EKS-LAC-00337
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-LAC-00337
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20294.67.3E-881210210
StatusUnreviewed
Ensembl ProteinENSLACP00000011822
UniProt AccessionH3AQA0;
Protein NameMitogen-activated protein kinase kinase kinase kinase
Protein Synonyms/Alias
Gene NameMAP4K3
Gene Synonyms/Alias MAP4K3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSLACG00000010406ENSLACP00000011822ENSLACT00000011912
ENSLACG00000010406ENSLACP00000011821ENSLACT00000011911
OrganismLatimeria chalumnae
Functional Description
Protein Length831
Protein Sequence
(FASTA)
MMKDCKHPNI VAYFGSYLRR DKLWICMEFC GGGSLQDIYH VTGPLLEHQI AYVCRETLQG 60
LNYLHIKGKM HRDIKGANIL LTDNGHVKLA DFGVSAQITA TIAKRKSFIG TPYWMAPEVA 120
AVERKGGYNQ LCDIWAVGIT AIELAELQPP MFDLHPMRAL FLMTKSNFQP PRLKDKLKWS 180
TNFQHFVKVA LTKNPKKRPT AEKILQHPFV SQPLSRTLAI ELLEKVNNPD HCSYHEFDDD 240
DPEPPVPVPH RIHSTSRNVR EEKTRSEINF GQVKFDPPLR KETEPHHEIL DSDDILDSSE 300
EIYYTARSNL DLQFEYGQGP QSSYFFGGNK SLLKSVEEEL HQRGHVAHLE DDDGGEYDET 360
KHATIKSKVP PPLPPKPKSV YIPEESQGTI KRCPTSESPA RPISQVPPRP PPPRLPPHKP 420
SILGNGVGST QINGEKDISP YQQQQGENRS SNPPGLPPRK EKKELPKPIS NGLPPTPKVH 480
MGACFSKVFN GCPLKIHCAT SWINPDTRDQ YLIFGAEEGI YTLNLNELHE TSMEQLFPRR 540
CTWLYVMNNS LLSISGKASQ LYSHNLAGLF EYARQMQKLP VAIPTHKLPD RILPRKFAVS 600
TKIPETKGCQ RCCVVRNPYT GLKYLCGALQ YSIVLLEWVE QMQKFMLIKN IDFPLPCPLT 660
VFEMLVVPEQ EYPLLCVGVT KGTELNQVVK FETINPSSTS SWFTDTDTSQ TSVIHITQLE 720
RDTILVCLDR CIKIVNLQGR LKSSRKLSSE LTFNFQIESI VCLQDSVLAF WRHGMQGRSF 780
KSNEITQEIS DNSRMFRLLG SDRVVVLESR PTDNPTANSN LYTLAGHENS Y 831
Nucleotide Sequence
(FASTA)
ATGATGAAAG ACTGTAAGCA TCCAAACATT GTGGCATATT TTGGCAGTTA TCTCAGGCGT 60
GATAAATTAT GGATTTGTAT GGAATTTTGT GGAGGCGGGT CCTTGCAAGA TATTTATCAT 120
GTGACTGGAC CGCTTTTAGA ACACCAAATA GCATATGTTT GCAGAGAAAC GCTCCAGGGT 180
TTGAATTATC TACACATTAA AGGAAAAATG CACAGAGACA TAAAGGGTGC TAATATTCTT 240
CTAACAGATA ATGGCCATGT GAAATTAGCT GACTTTGGAG TATCGGCACA GATAACTGCG 300
ACAATTGCAA AAAGGAAGTC TTTCATCGGT ACACCTTACT GGATGGCTCC AGAAGTAGCT 360
GCAGTGGAGA GGAAGGGTGG ATATAACCAG CTGTGTGATA TTTGGGCAGT AGGTATAACC 420
GCTATAGAGC TGGCAGAGCT TCAGCCTCCT ATGTTCGACT TGCATCCCAT GAGGGCTTTA 480
TTTTTAATGA CAAAAAGCAA CTTCCAGCCT CCCCGGTTGA AAGACAAATT GAAATGGTCA 540
