EKS-LAC-00327

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-LAC-00327

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	344.0	6.5E-103	21	277	257

Status

Unreviewed

Ensembl Protein

ENSLACP00000012421

UniProt Accession

H3AS00;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

MAP4K5

Gene Synonyms/Alias

MAP4K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSLACG00000010941	ENSLACP00000012421	ENSLACT00000012514

Organism

Latimeria chalumnae

Functional Description

Protein Length

847

Protein Sequence
(FASTA)

MDALSRPTGD ILRRNPQQDL ELIQRVGSGT YGDVYKARNL QTGELAAVKI IKLEPGDDFS 60

VIQQEIFMVK ECKHPNIVAY FGSYLSREKL WICMEYCGGG SLQDIYHVTG PLSELQIAYV 120

CKETLQGLAY LHSKGKMHRD IKGANILLTD HGDVKLADFG VAAKITATIA KRKSFIGTPY 180

WMAPEVAAVE KNGGYNQLCD IWAVGITAIE LAELQPPMFD LHPMRALFLM SKSNFQSPKL 240

KEKTKWTSPF HNFVKVSLTK NPKKRPTAEK LLTHSFMVQP GLVRALAVEL LDKVNNPDNH 300

QHYSELDDDD IEPLSVVRHT IRSTNKESRA ERTRSEINFD KVQFEPPLRK ETEAHSEMGL 360

VTNGSFCLYW GFFLGGGGKG KRATLKRAGP PPLPPKPRIN SSLEDLSPEE ERSQIAGHHS 420

DFEIGAPQLQ RRQSTPGSLH KTESSPLGTA EALSNLNGEN TGGGLEQPPV IPRRKEKREF 480

PKPIINGLPP TPKVLMGACF SKVFDGCPLK INCATSWIHP DTKDQYLIFG TEDGIYTLNL 540

NELHEATMEQ LFPRRCTWLY VINNTLMSLS GKTFQLYSHN LIGLFEQARK PGLAAHIQTH 600

RFPDRILPRR FALTMKIPDT KGCHKCCIVR NPYTGHKYLC GALQSGIVLL QWYEPMQKFM 660

LIKHFDFPLP NPLKVFEMLV IPEQEYPMVC VAISKGSEST QVVRFETINL NSSSSWFTEI 720

GSGTQQLDAI HVTQLERDTV LVCMDKNVKI VNLQGKLKSS KKLASELSFD FGIESVVCLQ 780

DSVLAFWKHG MQGKSFKSNE VTQEISDQSR VFRLLGSDRV VVLESRPTDH PTAHSNLYIL 840

AGHENSY 847

Nucleotide Sequence
(FASTA)

