EKS-LAC-00291

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00291

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	441.5	1.5E-132	205	492	288

Status

Unreviewed

Ensembl Protein

ENSLACP00000011323

UniProt Accession

H3ANV2;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1

Gene Synonyms/Alias

ACVR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000009962	ENSLACP00000021853	ENSLACT00000025709
ENSLACG00000009962	ENSLACP00000011323	ENSLACT00000011409
ENSLACG00000009962	ENSLACP00000011324	ENSLACT00000011410

Organism

Latimeria chalumnae

Functional Description

Protein Length

506

Protein Sequence
(FASTA)

MLDGVMILPV LMILAFPPSS IEEEESKLNT ILYECVCEGM SCENGDRCSG QQCFASLSIN 60

DGTPVYQKGC FQVYEQGKMN CKTPPSSDQA VECCQGHLCN QNITTQLPVG QHGDSYSVTT 120

LTIVIIAPVV MLIILSLLAV MTFRKIHHHQ MERLNARDAE YGTIDGLISS NVGDSTLADL 180

LDHSCTSGSG SGLPFLVQRT VARQITLMEC VGKGRYGEVW RGLWQGENVA VKIFSSRDER 240

SWCRETEIYN TVLLRHENIL GFIASDMTSR NSSTQLWLIS HYHEMGSLYD YLQLTTLDSV 300

GCLRIVLSIA CGLAHLHVEI YGTQGKPAIA HRDLKSKNIL VKKNGQCCIA DLGLAVMHCQ 360

STNQLDVGNN PRVGTKRYMS PEVLDEIIQV DCFDSYKRVD IWAFGLVLWE VARRTVSNGI 420

VEDYKPPFHD VVPNDPSFED MRKVVCVDQQ RPIIPNRWFS DPTLTSLAKL MKECWYQNPS 480

ARLTALRIKK TLTKIDNSLD KLKPEC 506

Nucleotide Sequence
(FASTA)

ATGTTAGATG GAGTTATGAT TCTTCCTGTT CTGATGATAC TAGCTTTCCC CCCTTCCAGT 60

ATAGAAGAAG AAGAGTCAAA GTTGAATACG ATCCTCTATG AATGCGTATG TGAAGGAATG 120

TCCTGTGAGA ATGGAGACCG TTGTTCTGGC CAGCAGTGCT TTGCCTCACT AAGCATAAAT 180

GACGGCACTC CAGTTTACCA AAAAGGCTGT TTCCAAGTGT ATGAACAGGG AAAAATGAAC 240

TGTAAGACAC CGCCATCATC TGACCAAGCT GTGGAGTGCT GTCAGGGACA TCTCTGTAAC 300

CAGAATATTA CAACACAGCT GCCTGTAGGT CAACATGGCG ACAGTTATAG TGTGACAACA 360

TTGACTATTG TTATCATAGC TCCTGTGGTA ATGTTGATCA TCCTTTCTCT TTTGGCTGTA 420

ATGACTTTTC GGAAAATCCA TCACCATCAA ATGGAAAGAC TAAATGCTAG AGATGCAGAG 480

TATGGAACCA TAGATGGACT GATTTCATCA AATGTTGGGG ACAGCACATT AGCAGATTTG 540

CTAGATCATT CTTGCACATC AGGGAGTGGA TCAGGTCTTC CTTTCCTTGT ACAACGGACA 600

GTGGCTCGTC AGATAACACT TATGGAATGT GTTGGAAAAG GTAGATATGG AGAAGTATGG 660

AGAGGTCTTT GGCAAGGGGA GAATGTTGCA GTGAAGATTT TCTCCTCTCG GGATGAAAGA 720

TCTTGGTGCA GAGAGACTGA AATTTACAAC ACTGTGTTAC TACGGCATGA AAACATTTTA 780

GGTTTTATTG CCTCTGACAT GACATCTAGA AACTCGAGCA CTCAACTTTG GCTGATTTCA 840

CACTATCATG AAATGGGATC TCTTTATGAC TACTTGCAGC TTACAACACT GGATTCAGTT 900

GGTTGTCTAC GAATTGTCCT GTCTATTGCT TGTGGTCTGG CACATTTGCA TGTGGAAATA 960

TATGGCACAC AAGGAAAGCC TGCTATAGCT CATCGGGACT TAAAGAGCAA AAATATCCTT 1020

GTTAAGAAGA ATGGACAGTG CTGCATAGCA GATTTAGGTC TTGCTGTAAT GCATTGCCAA 1080

AGCACTAATC AGTTAGATGT GGGCAATAAT CCCAGAGTGG GGACCAAGCG CTACATGTCT 1140

CCTGAAGTTT TAGATGAAAT CATCCAGGTG GACTGCTTTG ACTCCTATAA AAGAGTAGAT 1200

ATCTGGGCTT TTGGGTTGGT CTTGTGGGAA GTAGCCAGGA GGACAGTTAG TAATGGTATT 1260

GTAGAAGATT ATAAGCCACC TTTTCATGAT GTGGTTCCAA ATGACCCTAG CTTTGAAGAT 1320

ATGAGGAAAG TGGTCTGTGT AGATCAGCAG AGGCCAATTA TTCCTAATAG ATGGTTTTCA 1380

GATCCAACAT TAACATCTCT TGCTAAGTTG ATGAAAGAAT GCTGGTATCA GAACCCATCT 1440

GCAAGACTTA CTGCACTGCG AATCAAAAAG ACTCTGACCA AAATTGACAA CTCTTTAGAT 1500

AAACTGAAAC CTGAATGCTG A 1521

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++l+e++gkGrygeVw++ ++ge+vAvKifs++de+sw rE+eiy+tvllrhenil+fia

Q: 205   ITLMECVGKGRYGEVWRGLWQGENVAVKIFSSRDERSWCRETEIYNTVLLRHENILGFIA  264

         789*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+++yhe+gsL+dyL+ +tld   +lr++ls+a+GlahLH ei gt+

Q: 265   SDMTSRNSSTQLWLISHYHEMGSLYDYLQLTTLDSVGCLRIVLSIACGLAHLHVEIYGTQ  324

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk+++cciaDlGLa+++ +++++ld+ +n +vGtkRYm+PE

Q: 325   G--KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHCQSTNQLDVGNNPRVGTKRYMSPE  382

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e +++++f+++kr+D++++gLvlWEva+R+ + +++ve+yk+pf++vv++dPs+e+m

Q: 383   VLDEIIQVDCFDSYKRVDIWAFGLVLWEVARRTVS-NGIVEDYKPPFHDVVPNDPSFEDM  441

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++++rP ip++w ++++l++l+kl++ecW+++p+aRltalr+kk+l

Q: 442   RKVVCVDQQRPIIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTL  492

         *************************************************97

Domain Sequence
(FASTA)

ITLMECVGKG RYGEVWRGLW QGENVAVKIF SSRDERSWCR ETEIYNTVLL RHENILGFIA 60

SDMTSRNSST QLWLISHYHE MGSLYDYLQL TTLDSVGCLR IVLSIACGLA HLHVEIYGTQ 120

GKPAIAHRDL KSKNILVKKN GQCCIADLGL AVMHCQSTNQ LDVGNNPRVG TKRYMSPEVL 180

DEIIQVDCFD SYKRVDIWAF GLVLWEVARR TVSNGIVEDY KPPFHDVVPN DPSFEDMRKV 240

VCVDQQRPII PNRWFSDPTL TSLAKLMKEC WYQNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013