ACCAATTTCC AACATTTTGT TAAAGTGGCA CTTACGAAAA ACCCCAAGAA AAGGCCTACA 600
GCTGAGAAAA TATTGCAGCA TCCCTTCGTA TCACAGCCTT TGAGCCGAAC ACTCGCTATT 660
GAATTGTTGG AAAAAGTCAA CAATCCTGAT CACTGCAGTT ACCATGAGTT TGATGATGAT 720
GACCCTGAGC CTCCTGTACC TGTACCTCAC AGAATTCACT CAACAAGCCG AAATGTTAGA 780
GAAGAGAAGA CACGTTCTGA GATCAATTTT GGTCAAGTAA AATTTGATCC ACCCTTGAGG 840
AAGGAAACAG AACCACATCA TGAGATTCTC GACAGTGATG ATATTTTGGA CAGTTCAGAA 900
GAAATATACT ACACTGCAAG ATCTAATCTG GATTTACAGT TCGAATATGG ACAAGGACCC 960
CAGAGCAGTT ATTTCTTTGG TGGAAACAAG AGTCTTCTAA AATCAGTTGA AGAAGAACTG 1020
CATCAGCGGG GACATGTGGC ACATTTAGAG GATGATGATG GTGGTGAATA TGATGAAACT 1080
AAACACGCGA CCATAAAATC TAAAGTACCA CCTCCTCTTC CACCAAAACC TAAATCCGTC 1140
TACATACCGG AAGAAAGCCA GGGAACAATC AAGAGGTGTC CCACATCAGA AAGTCCTGCG 1200
AGACCTATTT CACAAGTTCC GCCTCGACCC CCTCCTCCCC GGCTACCCCC ACACAAGCCC 1260
AGCATCTTAG GTAATGGAGT GGGTTCTACC CAGATAAATG GCGAAAAGGA CATTTCTCCA 1320
TATCAACAGC AGCAGGGGGA AAACCGAAGT AGCAATCCTC CCGGCCTTCC TCCCAGGAAA 1380
GAAAAGAAGG AACTGCCAAA GCCAATTAGC AATGGCCTTC CTCCAACTCC AAAAGTACAT 1440
ATGGGGGCTT GCTTTTCAAA GGTCTTCAAT GGATGTCCAT TAAAAATTCA TTGTGCCACA 1500
TCATGGATTA ATCCAGACAC TAGAGATCAG TATCTAATAT TTGGTGCTGA AGAAGGTATT 1560
TATACCTTAA ATCTAAATGA GCTACACGAA ACATCAATGG AACAGCTTTT TCCACGAAGA 1620
TGCACATGGC TATATGTAAT GAACAATTCA TTGTTATCAA TATCTGGGAA AGCGTCTCAG 1680
CTTTATTCCC ATAATTTGGC AGGATTATTT GAGTATGCTA GACAAATGCA AAAGTTGCCT 1740
GTTGCCATTC CCACACATAA GCTTCCAGAT AGGATTCTTC CCAGGAAATT TGCAGTATCT 1800
ACTAAAATTC CTGAAACAAA AGGCTGCCAA AGGTGTTGTG TTGTGAGGAA TCCTTACACA 1860
GGACTCAAGT ACCTTTGTGG GGCATTGCAG TACAGCATTG TTTTGCTAGA GTGGGTAGAA 1920
CAAATGCAGA AATTCATGTT AATCAAAAAC ATAGATTTTC CTCTGCCTTG TCCGCTTACA 1980
GTGTTTGAAA TGTTAGTCGT TCCGGAGCAG GAGTACCCTT TGTTGTGTGT GGGTGTGACT 2040
AAAGGAACAG AACTGAACCA GGTGGTCAAG TTTGAGACCA TCAACCCCAG CTCTACCTCA 2100
TCATGGTTTA CAGACACAGA TACATCACAA ACGAGTGTCA TCCACATAAC ACAGCTGGAG 2160
AGAGACACCA TTCTAGTCTG TCTAGACCGC TGCATAAAAA TAGTAAACCT ACAAGGTCGA 2220
TTGAAGTCCA GCAGAAAATT GTCATCAGAG CTTACATTCA ATTTTCAGAT TGAGTCTATA 2280
GTTTGTCTAC AAGATAGTGT GCTGGCTTTC TGGAGACATG GAATGCAAGG AAGAAGTTTC 2340
AAGTCAAATG AGATCACACA AGAAATTTCA GATAATTCGA GAATGTTCCG ACTCCTTGGT 2400
TCTGACAGAG TGGTGGTTTT AGAAAGCAGG CCAACAGACA ACCCTACTGC CAATAGCAAT 2460