ATGGACGCCC TGTCCCGTCC GACCGGGGAC ATCCTGCGGA GGAACCCGCA GCAGGATTTG 60

GAGCTGATCC AGAGGGTTGG CAGCGGCACC TATGGAGATG TCTATAAGGC AAGAAATCTA 120

CAAACAGGGG AGCTGGCTGC AGTTAAAATA ATTAAGTTAG AGCCAGGAGA TGACTTTTCT 180

GTTATACAGC AAGAAATTTT TATGGTGAAA GAATGCAAGC ATCCCAACAT TGTAGCTTAC 240

TTTGGGAGTT ATCTCAGTCG TGAGAAGCTG TGGATCTGTA TGGAATACTG TGGAGGTGGA 300

TCTTTACAAG ATATATACCA TGTAACTGGA CCATTGTCGG AATTGCAAAT TGCTTACGTG 360

TGCAAGGAAA CATTACAGGG TCTTGCATAT TTACATAGCA AGGGTAAAAT GCACAGAGAC 420

ATAAAGGGTG CAAATATTCT GCTGACAGAC CATGGTGATG TAAAATTGGC TGACTTTGGT 480

GTTGCAGCTA AAATAACAGC TACTATTGCA AAGAGGAAGT CTTTTATTGG CACACCTTAT 540

TGGATGGCTC CAGAAGTTGC TGCAGTTGAA AAGAATGGAG GTTATAACCA GCTCTGTGAT 600

ATCTGGGCAG TAGGCATTAC TGCCATTGAG CTTGCAGAAT TACAGCCACC TATGTTTGAT 660

TTGCATCCAA TGAGGGCATT GTTTTTAATG TCAAAAAGTA ACTTTCAGTC ACCAAAGCTG 720

AAGGAAAAAA CGAAATGGAC TTCACCATTC CACAACTTTG TCAAAGTTTC TCTAACAAAA 780

AACCCAAAGA AAAGACCAAC TGCAGAGAAA CTACTAACTC ATTCTTTTAT GGTCCAGCCT 840

GGTCTTGTCC GAGCATTGGC AGTTGAACTG TTAGATAAAG TTAATAATCC AGACAATCAC 900

CAGCATTACA GTGAACTGGA TGATGATGAC ATTGAACCCC TCTCTGTTGT TCGTCACACA 960

ATTCGTTCCA CTAACAAGGA ATCAAGAGCA GAACGCACAC GCTCGGAGAT TAACTTTGAT 1020

AAGGTCCAAT TTGAACCCCC TCTACGGAAG GAAACTGAAG CTCACAGTGA AATGGGATTG 1080

GTAACAAATG GAAGTTTTTG TTTGTATTGG GGATTTTTTT TGGGGGGGGG AGGCAAGGGG 1140

AAGAGAGCGA CTTTAAAGCG AGCAGGGCCA CCTCCTCTAC CTCCTAAGCC AAGGATAAAC 1200

AGCAGCTTAG AAGATCTCTC TCCAGAAGAA GAGAGATCTC AGATTGCCGG ACACCATTCA 1260

GATTTTGAAA TCGGAGCACC CCAATTGCAA AGGAGACAAA GTACTCCAGG CTCACTGCAT 1320

AAGACTGAAT CTTCTCCTCT AGGGACTGCA GAAGCCCTCT CAAACTTAAA TGGAGAAAAT 1380

ACAGGAGGAG GATTGGAACA GCCACCAGTA ATACCACGTA GAAAAGAAAA GAGGGAATTC 1440

CCTAAGCCAA TAATTAATGG CCTTCCCCCT ACACCAAAGG TTTTAATGGG AGCCTGCTTT 1500

TCAAAAGTAT TTGATGGGTG TCCCTTGAAA ATTAACTGTG CAACATCTTG GATACATCCT 1560

GATACCAAAG ATCAATACTT AATCTTTGGG ACTGAAGATG GTATTTATAC TTTAAACCTA 1620

AATGAACTCC ATGAGGCTAC TATGGAACAG CTATTTCCAA GGAGATGCAC ATGGCTGTAT 1680

GTGATTAATA ATACATTAAT GTCATTATCA GGAAAAACAT TCCAACTTTA TTCACACAAC 1740

TTGATTGGTT TGTTTGAACA AGCTAGAAAG CCTGGATTGG CTGCTCACAT TCAAACACAC 1800

AGATTTCCTG ACAGGATATT ACCCAGGAGG TTTGCATTAA CAATGAAAAT TCCTGATACA 1860

AAAGGCTGTC ACAAATGCTG TATAGTGAGA AATCCATACA CAGGACATAA GTACCTTTGT 1920

GGGGCACTGC AGTCTGGTAT TGTCCTCCTC CAGTGGTATG AGCCAATGCA GAAATTCATG 1980

TTAATAAAGC ACTTTGATTT TCCTCTGCCA AACCCTCTCA AAGTGTTTGA GATGCTTGTG 2040

ATACCAGAGC AGGAATACCC AATGGTTTGT GTAGCCATAA GTAAGGGCAG CGAATCCACT 2100

CAGGTTGTCC GTTTCGAAAC AATTAACTTA AACTCCTCTT CTTCCTGGTT TACAGAGATA 2160

GGGTCAGGAA CTCAACAGTT AGATGCCATT CATGTAACCC AACTAGAGAG AGACACAGTG 2220

CTGGTTTGCA TGGATAAAAA TGTAAAGATC GTCAATCTAC AAGGAAAACT GAAATCAAGT 2280

AAAAAGCTGG CATCTGAGCT AAGTTTTGAT TTTGGAATTG AATCTGTAGT GTGCCTTCAA 2340

GATAGTGTGT TAGCTTTCTG GAAGCATGGA ATGCAGGGAA AAAGCTTTAA GTCAAATGAA 2400

GTTACACAAG AGATTTCAGA TCAAAGCAGA GTGTTTCGTC TCTTAGGATC AGACAGGGTT 2460

GTAGTATTGG AAAGTCGACC AACAGACCAT CCTACAGCAC ACAGCAATCT CTACATTTTG 2520

GCTGGTCACG AAAACAGTTA CTAA 2544

Domain Profile

S: 2     elleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnivey  61

         el++++g+G++g+vy+ar+ +tgel+a+k+i+le  ++ + +q+ei ++k++khpniv+y

Q: 21    ELIQRVGSGTYGDVYKARNLQTGELAAVKIIKLEPGDDFSVIQQEIFMVKECKHPNIVAY  80

         7899********************************************************

S: 62    lesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviH  121

         ++s+l +e+lw++mey+ gGsl+d+++  ++ +l+E qiay+++e+l++L+ylHsk+++H

Q: 81    FGSYLSREKLWICMEYCGGGSLQDIYH--VTGPLSELQIAYVCKETLQGLAYLHSKGKMH  138

         ***************************..*******************************

S: 122   rdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYdek  180

         rdik++niLlt++g+VkL+dfgvaa++++t +krk+++gtpywmAPEv a+e + gY++

Q: 139   RDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEkNGGYNQL  198

         ***************************************************98889****

S: 181   aDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekcl  238

         +Diw++GItaielae +pP++dl+p++al++++k++  +pklk+k+k+++ f++fv+  l

Q: 199   CDIWAVGITAIELAELQPPMFDLHPMRALFLMSKSNfqSPKLKEKTKWTSPFHNFVKVSL  258

         *******************************99999889*********************

S: 239   qknpekRpsasellkhkFl  257

         +knp+kRp+a++ll+h+F+

Q: 259   TKNPKKRPTAEKLLTHSFM  277

         *****************96

Domain Sequence
(FASTA)

ELIQRVGSGT YGDVYKARNL QTGELAAVKI IKLEPGDDFS VIQQEIFMVK ECKHPNIVAY 60

FGSYLSREKL WICMEYCGGG SLQDIYHVTG PLSELQIAYV CKETLQGLAY LHSKGKMHRD 120

IKGANILLTD HGDVKLADFG VAAKITATIA KRKSFIGTPY WMAPEVAAVE KNGGYNQLCD 180

IWAVGITAIE LAELQPPMFD LHPMRALFLM SKSNFQSPKL KEKTKWTSPF HNFVKVSLTK 240

NPKKRPTAEK LLTHSFM 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013