGRQ PIIMHGSANN KFSFPSGRAG LQNGGGQPDF 360

MAHQNVIGSN QVNRQPPPPY PVGQTNRQSP TALQMQAGGS AASSTYTNGN IPQSMIVPNR 420

NSHNMDVYNL SIPGMQTSWS QLSSTQPQSQ SCNGHEIPTW QHNIPVRSSS FNTHLLANRQ 480

THPASSQPSA TTVTAITQAP ILQPVKSMRV PKPELQTALA PTHPPWVQQS MQAAQPSPFP 540

DGPSVVPQVT DTPSYQGPPP PYPKHLLQQI QPAPPYDSAA KPGKEDAGAL AQGRREEDES 600

EVASEVVVDG AGREKKQITT SPVPVRKNKR DEERRESRIQ LYSPQAFKFY MEQHVENILK 660

CHHQRLHRQK QLENEMMRVG LSPDAQDQMR KMLCQKESNY IRLKRAKMDK SMFVKIQTLG 720

IGAFGEVCLA QKVDTNALYA MKTLRKKEVL LRNQVAHVKA ERDILAEADN EWVVRLYYSF 780

QDKDNLYFVM DYIPGGDMMS LLIRLGIFPE DLAQFYIAEL TCAVESVHKM GFIHRDIKPD 840

NILIDRDGHI KLTDFGLCTG FRWTHDSKYY QSGDHPRQDS MDFSSEWGDP ASCRCGDRLK 900

PLQRRAARQH QRCLAHSLVG TPNYIAPEVL LRTGYTQLCD WWSVGVILYE MLVGQPPFLA 960

QTPLETQMKV INWQATLHIP PKAKLSPEAS DLIIKLCRGP EDRLGKNGAD EIKAHPFFKT 1020

IDFSSDLRQQ QAPYIPKITH STDTSNFDPV DPDKLRNDDD KEGNINDTLN GWYRNGKHPE 1080

HAFYEFTFRR FFDDNGYPYS YPKPIEYDYT DTEDSEQQHL DEEGNQKTGG SSQNRDLVYV 1140

Nucleotide Sequence
(FASTA)

