EKS-LAC-00272

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00272

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	428.0	1.4E-128	125	377	253

Status

Unreviewed

Ensembl Protein

ENSLACP00000011814

UniProt Accession

H3AQ93;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK2

Gene Synonyms/Alias

PLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000010400	ENSLACP00000011814	ENSLACT00000011904

Organism

Latimeria chalumnae

Functional Description

Protein Length

731

Protein Sequence
(FASTA)

MRLIRTSAGC EAVRVAVYKR RQLNYRLVDD GCRLVFEVAV FKYLWLERIG GKNKKRKRKT 60

KEKKEEVVMD ILRTIAYQPP NGSVKVCEQA LTKTGELKRK KSEDQSHSVP EMSRIITDPT 120

TGKCYCRGKV LGKGGFAKCY EMTDLTTNKV YAAKIIPHTR VAKPHQREKI DREIELHRIL 180

HHRHIVQFYH YFEDKENIYI LLEYCSRRSM AHILKARKIL TEPEVRYYLK QIVSGLKYLH 240

EQEILHRDLK LGNFFINETM DVKVGDFGLA AKLEPLEQRR RTICGTPNYL SPEVLNKQGH 300

GCESDIWALG CVMYTMLLGR PPFETTNLKE TYRCIREARY TMPSSLTATA KHLIASMLSK 360

NPEDRPSLED IVQHDFFTQG FIPDRLSPSC CHSAPDFHLS SPAKNFFKKA AAALFGSKKE 420

KNKYLDNQSK LAKEEDDFYR LRHDLKKISI SHQAHKHRAA EEVQMVKTQV APVCKSGLVV 480

KDNAQQIRDS IRMIVRGTLG SCSSSSECLE DSTMGSVADT VARVLRGCLE NMPEVDSIPK 540

EQMSSSFQWV TKWVDYSNKY GFGYQLSDHT VGVLFNNGTH MSLLQDKKTV HYYAELGQCS 600

VFSTSEAPEH FISQVTVLKY FAHYMEENLM DGGDLPSVTD TRKPRLYLLQ WLKSDRALMM 660

LFNDGTFQVN FYHDHTKIII CNENEEYLLT YINEDRIATT FCLATLLISG CSTELRNRME 720

YALNMLLQRC N 731

Nucleotide Sequence
(FASTA)