TTATATACCT TGGCGGGCCA TGAAAACAGC TACTGA 2496
Domain Profile
S: 49    vlkklkhpniveylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevl  108
         ++k++khpniv+y++s+l++++lw++me++ gGsl+d+++  ++ +l E+qiay++re+l
Q: 1     MMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYH--VTGPLLEHQIAYVCRETL  58
         69**************************************..******************
S: 109   kaLeylHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPE  168
         ++L+ylH k+++Hrdik++niLlt++g+VkL+dfgv+aq+++t +krk+++gtpywmAPE
Q: 59    QGLNYLHIKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPE  118
         ************************************************************
S: 169   viaqe.ekgYdekaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkk  225
         v a+e + gY++ +Diw++GItaielae +pP++dl+p++al++++k++  pp+lk+k k
Q: 119   VAAVErKGGYNQLCDIWAVGITAIELAELQPPMFDLHPMRALFLMTKSNfqPPRLKDKLK  178
         ****98889*********************************999999888*********
S: 226   fskefkefvekclqknpekRpsasellkhkFl  257
         +s++f++fv+ +l+knp+kRp+a+++l+h+F+
Q: 179   WSTNFQHFVKVALTKNPKKRPTAEKILQHPFV  210
         *******************************7
Domain Sequence
(FASTA)
MMKDCKHPNI VAYFGSYLRR DKLWICMEFC GGGSLQDIYH VTGPLLEHQI AYVCRETLQG 60
LNYLHIKGKM HRDIKGANIL LTDNGHVKLA DFGVSAQITA TIAKRKSFIG TPYWMAPEVA 120
AVERKGGYNQ LCDIWAVGIT AIELAELQPP MFDLHPMRAL FLMTKSNFQP PRLKDKLKWS 180
TNFQHFVKVA LTKNPKKRPT AEKILQHPFV 210
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00314
EKS-ANC-00316
EKS-BOT-00314
EKS-CAJ-00322
EKS-CAF-00317
EKS-CAP-00370
EKS-DAR-00677
EKS-DIO-00040
EKS-EQC-00314
EKS-FEC-00310
EKS-GAG-00265
EKS-GAA-00395
EKS-GOG-00311
EKS-HOS-00323
EKS-ICT-00315
EKS-LOA-00323
EKS-MAM-00317
EKS-MEG-00270
EKS-MOD-00308
EKS-MUM-00349
EKS-MUP-00330
EKS-MYL-00322
EKS-NOL-00289
EKS-ORN-00417
EKS-ORA-00283
EKS-ORC-00316
EKS-ORL-00400
EKS-OTG-00337
EKS-PAT-00299
EKS-PES-00285
EKS-PEM-00174
EKS-POA-00305
EKS-RAN-00333
EKS-SAH-00307
EKS-TAG-00329
EKS-TAR-00419
EKS-TEN-00413
EKS-VIP-00037
EKS-XET-00383
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR021160; MAPKKKK.
IPR000719; Prot_kinase_cat_dom.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
Prosites
PS50219; CNH; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013