ATGAAGAGAG GAGAGAAACC TGAAGGGTAC AGACAGATGC GACCCAAAAC CTTCCCTGCT 60

AGCAACTACA CTGGCAGTAG CCGGCAGATG CTGCAGGAAA TTCGGGAGAG TCTGCGGAAC 120

TTGCCCAAGC CTTCAGATAC TACCAAGGTT GAACAGAATG CTGTGAAATT AGCGGCTGAA 180

GATCCCAGGC ACCCAGGCCG GGCCCCCCCA AAGTTTGGGA CCCACCACAA AGCTCTGCAA 240

GAAATCCGGA ACTCCTTGCT TCCCTTTGCA AATGAAACCA ATTCTTCAGC TAGAGGTGCT 300

TCTGAAGTCA ATAGGAAAAT GCTACAAGAT TTACAAGCTG CGGGGTTTGA TGAGGACATG 360

GTGATTCGAG CTCTCCGACA GACTAACAGC CGGAGTTTGG AGGCAGCAAT TGAATACATC 420

AGTAAGATGA GCTACCAGGA CCCACGACGG GAACAGATGG TTGCTGTAGT CAATGCAGGC 480

ATGAAACTTC CTGGGCCTGG AGGTGTTCAG TCGGTGAATC GTAAGCAAAG CTGGAAAGGT 540

TCCAAAGAGT CCCTGGTCCC CCAAAGACAT GGTCCTTCAA TGGTTGATAG TGTGGTGTAT 600

CGCTCAGAGA GTCCTAGCTC ACAAACAGAA ATGGTCAGGC CTTTGTCAGG GTCAGGCCTT 660

GCAGCATTCA CACAGGGCCA TCCAGGAAAT GGACAAAGAG TAAACCCACC CCCTCCTCCA 720

CAGGTTAGGA GTGTAACACC ACCACCACCC CCACCAAGGG GGCAGACTCC CCCACCCAGA 780

GGAACCACTC CACCACCACC ATCTTGGGAC CCTAACTCTC AGCCCAAGCG GTATTCTGGG 840

AGCATAGAGT ATGTGATCCC TCGGATCTCT CCTGTTCCCC AGGGAGCATG GCAAGATGGA 900

TATTCTGCAT CTGCCATGAA CACCAGTCCA ATGATGAATC CTTCACCACA AGGCCAAAGA 960

GGCATCAGTC CTGTTCCTGT TGGCAGGCAA CCAATCATCA TGCATGGCTC AGCCAACAAC 1020

AAGTTCAGTT TCCCATCAGG AAGGGCTGGG CTTCAGAATG GGGGTGGTCA GCCAGACTTC 1080

ATGGCTCATC AGAATGTTAT AGGCAGCAAC CAAGTTAATC GCCAGCCGCC ACCACCTTAT 1140

CCAGTAGGCC AGACTAACAG GCAGAGTCCC ACAGCCCTAC AGATGCAGGC AGGAGGATCA 1200

GCAGCCTCCT CTACATACAC CAATGGTAAC ATTCCACAGT CCATGATTGT ACCAAACCGG 1260

AACAGCCACA ACATGGATGT TTACAACCTC AGCATACCTG GAATGCAGAC CTCATGGTCA 1320

CAGTTGTCGT CCACCCAGCC CCAGTCTCAG TCCTGCAATG GCCATGAGAT ACCTACATGG 1380

CAGCATAACA TTCCTGTAAG GTCCAGCTCC TTCAATACCC ATCTTCTTGC AAATAGGCAG 1440

ACTCACCCTG CTAGCTCCCA GCCTTCAGCT ACCACAGTGA CAGCCATTAC CCAAGCACCC 1500

ATTCTGCAAC CTGTGAAGAG CATGCGGGTA CCAAAGCCAG AGTTGCAGAC TGCTTTAGCA 1560

CCCACCCATC CACCTTGGGT GCAACAGTCC ATGCAGGCAG CACAGCCCAG TCCCTTCCCA 1620

GATGGTCCCT CTGTGGTCCC CCAGGTTACA GATACCCCAA GTTACCAAGG CCCTCCGCCT 1680

CCCTACCCAA AGCACTTACT TCAGCAGATT CAGCCTGCAC CACCATATGA TTCAGCAGCT 1740

AAGCCGGGGA AAGAAGATGC AGGTGCTCTT GCACAGGGCC GTAGGGAAGA GGACGAAAGT 1800

GAGGTGGCCT CAGAGGTGGT GGTGGATGGG GCAGGCAGAG AAAAGAAACA GATTACAACC 1860

TCACCTGTTC CAGTGAGAAA AAACAAGCGT GATGAAGAAC GCCGGGAGTC ACGCATTCAG 1920

TTGTACTCGC CCCAGGCCTT CAAATTTTAC ATGGAGCAGC ATGTGGAGAA TATCCTGAAG 1980

TGTCACCATC AGCGACTGCA TCGCCAGAAG CAACTGGAGA ATGAAATGAT GCGGGTTGGG 2040

TTGTCTCCAG ATGCCCAAGA TCAGATGCGT AAAATGCTGT GCCAGAAGGA GTCCAACTAT 2100

ATCCGCCTCA AGAGGGCAAA AATGGACAAG TCCATGTTTG TGAAGATCCA GACCTTGGGA 2160

ATAGGGGCCT TTGGCGAGGT GTGTCTAGCG CAAAAGGTAG ACACTAATGC CCTGTACGCA 2220

ATGAAGACCC TGAGGAAGAA GGAGGTACTG CTGCGGAATC AGGTCGCTCA TGTCAAGGCT 2280

GAACGGGATA TCCTGGCAGA AGCTGACAAC GAATGGGTGG TTCGCCTGTA TTATTCATTC 2340

CAAGACAAAG ACAACTTGTA CTTTGTAATG GACTACATCC CAGGAGGAGA CATGATGAGC 2400

CTTCTCATTA GACTGGGCAT CTTCCCAGAG GACCTGGCCC AGTTTTACAT CGCTGAGCTG 2460

ACCTGTGCAG TCGAAAGTGT GCACAAGATG GGCTTCATTC ACAGGGACAT TAAGCCAGAT 2520

AACATCCTGA TTGATCGTGA TGGGCACATT AAACTGACTG ACTTTGGGCT GTGCACTGGC 2580