ATGCGGCTGA TCAGAACGTC AGCGGGTTGC GAGGCGGTGC GCGTGGCGGT GTATAAAAGG 60

CGGCAGCTCA ACTACCGGTT GGTAGACGAC GGCTGTCGGT TGGTGTTTGA GGTGGCTGTT 120

TTTAAGTACC TTTGGCTGGA GAGAATAGGG GGGAAAAACA AGAAAAGAAA ACGCAAAACA 180

AAAGAAAAGA AAGAGGAGGT GGTTATGGAT ATACTGAGGA CTATCGCTTA TCAACCGCCG 240

AATGGTAGCG TGAAAGTGTG TGAGCAGGCG CTCACCAAAA CGGGCGAGCT GAAGCGAAAG 300

AAGTCAGAGG ACCAGAGCCA CTCGGTGCCC GAGATGTCGA GGATCATAAC CGATCCGACC 360

ACAGGGAAAT GTTACTGCAG AGGGAAGGTG TTAGGAAAGG GAGGATTTGC CAAATGTTAC 420

GAGATGACGG ACTTGACCAC CAACAAAGTA TATGCTGCAA AAATTATTCC TCATACCAGA 480

GTAGCCAAAC CTCACCAAAG GGAAAAGATC GACAGAGAAA TTGAGCTGCA CAGAATCCTT 540

CATCACAGGC ACATCGTTCA GTTCTATCAC TATTTTGAAG ATAAGGAGAA TATTTATATC 600

CTCTTGGAGT ACTGCAGTAG GAGATCGATG GCACACATCT TGAAGGCGAG GAAGATACTG 660

ACTGAACCAG AAGTGCGATA TTATCTTAAA CAGATAGTGT CTGGGCTGAA ATATCTCCAC 720

GAACAAGAAA TACTCCATAG AGACCTCAAA CTAGGTAATT TCTTTATCAA TGAAACCATG 780

GATGTTAAAG TAGGAGATTT TGGGTTGGCA GCAAAATTAG AACCATTGGA GCAGAGAAGA 840

AGAACTATCT GTGGCACACC AAATTACCTT TCCCCAGAGG TTCTCAACAA ACAAGGACAT 900

GGCTGCGAGT CGGATATCTG GGCTTTGGGG TGTGTTATGT ATACCATGCT GTTGGGAAGA 960

CCTCCATTTG AGACCACAAA CTTAAAGGAA ACTTATAGGT GTATAAGAGA AGCAAGATAC 1020

ACAATGCCTT CTTCACTCAC AGCCACTGCA AAGCACTTAA TAGCAAGCAT GTTATCAAAA 1080

AATCCAGAGG ATCGTCCCAG CTTAGAGGAT ATTGTTCAAC ATGACTTCTT CACACAGGGT 1140

TTCATACCAG ACAGACTTTC TCCCAGCTGT TGTCATTCTG CTCCTGATTT TCATTTGTCA 1200

AGTCCTGCCA AGAACTTCTT TAAGAAAGCA GCTGCAGCCT TATTCGGCAG TAAAAAGGAA 1260

AAGAACAAAT ATTTGGATAA TCAGAGTAAA CTAGCCAAAG AAGAAGACGA TTTCTACAGG 1320

CTTAGACATG ATCTGAAAAA GATTTCCATT AGCCATCAGG CTCACAAGCA CAGAGCAGCA 1380

GAGGAAGTGC AGATGGTAAA GACGCAAGTT GCACCAGTTT GTAAATCTGG CTTGGTGGTG 1440

AAAGATAATG CACAACAGAT CCGGGACTCC ATTCGAATGA TAGTGAGGGG AACGCTTGGA 1500

AGCTGCAGTA GTAGTAGTGA ATGCCTTGAA GACAGTACTA TGGGAAGCGT TGCAGACACA 1560

GTGGCAAGAG TGTTGAGGGG CTGCCTAGAA AATATGCCTG AAGTGGACAG TATTCCAAAA 1620

GAACAGATGA GCAGTTCCTT CCAGTGGGTT ACAAAATGGG TGGACTACTC GAACAAATAT 1680

GGCTTTGGTT ACCAGTTGTC TGACCACACA GTTGGTGTTC TCTTCAATAA TGGGACTCAC 1740

ATGAGCCTGC TGCAAGACAA AAAAACTGTT CATTACTATG CTGAACTTGG TCAATGCTCT 1800

GTTTTCTCAA CATCTGAAGC CCCTGAGCAC TTCATCAGCC AAGTAACAGT TCTTAAGTAT 1860

TTTGCACACT ACATGGAGGA GAATTTGATG GATGGAGGTG ATCTGCCCAG TGTAACAGAC 1920

ACCCGGAAAC CCAGACTCTA CCTCCTTCAG TGGCTAAAAT CTGACCGGGC CTTAATGATG 1980

CTTTTCAATG ATGGCACATT CCAGGTTAAC TTTTACCATG ATCACACAAA AATTATTATT 2040

TGCAATGAAA ATGAAGAATA CCTGCTGACT TACATTAATG AAGATAGGAT TGCAACAACA 2100

TTTTGTCTGG CCACCTTATT GATATCTGGC TGCTCAACAG AGCTAAGAAA CCGAATGGAG 2160

TATGCCTTGA ACATGCTATT GCAAAGATGT AATTGA 2196

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y+rgk+lGkGgfakcye++dl+t++v+a+k++p++++ak++qrek+++eie+hr l+h++

Q: 125   YCRGKVLGKGGFAKCYEMTDLTTNKVYAAKIIPHTRVAKPHQREKIDREIELHRILHHRH  184

         99**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         iv++y++fedken+y++le+csrrs+a++lk+rk ltepevryyl+qivsglkylhe++i

Q: 185   IVQFYHYFEDKENIYILLEYCSRRSMAHILKARKILTEPEVRYYLKQIVSGLKYLHEQEI  244

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+ne+++vk+gdfGla++le+ e+r++t+cGtPny++Pevl+k+gh++e+

Q: 245   LHRDLKLGNFFINETMDVKVGDFGLAAKLEPLEQRRRTICGTPNYLSPEVLNKQGHGCES  304

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         diW+lGc++yt+l+G+PPfet++lkety++i++a+y++Pssl+++ak+lia++l+k+Pe+

Q: 305   DIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLTATAKHLIASMLSKNPED  364

         ************************************************************

S: 241   rpsleevlkdefl  253

         rpsle++++++f+

Q: 365   RPSLEDIVQHDFF  377

         ************8

Domain Sequence
(FASTA)

YCRGKVLGKG GFAKCYEMTD LTTNKVYAAK IIPHTRVAKP HQREKIDREI ELHRILHHRH 60

IVQFYHYFED KENIYILLEY CSRRSMAHIL KARKILTEPE VRYYLKQIVS GLKYLHEQEI 120

LHRDLKLGNF FINETMDVKV GDFGLAAKLE PLEQRRRTIC GTPNYLSPEV LNKQGHGCES 180

DIWALGCVMY TMLLGRPPFE TTNLKETYRC IREARYTMPS SLTATAKHLI ASMLSKNPED 240

RPSLEDIVQH DFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013