TTCCGGTGGA CGCATGATTC CAAGTACTAC CAGAGTGGTG ATCATCCACG TCAAGACAGC 2640

ATGGATTTCA GTAGTGAGTG GGGTGATCCA GCTAGCTGCA GGTGTGGAGA CCGCCTCAAG 2700

CCCCTTCAAC GGAGGGCAGC ACGTCAGCAT CAGCGGTGCC TGGCACACTC GCTAGTTGGG 2760

ACACCAAACT ATATTGCACC AGAGGTTTTA TTACGCACAG GCTACACACA GCTGTGTGAC 2820

TGGTGGAGTG TAGGTGTCAT TCTTTATGAA ATGTTGGTGG GGCAACCTCC TTTCCTGGCA 2880

CAGACACCAT TGGAAACACA AATGAAGGTC ATCAACTGGC AAGCAACTCT TCACATCCCA 2940

CCAAAAGCCA AGCTGAGTCC AGAAGCCTCT GACCTCATCA TAAAACTGTG CCGAGGACCA 3000

GAAGATCGCT TGGGGAAAAA TGGTGCAGAT GAAATCAAAG CTCACCCCTT TTTTAAAACG 3060

ATAGATTTCT CAAGTGACTT GCGCCAGCAA CAGGCTCCAT ACATTCCAAA AATCACTCAT 3120

TCCACTGACA CATCAAACTT CGATCCTGTG GATCCAGATA AGTTACGGAA TGATGATGAT 3180

AAGGAGGGGA ACATCAATGA CACACTCAAT GGCTGGTACA GAAACGGCAA ACATCCTGAG 3240

CATGCCTTTT ATGAATTCAC GTTTCGCAGG TTCTTTGATG ACAATGGCTA CCCATACAGC 3300

TACCCAAAGC CTATTGAATA TGACTACACG GACACTGAAG ACTCAGAGCA ACAGCATTTG 3360

GATGAGGAAG GAAACCAGAA AACTGGTGGC AGCAGCCAGA ATCGGGATTT GGTTTATGTC 3420

TGA 3423

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         f k++++g+GafGev+l++k dt+++ya+k+lrkk++l +nqvahvkaerdilaead+ew

Q: 713   FVKIQTLGIGAFGEVCLAQKVDTNALYAMKTLRKKEVLLRNQVAHVKAERDILAEADNEW  772

         789*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vv+lyysfqdk+nly+vm+y+PGGd+m+lli+ +i++e+la+fyiael++avesvhk+Gf

Q: 773   VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRLGIFPEDLAQFYIAELTCAVESVHKMGF  832

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddlease.......  173

         ihrd+kPdn+lid++GhikltdfGlctG+++th+s+yy++ ++ ++d++++s+

Q: 833   IHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSSewgdpas  892

         **************************************************9999******

S: 174   .....elkvlerrkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyeml  228

              +lk+l+rr++++++r+la+slvGtp+yiapevl+++gy++lcdwWs+Gvilyeml

Q: 893   crcgdRLKPLQRRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILYEML  952

         ************************************************************

S: 229   vGypPflaetpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdei  288

         vG+pPfla+tp et++kvinw+ tl++p++++ls+ea+dli +l+  +e+rlgk+G+dei

Q: 953   VGQPPFLAQTPLETQMKVINWQATLHIPPKAKLSPEASDLIIKLCRGPEDRLGKNGADEI  1012

         ************************************************************

S: 289   kkhpff  294

         k+hpff

Q: 1013  KAHPFF  1018

         *****9

Domain Sequence
(FASTA)

FVKIQTLGIG AFGEVCLAQK VDTNALYAMK TLRKKEVLLR NQVAHVKAER DILAEADNEW 60

VVRLYYSFQD KDNLYFVMDY IPGGDMMSLL IRLGIFPEDL AQFYIAELTC AVESVHKMGF 120

IHRDIKPDNI LIDRDGHIKL TDFGLCTGFR WTHDSKYYQS GDHPRQDSMD FSSEWGDPAS 180

CRCGDRLKPL QRRAARQHQR CLAHSLVGTP NYIAPEVLLR TGYTQLCDWW SVGVILYEML 240

VGQPPFLAQT PLETQMKVIN WQATLHIPPK AKLSPEASDL IIKLCRGPED RLGKNGADEI 300

KAHPFF 306

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR009060	; UBA-like.
IPR000449	; UBA/transl_elong_EF1B_N.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.
PF00627	; UBA; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013